Anguinomycins and derivatives: Total syntheses, modeling, and biological evaluation of the inhibition of nucleocytoplasmic transport

Journal of the American Chemical Society

Volumn 132, Issue 4, 2010, Pages 1432-1442

  Bonazzi, Simone ^a,d   Eidam, Oliv ^b   Güttinger, Stephan ^c   Wach, Jean Yves ^a   Zemp, Ivo ^c   Kutay, Ulrike ^c   Gademann, Karl ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ETH ZURICH   (Switzerland)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIONS; BIOLOGICAL ACTIVITIES; BIOLOGICAL EVALUATION; CROSS-COUPLINGS; HETERO DIELS-ALDER REACTION; KEYPOINTS; LEPTOMYCIN; NATURAL PRODUCTS; NUCLEAR EXPORT; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT; POLYKETIDES; STEREOINVERSION; STRUCTURAL BASIS; SUZUKI-MIYAURA; TOTAL SYNTHESIS; TRANSPORT INHIBITORS; X RAY CRYSTAL STRUCTURES;

CHROMIUM; CHROMIUM COMPOUNDS;

CHEMICAL REACTIONS;

ANGUINOMYCIN C; ANGUINOMYCIN D; EVANS BLUE; LEPTOMYCIN B; NATURAL PRODUCT; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; POLYKETIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; DIASTEREOISOMER; DIELS ALDER REACTION; HELA CELL; HUMAN; HUMAN CELL; NUCLEAR EXPORT SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; SYNTHESIS;

BIOLOGICAL TRANSPORT; CELL NUCLEUS; CRYSTALLOGRAPHY, X-RAY; CYTOPLASM; FATTY ACIDS, UNSATURATED; HELA CELLS; HUMANS; KARYOPHERINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 75749144221     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9097093     Document Type: Article

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