Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 22, 2008, Pages 9764-9771

  Chakrapani, Harinath ^a   Kalathur, Ravi C ^a   Maciag, Anna E ^b   Citro, Michael L ^b   Ji, Xinhua ^a   Keefer, Larry K ^a   Saavedra, Joseph E ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Cancer; Diazeniumdiolate; GST; JS K; Nitric oxide; Prodrug

Indexed keywords

2 O (2,4 DINITROPHENYL) 1 [(4 ETHOXYCARBONYL)PIPERAZIN 1 YL]DIAZEN 1 IUM 1,2 DIOLATE; ANION; DIAZENIUM DIOLATE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; NITRIC OXIDE; NITRIC OXIDE DONOR; PRODRUG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 84954358567     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.063     Document Type: Article

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