Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells

Nature Immunology

Volumn 2, Issue 5, 2001, Pages 430-435

  Ugolini, Sophie ^a,g   Arpin, Christophe ^b   Anfossi, Nicolas ^a   Walzer, Thierry ^b   Cambiaggi, Anna ^c   Förster, Reinhold ^d   Lipp, Martin ^d   Toes, René E M ^e   Melief, Cornelius J ^e   Marvel, Jacqueline ^b   Vivier, Eric ^a,f  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b INSERM   (France)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f INSTITUT UNIVERSITAIRE DE FRANCE   (France)

^g INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA C ANTIGEN; HLA CW3 ANTIGEN; HLA-CW3; IMMUNOGLOBULIN RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR;

ANIMAL; ARTICLE; CD8+ T LYMPHOCYTE; CELL DEATH; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MOUSE; NATURAL KILLER CELL; PHENOTYPE; SPLEEN; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE; VACCINATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; HLA-C ANTIGENS; IMMUNOLOGIC MEMORY; KILLER CELLS, NATURAL; MICE; MICE, TRANSGENIC; PHENOTYPE; RECEPTORS, IMMUNOLOGIC; SPLEEN; T-LYMPHOCYTE SUBSETS; VACCINATION;

EID: 5944231608     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/87740     Document Type: Article

References (29)

1. Lanier, L. L. NK Cell Receptors. Ann. Rev. Immunol. 16, 359-393 (1998).
2. Long, E. O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17, 875-904 (1999).
3. Tomasello, E., Bléry, M., Véfy, F. & Vivier, E. Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells. Semin. Immunol. 12, 139-147 (2000).
4. Colonna, M. et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186, 1809-1818 (1997).
5. Borges, L., Fanger, N. & Cosman, D. Interactions of LIRs, a family of immunoreceptors expressed in myeloid and lymphoid cells, with viral and cellular MHC class I antigens. Curr. Top. Microbiol. Immunol. 244, 123-136 (1999).
6. Chapman, T. L., Heikeman, A. P. & Bjorkman, P. J. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 11, 603-613 (1999).
7. Mingari, M. C., Moretta, A. & Moretta, L. Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol. Today 19, 153-157 (1998).
8. Speiser, D. E. et al. In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J. Exp. Med. 190, 775-782 (1999).
9. Anfossi, N., Pascal, V., Vivier, E. & Ugolini, S. Biology of Tm1 cells. Immunol. Rev. 181 (in the press, 2001).
10. + T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc. Natl. Acad. Sci. USA 93, 12433-12438 (1996).
11. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 703-712 (1999).
12. Coles, M. C., McMahon, C. W., Takizawa, H. & Raulet, D. H. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur. J. Immunol. 30, 236-244 (2000).
13. Mingari, M. C. et al. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int. Immunol. 7, 697-703 (1995).
14. Mingari, M. C. et al. HLA-class I-specific inhibitory receptors in human cytolytic T lymphocytes: molecular characterization, distribution in lymphoid tissues and co-expression by individual T cells. Int. Immunol. 9, 485-491 (1997).
15. Phillips, J. H., Gumperz, J. E., Parham, P. & Lanier, L. L. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268, 403-405 (1995).
16. D'Andrea, A., Chang, C., Phillips, J. H. & Lanier, L. L. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 184, 789-794 (1996).
17. Ikeda, H. et al. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity 6, 199-208 (1997).
18. Cambiaggi, A. et al. Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor. Proc. Natl. Acad. Sci. USA 94, 8088-8092 (1997).
19. Cambiaggi, A. et al. Modulation of T-Cell Functions in KIR2DL3 (CD158b) Transgenic Mice. Blood 94, 2396-2402 (1999).
20. + T cells identified by expression of Pgp-1. J. Immunol. 138, 3583-3586 (1987).
21. + T cells. J. Immunol. 155, 1873-1883 (1995).
22. + T cells are hyper-reactive to antigenic challenge in vitro. J. Exp. Med. 184, 2141-2151 (1996).
23. Kundig, T. M. et al. On T cell memory: arguments for antigen dependence. Immunol. Rev. 150, 63-90 (1996)
24. Oehen, S. & Brduscha-Riem, K. Differentiation of naïve CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J. Immunol. 161, 5338-5346 (1998).
25. Pircher, H.-P., Bürki, K., Lang, R., Hengartner, H. & Zinkernagel, R. M. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559-561 (1989).
26. Diehl, L. et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nature Med. 5, 774-779 (1999).
27. + cells. J. Immunol. 160, 1158-1165 (1998).
28. Marti, F. et al. LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 95, 11810-11815 (1998).
29. + T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. J. Immunol. 162, 1765-1771 (1999).