Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester

Neuropsychopharmacology

Volumn 32, Issue 3, 2007, Pages 505-513

  Bennett, Brian M ^a   Reynolds, James N ^a   Prusky, Glen T ^b   Douglas, Robert M ^c   Sutherland, Robert J ^b   Thatcher, Gregory R J ^d  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF LETHBRIDGE   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Alzheimer's disease; cGMP; Cognition; ERK; Memory; Nitric oxide

Indexed keywords

4 METHYL 5 (2 NITROXYETHYL)THIAZOLE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GT 1061; GUANYLATE CYCLASE; NITRIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CHOLINERGIC NERVE CELL; CHOLINERGIC SYSTEM; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FOREBRAIN; HIPPOCAMPUS; LEARNING; LONG TERM MEMORY; MEMORY; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPATIAL MEMORY; TASK PERFORMANCE; VASCULARIZATION; VISUAL MEMORY;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CHOICE BEHAVIOR; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDANS; MALE; MAZE LEARNING; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRATES; NOOTROPIC AGENTS; PHOSPHORYLATION; PIPERIDINES; PROSENCEPHALON; PROTEIN BINDING; PSYCHOLOGICAL TESTS; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; REACTION TIME;

EID: 33847031370     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301054     Document Type: Article

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