Synthesis and anti-inflammatory analgesic activities of 2-(2, 6-dichlorophenylamino)-benzeneacetic acid (3-nitroxymethyl) phenyl ester

Journal of China Pharmaceutical University

Volumn 34, Issue 1, 2003, Pages 13-16

  Wang, Wei Dong ^a   Zhang, Yi Hua ^a   Zhang, Zhi Guo ^a   Ji, Hui ^a   Yu, Xiao Lin ^a   Peng, Si Xun ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Analgesic activities; Anti inflammatory; NO releasing DC; Side effects; Synthesis; ZLR 9

Indexed keywords

2 (2,6 DICHLOROPHENYLAMINO)BENZENACETIC ACID(3 NITROXYMETHYL)PHENYL ESTER; 3 HYDROXYBENZALDEHYDE; CARRAGEENAN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; XYLENE; ZLR 9;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BROMINATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; GASTROINTESTINAL DISEASE; HOT PLATE TEST; IN VITRO STUDY; IN VIVO STUDY; INFRARED RADIATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; OTITIS; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REDUCTION; WRITHING TEST;

EID: 30044431944     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Zhang YH, Peng SX. J China Pharm Uni, 2001,32(5):321-328.
2. HCT-1026 [J]. Drugs Future, 2001, 26(8): 801-802.
3. NCX-4016[J]. Drugs Future, 2001, 26(11): 1120-1121.
4. Li RW, Zhang YH, Ji H. Acta Pharm Sin, 2001, 36(11): 821-825.
5. Li RW, Zhang YH, Ji H. Acta Pharm Sin, 2002,37(1): 27-32.
6. Yu XL, Ji H, Zhang YH. J Chin Pharm Uni, 2001,32(4):301-305.
7. NCX-4016[J]. Drugs Future, 1997, 22(11):1231-1233.
8. Lane CF, Myatt HL, Daniels J, et al. Organic synthesis using borane-methyl sufide. II. Reduction of aromatic carboxylic acids in the presence of trimethyl borate[J]. J org chem, 1974, 39(20): 3052-3054.
9. Serra MX, Pi SJ. Nitric ester of 2-(2, 6-dihalophenylamino) phenylacetoacetic acid derivatives and their preparation process [P]. EP738706, 1996-10-23.
10. Cirino G, Peers SH, Flower RJ, et al. Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test [J]. Proc Natl Sci USA. 1989, 86(9): 3428-3432.
11. Gasco AM, Boschi D, Stilo AD, et al. Characterization of furoxan-carbonitriles as a new class of vasodilators[J]. Arzneim-Forsch/Drug Res. 1998, 48(1): 212-218.
12. Sorba G, Medana C, Fruttero R, et al. Water soluble furoxan derivatives as NO prodrugs[J]. J Med Chem. 1997,40(4):463-469.