Short-term exercise does not increase ER stress protein expression in cardiac muscle

Medicine and Science in Sports and Exercise

Volumn 39, Issue 9, 2007, Pages 1522-1528

  Murlasits, Zsolt ^a   Lee, Youngil ^a   Powers, Scott K ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Apoptosis; Cardioprotection; Endurance exercise; Ischemia reperfusion injury

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; CALRETICULIN; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 72; PROTEIN NOXA; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EXERCISE; HEART INFARCTION SIZE; HEART MUSCLE; HEART MUSCLE INJURY; HEART PROTECTION; HYPOTHESIS; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; TREADMILL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; ENDOPLASMIC RETICULUM; EXERCISE TEST; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MEMBRANE PROTEINS; MOLECULAR CHAPERONES; MOTOR ACTIVITY; MYOCARDIUM; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 34548387856     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/mss.0b013e3180cc25c7     Document Type: Article

References (30)

1. BOYA, P., I. COHEN, N. ZAMZAMI, H. L. VIEIRA, and G. KROEMER. Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization. Cell Death Differ. 9:465-467, 2002.
2. BRECKENRIDGE, D. G., M. GERMAIN, J. P. MATHAI, M. NGUYEN, and G. C. SHORE. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22:8608-8618, 2003.
3. FRENCH, J. P., J. C. QUINDRY, D. J. FALK, et al. Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition. Am. J. Physiol. Heart Circ. Physiol. 290:H128-H136, 2006.
4. GONZALEZ, B., R. HERNANDO, and R. MANSO. Stress proteins of 70 kDa in chronically exercised skeletal muscle. Pflugers Arch. 440:42-49, 2000.
5. GONZALEZ, B., and R. MANSO. Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses. J. Physiol. 556:369-385, 2004.
6. HAMILTON, K. L., S. K. POWERS, T. SUGIURA, et al. Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins. Am. J. Physiol. Heart Circ. Physiol. 281:H1346-H1352, 2001.
7. HAMILTON, K. L., J. C. QUINDRY, J. P. FRENCH, et al. MnSOD antisense treatment and exercise-induced protection against arrhythmias. Free Radic. Biol. Med. 37:1360-1368, 2004.
8. HARRIS, M. B., and J. W. STARNES. Effects of body temperature during exercise training on myocardial adaptations. Am. J. Physiol. Heart Circ. Physiol. 280:H2271-H2280, 2001.
9. HUNTER, R. B., H. MITCHELL-FELTON, D. A. ESSIG, and S. C. KANDARIAN. Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy. Am. J. Physiol. Cell Physiol. 281:C1285-C1290, 2001.
10. HUTTER, J. J., R. MESTRIL, E. K. TAM, R. E. SIEVERS, W. H. DILLMANN, and C. L. WOLFE. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo. Circulation 94:1408-1411, 1996.
11. LAUGHLIN, M. H., and R. M. MCALLISTER. Exercise training-induced coronary vascular adaptation. J. Appl. Physiol. 73:2209-2225, 1992.
12. LAWLER, J. M., S. K. POWERS, J. HAMMEREN, and A. D. MARTIN. Oxygen cost of treadmill running in 24-month-old Fischer-344 rats. Med. Sci. Sports Exerc. 25:1259-1264, 1993.
13. LENNON, S. L., J. C. QUINDRY, J. P. FRENCH, S. KIM, J. L. MEHTA, and S. K. POWERS. Exercise and myocardial tolerance to ischaemia-reperfusion. Acta Physiol. Scand. 182:161-169, 2004.
14. LI, J., B. LEE, and A. S. LEE. Endoplasmic reticulum stressinduced apoptosis: multiple pathways and activation of p53-upregulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281:7260-7270, 2006.
15. LOGUE, S. E., A. B. GUSTAFSSON, A. SAMALI, and R. A. GOTTLIEB. Ischemia/reperfusion injury at the intersection with cell death. J. Mol. Cell Cardiol. 38:21-33, 2005.
16. MARTINDALE, J. J., R. FERNANDEZ, D. THUERAUF, et al. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ. Res. 98:1186-1193, 2006.
17. MESTRIL, R., F. J. GIORDANO, A. G. CONDE, and W. H. DILLMANN. Adenovirus-mediated gene transfer of a heat shock protein 70 (hsp 70i) protects against simulated ischemia. J. Mol. Cell Cardiol. 28:2351-2358, 1996.
18. MORAN, M., J. DELGADO, B. GONZALEZ, R. MANSO, and A. MEGIAS. Responses of rat myocardial antioxidant defences and heat shock protein HSP72 induced by 12 and 24-week treadmill training. Acta Physiol. Scand. 180:157-166, 2004.
19. OKADA, K., T. MINAMINO, Y. TSUKAMOTO, et al. Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation 110:705-712, 2004.
20. POWERS, S. K., H. A. DEMIREL, H. K. VINCENT, et al. Exercise training improves myocardial tolerance to in vivo ischemiareperfusion in the rat. Am. J. Physiol. 275:R1468-R1477, 1998.
21. POWERS, S. K., S. L. LENNON, J. QUINDRY, and J. L. MEHTA. Exercise and cardioprotection. Curr. Opin. Cardiol. 17:495-502, 2002.
22. QUINDRY, J., J. FRENCH, K. HAMILTON, Y. LEE, J. L. MEHTA, and S. POWERS. Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals. Exp. Gerontol. 40:416-425, 2005.
23. RADAK, Z., A. W. TAYLOR, H. OHNO, and S. GOTO. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc. Immunol. Rev. 7:90-107, 2001.
24. SIU, P. M., R. W. BRYNER, J. K. MARTYN, and S. E. ALWAY. Apoptotic adaptations from exercise training in skeletal and cardiac muscles. FASEB J. 18:1150-1152, 2004.
25. TAYLOR, R. P., M. B. HARRIS, and J. W. STARNES. Acute exercise can improve cardioprotection without increasing heat shock protein content. Am. J. Physiol. 276:H1098-H1102, 1999.
26. TOTH, A., J. R. JEFFERS, P. NICKSON, et al. Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 291:H52-H60, 2006.
27. VITADELLO, M., D. PENZO, V. PETRONILLI, et al. Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia. FASEB J. 17:923-925, 2003.
28. WU, J., and R. J. KAUFMAN. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ. 13:374-384, 2006.
29. YOSHIDA, H. ER stress and diseases. FEBS J. 274:630-658, 2007.
30. ZHANG, P. L., M. LUN, J. TENG, et al. Preinduced molecular chaperones in the endoplasmic reticulum protect cardiomyocytes from lethal injury. Ann. Clin. Lab. Sci. 34:449-457, 2004.