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Volumn 19, Issue 2, 2010, Pages 153-159

The p38 MAPK pathway is critical for 5,5′-dibromodiindolylmethane- induced apoptosis to prevent oral squamous carcinoma cells

Author keywords

5,5 dibromodiindolylmethane; Apoptosis; Bcl 2; Human oral squamous carcinoma cells; Mitochondrial membrane potentials; P38 mitogen activated protein kinase

Indexed keywords

5,5' DIBROMODIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 76449102161     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e328333d088     Document Type: Article
Times cited : (13)

References (31)
  • 1
    • 25444449603 scopus 로고    scopus 로고
    • Molecular targets and anticancer potential of indole-3-carbinol and its derivatives
    • Aggarwal BB, Ichikawa H (2005). Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4:1201-1215.
    • (2005) Cell Cycle , vol.4 , pp. 1201-1215
    • Aggarwal, B.B.1    Ichikawa, H.2
  • 2
    • 0031737857 scopus 로고    scopus 로고
    • The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part II]
    • Broadbent TA, Broadbent HS (1998). The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part II]. Curr Med Chem 5:469-491.
    • (1998) Curr Med Chem , vol.5 , pp. 469-491
    • Broadbent, T.A.1    Broadbent, H.S.2
  • 3
    • 11344292132 scopus 로고    scopus 로고
    • The role of natural product chemistry in drug discovery
    • Butler MS (2004). The role of natural product chemistry in drug discovery. J Nat Prod 67:2141-2153.
    • (2004) J Nat Prod , vol.67 , pp. 2141-2153
    • Butler, M.S.1
  • 4
    • 17844381889 scopus 로고    scopus 로고
    • 3,30-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice
    • Chang X, Tou JC, Hong C, Kim HA, Riby JE, Firestone GL, Bjeldanes LF (2005). 3,30-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis 26:771-778.
    • (2005) Carcinogenesis , vol.26 , pp. 771-778
    • Chang, X.1    Tou, J.C.2    Hong, C.3    Kim, H.A.4    Riby, J.E.5    Firestone, G.L.6    Bjeldanes, L.F.7
  • 5
    • 0031715037 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptormediated antiestrogenic and antitumorigenic activity of diindolylmethane
    • Chen I, McDougal A, Wang F, Safe S (1998). Aryl hydrocarbon receptormediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 19:1631-1639.
    • (1998) Carcinogenesis , vol.19 , pp. 1631-1639
    • Chen, I.1    McDougal, A.2    Wang, F.3    Safe, S.4
  • 6
    • 30044435268 scopus 로고    scopus 로고
    • Critical role of the c-JunNH2-terminal kinase and p38 mitogen-activated protein kinase pathways on sodium butyrate-induced apoptosis in DU145 human prostate cancer cells
    • Cho SD, Ahn NS, Jung JW, Yang SR, Park JS, Lee YS, et al. (2006). Critical role of the c-JunNH2-terminal kinase and p38 mitogen-activated protein kinase pathways on sodium butyrate-induced apoptosis in DU145 human prostate cancer cells. Eur J Cancer Prev 15:57-63.
    • (2006) Eur J Cancer Prev , vol.15 , pp. 57-63
    • Cho, S.D.1    Ahn, N.S.2    Jung, J.W.3    Yang, S.R.4    Park, J.S.5    Lee, Y.S.6
  • 7
    • 51049100003 scopus 로고    scopus 로고
    • 5,50-Dibromo-bis(30-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells
    • Cho SD, Chintharlapalli S, Abdelrahim M, Papineni S, Liu S, Guo J, et al. (2008). 5,50-Dibromo-bis(30-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. Mol Cancer Ther 7:2109-2120.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2109-2120
    • Cho, S.D.1    Chintharlapalli, S.2    Abdelrahim, M.3    Papineni, S.4    Liu, S.5    Guo, J.6
  • 8
    • 33646428633 scopus 로고    scopus 로고
    • 3,30-Diindolylmethane is a novel mitochondrial H( + )-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells
    • Gong Y, Sohn H, Xue L, Firestone GL, Bjeldanes LF (2006). 3,30-Diindolylmethane is a novel mitochondrial H( + )-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Cancer Res 66:4880-4887.
    • (2006) Cancer Res , vol.66 , pp. 4880-4887
    • Gong, Y.1    Sohn, H.2    Xue, L.3    Firestone, G.L.4    Bjeldanes, L.F.5
  • 9
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC (1998). Mitochondria and apoptosis. Science 281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 11
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO (2000). The biochemistry of apoptosis. Nature 407:770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 12
    • 37349028270 scopus 로고    scopus 로고
    • Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells
    • Jo EH, Kim SH, Ahn NS, Park JS, Hwang JW, Lee YS, Kang KS (2007). Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells. Eur J Cancer Prev 16:505-510.
    • (2007) Eur J Cancer Prev , vol.16 , pp. 505-510
    • Jo, E.H.1    Kim, S.H.2    Ahn, N.S.3    Park, J.S.4    Hwang, J.W.5    Lee, Y.S.6    Kang, K.S.7
  • 13
    • 0034235663 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells
    • Kikuchi M, Tenneti L, Lipton SA (2000). Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells. J Neurosci 20:5037-5044.
    • (2000) J Neurosci , vol.20 , pp. 5037-5044
    • Kikuchi, M.1    Tenneti, L.2    Lipton, S.A.3
  • 14
    • 40849145457 scopus 로고    scopus 로고
    • Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes
    • Kim BM, Chung HW (2008). Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes. Toxicol Appl Pharmacol 228:24-31.
    • (2008) Toxicol Appl Pharmacol , vol.228 , pp. 24-31
    • Kim, B.M.1    Chung, H.W.2
  • 15
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997). The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 16
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • Koehn FE, Carter GT (2005). The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4:206-220.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 17
    • 12844260806 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3,30-diindolylmethane induce expression of NAG-1 in a p53-independent manner
    • Lee SH, Kim JS, Yamaguchi K, Eling TE, Baek SJ (2005). Indole-3-carbinol and 3,30-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem Biophys Res Commun 328:63-69.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 63-69
    • Lee, S.H.1    Kim, J.S.2    Yamaguchi, K.3    Eling, T.E.4    Baek, S.J.5
  • 18
    • 0034646769 scopus 로고    scopus 로고
    • Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane
    • McDougal A, Sethi Gupta M, Ramamoorthy K, Sun G, Safe SH (2000). Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Lett 151:169-179.
    • (2000) Cancer Lett , vol.151 , pp. 169-179
    • McDougal, A.1    Sethi Gupta, M.2    Ramamoorthy, K.3    Sun, G.4    Safe, S.H.5
  • 19
    • 0035016018 scopus 로고    scopus 로고
    • Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats
    • McDougal A, Gupta MS, Morrow D, Ramamoorthy K, Lee JE, Safe SH (2001). Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. Breast Cancer Res Treat 66:147-157.
    • (2001) Breast Cancer Res Treat , vol.66 , pp. 147-157
    • McDougal, A.1    Gupta, M.S.2    Morrow, D.3    Ramamoorthy, K.4    Lee, J.E.5    Safe, S.H.6
  • 20
    • 0038402729 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3,30-diindolylmethane induce apoptosis in human prostate cancer cells
    • Nachshon-Kedmi M, Yannai S, Haj A, Fares FA (2003). Indole-3-carbinol and 3,30 -diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol 41:745-752.
    • (2003) Food Chem Toxicol , vol.41 , pp. 745-752
    • Nachshon-Kedmi, M.1    Yannai, S.2    Haj, A.3    Fares, F.A.4
  • 21
    • 6944231023 scopus 로고    scopus 로고
    • Induction of apoptosis in human prostate cancer cell line, PC3, by 3,30-diindolylmethane through the mitochondrial pathway
    • Nachshon-Kedmi M, Yannai S, Fares FA (2004). Induction of apoptosis in human prostate cancer cell line, PC3, by 3,30-diindolylmethane through the mitochondrial pathway. Br J Cancer 91:1358-1363.
    • (2004) Br J Cancer , vol.91 , pp. 1358-1363
    • Nachshon-Kedmi, M.1    Yannai, S.2    Fares, F.A.3
  • 22
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman DJ, Cragg GM, Snader KM (2003). Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66:1022-1037.
    • (2003) J Nat Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 23
    • 0027892169 scopus 로고
    • Ascorbigen and other indole-derived compounds from Brassica vegetables and their analogs as anticarcinogenic and immunomodulating agents
    • Preobrazhenskaya MN, Bukhman VM, Korolev AM, Efimov SA (1993). Ascorbigen and other indole-derived compounds from Brassica vegetables and their analogs as anticarcinogenic and immunomodulating agents. Pharmacol Ther 60:301-313.
    • (1993) Pharmacol Ther , vol.60 , pp. 301-313
    • Preobrazhenskaya, M.N.1    Bukhman, V.M.2    Korolev, A.M.3    Efimov, S.A.4
  • 24
    • 0037971286 scopus 로고    scopus 로고
    • Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
    • Rahman KM, Aranha O, Sarkar FH (2003). Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. Nutr Cancer 45:101-112.
    • (2003) Nutr Cancer , vol.45 , pp. 101-112
    • Rahman, K.M.1    Aranha, O.2    Sarkar, F.H.3
  • 25
    • 3042642131 scopus 로고    scopus 로고
    • Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells
    • Rahman KM, Li Y, Sarkar FH (2004). Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr Cancer 48:84-94.
    • (2004) Nutr Cancer , vol.48 , pp. 84-94
    • Rahman, K.M.1    Li, Y.2    Sarkar, F.H.3
  • 27
    • 1842529307 scopus 로고    scopus 로고
    • Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2
    • Tikhomirov O, Carpenter G (2004). Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. J Biol Chem 279:12988-12996.
    • (2004) J Biol Chem , vol.279 , pp. 12988-12996
    • Tikhomirov, O.1    Carpenter, G.2
  • 28
    • 33746400238 scopus 로고    scopus 로고
    • Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(30-indolyl)methane (DIM) and 5,50-dibromoDIM
    • Vanderlaag K, Samudio I, Burghardt R, Barhoumi R, Safe S (2006). Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(30-indolyl)methane (DIM) and 5,50-dibromoDIM. Cancer Lett 236:198-212.
    • (2006) Cancer Lett , vol.236 , pp. 198-212
    • Vanderlaag, K.1    Samudio, I.2    Burghardt, R.3    Barhoumi, R.4    Safe, S.5
  • 30
    • 16444364134 scopus 로고    scopus 로고
    • DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways
    • Xue L, Firestone GL, Bjeldanes LF (2005). DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. Oncogene 24:2343-2353.
    • (2005) Oncogene , vol.24 , pp. 2343-2353
    • Xue, L.1    Firestone, G.L.2    Bjeldanes, L.F.3
  • 31
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, et al. (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5    Cai, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.