Altered DNA repair and dysregulation of p53 in IRF-1 null hepatocytes

FASEB Journal

Volumn 12, Issue 2, 1998, Pages 181-188

  Prost, S ^a   Bellamy, C O C ^a   Cunningham, D S ^a   Harrison, D J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Apoptosis; Cell cycle; Cell proliferation; Liver; UV irradiation

Indexed keywords

ALPHA INTERFERON; PROTEIN KINASE; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; GENE REPRESSION; GROWTH INHIBITION; IMMUNOCYTOCHEMISTRY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET IRRADIATION;

ANIMALIA;

EID: 0031913275     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.2.181     Document Type: Article

References (38)

1. Kirchhoff, S., Schaper, F., and Hauser, H. (1993) Interferon regulatory factor l (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes. Nucleic Acids Res. 21, 2881-2889
2. Kirchhoff, S., Koromilas, A. E., Schaper, F., Grashoff, M., Sonenberg, N., and Hauser, H. (1995) IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein PKR. Oncogene 11, 439-445
3. Taniguchi, T., Harada, H., and Lamphier, M. S. (1995) Regulation of the interferon system and cell growth by the IRF transcription factors. J. Cancer Res. Clin. Oncol. 121, 416-520
4. Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., and Taniguchi, T. (1995) An IRF-l-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (London) 376, 596-599
5. Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., and Taniguchi, T. (1994) Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 17, 829-840
6. Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., and Taniguchi, T. (1996) Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature (London) 382, 816-818
7. Lu, X., and Lane, D. P. (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75, 765-778
8. Bellamy, C. O. C. (1997) p53 and apoptosis. Br. Med. Bull. 53, 522-538
9. MacCallum, D. E., Hupp, T. R., Midgley, C. A., Stuart, D., Campbell, S. J., Harper, A., Walsh, F. S., Wright, E. G., Balmain, A., Lane, D. P., Hall, D. J., and Hall, P. A. (1996) The p53 response to ionising radiation in adult and developing murine tissues. Oncogene 13, 2575-2587
10. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816
11. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J.-M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K., Harris, C. C., Egly, J. M., Freidberg, E. C., et al. (1995) p53 modulation of TFIIH-associated nucleotide excision repair activity. Nature Genet. 10, 188-195
12. Wang, X. W., Vermeiden, W., Coursen, J. D., Gibson, M., Lupold, S. E., Forrester, K., Xu, G. W., Elmore, L., Yeh, H., Hoeijmakers, J. H. J., and Harris, C. C. (1996) The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes & Dev. 10, 1219-1232
13. Marx, J. (1994) New link found between p53 and DNA repair. Science 266, 1321-1322
14. Ishizaki, K., Ejima, Y., Matsunaga, T., Hara, R., Sakamoto, A., Ikenaga, M., Ikawa, Y., and Aizawa, S. (1994) Increased UV-induced SCEs but normal repair of DNA damage in p53-deficient mouse cells. Int. J. Cancer 58, 254-257
15. Ford, J. M., and Hanawalt, P. C. (1995) Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc. Natl. Acad. Sci. USA 92, 8876-8880
16. Smith, M. L., Chen, I. T., Zhan, Q., O'Connor, P. M., and Fornace, A. J., Jr. (1995) Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 10, 10531059
17. Li, G., Mitchell, D. L., Ho, V. C., Reed, J. C., and Tron, V. A. (1996) Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice. Am. J. Pathol. 148, 1113-1123
18. Li, G., Ho, V. C., Mitchell D. L., Trotter, M. J., and Tron, V. A. (1997) Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes. Am. J. Pathol. 150, 1457-1464
19. Mirzayans, R., Enns, L., Dietrich, K., Barley, R. D. C., Paterson, M. C., and Barley, R. D. (1996) Faulty DNA polymerase δ/ε-mediated excision repair in response to gamma radiation or ultraviolet light in p53-deficient fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome. Carcinogenesis 17, 691-698
20. Bellamy, C. O. C., Clarke, A. R., Wyllie, A. H., and Harrison, D. J. (1997) p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage. FASEB J. 11, 591-599
21. Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kundig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75, 83-97
22. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways [see comments]. Nature (London) 362, 849-852
23. Bellamy, G. O. G., Frost, S., Wyllie, A. H., and Harrison, D. J. (1997) UV but not gamma irradiation induces specific transcriptional activity of p53 in primry hepatocytes. J. Pathol. 183, 177-181
24. Scheidtmann, K. H., and Landsberg, G. (1996) UV irradiation leads to transient changes in phosphorylation and stability of tumor suppressor protein p53. Int. J. Oncol. 9, 1277-1285
25. Zhang, W., McClain, C., Gau, J. P., Gno, X. Y., and Deisseroth, A. B. (1994) Hyperphosphorylation of p53 induced by okadaic acid attenuates its transcriptional activation function. Cancer Res. 54, 4448-4453
26. Lohrum, M., and Scheidtmann, K. H. (1996) Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes. Oncogene 13, 2527-2539
27. Steegenga, W. T., Van der Eb, A. J., and Jochemsen, A. G. (1996) How phosphorylation regulates the activity of p53. J. Mol. Biol. 263, 103-113
28. Abrahams, P. J., Schonten, R., Van Laar, T., Houweling, A., Terleth, C., and Van der Eb, A. J. (1995) Different regulation of p53 stability in UV-irradiated normal and DNA repair deficient human cells. Mutat. Res. 336, 169-180
29. Di Leonardo, A., Linke, S. P., Glarkin, K., and Wahl, G. M. (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes & Dev. 8, 2540-2551
30. 1 arrest. Proc. Natl. Acad. Sci. USA 93, 4827-4832
31. Chen, X., Ko, L. J., Jayaraman, L., and Prives, C. (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes & Dev. 10, 2438-2451
32. Pan, Z. Q., Reardon,J. T., Li, L., Flores-Rozas, H., Legerski, R., Sancar, A., and Hurwitz, J. (1995) Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21. J. Biol. Chem. 270, 22008-22016
33. McDonald, E. R., 3rd, Wu, G. S., Waldman, T., and El-Deiry, W. S. (1996) Repair detect in p21 WAF1/CIP1 -/- human cancer cells. Cancer Res. 56, 2250-2255
34. Sheikh, M. S., Chen, Y. Q., Smith, M. L., and Fornace AJ Jr (1997) Role of p21(Waf1/Cip1/Sdi1) in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14, 1875-1882
35. Li, R., Waga, S., Hannon, G. J., Beach, D.,and Stillman, B. (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature (London) 371, 534-537
36. Shivji, M. K., Grey, S. J., Strausfeld, U. P., Wood, R. D., and Blow, J. J. (1994) Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4, 1062-1068
37. Yamaizumi, M., and Sugano, T. (1994) U.V.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9, 2775-2784
38. McWhir, J., Selfridge, J., Harrison, D. J., Squires, S., and Melton, D. W. (1993) Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning [see comments]. Nature Genet. 5, 217-224