3,5-bis(phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A novel group of cytotoxic agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 4, 2003, Pages 325-332

  Dimmock, J R ^a   Jha, A ^a   Zello, G A ^a   Sharma, R K ^b   Shrivastav, A ^b   Selvakumar, P ^b   Allen, T M ^c   Santos, C L ^c   Balzarini, J ^d   De Clercq, E ^d   Manavathu, E K ^e   Stables, J P ^f  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

4 piperidones; Cytotoxicity; Human N myristoyltransferase; Maleamic acids; Molecular modeling

Indexed keywords

3,5 BIS(PHENYLMETHYLENE) 1 (N ARYLMALEAMOYL) 4 PIPERIDONE DERIVATIVE; CARBOXYLIC ACID; N ARYLMALEAMIC ACID DERIVATIVE; PIPERIDONE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN N MYRISTOYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL BOND; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTICONVULSANTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; LEUKEMIA L1210; LEUKEMIA P388; LEUKEMIA, T-CELL; MICE; PIPERIDONES; T-LYMPHOCYTES;

ANIMALIA; MURINAE;

EID: 12444334525     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636031000121938     Document Type: Article

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