메뉴 건너뛰기




Volumn 44, Issue 11, 2009, Pages 1200-1210

Advances in the study of nitric oxide-donating drugs

Author keywords

Effector; Messenger; Nitric oxide (NO); NO donating drugs

Indexed keywords

ACETYLSALICYLIC ACID; NITRIC OXIDE; TACRINE DERIVATIVE;

EID: 76049116952     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (70)
  • 1
    • 22744435192 scopus 로고    scopus 로고
    • Nitric oxide donor drugs: An update on pathophysiology and therapeutic potential [J]
    • Scatena R, Bottoni P, Martorana GE, et al. Nitric oxide donor drugs: an update on pathophysiology and therapeutic potential [J]. Expert Opin Investig Drugs, 2005, 14: 835-846.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 835-846
    • Scatena, R.1    Bottoni, P.2    Martorana, G.E.3
  • 2
    • 34249683823 scopus 로고    scopus 로고
    • Recent developments in nitric oxide donor drugs [J]
    • Miller MR, Megson IL. Recent developments in nitric oxide donor drugs [J]. Br J Pharmacol, 2007, 151: 305-321.
    • (2007) Br J Pharmacol , vol.151 , pp. 305-321
    • Miller, M.R.1    Megson, I.L.2
  • 3
    • 33750726199 scopus 로고    scopus 로고
    • Targeting of nitric oxide-donor and related drugs [J]
    • Zhang YH, Tian JD, Peng SX. Targeting of nitric oxide-donor and related drugs [J]. Acta Pharm Sin 2006, 41: 481-486.
    • (2006) Acta Pharm Sin , vol.41 , pp. 481-486
    • Zhang, Y.H.1    Tian, J.D.2    Peng, S.X.3
  • 4
    • 4444323426 scopus 로고    scopus 로고
    • Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation [J]
    • Liu J, Li C, Qu W, et al. Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation [J]. Mol Cancer Ther, 2004, 3: 709-714.
    • (2004) Mol Cancer Ther , vol.3 , pp. 709-714
    • Liu, J.1    Li, C.2    Qu, W.3
  • 5
    • 31044449239 scopus 로고    scopus 로고
    • PABA/NO as an anticancer lead: Analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity [J]
    • Saavedra JE, Srinivasan A, Buzard GS, et al. PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity [J]. J Med Chem, 2006, 49: 1157-1164.
    • (2006) J Med Chem , vol.49 , pp. 1157-1164
    • Saavedra, J.E.1    Srinivasan, A.2    Buzard, G.S.3
  • 6
    • 84954358567 scopus 로고    scopus 로고
    • Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/ glutathione S-transferase-activated nitric oxide prodrugs [J]
    • Chakrapani H, Kalathur RC, Maciag AE, et al. Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/ glutathione S-transferase-activated nitric oxide prodrugs [J]. Bioorg Med Chem, 2008, 16: 9764-9771.
    • (2008) Bioorg Med Chem , vol.16 , pp. 9764-9771
    • Chakrapani, H.1    Kalathur, R.C.2    Maciag, A.E.3
  • 7
    • 40749161463 scopus 로고    scopus 로고
    • Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/ NO, an anti-cancer lead compound [J]
    • Chakrapani H, Wilde TC, Citro ML, et al. Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: structural analogues of PABA/ NO, an anti-cancer lead compound [J]. Bioorg Med Chem, 2008, 16: 2657-2664.
    • (2008) Bioorg Med Chem , vol.16 , pp. 2657-2664
    • Chakrapani, H.1    Wilde, T.C.2    Citro, M.L.3
  • 8
    • 33747072593 scopus 로고    scopus 로고
    • A glycosylated nitric oxide donor, β-Gal-NONOate, and its site-specific antitumor activity [J]
    • Chen C, Shi YQ, Song J, et al. A glycosylated nitric oxide donor, β-Gal-NONOate, and its site-specific antitumor activity [J]. Arch Pharm (Weinheim), 2006, 339: 366-371.
    • (2006) Arch Pharm (Weinheim) , vol.339 , pp. 366-371
    • Chen, C.1    Shi, Y.Q.2    Song, J.3
  • 9
    • 0035795048 scopus 로고    scopus 로고
    • Synthesis of peptide-diazeniumdiolate conjugates: Towards enzyme activated antitumor agents [J]
    • Tang XP, Xian M, Trikha M, et al. Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents [J]. Tetrahedron Lett, 2001, 42: 2625-2629.
    • (2001) Tetrahedron Lett , vol.42 , pp. 2625-2629
    • Tang, X.P.1    Xian, M.2    Trikha, M.3
  • 10
    • 47149085610 scopus 로고    scopus 로고
    • Solid tumor physiology and hypoxia-induced chemo/radio- resistance: Novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer [J]
    • Yasuda H. Solid tumor physiology and hypoxia-induced chemo/radio- resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer [J]. Nitric Oxide, 2008, 19: 205-216.
    • (2008) Nitric Oxide , vol.19 , pp. 205-216
    • Yasuda, H.1
  • 11
    • 33644838950 scopus 로고    scopus 로고
    • Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small cell lung cancer [J]
    • Yasuda H, Yamaya M, Nakayama K. Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small cell lung cancer [J]. J Clin Oncol, 2006, 24: 688-694.
    • (2006) J Clin Oncol , vol.24 , pp. 688-694
    • Yasuda, H.1    Yamaya, M.2    Nakayama, K.3
  • 12
    • 41649090964 scopus 로고    scopus 로고
    • Anticancer properties of the novel nitric oxide-donating compound (S, R)-3-phenyl-4, 5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo [J]
    • Maksimovic-Ivanic D, Mijatovic S, Harhaji L, et al. Anticancer properties of the novel nitric oxide-donating compound (S, R)-3-phenyl-4, 5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo [J]. Mol Cancer Ther, 2008, 7: 510-520.
    • (2008) Mol Cancer Ther , vol.7 , pp. 510-520
    • Maksimovic-Ivanic, D.1    Mijatovic, S.2    Harhaji, L.3
  • 13
    • 0242329795 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates [J]
    • Cai TB, Tang XP, Nagorski J, et al. Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates [J]. Bioorg Med Chem, 2003, 11: 4971-4975.
    • (2003) Bioorg Med Chem , vol.11 , pp. 4971-4975
    • Cai, T.B.1    Tang, X.P.2    Nagorski, J.3
  • 14
    • 3042837373 scopus 로고    scopus 로고
    • Nitric oxide-donating NSAIDs as agents for cancer prevention [J]
    • Rigas B, Kashfi K. Nitric oxide-donating NSAIDs as agents for cancer prevention [J]. Trends Mol Med, 2004, 10: 324-330.
    • (2004) Trends Mol Med , vol.10 , pp. 324-330
    • Rigas, B.1    Kashfi, K.2
  • 15
    • 36749022313 scopus 로고    scopus 로고
    • Novel agents for cancer prevention based on nitric oxide [J]
    • Rigas B. Novel agents for cancer prevention based on nitric oxide [J]. Biochem Soc Trans, 2007, 35: 136-138.
    • (2007) Biochem Soc Trans , vol.35 , pp. 136-138
    • Rigas, B.1
  • 16
    • 58149388709 scopus 로고    scopus 로고
    • NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signaling pathway [J]
    • Stewart GD, Nanda J, Brown DJ, et al. NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signaling pathway [J]. Int J Cancer, 2009, 124: 223-232.
    • (2009) Int J Cancer , vol.124 , pp. 223-232
    • Stewart, G.D.1    Nanda, J.2    Brown, D.J.3
  • 17
    • 33947376041 scopus 로고    scopus 로고
    • Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats [J]
    • Jeong DW, Kim YH, Kim HH, et al. Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats [J]. Biopharm Drug Dispos, 2007, 28: 51-57.
    • (2007) Biopharm Drug Dispos , vol.28 , pp. 51-57
    • Jeong, D.W.1    Kim, Y.H.2    Kim, H.H.3
  • 18
    • 8444253806 scopus 로고    scopus 로고
    • Pentacyclic triterpenoic acids: New chemoprotective compounds [J]
    • Ovesna Z, Vachalkova A, Horvathova K, et al. Pentacyclic triterpenoic acids: new chemoprotective compounds [J]. Neoplasma, 2004, 51: 327-333.
    • (2004) Neoplasma , vol.51 , pp. 327-333
    • Ovesna, Z.1    Vachalkova, A.2    Horvathova, K.3
  • 19
    • 33745056480 scopus 로고    scopus 로고
    • Dual activity of triterpenoids: Apoptotic versus antidifferentiation effects [J]
    • Cipak L, Grausova L, Miadokova E, et al. Dual activity of triterpenoids: apoptotic versus antidifferentiation effects [J]. Arch Toxicol, 2006, 80: 429-435.
    • (2006) Arch Toxicol , vol.80 , pp. 429-435
    • Cipak, L.1    Grausova, L.2    Miadokova, E.3
  • 20
    • 33644650897 scopus 로고    scopus 로고
    • Anti-tumor activity of a 3-oxo derivative of oleanolic acid [J]
    • Huang D, Ding Y, Li Y, et al. Anti-tumor activity of a 3-oxo derivative of oleanolic acid [J]. Cancer Lett, 2006, 233: 289-296.
    • (2006) Cancer Lett , vol.233 , pp. 289-296
    • Huang, D.1    Ding, Y.2    Li, Y.3
  • 21
    • 39749129039 scopus 로고    scopus 로고
    • A novel synthetic oleanolic acid derivative (CPU-II(2)) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells [J]
    • Wu LM, Wu XX, Sun Y, et al. A novel synthetic oleanolic acid derivative (CPU-II(2)) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells [J]. J Biomed Sci, 2008, 15: 251-259.
    • (2008) J Biomed Sci , vol.15 , pp. 251-259
    • Wu, L.M.1    Wu, X.X.2    Sun, Y.3
  • 22
    • 49449090229 scopus 로고    scopus 로고
    • Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid [J]
    • Chen L, Zhang YH, Kong X, et al. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid [J]. J Med Chem, 2008, 51: 4834-4838.
    • (2008) J Med Chem , vol.51 , pp. 4834-4838
    • Chen, L.1    Zhang, Y.H.2    Kong, X.3
  • 23
    • 0036240316 scopus 로고    scopus 로고
    • Synthesis and cytotoxicities of mannose conjugated S-nitroso-N-acetylpenicillamine (SNAP) [J]
    • Wu XJ, Tang XP, Xian M, et al. Synthesis and cytotoxicities of mannose conjugated S-nitroso-N-acetylpenicillamine (SNAP) [J]. Bioorg Med Chem, 2002, 10: 2303-2307.
    • (2002) Bioorg Med Chem , vol.10 , pp. 2303-2307
    • Wu, X.J.1    Tang, X.P.2    Xian, M.3
  • 24
    • 76049092390 scopus 로고    scopus 로고
    • Studies on design, synthesis of site-targeting and NO-donating oleanolic acid derivatives as anti-hepatocellular carcinoma agents [D]
    • Huang Z. Studies on design, synthesis of site-targeting and NO-donating oleanolic acid derivatives as anti-hepatocellular carcinoma agents [D]. Nanjing: China Pharmaceutical University, 2009.
    • (2009) Nanjing: China Pharmaceutical University
    • Huang, Z.1
  • 25
    • 43749088058 scopus 로고    scopus 로고
    • Synthesis and anti-tumor activities of nitrate derivatives of glycyrrhetinic acid [J]
    • Shen LH, Lai YS, Zhang YH, et al. Synthesis and anti-tumor activities of nitrate derivatives of glycyrrhetinic acid [J]. J China Pharm Univ, 2008, 39: 103-107.
    • (2008) J China Pharm Univ , vol.39 , pp. 103-107
    • Shen, L.H.1    Lai, Y.S.2    Zhang, Y.H.3
  • 26
    • 56149094121 scopus 로고    scopus 로고
    • Synthesis and cytotoxic evaluation of novel dimethyl [1,1′-biphenyl]-2,2′-dicarboxylates bearing 1,3,4-thiadiazole moieties [J]
    • Kong XW, Zhang YH, Wang T, et al. Synthesis and cytotoxic evaluation of novel dimethyl [1,1′-biphenyl]-2,2′-dicarboxylates bearing 1,3,4-thiadiazole moieties [J]. Chem Biodivers, 2008, 5: 1743-1752.
    • (2008) Chem Biodivers , vol.5 , pp. 1743-1752
    • Kong, X.W.1    Zhang, Y.H.2    Wang, T.3
  • 27
    • 65649133605 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents [J]
    • Wang T, Zhang YH, Kong XW, et al. Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents [J]. Chem Biodivers, 2009, 6: 466-474.
    • (2009) Chem Biodivers , vol.6 , pp. 466-474
    • Wang, T.1    Zhang, Y.H.2    Kong, X.W.3
  • 28
    • 34547280054 scopus 로고    scopus 로고
    • Studies on synthesis and anti-tumor activity of conjugates of furoxans to N-(4-hydroxyphenyl) retinamide [J]
    • He BC, Zhang YH, Lai YS, et al. Studies on synthesis and anti-tumor activity of conjugates of furoxans to N-(4-hydroxyphenyl) retinamide [J]. Chin J Org Chem, 2007, 27: 629-635.
    • (2007) Chin J Org Chem , vol.27 , pp. 629-635
    • He, B.C.1    Zhang, Y.H.2    Lai, Y.S.3
  • 29
    • 0036562261 scopus 로고    scopus 로고
    • Potential cardioprotective actions of no-releasing aspirin [J]
    • Wallace JL, Ignarro LJ, Fiorucci S. Potential cardioprotective actions of no-releasing aspirin [J]. Nat Rev Drug Discov, 2002, 1: 375-382.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 375-382
    • Wallace, J.L.1    Ignarro, L.J.2    Fiorucci, S.3
  • 30
    • 0037407324 scopus 로고    scopus 로고
    • Nitric oxide donating aspirins: Novel drugs for the treatment of saphenous vein graft failure [J]
    • Shukla N, Angelini GD, Ascione R. Nitric oxide donating aspirins: novel drugs for the treatment of saphenous vein graft failure [J]. Ann Thorac Surg, 2003, 75: 1437-1442.
    • (2003) Ann Thorac Surg , vol.75 , pp. 1437-1442
    • Shukla, N.1    Angelini, G.D.2    Ascione, R.3
  • 31
    • 41149115687 scopus 로고    scopus 로고
    • Searching for new NO-donor aspirin-like molecules: A new class of nitrooxy-acyl derivatives of salicylic acid [J]
    • Lazzarato L, Donnola M, Rolando B, et al. Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid [J]. J Med Chem, 2008, 51: 1894-1903.
    • (2008) J Med Chem , vol.51 , pp. 1894-1903
    • Lazzarato, L.1    Donnola, M.2    Rolando, B.3
  • 32
    • 33750715208 scopus 로고    scopus 로고
    • Synthesis and antithrombotic activity of acetylsalicyl p-coumaric acid coupled with furoxans and nitrates [J]
    • Zhou Z, Jiang LY, Zhang YH, et al. Synthesis and antithrombotic activity of acetylsalicyl p-coumaric acid coupled with furoxans and nitrates [J]. Chin J Org Chem 2006, 26: 1403-1408.
    • (2006) Chin J Org Chem , vol.26 , pp. 1403-1408
    • Zhou, Z.1    Jiang, L.Y.2    Zhang, Y.H.3
  • 33
    • 33846180670 scopus 로고    scopus 로고
    • Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates [J]
    • Zhou Z, Jiang LY, Zhang YH, et al. Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates [J]. Acta Pharm Sin, 2006, 41: 1050-1056.
    • (2006) Acta Pharm Sin , vol.41 , pp. 1050-1056
    • Zhou, Z.1    Jiang, L.Y.2    Zhang, Y.H.3
  • 34
    • 46449113571 scopus 로고    scopus 로고
    • Zhou Z, Lai YS, Zhang YH, et al. Synthesis and antithrombotic activity of 3-aryl-1,2,3,4-oxatriazole-5-imine-aoupled aspirin [J]. Chin J Org Chem, 2008, 286: 819-824.
    • Zhou Z, Lai YS, Zhang YH, et al. Synthesis and antithrombotic activity of 3-aryl-1,2,3,4-oxatriazole-5-imine-aoupled aspirin [J]. Chin J Org Chem, 2008, 286: 819-824.
  • 35
    • 16344396144 scopus 로고    scopus 로고
    • Effects of 2-(1-hydroxypentyl)-benzoate on platelet aggregation and thrombus formation in rats [J]
    • Zhang Y, Wang L, Zhang L, et al. Effects of 2-(1-hydroxypentyl)-benzoate on platelet aggregation and thrombus formation in rats [J]. Drug Dev Res, 2004, 63: 174-180.
    • (2004) Drug Dev Res , vol.63 , pp. 174-180
    • Zhang, Y.1    Wang, L.2    Zhang, L.3
  • 36
    • 55749097193 scopus 로고    scopus 로고
    • Synthesis and anti-platelet activities of nitric oxide-releasing derivatives of 3-butylphthalide [J]
    • Min ZL, Zhang YH, Zhuang P, et al. Synthesis and anti-platelet activities of nitric oxide-releasing derivatives of 3-butylphthalide [J]. J China Pharm Univ, 2008, 39: 392-397.
    • (2008) J China Pharm Univ , vol.39 , pp. 392-397
    • Min, Z.L.1    Zhang, Y.H.2    Zhuang, P.3
  • 37
    • 0028858215 scopus 로고
    • The furoxan system as a useful tool for balancing "hybrids" with mixed alpha 1-antagonist and NO-like vasodilator activities [J]
    • Fruttero R, Boschi D, Di Stilo A, et al. The furoxan system as a useful tool for balancing "hybrids" with mixed alpha 1-antagonist and NO-like vasodilator activities [J]. J Med Chem, 1995, 38: 4944-4949.
    • (1995) J Med Chem , vol.38 , pp. 4944-4949
    • Fruttero, R.1    Boschi, D.2    Di Stilo, A.3
  • 38
    • 4444316090 scopus 로고    scopus 로고
    • Synthesis and vasorelaxant properties of hybrid molecules out of NO-donors and the beta-receptor blocking drug propranolol [J]
    • Decker M, König A, Glusa E, et al. Synthesis and vasorelaxant properties of hybrid molecules out of NO-donors and the beta-receptor blocking drug propranolol [J]. Bioorg Med Chem Lett, 2004, 14: 4995-4997.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 4995-4997
    • Decker, M.1    König, A.2    Glusa, E.3
  • 39
    • 46149088232 scopus 로고    scopus 로고
    • Therapeutic dose of nebivolol, a nitric oxide-releasing b-blocker, reduces atherosclerosis in cholesterol-fed rabbits [J]
    • de Nigris F, Mancini FP, Balestrieri ML, et al. Therapeutic dose of nebivolol, a nitric oxide-releasing b-blocker, reduces atherosclerosis in cholesterol-fed rabbits [J]. Nitric Oxide, 2008, 19: 57-63.
    • (2008) Nitric Oxide , vol.19 , pp. 57-63
    • de Nigris, F.1    Mancini, F.P.2    Balestrieri, M.L.3
  • 40
    • 0032585546 scopus 로고    scopus 로고
    • New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities [J]
    • Di Stilo A, Visentin S, Cena C, et al. New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities [J]. J Med Chem, 1998, 41: 5393-5401.
    • (1998) J Med Chem , vol.41 , pp. 5393-5401
    • Di Stilo, A.1    Visentin, S.2    Cena, C.3
  • 41
    • 3042703980 scopus 로고    scopus 로고
    • NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels [J]
    • Harada N, Miura T, Dairaku Y, et al. NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels [J]. J Cardiovasc Pharmacol, 2004, 44: 35-41.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 35-41
    • Harada, N.1    Miura, T.2    Dairaku, Y.3
  • 42
    • 30544448498 scopus 로고    scopus 로고
    • Study on NO-donating antihypertensive agents I. Synthesis and antihypertensive activity of C-3 nitrate or furoxan substituted benzopyrans [J]
    • Xu X, Zhang YH, Peng SX, et al. Study on NO-donating antihypertensive agents I. Synthesis and antihypertensive activity of C-3 nitrate or furoxan substituted benzopyrans [J]. J China Pharm Univ, 2005, 36: 488-495.
    • (2005) J China Pharm Univ , vol.36 , pp. 488-495
    • Xu, X.1    Zhang, Y.H.2    Peng, S.X.3
  • 43
    • 0037352294 scopus 로고    scopus 로고
    • S-nitrosocaptopril: In vitro characterization of pulmonary vascular effects in rats [J]
    • Tsui DY, Gambino A, Wanstall JC. S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats [J]. Br J Pharmacol, 2003, 138: 855-864.
    • (2003) Br J Pharmacol , vol.138 , pp. 855-864
    • Tsui, D.Y.1    Gambino, A.2    Wanstall, J.C.3
  • 44
    • 2442640601 scopus 로고    scopus 로고
    • A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure [J]
    • Iwanaga Y, Gu Y, Dieterle T, et al. A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure [J]. FASEB J, 2004, 18: 587-588.
    • (2004) FASEB J , vol.18 , pp. 587-588
    • Iwanaga, Y.1    Gu, Y.2    Dieterle, T.3
  • 45
    • 7444244389 scopus 로고    scopus 로고
    • NO sartans: A new class of pharmacodynamic hybrids as cardiovascular drugs [J]
    • Breschi MC, Calderone V, Digiacomo M, et al. NO sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs [J]. J Med Chem, 2004, 47: 5597-5600.
    • (2004) J Med Chem , vol.47 , pp. 5597-5600
    • Breschi, M.C.1    Calderone, V.2    Digiacomo, M.3
  • 46
    • 33646078807 scopus 로고    scopus 로고
    • New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: Design, synthesis, and biopharmacological properties [J]
    • Breschi MC, Calderone V, Digiacomo M, et al. New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties [J]. J Med Chem, 2006, 49: 2628-2639.
    • (2006) J Med Chem , vol.49 , pp. 2628-2639
    • Breschi, M.C.1    Calderone, V.2    Digiacomo, M.3
  • 47
    • 35449004560 scopus 로고    scopus 로고
    • WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats [J]
    • Li YQ, Ji H, Zhang YH, et al. WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats [J]. Eur J Pharmacol, 2007, 577: 100-108.
    • (2007) Eur J Pharmacol , vol.577 , pp. 100-108
    • Li, Y.Q.1    Ji, H.2    Zhang, Y.H.3
  • 48
    • 34249687023 scopus 로고    scopus 로고
    • 2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): Synthesis, nitric oxide release, and biological evaluation studies [J]
    • 2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies [J]. Bioorg Med Chem, 2007, 15: 4767-4774.
    • (2007) Bioorg Med Chem , vol.15 , pp. 4767-4774
    • Velázquez, C.A.1    Praveen Rao, P.N.2    Citro, M.L.3
  • 49
    • 40949102676 scopus 로고    scopus 로고
    • Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl) acrylic acids: Synthesis, cyclooxygenase inhibition, and nitric oxide release studies [J]
    • Abdellatif KR, Chowdhury MA, Dong Y, et al. Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl) acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies [J]. Bioorg Med Chem, 2008, 16: 3302-3308.
    • (2008) Bioorg Med Chem , vol.16 , pp. 3302-3308
    • Abdellatif, K.R.1    Chowdhury, M.A.2    Dong, Y.3
  • 50
    • 65549135036 scopus 로고    scopus 로고
    • Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: Synthesis, biological evaluation and nitric oxide release studies [J]
    • Abdellatif KR, Chowdhury MA, Dong Y, et al. Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies [J]. Bioorg Med Chem Lett, 2009, 19: 3014- 3018.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 3014-3018
    • Abdellatif, K.R.1    Chowdhury, M.A.2    Dong, Y.3
  • 51
    • 54849404481 scopus 로고    scopus 로고
    • Anti-inflammatory activity of a new class of nitric oxide synthase inhibitors that release nitric oxide [J]
    • Botta M, Distrutti E, Mencarelli A, et al. Anti-inflammatory activity of a new class of nitric oxide synthase inhibitors that release nitric oxide [J]. ChemMedChem, 2008, 3: 1580-1588.
    • (2008) ChemMedChem , vol.3 , pp. 1580-1588
    • Botta, M.1    Distrutti, E.2    Mencarelli, A.3
  • 52
    • 0042232431 scopus 로고    scopus 로고
    • Synthesis and anti-inflammatory activity of benzenesulfonylfuroxan-coupled diclofenac [J]
    • Li RW, Zhang YH, Ji H, et al. Synthesis and anti-inflammatory activity of benzenesulfonylfuroxan-coupled diclofenac [J]. Acta Pharm Sin, 2001, 36: 821-826.
    • (2001) Acta Pharm Sin , vol.36 , pp. 821-826
    • Li, R.W.1    Zhang, Y.H.2    Ji, H.3
  • 53
    • 0041912310 scopus 로고    scopus 로고
    • Synthesis and anti-inflammatory analgesic activities of phenylfuroxan-coupled diclofenac [J]
    • Li R, Zhang YH, Ji H, et al. Synthesis and anti-inflammatory analgesic activities of phenylfuroxan-coupled diclofenac [J]. Acta Pharm Sin, 2002, 37: 27-32.
    • (2002) Acta Pharm Sin , vol.37 , pp. 27-32
    • Li, R.1    Zhang, Y.H.2    Ji, H.3
  • 54
    • 5444239546 scopus 로고    scopus 로고
    • Effect of ZLR-8 on the healing of gastric ulcer and NO releasing in vitro [J]
    • Feng XC, Ji H, Zhang YH, et al. Effect of ZLR-8 on the healing of gastric ulcer and NO releasing in vitro [J]. J China Pharm Univ, 2004, 35: 357-360.
    • (2004) J China Pharm Univ , vol.35 , pp. 357-360
    • Feng, X.C.1    Ji, H.2    Zhang, Y.H.3
  • 55
    • 30044431944 scopus 로고    scopus 로고
    • Synthesis and anti-inflammatory analgesic activities of 2-(2,6-dichlorophenyl-amino)-benzeneacetic acid (3-nitroxymethyl) phenyl ester [J]
    • Wang WD, Zhang YH, Zhang ZG, et al. Synthesis and anti-inflammatory analgesic activities of 2-(2,6-dichlorophenyl-amino)-benzeneacetic acid (3-nitroxymethyl) phenyl ester [J]. J China Pharm Univ, 2003, 34: 13-16.
    • (2003) J China Pharm Univ , vol.34 , pp. 13-16
    • Wang, W.D.1    Zhang, Y.H.2    Zhang, Z.G.3
  • 56
    • 20844461153 scopus 로고    scopus 로고
    • Nitric oxide mimetic molecules as therapeutic agents in Alzheimer's disease [J]
    • Thatcher GRJ, Bennett BM, Reynolds JN. Nitric oxide mimetic molecules as therapeutic agents in Alzheimer's disease [J]. Curr Alzheimer Res, 2005, 2: 171-182.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 171-182
    • Thatcher, G.R.J.1    Bennett, B.M.2    Reynolds, J.N.3
  • 57
    • 33847031370 scopus 로고    scopus 로고
    • Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester [J]
    • Bennet BM, Reynolds JN, Prusky GT, et al. Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester [J]. Neuropsychopharmacology, 2007, 32: 505-513.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 505-513
    • Bennet, B.M.1    Reynolds, J.N.2    Prusky, G.T.3
  • 58
    • 84884669864 scopus 로고    scopus 로고
    • Green A, Bender R. Therapies for cognition and learning enhancement: CA 2649760 [P]. 2009-7-14.
    • Green A, Bender R. Therapies for cognition and learning enhancement: CA 2649760 [P]. 2009-7-14.
  • 59
    • 84884675070 scopus 로고    scopus 로고
    • Munoz B, Prasit P, Reger TS. Nitric oxide releasing drugs for Alzheimer's disease: US 20050054714 [P, 2005-3-10
    • Munoz B, Prasit P, Reger TS. Nitric oxide releasing drugs for Alzheimer's disease: US 20050054714 [P]. 2005-3-10.
  • 60
    • 39749166281 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-alzheimer drug candidates [J]
    • Fang L, Appenroth D, Decker M, et al. Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-alzheimer drug candidates [J]. J Med Chem, 2008, 51: 713-716.
    • (2008) J Med Chem , vol.51 , pp. 713-716
    • Fang, L.1    Appenroth, D.2    Decker, M.3
  • 61
    • 58149087995 scopus 로고    scopus 로고
    • NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity [J]
    • Fang L, Appenroth D, Decker M, et al. NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity [J]. J Med Chem, 2008, 51: 7666-7669.
    • (2008) J Med Chem , vol.51 , pp. 7666-7669
    • Fang, L.1    Appenroth, D.2    Decker, M.3
  • 62
    • 4444384291 scopus 로고    scopus 로고
    • Overexpression of iNOS gene suppresses the tumorigenicity and metastasis of oral cancer cells [J]
    • Harada K, Supriatno, Kawaguchi S, et al. Overexpression of iNOS gene suppresses the tumorigenicity and metastasis of oral cancer cells [J]. In Vivo, 2004, 18: 449-455.
    • (2004) In Vivo , vol.18 , pp. 449-455
    • Harada, K.1    Supriatno, K.S.2
  • 63
    • 1242338769 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity [J]
    • Wang Z, Cook T, Alber S, et al. Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity [J]. Cancer Res, 2004, 64: 1386-1395.
    • (2004) Cancer Res , vol.64 , pp. 1386-1395
    • Wang, Z.1    Cook, T.2    Alber, S.3
  • 64
    • 0036481660 scopus 로고    scopus 로고
    • Microencapsulated iNOS-expressing cells cause tumor suppression in mice [J]
    • Xu W, Liu L, Charles IG. Microencapsulated iNOS-expressing cells cause tumor suppression in mice [J]. FASEB J, 2002, 16: 213-215.
    • (2002) FASEB J , vol.16 , pp. 213-215
    • Xu, W.1    Liu, L.2    Charles, I.G.3
  • 65
    • 46249126587 scopus 로고    scopus 로고
    • A lifeline for suffocating tissues [J]
    • Mazzone M, Carmeliet P. A lifeline for suffocating tissues [J]. Nature, 2008, 453: 1194-1195.
    • (2008) Nature , vol.453 , pp. 1194-1195
    • Mazzone, M.1    Carmeliet, P.2
  • 66
    • 44949238763 scopus 로고    scopus 로고
    • Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis [J]
    • Kumar D, Branch BG, Pattillo CB, et al. Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis [J]. Proc Natl Acad Sci USA, 2008, 105: 7540-7545.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7540-7545
    • Kumar, D.1    Branch, B.G.2    Pattillo, C.B.3
  • 67
    • 0037709917 scopus 로고    scopus 로고
    • Relationship between nitric oxide production and choroidal blood flow [J]
    • Xuan B, Xu XR, Chiou GC, et al. Relationship between nitric oxide production and choroidal blood flow [J]. J Ocular Pharmacol Ther, 2003, 19: 247-253.
    • (2003) J Ocular Pharmacol Ther , vol.19 , pp. 247-253
    • Xuan, B.1    Xu, X.R.2    Chiou, G.C.3
  • 69
    • 67249157661 scopus 로고    scopus 로고
    • Strategy of molecular drug design: Dual-target drug design [J]
    • Guo Z. Strategy of molecular drug design: dual-target drug design [J]. Acta Pharm Sin, 2009, 44: 209-218.
    • (2009) Acta Pharm Sin , vol.44 , pp. 209-218
    • Guo, Z.1
  • 70
    • 67249123401 scopus 로고    scopus 로고
    • Multi-target therapeutics and new drug discovery [J]
    • Xu Y, Li X. Multi-target therapeutics and new drug discovery [J]. Acta Pharm Sin, 2009, 44: 226-230..
    • (2009) Acta Pharm Sin , vol.44 , pp. 226-230
    • Xu, Y.1    Li, X.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.