Stereoselective synthesis and antiviral activity of d-2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro-4 ′-thionucleosides

Journal of Medicinal Chemistry

Volumn 45, Issue 22, 2002, Pages 4888-4898

  Chong, Youhoon ^a   Choo, Hyunah ^a   Choi, Yongseok ^a   Mathew, Judy ^b   Schinazi, Raymond F ^b   Chu, Chung K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2,3 DIDEOXY 2,3 DIDEHYDRO 2 FLUORO 4 THIO BETA DEXTRO RIBOFURANOSYL) 2 FLUOROADENOSINE; (2,3 DIDEOXY 2,3 DIDEHYDRO 2 FLUORO 4 THIO BETA DEXTRO RIBOFURANOSYL) 5 FLUOROCYTOSINE; (2,3 DIDEOXY 2,3 DIDEHYDRO 2 FLUORO 4 THIO BETA DEXTRO RIBOFURANOSYL)ADENINE; (2,3 DIDEOXY 2,3 DIDEHYDRO 2 FLUORO 4 THIO BETA DEXTRO RIBOFURANOSYL)CYTOSINE; ANTIVIRUS AGENT; LAMIVUDINE; METHIONINE; NUCLEOSIDE DERIVATIVE; SULFUR; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MONONUCLEAR CELL; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; LAMIVUDINE; LEUKOCYTES, MONONUCLEAR; MODELS, MOLECULAR; MUTATION; PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; QUANTUM THEORY; STEREOISOMERISM; ZALCITABINE;

EID: 0037168035     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020246+     Document Type: Article

References (46)

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