Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4- piperidones and related compounds

European Journal of Medicinal Chemistry

Volumn 37, Issue 12, 2002, Pages 961-972

  Dimmock, Jonathan R ^a   Jha, Amitabh ^a   Zello, Gordon A ^a   Quail, J Wilson ^a   Oloo, Eliud O ^a   Nienaber, Kurt H ^a   Kowalczyk, Earl S ^a   Allen, Theresa M ^b   Santos, Cheryl L ^b   De Clercq, Erik ^c   Balzarini, Jan ^c   Manavathu, Elias K ^d   Stables, James P ^e  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

4 Piperidones; Cytotoxicity; Murine toxicity; Structure activity relationships

Indexed keywords

ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; FUNCTIONAL GROUP; PIPERIDONE DERIVATIVE;

ANIMAL CELL; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CELL DEATH; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYTOTOXINS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; PIPERIDONES; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES;

EID: 0036948054     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01414-9     Document Type: Article

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