An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3241-3247

  Tsoukala, Evangelia ^a   Agelis, George ^a   Dolinšek, Jan ^b   Botić, Tanja ^b   Cencič, Avrelija ^b   Komiotis, Dimitri ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY OF MARIBOR   (Slovenia)

Author keywords

3 Deoxy 3 fluoro 5 thio xylofuranose; 5 Fluorouracil; Antitumor agent; Antiviral; Nucleoside; Thymine; Uracil

Indexed keywords

1 (5 S ACETYL 3 DEOXY 3 FLUORO 5 THIO BETA DEXTRO XYLOFURANOSYL) 5 FLUOROURACIL; 1 (5 S ACETYL 3 DEOXY 3 FLUORO 5 THIO BETA DEXTRO XYLOFURANOSYL)THYMINE; 1 (5 S ACETYL 3 DEOXY 3 FLUORO 5 THIO BETA DEXTRO XYLOFURANOSYL)URACIL; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; AZATHIOPRINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG OXIDATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; SILYLATION; TUMOR CELL; TUMOR GROWTH; VIRUS INFECTION;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CACO-2 CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HUMANS; INTESTINES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOSIDES; ROTAVIRUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMINE; URACIL; XYLOSE; ZIDOVUDINE;

ROTAVIRUS;

EID: 33947699445     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.031     Document Type: Article

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