메뉴 건너뛰기




Volumn 3, Issue 1, 2010, Pages 133-139

Forskolin, a Hedgehog signal inhibitor, inhibits cell proliferation and induces apoptosis in pediatric tumor cell lines

Author keywords

Forskolin; Glioma associated oncogene homolog 1; Hedgehog signaling pathway; Pediatric tumor

Indexed keywords

ANTIMITOTIC AGENT; CYCLOPAMINE; FORSKOLIN; MESSENGER RNA; MYC PROTEIN; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1;

EID: 76149098821     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr-00000230     Document Type: Article
Times cited : (20)

References (48)
  • 1
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW and McMahon AP: Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087, 2001.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 2
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumors, embryos and stem cells
    • Ruiz i Altaba A, Sánchez P and Dahmane N: Gli and hedgehog in cancer: tumors, embryos and stem cells. Nat Rev Cancer 2: 361-372, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 361-372
    • Ruiz i Altaba, A.1    Sánchez, P.2    Dahmane, N.3
  • 3
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J, Platt KA, Censullo P and Ruiz i Altaba A: Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124: 2537-2552, 1997.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz i Altaba, A.4
  • 4
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432: 324-331, 2004.
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 5
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancet
    • Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA and Baylin SB: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancet; Nature 422; 313-317, 2003.
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3    Wang, B.4    Beachy, P.A.5    Baylin, S.B.6
  • 6
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by hedgehog pathway blockade
    • Berman DM, Karhadkar SS, Hallahan AR, et al: Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559-1561, 2002.
    • (2002) Science , vol.297 , pp. 1559-1561
    • Berman, D.M.1    Karhadkar, S.S.2    Hallahan, A.R.3
  • 7
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors
    • Berman DM, Karhadkar SS, Maitra A, et al: Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors. Nature 425: 846-851, 2003.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 8
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • Karhadkar SS, Bova GS, Abdallah N, et al: Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431: 707-712, 2004.
    • (2004) Nature , vol.431 , pp. 707-712
    • Karhadkar, S.S.1    Bova, G.S.2    Abdallah, N.3
  • 9
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer SP, Di Magliano MP, Heiser PW, et al: Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851-856, 2003.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    Di Magliano, M.P.2    Heiser, P.W.3
  • 10
    • 29744463531 scopus 로고    scopus 로고
    • Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
    • Tostar U, Malm CJ, Meis-Kindblom JM, Kindblom LG, Toftgard R and Unden AB: Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol 208: 17-25, 2006.
    • (2006) J Pathol , vol.208 , pp. 17-25
    • Tostar, U.1    Malm, C.J.2    Meis-Kindblom, J.M.3    Kindblom, L.G.4    Toftgard, R.5    Unden, A.B.6
  • 11
    • 4344659678 scopus 로고    scopus 로고
    • Inhibition of prostate cancer proliferation by interference with sonic hedgehog-Gli1 signaling
    • Sanchez P, Hernandez AM and Stecca B: Inhibition of prostate cancer proliferation by interference with sonic hedgehog-Gli1 signaling. Proc Natl Acad Sci USA 101: 12561-12566, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12561-12566
    • Sanchez, P.1    Hernandez, A.M.2    Stecca, B.3
  • 12
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    • Taipale J, Chen JK, Cooper MK, et al: Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009, 2000.
    • (2000) Nature , vol.406 , pp. 1005-1009
    • Taipale, J.1    Chen, J.K.2    Cooper, M.K.3
  • 13
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
    • Incardona JP, Gaffield W, Kapur RP et al: The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125: 3553-3562, 1998.
    • (1998) Development , vol.125 , pp. 3553-3562
    • Incardona, J.P.1    Gaffield, W.2    Kapur, R.P.3
  • 14
    • 4344586961 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
    • Kubo M, Nakamura M, Tasaki A, et al: Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 64: 6071-6074, 2004.
    • (2004) Cancer Res , vol.64 , pp. 6071-6074
    • Kubo, M.1    Nakamura, M.2    Tasaki, A.3
  • 15
    • 27144541492 scopus 로고    scopus 로고
    • Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
    • Ma X, Chen K, Huang S, et al: Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26: 1698-1705, 2005.
    • (2005) Carcinogenesis , vol.26 , pp. 1698-1705
    • Ma, X.1    Chen, K.2    Huang, S.3
  • 16
    • 75749133243 scopus 로고    scopus 로고
    • The increased expression of the Hedgehog signaling pathway in pediatric solid malignancies
    • In press
    • Oue T, Yoneda A, Uehara S, Yamanaka H and Fukuzawa M: The increased expression of the Hedgehog signaling pathway in pediatric solid malignancies. J Pediatr Surg (In press).
    • J Pediatr Surg
    • Oue, T.1    Yoneda, A.2    Uehara, S.3    Yamanaka, H.4    Fukuzawa, M.5
  • 18
    • 0033859849 scopus 로고    scopus 로고
    • Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
    • Wang QT and Holmgren RA: Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127: 3131-3139, 2000.
    • (2000) Development , vol.127 , pp. 3131-3139
    • Wang, Q.T.1    Holmgren, R.A.2
  • 19
    • 0029041177 scopus 로고
    • Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
    • Fan CM, Porter JA, Chiang C, Chang DT, Beachy PA and Tessier-Lavigne M: Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81: 457-465, 1995.
    • (1995) Cell , vol.81 , pp. 457-465
    • Fan, C.M.1    Porter, J.A.2    Chiang, C.3    Chang, D.T.4    Beachy, P.A.5    Tessier-Lavigne, M.6
  • 21
    • 0030032263 scopus 로고    scopus 로고
    • cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog
    • Noveen A, Jiang TX and Chuong CM: cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog. Biochem Biophys Res Commun 219: 180-185, 1996.
    • (1996) Biochem Biophys Res Commun , vol.219 , pp. 180-185
    • Noveen, A.1    Jiang, T.X.2    Chuong, C.M.3
  • 22
    • 0035735270 scopus 로고    scopus 로고
    • Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ
    • Cobourne MT, Hardcastle Z and Sharpe PT: Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J Dent Res 80: 1974-1979, 2001.
    • (2001) J Dent Res , vol.80 , pp. 1974-1979
    • Cobourne, M.T.1    Hardcastle, Z.2    Sharpe, P.T.3
  • 23
    • 0036067874 scopus 로고    scopus 로고
    • Disruption of testis cords by cyclopamine or Forskolin reveals independent cellular pathways in testis osganogenesis
    • Yao HH and Capel B: Disruption of testis cords by cyclopamine or Forskolin reveals independent cellular pathways in testis osganogenesis. Dev Biol 246: 356-365, 2002.
    • (2002) Dev Biol , vol.246 , pp. 356-365
    • Yao, H.H.1    Capel, B.2
  • 24
    • 40249096492 scopus 로고    scopus 로고
    • Shahi MH, Lorente A and and Castresana JS: Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma. Oncol Rep 19: 681-688, 2008.
    • Shahi MH, Lorente A and and Castresana JS: Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma. Oncol Rep 19: 681-688, 2008.
  • 25
    • 61949180747 scopus 로고    scopus 로고
    • Blocking the Hedgehog pathway inhibits hepatoblastoma growth
    • Eichenmuller M, Gruner I, Hagl B, et al: Blocking the Hedgehog pathway inhibits hepatoblastoma growth. Hepatology 49: 482-490, 2009.
    • (2009) Hepatology , vol.49 , pp. 482-490
    • Eichenmuller, M.1    Gruner, I.2    Hagl, B.3
  • 26
    • 0029821890 scopus 로고    scopus 로고
    • Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
    • Epstein DJ, Marti E, Scott MP and McMahon AP: Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122: 2885-2894, 1996.
    • (1996) Development , vol.122 , pp. 2885-2894
    • Epstein, D.J.1    Marti, E.2    Scott, M.P.3    McMahon, A.P.4
  • 27
    • 0029041177 scopus 로고
    • Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
    • Fan CM, Porter JA, Chiang C, Chang DT, Beachy PA and Tessier-Lavigne M: Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81: 457-465, 1995.
    • (1995) Cell , vol.81 , pp. 457-465
    • Fan, C.M.1    Porter, J.A.2    Chiang, C.3    Chang, D.T.4    Beachy, P.A.5    Tessier-Lavigne, M.6
  • 28
    • 0029879687 scopus 로고    scopus 로고
    • Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
    • Hammerschmidt M, Bitgood MJ and McMahon AP: Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 10: 647-658, 1996.
    • (1996) Genes Dev , vol.10 , pp. 647-658
    • Hammerschmidt, M.1    Bitgood, M.J.2    McMahon, A.P.3
  • 30
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray SJ: Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 31
    • 0346094301 scopus 로고    scopus 로고
    • The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
    • Kim JH, Yoon SY, Kim CN, et al: The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett 203: 217-224, 2004.
    • (2004) Cancer Lett , vol.203 , pp. 217-224
    • Kim, J.H.1    Yoon, S.Y.2    Kim, C.N.3
  • 33
    • 5644264887 scopus 로고    scopus 로고
    • Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    • Athar M, Li C, Tang X, et al: Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res 64: 7545-7552, 2004.
    • (2004) Cancer Res , vol.64 , pp. 7545-7552
    • Athar, M.1    Li, C.2    Tang, X.3
  • 34
    • 2942533929 scopus 로고    scopus 로고
    • Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment
    • Qualtrough D, Buda A, Gaffield W, Williams AC and Paraskeva C: Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer 110: 831-837, 2004.
    • (2004) Int J Cancer , vol.110 , pp. 831-837
    • Qualtrough, D.1    Buda, A.2    Gaffield, W.3    Williams, A.C.4    Paraskeva, C.5
  • 35
    • 0037447269 scopus 로고    scopus 로고
    • Identification of a small molecule inhibitor of the hedgehog signaling pathway. Effects on basal cell carcinoma-like lesions
    • Williams JA, Guicherit OM, Zaharian BI, et al: Identification of a small molecule inhibitor of the hedgehog signaling pathway. Effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA 100: 4616-4621, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4616-4621
    • Williams, J.A.1    Guicherit, O.M.2    Zaharian, B.I.3
  • 36
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
    • Dahmane N, Lee J, Robins F, Heller P and Altaba A: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389: 876-881, 1997.
    • (1997) Nature , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, F.3    Heller, P.4    Altaba, A.5
  • 39
    • 20444433526 scopus 로고    scopus 로고
    • Gli1 is important for medulloblastoma fonnation in Ptc1+/- mice
    • Kimura H, Stephen D, Joyner A and Curran T: Gli1 is important for medulloblastoma fonnation in Ptc1+/- mice. Oncogene 24: 4026-4036, 2005.
    • (2005) Oncogene , vol.24 , pp. 4026-4036
    • Kimura, H.1    Stephen, D.2    Joyner, A.3    Curran, T.4
  • 40
    • 0037105656 scopus 로고    scopus 로고
    • Dissecting the oncogenic potential of Gli2: Deletion of an NH(2)-terminal fragment alters skin tumor phenotype
    • Sheng H, Goich S, Wang A, et al: Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. Cancer Res 62: 5308-5316, 2002.
    • (2002) Cancer Res , vol.62 , pp. 5308-5316
    • Sheng, H.1    Goich, S.2    Wang, A.3
  • 41
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    • Svard J, Heby-Henricson K, Persson-Lek M, et al: Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10: 187-197, 2006.
    • (2006) Dev Cell , vol.10 , pp. 187-197
    • Svard, J.1    Heby-Henricson, K.2    Persson-Lek, M.3
  • 42
    • 3242722919 scopus 로고    scopus 로고
    • REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
    • Di Marcotullio L, Ferretti E, De Smaele E, et al: REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci USA 101: 10833-10838, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10833-10838
    • Di Marcotullio, L.1    Ferretti, E.2    De Smaele, E.3
  • 43
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G and Zimmer A: Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 4: 619-622, 1998.
    • (1998) Nat Med , vol.4 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Zimmer, A.M.3    Hall, J.4    Miller, G.5    Zimmer, A.6
  • 44
    • 0032694528 scopus 로고    scopus 로고
    • Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
    • Aszterbaum M, Epstein J, Oro A, Douglas V, LeBoit PE, Scott MP and Epstein EH Jr: Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 5: 1285-1291, 1999.
    • (1999) Nat Med , vol.5 , pp. 1285-1291
    • Aszterbaum, M.1    Epstein, J.2    Oro, A.3    Douglas, V.4    LeBoit, P.E.5    Scott, M.P.6    Epstein Jr, E.H.7
  • 46
    • 15844382075 scopus 로고    scopus 로고
    • A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
    • Hahn H, Christiansen J, Wicking C, et al: A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. J Biol Chem 271: 12125-12128, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 12125-12128
    • Hahn, H.1    Christiansen, J.2    Wicking, C.3
  • 47
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin RJ: Nevoid basal-cell carcinoma syndrome. Medicine 66: 98-113, 1987.
    • (1987) Medicine , vol.66 , pp. 98-113
    • Gorlin, R.J.1
  • 48
    • 0033711384 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer
    • Toftgård R: Hedgehog signalling in cancer. Cell Mol Life Sci 57: 1720-1731, 2000.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1720-1731
    • Toftgård, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.