IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal

Journal of Leukocyte Biology

Volumn 76, Issue 5, 2004, Pages 1019-1027

  Wynes, Murry W ^a,b   Frankel, Stephen K ^a,b   Riches, David W H ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cytokines; Gene regulation; Lung; Monocytes macrophages

Indexed keywords

COLLAGEN; CYTOKINE; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; INTERLEUKIN 13; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; DISEASE SEVERITY; GENE CONTROL; LUNG FIBROSIS; LUNG PARENCHYMA; MACROPHAGE; MOUSE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TH2 CELL;

ANIMALS; APOPTOSIS; CELL COMMUNICATION; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; FIBROBLASTS; GROWTH SUBSTANCES; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-4; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C3H; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY FIBROSIS; TH2 CELLS;

ANIMALIA;

EID: 7644234027     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0504288     Document Type: Article

References (54)

1. Thannickal, V. J., Toews, G. B., White, E. S., Lynch III, J. P., Martinez, F. J. (2004) Mechanisms of pulmonary fibrosis. Annu. Rev. Med. 55, 395-417.
2. Riches, D. W. H., Worthen, G. S., Augustin, A., Lapadat, R., Chan, E. D. (2003) Inflammation in the pathogensis of interstitial lung diseases. In Intersitital Lung Disease (M. I. Schwarz, T. E. King, eds.), Hamilton, Ontario, B. C. Decker, 187-220.
3. Kuhn III, C., Boldt, J., King Jr., T. E., Crouch, E., Vartio, T., McDonald, J. A. (1989) An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis. Am. Rev. Respir. Dis. 140, 1693-1703.
4. Kuhn, C., McDonald, J. A. (1991) The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Am. J. Pathol. 138, 1257-1265.
5. Darby, I., Skalli, O., Gabbiani, G. (1990) α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Invest. 63, 21-29.
6. Bitterman, P. B., Adelberg, S., Crystal, R. G. (1983) Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders. J. Clin. Invest. 72, 1801-1813.
7. Homma, S., Nagaoka, I., Abe, H., Takahashi, K., Seyama, K., Nukiwa, T., Kira, S. (1995) Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung. Am. J. Respir. Crit. Care Med. 152, 2084-2089.
8. Rom, W. N., Basset, P., Fells, G. A., Nukiwa, T., Trapnell, B. C., Crysal, R. G. (1988) Alveolar macrophages release an insulin-like growth factor I-type molecule. J. Clin. Invest. 82, 1685-1693.
9. Martinet, Y., Rom, W. N., Grotendorst, G. R., Martin, G. R., Crystal, R. G. (1987) Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 317, 202-209.
10. Khalil, N., O'Connor, R. N., Unruh, H. W., Warren, P. W., Flanders, K. C., Kemp, A., Bereznay, O. H., Greenberg, A. H. (1991) Increased production and immunohistochemical localization of transforming growth factor-β in idiopathic pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 5, 155-162.
11. Bonner, J. C., Osornio-Vargas, A. R., Badgett, A., Brody, A. R. (1991) Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 5, 539-547.
12. Henke, C., Marineili, W., Jessurun, J., Fox, J., Harms, D., Peterson, M., Chiang, L., Doran, P. (1993) Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am. J. Pathol. 143, 1189-1199.
13. Gillery, P., Leperre, A., Maquart, F. X., Borel, J. P. (1992) Insulin-like growth factor-I (IGF-I) stimulates protein synthesis and collagen gene expression in monolayer and lattice cultures of fibroblasts. J. Cell. Physiol. 152, 389-396.
14. Goldstein, R. H., Poliks, C. F., Pilch, P. F., Smith, B. D., Fine, A. (1989) Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts. Endocrinology 124, 964-970.
15. Krupsky, M., Fine, A., Kuang, P. P., Berk, J. L., Goldstein, R. H. (1996) Regulation of type I collagen production by insulin and transforming growth factor-β in human lung fibroblasts. Connect. Tissue Res. 34, 53-62.
16. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., Greenberg, M. E. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
17. Kulik, G., Weber, M. J. (1998) Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol. Cell. Biol. 18, 6711-6718.
18. Linseman, D. A., Phelps, R. A., Bouchard, R. J., Le, S. S., Laessig, T. A., McClure, M. L., Heidenreich, K. A. (2002) Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J. Neurosci. 22, 9287-9297.
19. Zhang, H. Y., Phan, S. H. (1999) Inhibition of myofibroblast apoptosis by transforming growth factor β(1). Am. J. Respir. Cell Mol. Biol. 21, 658-665.
20. Maeda, A., Hiyama, K., Yamakido, H., Ishioka, S., Yamakido, M. (1996) Increased expression of platelet-derived growth factor A and insulin-like growth factor-I in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice. Chest 109, 780-786.
21. Uh, S. T., Inoue, Y., King Jr., T. E., Chan, E. D., Newman, L. S., Riches, D. W. (1998) Morphometric analysis of insulin-like growth factor-I localization in lung tissues of patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 158, 1626-1635.
22. Gharaee-Kermani, M., Nozaki, Y., Hatano, K., Phan, S. H. (2001) Lung interleukin-4 gene expression in a murine model of bleomycin-induced pulmonary fibrosis. Cytokine 15, 138-147.
23. Ando, M., Miyazaki, E., Fukami, T., Kumamoto, T., Tsuda, T. (1999) Interleukin-4-producing cells in idiopathic pulmonary fibrosis: an immunohistochemical study. Respirology 4, 383-391.
24. Wallace, W. A., Ramage, E. A., Lamb, D., Howie, S. E. (1995) A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA). Clin. Exp. Immunol. 101, 436-441.
25. Huaux, F., Liu, T., McGarry, B., Ullenbruch, M., Phan, S. H. (2003) Dual roles of IL-4 in lung injury and fibrosis. J. Immunol. 170, 2083-2092.
26. Jakubzick, C., Choi, E. S., Joshi, B. H., Keane, M. P., Kunkel, S. L., Puri, R. K., Hogaboam, C. M. (2003) Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells. J. Immunol. 171, 2684-2693.
27. Wynes, M. W., Riches, D. W. (2003) Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J. Immunol. 171, 3550-3559.
28. Lake, F. R., Noble, P. W., Henson, P. M., Riches, D. W. (1994) Functional switching of macrophage responses to tumor necrosis factor-α (TNF α) by interferons. Implications for the pleiotropic activities of TNF α. J. Clin. Invest. 93, 1661-1669.
29. Arkins, S., Rebeiz, N., Brunke-Reese, D. L., Biragyn, A., Kelley, K. W. (1995) Interferon-γ inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level. Mol. Endocrinol. 9, 350-360.
30. Chalmers, C. J., Balmanno, K., Hadfield, K., Ley, R., Cook, S. J. (2003) Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. Biochem. J. 375, 99-109.
31. Le Gall, M., Chambard, J. C., Breittmayer, J. P., Grall, D., Pouyssegur, J., Van Obberghen-Schilling, E. (2000) The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal. Mol. Biol. Cell 11, 1103-1112.
32. Riches, D. W., Underwood, G. A. (1991) Expression of interferon-β during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state. J. Biol. Chem. 266, 24785-24792.
33. Chan, E. D., Winston, B. W., Uh, S. T., Wynes, M. W., Rose, D. M., Riches, D. W. (1999) Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-γ and TNF-α in mouse macrophages. J. Immunol. 162, 415-422.
34. Chaudhary, L. R., Hruska, K. A. (2001) The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J. Cell. Biochem. 81, 304-311.
35. Guilbert, L. J., Tynan, P. W., Stanley, E. R. (1986) Uptake and destruction of 125I-CSF-1 by peritoneal exudate macrophages. J. Cell. Biochem. 31, 203-216.
36. Tushinski, R. J., Oliver, I. T., Guilbert, L. J., Tynan, P. W., Warner, J. R., Stanley, E. R. (1982) Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 28, 71-81.
37. Vlahos, C. J., Matter, W. F., Brown, R. F., Traynor-Kaplan, A. E., Heyworth, P. G., Prossnitz, E. R., Ye, R. D., Marder, P., Schelm, J. A., Rothfuss, K. J., et al. (1995) Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154, 2413-2422.
38. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., Saltiel, A. R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92, 7686-7689.
39. King Jr., T. E., Schwarz, M. I., Brown, K., Tooze, J. A., Colby, T. V., Waldron Jr., J. A., Flint, A., Thurlbeck, W., Cherniack, R. M. (2001) Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am. J. Respir. Crit. Care Med. 164, 1025-1032.
40. Stiles, A. D., Chrysis, D., Jarvis, H. W., Brighton, B., Moats-Staats, B. M. (2001) Programmed cell death in normal fetal rat lung development. Exp. Lung Res. 27, 569-587.
41. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., Greenberg, M. E. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
42. Datta, S. R., Brunet, A., Greenberg, M. E. (1999) Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927.
43. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., Reed, J. C. (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321.
44. Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., Greenberg, M. E. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358-1362.
45. Allan, L. A., Morrice, N., Brady, S., Magee, G., Pathak, S., Clarke, P. R. (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat. Cell Biol. 5, 647-654.
46. Stein, M., Keshav, S., Harris, N., Gordon, S. (1992) Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176, 287-292.
47. Gordon, S. (2003) Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35.
48. Mantovani, A., Sozzani, S., Locati, M., Allavena, P., Sica, A. (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555.
49. Gratchev, A., Guillot, P., Hakiy, N., Politz, O., Orfanos, C. E., Schledzewski, K., Goerdt, S. (2001) Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3. Scand. J. Immunol. 53, 386-392.
50. Gratchev, A., Schledzewski, K., Guillot, P., Goerdt, S. (2001) Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing. Skin Pharmacol. Appl. Skin Physiol. 14, 272-279.
51. Song, E., Ouyang, N., Horbelt, M., Antus, B., Wang, M., Exton, M. S. (2000) Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell. Immunol. 204, 19-28.
52. Baetselier, P. D., Namangala, B., Noel, W., Brys, L., Pays, E., Beschin, A. (2001) Alternative versus classical macrophage activation during experimental African trypanosomosis. Int. J. Parasitol. 31, 575-587.
53. Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J., Dalton, S. L., Wu, J., Pittet, J. F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) The integrin α v β 6 binds and activates latent TGF β 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319-328.
54. Lee, T. C., Gold, L. I., Reibman, J., Aston, C., Begin, R., Rom, W. N., Jagirdar, J. (1997) Immunohistochemical localization of transforming growth factor-β and insulin-like growth factor-I in asbestosis in the sheep model. Int. Arch. Occup. Environ. Health 69, 157-164.