-
1
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates? [J]
-
Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? [J]. Nat Rev Drug Discov, 2004, 3: 711-716.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-716
-
-
Kola, I.1
Landis, J.2
-
2
-
-
57749099247
-
Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease [J]
-
Bolognesi ML, Cavalli A, Meichiorre C. Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease [J]. Neurotherapeutics, 2009, 6: 152-162.
-
(2009)
Neurotherapeutics
, vol.6
, pp. 152-162
-
-
Bolognesi, M.L.1
Cavalli, A.2
Meichiorre, C.3
-
3
-
-
44449106003
-
A reporter assay for target validation in primary neuronal cultures [J]
-
Pollio G Roncarati R, Seredenina T, et al. A reporter assay for target validation in primary neuronal cultures [J]. J Neurosci Meth, 2008, 172: 34-37.
-
(2008)
J Neurosci Meth
, vol.172
, pp. 34-37
-
-
Pollio, G.1
Roncarati, R.2
Seredenina, T.3
-
4
-
-
47349124275
-
What does systems biology mean for drug development? [J]
-
Schrattenholz A, Soskic V. What does systems biology mean for drug development? [J]. Cur Med Chem, 2008, 15: 1520-1528.
-
(2008)
Cur Med Chem
, vol.15
, pp. 1520-1528
-
-
Schrattenholz, A.1
Soskic, V.2
-
5
-
-
33845762340
-
Multi-target therapeutics: When the whole is greater than the sum of the parts [J]
-
Zimmermann GR, Lehar J, Keith CT. Multi-target therapeutics: When the whole is greater than the sum of the parts [J]. Drug Discov Today, 2007, 12: 34-42.
-
(2007)
Drug Discov Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehar, J.2
Keith, C.T.3
-
6
-
-
34147220392
-
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis [J]
-
Gupta GP, Nguyen DX, Chiang AC, et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis [J]. Nature, 2007, 446: 765-770.
-
(2007)
Nature
, vol.446
, pp. 765-770
-
-
Gupta, G.P.1
Nguyen, D.X.2
Chiang, A.C.3
-
7
-
-
38849161398
-
The role of alemtuzumab in the treatment of chronic lymphocytic leukemia [J]
-
Zent CS. The role of alemtuzumab in the treatment of chronic lymphocytic leukemia [J]. Leuk Lymphoma, 2008, 49: 175-176.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 175-176
-
-
Zent, C.S.1
-
8
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery [J]
-
Hopkins AL. Network pharmacology: The next paradigm in drug discovery [J]. Nat Chem Biol, 2008, 4: 682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
9
-
-
41549108420
-
From single-to multi-target drugs in cancer therapy: When a specificity becomes an advantage [J]
-
Petrelli A, Giordano S. From single-to multi-target drugs in cancer therapy: When a specificity becomes an advantage [J]. Curr Med Chem, 2008, 15: 422-432.
-
(2008)
Curr Med Chem
, vol.15
, pp. 422-432
-
-
Petrelli, A.1
Giordano, S.2
-
10
-
-
33750811447
-
Cell based assays using primary endotheial cells to study multiple steps in inflammation [J]
-
Mayer T, Jagla B, Wyler MR, et al. Cell based assays using primary endotheial cells to study multiple steps in inflammation [J]. Method Enzymul, 2006, 414: 266-283.
-
(2006)
Method Enzymul
, vol.414
, pp. 266-283
-
-
Mayer, T.1
Jagla, B.2
Wyler, M.R.3
-
11
-
-
45349105370
-
Fishing for drugs from nature: Zebrafish as a technology platform for natural product discovery [J]
-
Crawford AD, Esguerra CV, de Witte PA. Fishing for drugs from nature: Zebrafish as a technology platform for natural product discovery [J]. Planta Mcd, 2008, 74: 624-632.
-
(2008)
Planta Mcd
, vol.74
, pp. 624-632
-
-
Crawford, A.D.1
Esguerra, C.V.2
de Witte, P.A.3
-
12
-
-
17244375049
-
Specific killing of BRCA2 - deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J]
-
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2 - deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J]. Nature, 2005, 434: 913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
-
13
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics [J]
-
Borisy AA, Elliott PJ, Hurst NW, et al. Systematic discovery of multicomponent therapeutics [J]. PNAS, 2003, 100: 7977-7982.
-
(2003)
PNAS
, vol.100
, pp. 7977-7982
-
-
Borisy, A.A.1
Elliott, P.J.2
Hurst, N.W.3
-
14
-
-
3242794178
-
From magic bullets to designed multiple ligands [J]
-
Morphy R, Kay C, Rankovic Z. From magic bullets to designed multiple ligands [J]. Drug Discov Today, 2004, 9: 641-651.
-
(2004)
Drug Discov Today
, vol.9
, pp. 641-651
-
-
Morphy, R.1
Kay, C.2
Rankovic, Z.3
-
15
-
-
57749195942
-
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression [J]
-
Cashman JR, Voelker T, Johnson R, et al. Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression [J]. Bioorg Med Chem, 2009, 17: 337-343.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 337-343
-
-
Cashman, J.R.1
Voelker, T.2
Johnson, R.3
-
16
-
-
0037194633
-
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists [J]
-
Murugesan N, Tellew JE, Gu ZX, et al. Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists [J]. J Med Chem, 2002, 45: 3829-3835.
-
(2002)
J Med Chem
, vol.45
, pp. 3829-3835
-
-
Murugesan, N.1
Tellew, J.E.2
Gu, Z.X.3
-
17
-
-
59349111624
-
The rise of second-generation non-nucleoside reverse transcriptase inhibitors: Etravirine, rilpivirine, UK-453061 and RDEA-806 [J]
-
Abdel-Malak M, Gallati C, Mousa SA. The rise of second-generation non-nucleoside reverse transcriptase inhibitors: Etravirine, rilpivirine, UK-453061 and RDEA-806 [J]. Drug Future, 2008, 33: 691-699.
-
(2008)
Drug Future
, vol.33
, pp. 691-699
-
-
Abdel-Malak, M.1
Gallati, C.2
Mousa, S.A.3
-
18
-
-
33845618105
-
Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation [J]
-
Chen X, Zhou H, Liu YB, et al. Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation [J]. Br I Pharmacol, 2006, 149: 1092-1103.
-
(2006)
Br I Pharmacol
, vol.149
, pp. 1092-1103
-
-
Chen, X.1
Zhou, H.2
Liu, Y.B.3
-
19
-
-
51349137454
-
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins [J]
-
Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins [J]. Cancer Lett, 2008, 269: 199-225.
-
(2008)
Cancer Lett
, vol.269
, pp. 199-225
-
-
Kunnumakkara, A.B.1
Anand, P.2
Aggarwal, B.B.3
-
20
-
-
33847369020
-
Lapatinib induces apoptosis in trastuzumab - resistant breast cancer cells: Effects on insulin-like growth factor I signaling [J]
-
Nahta R, Yuan LXH, Du Y, et al. Lapatinib induces apoptosis in trastuzumab - resistant breast cancer cells: Effects on insulin-like growth factor I signaling [J]. Mol Cancer Ther, 2007, 6: 667-674.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 667-674
-
-
Nahta, R.1
Yuan2
LXH, D.Y.3
-
21
-
-
34250809004
-
Metformin/rosiglitazone combination pill (Avandamet) for the treatment of patients with Type 2 diabetes [J]
-
Smlley D, Umpierrez U Metformin/rosiglitazone combination pill (Avandamet) for the treatment of patients with Type 2 diabetes [J]. Expert Opin Pharmacother, 2007, 8: 1353-1364.
-
(2007)
Expert Opin Pharmacother
, vol.8
, pp. 1353-1364
-
-
Smlley, D.1
Umpierrez, U.2
-
22
-
-
43849110759
-
Current and future antiretroviral treatment options in paediatric HIV infection [J]
-
Giaquinto C, Morelli E, Fregonese F, et al. Current and future antiretroviral treatment options in paediatric HIV infection [J]. Clin Drug Invest, 2008, 28: 375-397.
-
(2008)
Clin Drug Invest
, vol.28
, pp. 375-397
-
-
Giaquinto, C.1
Morelli, E.2
Fregonese, F.3
-
23
-
-
43649099086
-
Turning promiscuous kinase inhibitors into safer drugs [J]
-
Zhang X, Crespo A, Fernandez A. Turning promiscuous kinase inhibitors into safer drugs [J]. Trends Biotechnol, 2008, 26: 295-301.
-
(2008)
Trends Biotechnol
, vol.26
, pp. 295-301
-
-
Zhang, X.1
Crespo, A.2
Fernandez, A.3
|