-
1
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW and McMahon AP: Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
2
-
-
0036559186
-
Gli and hedgehog in cancer: Tumors, embryos and stem cells
-
Ruiz i Altaba A, Sánchez P and Dahmane N: Gli and hedgehog in cancer: tumors, embryos and stem cells. Nat Rev Cancer 2: 361-372, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 361-372
-
-
Ruiz i Altaba, A.1
Sánchez, P.2
Dahmane, N.3
-
3
-
-
0030805592
-
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
-
Lee J, Platt KA, Censullo P and Ruiz i Altaba A: Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124: 2537-2552, 1997.
-
(1997)
Development
, vol.124
, pp. 2537-2552
-
-
Lee, J.1
Platt, K.A.2
Censullo, P.3
Ruiz i Altaba, A.4
-
4
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432: 324-331, 2004.
-
(2004)
Nature
, vol.432
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
5
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancet
-
Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA and Baylin SB: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancet; Nature 422; 313-317, 2003.
-
(2003)
Nature
, vol.422
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
6
-
-
0037200078
-
Medulloblastoma growth inhibition by hedgehog pathway blockade
-
Berman DM, Karhadkar SS, Hallahan AR, et al: Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559-1561, 2002.
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
Karhadkar, S.S.2
Hallahan, A.R.3
-
7
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors
-
Berman DM, Karhadkar SS, Maitra A, et al: Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors. Nature 425: 846-851, 2003.
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
-
8
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhadkar SS, Bova GS, Abdallah N, et al: Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431: 707-712, 2004.
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
-
9
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, Di Magliano MP, Heiser PW, et al: Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851-856, 2003.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
-
10
-
-
29744463531
-
Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
-
Tostar U, Malm CJ, Meis-Kindblom JM, Kindblom LG, Toftgard R and Unden AB: Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol 208: 17-25, 2006.
-
(2006)
J Pathol
, vol.208
, pp. 17-25
-
-
Tostar, U.1
Malm, C.J.2
Meis-Kindblom, J.M.3
Kindblom, L.G.4
Toftgard, R.5
Unden, A.B.6
-
11
-
-
4344659678
-
Inhibition of prostate cancer proliferation by interference with sonic hedgehog-Gli1 signaling
-
Sanchez P, Hernandez AM and Stecca B: Inhibition of prostate cancer proliferation by interference with sonic hedgehog-Gli1 signaling. Proc Natl Acad Sci USA 101: 12561-12566, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12561-12566
-
-
Sanchez, P.1
Hernandez, A.M.2
Stecca, B.3
-
12
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale J, Chen JK, Cooper MK, et al: Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009, 2000.
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
-
13
-
-
0031723219
-
The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
-
Incardona JP, Gaffield W, Kapur RP et al: The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125: 3553-3562, 1998.
-
(1998)
Development
, vol.125
, pp. 3553-3562
-
-
Incardona, J.P.1
Gaffield, W.2
Kapur, R.P.3
-
14
-
-
4344586961
-
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
-
Kubo M, Nakamura M, Tasaki A, et al: Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 64: 6071-6074, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 6071-6074
-
-
Kubo, M.1
Nakamura, M.2
Tasaki, A.3
-
15
-
-
27144541492
-
Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
-
Ma X, Chen K, Huang S, et al: Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26: 1698-1705, 2005.
-
(2005)
Carcinogenesis
, vol.26
, pp. 1698-1705
-
-
Ma, X.1
Chen, K.2
Huang, S.3
-
16
-
-
75749133243
-
The increased expression of the Hedgehog signaling pathway in pediatric solid malignancies
-
In press
-
Oue T, Yoneda A, Uehara S, Yamanaka H and Fukuzawa M: The increased expression of the Hedgehog signaling pathway in pediatric solid malignancies. J Pediatr Surg (In press).
-
J Pediatr Surg
-
-
Oue, T.1
Yoneda, A.2
Uehara, S.3
Yamanaka, H.4
Fukuzawa, M.5
-
18
-
-
0033859849
-
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
-
Wang QT and Holmgren RA: Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127: 3131-3139, 2000.
-
(2000)
Development
, vol.127
, pp. 3131-3139
-
-
Wang, Q.T.1
Holmgren, R.A.2
-
19
-
-
0029041177
-
Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
-
Fan CM, Porter JA, Chiang C, Chang DT, Beachy PA and Tessier-Lavigne M: Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81: 457-465, 1995.
-
(1995)
Cell
, vol.81
, pp. 457-465
-
-
Fan, C.M.1
Porter, J.A.2
Chiang, C.3
Chang, D.T.4
Beachy, P.A.5
Tessier-Lavigne, M.6
-
20
-
-
0029127630
-
Induction of midbrain dopaminergic neurons by Sonic hedgehog
-
Hynes M, Porter JA, Chiang C, Chang D, Tessier-Lavigne M, Beachy PA and Rosenthal A: Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15: 35-44, 1995.
-
(1995)
Neuron
, vol.15
, pp. 35-44
-
-
Hynes, M.1
Porter, J.A.2
Chiang, C.3
Chang, D.4
Tessier-Lavigne, M.5
Beachy, P.A.6
Rosenthal, A.7
-
21
-
-
0030032263
-
cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog
-
Noveen A, Jiang TX and Chuong CM: cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog. Biochem Biophys Res Commun 219: 180-185, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.219
, pp. 180-185
-
-
Noveen, A.1
Jiang, T.X.2
Chuong, C.M.3
-
22
-
-
0035735270
-
Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ
-
Cobourne MT, Hardcastle Z and Sharpe PT: Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J Dent Res 80: 1974-1979, 2001.
-
(2001)
J Dent Res
, vol.80
, pp. 1974-1979
-
-
Cobourne, M.T.1
Hardcastle, Z.2
Sharpe, P.T.3
-
23
-
-
0036067874
-
Disruption of testis cords by cyclopamine or Forskolin reveals independent cellular pathways in testis osganogenesis
-
Yao HH and Capel B: Disruption of testis cords by cyclopamine or Forskolin reveals independent cellular pathways in testis osganogenesis. Dev Biol 246: 356-365, 2002.
-
(2002)
Dev Biol
, vol.246
, pp. 356-365
-
-
Yao, H.H.1
Capel, B.2
-
24
-
-
40249096492
-
-
Shahi MH, Lorente A and and Castresana JS: Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma. Oncol Rep 19: 681-688, 2008.
-
Shahi MH, Lorente A and and Castresana JS: Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma. Oncol Rep 19: 681-688, 2008.
-
-
-
-
25
-
-
61949180747
-
Blocking the Hedgehog pathway inhibits hepatoblastoma growth
-
Eichenmuller M, Gruner I, Hagl B, et al: Blocking the Hedgehog pathway inhibits hepatoblastoma growth. Hepatology 49: 482-490, 2009.
-
(2009)
Hepatology
, vol.49
, pp. 482-490
-
-
Eichenmuller, M.1
Gruner, I.2
Hagl, B.3
-
26
-
-
0029821890
-
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
-
Epstein DJ, Marti E, Scott MP and McMahon AP: Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122: 2885-2894, 1996.
-
(1996)
Development
, vol.122
, pp. 2885-2894
-
-
Epstein, D.J.1
Marti, E.2
Scott, M.P.3
McMahon, A.P.4
-
27
-
-
0029041177
-
Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
-
Fan CM, Porter JA, Chiang C, Chang DT, Beachy PA and Tessier-Lavigne M: Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81: 457-465, 1995.
-
(1995)
Cell
, vol.81
, pp. 457-465
-
-
Fan, C.M.1
Porter, J.A.2
Chiang, C.3
Chang, D.T.4
Beachy, P.A.5
Tessier-Lavigne, M.6
-
28
-
-
0029879687
-
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
-
Hammerschmidt M, Bitgood MJ and McMahon AP: Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 10: 647-658, 1996.
-
(1996)
Genes Dev
, vol.10
, pp. 647-658
-
-
Hammerschmidt, M.1
Bitgood, M.J.2
McMahon, A.P.3
-
30
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray SJ: Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689, 2006.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
31
-
-
0346094301
-
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
-
Kim JH, Yoon SY, Kim CN, et al: The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett 203: 217-224, 2004.
-
(2004)
Cancer Lett
, vol.203
, pp. 217-224
-
-
Kim, J.H.1
Yoon, S.Y.2
Kim, C.N.3
-
32
-
-
0037102196
-
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells
-
Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, van Lohuizen M, Campisi J, Wazer DE and Band V: The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62: 4736-4745, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 4736-4745
-
-
Dimri, G.P.1
Martinez, J.L.2
Jacobs, J.J.3
Keblusek, P.4
Itahana, K.5
van Lohuizen, M.6
Campisi, J.7
Wazer, D.E.8
Band, V.9
-
33
-
-
5644264887
-
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
-
Athar M, Li C, Tang X, et al: Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res 64: 7545-7552, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 7545-7552
-
-
Athar, M.1
Li, C.2
Tang, X.3
-
34
-
-
2942533929
-
Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment
-
Qualtrough D, Buda A, Gaffield W, Williams AC and Paraskeva C: Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer 110: 831-837, 2004.
-
(2004)
Int J Cancer
, vol.110
, pp. 831-837
-
-
Qualtrough, D.1
Buda, A.2
Gaffield, W.3
Williams, A.C.4
Paraskeva, C.5
-
35
-
-
0037447269
-
Identification of a small molecule inhibitor of the hedgehog signaling pathway. Effects on basal cell carcinoma-like lesions
-
Williams JA, Guicherit OM, Zaharian BI, et al: Identification of a small molecule inhibitor of the hedgehog signaling pathway. Effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA 100: 4616-4621, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4616-4621
-
-
Williams, J.A.1
Guicherit, O.M.2
Zaharian, B.I.3
-
36
-
-
0030844141
-
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
-
Dahmane N, Lee J, Robins F, Heller P and Altaba A: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389: 876-881, 1997.
-
(1997)
Nature
, vol.389
, pp. 876-881
-
-
Dahmane, N.1
Lee, J.2
Robins, F.3
Heller, P.4
Altaba, A.5
-
37
-
-
0034724219
-
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
-
Nilsson M, Unden AB, Krause D, Malmqwist U, Raza K, Zaphiropoulos PG and Toftgard R: Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci USA 97: 3438-3443, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3438-3443
-
-
Nilsson, M.1
Unden, A.B.2
Krause, D.3
Malmqwist, U.4
Raza, K.5
Zaphiropoulos, P.G.6
Toftgard, R.7
-
38
-
-
0034091805
-
Basal cell carcinomas in mice overexpressing Gli2 in skin
-
Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui CC and Dlugosz AA: Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet 24: 216-217, 2000.
-
(2000)
Nat Genet
, vol.24
, pp. 216-217
-
-
Grachtchouk, M.1
Mo, R.2
Yu, S.3
Zhang, X.4
Sasaki, H.5
Hui, C.C.6
Dlugosz, A.A.7
-
39
-
-
20444433526
-
Gli1 is important for medulloblastoma fonnation in Ptc1+/- mice
-
Kimura H, Stephen D, Joyner A and Curran T: Gli1 is important for medulloblastoma fonnation in Ptc1+/- mice. Oncogene 24: 4026-4036, 2005.
-
(2005)
Oncogene
, vol.24
, pp. 4026-4036
-
-
Kimura, H.1
Stephen, D.2
Joyner, A.3
Curran, T.4
-
40
-
-
0037105656
-
Dissecting the oncogenic potential of Gli2: Deletion of an NH(2)-terminal fragment alters skin tumor phenotype
-
Sheng H, Goich S, Wang A, et al: Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. Cancer Res 62: 5308-5316, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 5308-5316
-
-
Sheng, H.1
Goich, S.2
Wang, A.3
-
41
-
-
31744451535
-
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
-
Svard J, Heby-Henricson K, Persson-Lek M, et al: Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10: 187-197, 2006.
-
(2006)
Dev Cell
, vol.10
, pp. 187-197
-
-
Svard, J.1
Heby-Henricson, K.2
Persson-Lek, M.3
-
42
-
-
3242722919
-
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
-
Di Marcotullio L, Ferretti E, De Smaele E, et al: REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci USA 101: 10833-10838, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10833-10838
-
-
Di Marcotullio, L.1
Ferretti, E.2
De Smaele, E.3
-
43
-
-
0031837454
-
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
-
Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G and Zimmer A: Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 4: 619-622, 1998.
-
(1998)
Nat Med
, vol.4
, pp. 619-622
-
-
Hahn, H.1
Wojnowski, L.2
Zimmer, A.M.3
Hall, J.4
Miller, G.5
Zimmer, A.6
-
44
-
-
0032694528
-
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
-
Aszterbaum M, Epstein J, Oro A, Douglas V, LeBoit PE, Scott MP and Epstein EH Jr: Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 5: 1285-1291, 1999.
-
(1999)
Nat Med
, vol.5
, pp. 1285-1291
-
-
Aszterbaum, M.1
Epstein, J.2
Oro, A.3
Douglas, V.4
LeBoit, P.E.5
Scott, M.P.6
Epstein Jr, E.H.7
-
45
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH Jr and Scott MP: Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272: 1668-1671, 1996.
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein Jr, E.H.10
Scott, M.P.11
-
46
-
-
15844382075
-
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
-
Hahn H, Christiansen J, Wicking C, et al: A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. J Biol Chem 271: 12125-12128, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 12125-12128
-
-
Hahn, H.1
Christiansen, J.2
Wicking, C.3
-
47
-
-
0023222358
-
Nevoid basal-cell carcinoma syndrome
-
Gorlin RJ: Nevoid basal-cell carcinoma syndrome. Medicine 66: 98-113, 1987.
-
(1987)
Medicine
, vol.66
, pp. 98-113
-
-
Gorlin, R.J.1
-
48
-
-
0033711384
-
Hedgehog signalling in cancer
-
Toftgård R: Hedgehog signalling in cancer. Cell Mol Life Sci 57: 1720-1731, 2000.
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 1720-1731
-
-
Toftgård, R.1
|