Synthesis and anti-tumor activities of nitrate derivatives of glycyrrhetinic acid

Journal of China Pharmaceutical University

Volumn 39, Issue 2, 2008, Pages 103-107

  Shen, Li Hong ^a   Lai, Yi Sheng ^a   Zhang, Yi Hua ^a   Luo, Xu Xin ^a   Yuan, Sheng Tao ^a   Zhang, Lu Yong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti tumor activity; Glycyrrhetinic acid; Nitrates; NO donors; Synthesis

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETIC ACID DERIVATIVE; AMINE; ANTINEOPLASTIC AGENT; CHLORIDE; GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID DERIVATIVE; HYDROXYL GROUP; NITRIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

EID: 43749088058     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Armanini D, Fiore C, Mattarello MJ, et al. History of the endocrine effects of licorice[J]. Exp Clin Endocrinol Diabetes,2002, 110(5):257-261.
2. Shim SB, Kim NJ, Kim DH. Beta-glucuronidase inhibitory activity and hepato protective effect of 18 beta-glycyrrhetinic acid from the rhizomes of glycyrrhiza uralensis[J]. Planta Med,2000,66 (1):40-43.
3. Cinatl J, Morgenstern B, Bauer G, et al. Glycyrrhizin, an active component of liquorice roots,and replication of SARS-associated coronavirus[J]. Lancet, 2003,361(9374):2045-2046.
4. Rudkin GH, Carlsen BT, Chung CY, et al. Retinoids inhibit squamous cell carcinoma growth and intercellular communication [J]. J Surg Res,2002, 103(2):183-189.
5. Wang ZY, Agarwal R, Zhou ZC, et al. Inhibition of mutagenicity in Salmonekka typhimurium and skin fum or initiating and tumor promoting activities in SENCAR mice by glycyrrhetinic acid: comparison of 18α and 18β-steroisomers [J]. Carcinogenesis, 1991,12(2):187-192.
6. Jin JM, Liu XF, Xu HS. Chin J Appl Chem,2001,18(11):869-872.
7. Jeong HG, Kim JY. Induction of inducible nitric oxide synthase expression by 18β-glycyrrhetinic acid in macrophages[J]. FEBS Lett,2002, 513(2-3):208-212.
8. Zhang YH, Tian JD, Peng SX. Acta Pharm Sin,2006,41(6):481-486.
9. Zhang YH, Peng SX. J China Pharm Univ,2006,37(5):387-396.
10. Xie K, Huang S. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency [J]. Free Radic Biol Med, 2003, 34(8):969-986.
11. Wang Y, Ding H, Xiao GF. Chin J Cander,2004,23(4):476-479.
12. Rigas B, Kashfi K. Nitric oxide-donating NSAIDs as agents for cancer prevention [J]. Trends Mol Med, 2004,10(7):324-330.
13. Leonetti C, Scarsella M, Zupi G, et al. Efficacy of a nitric oxide-releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenografts[J]. Mol Cancer Ther,2006,5(4):919-926.
14. Tatsuzaki J, Taniguchi M, Bastow KF, et al. Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents[J]. Bioorg Med Chem,2007,15(18):6 193-6 199.