Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: A convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-β-d-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4764-4771

  Manta, Stella ^a   Tzioumaki, Niki ^a   Tsoukala, Evangelia ^a   Panagiotopoulou, Aggeliki ^b   Pelecanou, Maria ^b   Balzarini, Jan ^c   Komiotis, Dimitri ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Elimination reaction; Antitumor activity; Antiviral; Unsaturated dideoxy fluoro ketonucleosides

Indexed keywords

1 (2 O ACETYL 3 DEOXY 3 FLUORO 4,6 O ISOPROPYLIDENE BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (2 O ACETYL 3 DEOXY 3 FLUORO 4,6 O ISOPROPYLIDENE BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (2 O ACETYL 3 DEOXY 3 FLUORO 4,6 O ISOPROPYLIDENE BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2 O ACETYL 3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (2 O ACETYL 3 DEOXY 3 FLUORO 6 IODO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2 O ACETYL 3 DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (2 O ACETYL 3 DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2 O ACETYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (2 O ACETYL 3,6 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2,4,6 TRI O ACETYL DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (2,4,6 TRI O ACETYL DEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (2,6 DIDEOXY 3 FLUORO 3 BETA DEXTRO GLYCERO HEX 2 ENOPYRANOSYL 4 ULOSE)URACIL; 1 (2,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 2 ENOPYRANOSYL 4 ULOSE) 5 FLUOROURACIL; 1 (2,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 2 ENOPYRANOSYL 4 ULOSE) N 4 BENZOYL CYTOSINE; 1 (2,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 2 ENOPYRANOSYL 4 ULOSE)THYMINE; 1 (2,6 DIDEOXY 3 FLUORO BETA DEXTRO GLYCERO HEX 2 ENOPYRANOSYL 4 ULOSE)URACIL; 1 (3 DEOXY 3 FLUORO 4,6 O ISOPROPYLIDENE BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (3 DEOXY 3 FLUORO 4,6 O ISOPROPYLIDENE BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (3,4 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (3,4 DIDEOXY 3 FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; ADENINE DERIVATIVE; CYTOSINE DERIVATIVE; CYTOSTATIC AGENT; FLUOROURACIL DERIVATIVE; N 4 BENZOYL CYTOSINE; N 6 BENZOYL ADENINE; NUCLEOSIDE ANALOG; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DEACETYLATION; DEPROTECTION REACTION; DNA VIRUS; DRUG SYNTHESIS; ELIMINATION REACTION; HUMAN; HUMAN CELL; HYDROGENATION; IC 50; IODINATION; NONHUMAN; OXIDATION; POLYMERIZATION; RNA VIRUS; SILYLATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSTATIC AGENTS; HUMANS; NUCLEOSIDES; VIRUSES;

EID: 70349932131     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.013     Document Type: Article

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