Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-β-d-glycero-hex-3-enopyranosyl)thymine

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5448-5456

  Agelis, George ^a   Tzioumaki, Niki ^a   Botić, Tanja ^b   Cencič, Avrelija ^b   Komiotis, Dimitri ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY OF MARIBOR   (Slovenia)

Author keywords

anti tumor activity; Antiviral; Exomethylene nucleosides; Ketonucleosides; Olefination; Unsaturated nucleosides

Indexed keywords

1 (2 DEOXY 2 METHYLENE 6 O TRITYL BETA DEXTRO LYXOHEXOPYRANOSYL)THYMINE; 1 (2 DEOXY 2 METHYLENE BETA DEXTRO LYXOHEXOPYRANOSYL)THYMINE; 1 (2,3,4 TRIDEOXY 2 METHYLENE BETA DEXTRO GLYCEROHEX 3 ENOPYRANOSYL)THYMINE; 1 (6 O TERT BUTYLDIMETHYLSILYL 3,4 O ISOPROPYLIDENE BETA DEXTRO LYXOHEXOPYRANOSYL 2 ULOSE)THYMINE; 1 (BETA DEXTRO GALACTOPYRANOSYL)THYMINE; 1 (BETA DEXTRO LYXOHEXOPYRANOSYL 2 ULOSE)THYMINE; ALKENE DERIVATIVE; ANTIVIRUS AGENT; GALACTOSE; HYDROXYL GROUP; METHYLENE PYRANONUCLEOSIDE; NUCLEOSIDE DERIVATIVE; OXONUCLEOSIDE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ACETYLATION; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; COLON CANCER; CYTOTOXICITY; DEPROTECTION REACTION; DRUG SYNTHESIS; EMBRYO; FETUS; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION; ROTAVIRUS; TRITYLATION; VIRUS INFECTION; WITTIG REACTION;

ANTIVIRAL AGENTS; CELL LINE; CELL PROLIFERATION; INHIBITORY CONCENTRATION 50; METHYLATION; MOLECULAR STRUCTURE; NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMINE;

ROTAVIRUS;

EID: 34250695046     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.055     Document Type: Article

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