Integrative genomic analyses of CXCR4: Transcriptional regulation of CXCR4 based on TGFβ, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors

International Journal of Oncology

Volumn 36, Issue 2, 2010, Pages 415-420

  Katoh, Masuko ^a   Katoh, Masaru ^b  

^a M&M Medical BioInformatics   (Japan)

^b NATIONAL CANCER CENTER   (Japan)

Author keywords

Bioinformatics; Bone metastasis; Breast cancer; Esophageal cancer; G protein coupled receptor; Gastric cancer; Peritoneal dissemination; Personalized medicine; Pleural effusion; Stem cells

Indexed keywords

ACTIVIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CHEMOKINE RECEPTOR CXCR4; HEPATOCYTE NUCLEAR FACTOR 3BETA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOID ENHANCER FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN NODAL; PROTEIN P53; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXC2; TRANSCRIPTION FACTOR FOXH1; TRANSCRIPTION FACTOR GFI1; TRANSCRIPTION FACTOR POU; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CANCER CELL; CANCER INVASION; CANCER STEM CELL; CONTROLLED STUDY; DOWN REGULATION; ETS1 GENE; GENE EXPRESSION; GENE MUTATION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME ANALYSIS; GLI1 GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ACTIVINS; ANIMALS; BASE SEQUENCE; COMPARATIVE GENOMIC HYBRIDIZATION; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASMS; NODAL PROTEIN; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; RATS; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; SOXF TRANSCRIPTION FACTORS; STEM CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 75449087368     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000514     Document Type: Article

References (83)

1. Rossant J: Stem cells and early lineage development. Cell 132: 527-531, 2008.
2. Sato T, Vries RG, Snippert HJ, et al: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262-265, 2009.
3. Sangiorgi E and Capecchi MR: Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. Proc Natl Acad Sci USA 106: 7101-7106, 2009.
4. Clevers H: Stem cells, asymmetric division and cancer. Nat Genet 37: 1027-1028, 2005.
5. Passegué E: A game of subversion. Nature 442: 754-755, 2006.
6. Katoh M: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change, and genetic alteration in gastric cancer. Cancer Biol Ther 6: 832-839, 2007.
7. Yin AH, Miraglia S, Zanjani ED, et al: AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90: 5002-5012, 1997.
8. Katoh Y and Katoh M: Comparative genomics on PROM1 gene encoding stem cell marker CD133. Int J Mol Med 19: 967-970, 2007.
9. Aruffo A, Stamenkovic I, Melnick M, et al: CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313, 1990.
10. Takaishi S, Okumura T, Tu S, et al: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27: 1006-1020, 2009.
11. Doyle LA, Yang W, Abruzzo LV, et al: A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 95: 15665-15670, 1998.
12. Kim M, Turnquist H, Jackson J, et al: The multidrug resistance transporter ABCG2 effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res 8: 22-28, 2002.
13. Loetscher M, Geiser T, O'Reilly T, et al: Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 269: 232-237, 1994.
14. Lapidot T and Kollet O: The essential roles of the chemokine SDF1 and its receptor CXCR4 in human stem cell homing. Leukemia 16: 1992-2003, 2002.
15. Feng Y, Broder CC, Kennedy PE and Berger EA: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872-877, 1996.
16. Oberlin E, Amara A, Bachelerie F, et al: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382: 833-835, 1996.
17. Lagerström MC and Schiöth HB: Structural diversity of G-protein coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7: 339-358, 2008.
18. Epstein RJ: The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies. Nat Rev Cancer 4: 901-909, 2004.
19. Ratajczak MZ, Zuba-Surma E, Kucia M, et al: The pleiotropic effects of the SDF1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. Leukemia 20: 1915-1924, 2006.
20. Busillo JM and Benovic JL: Regulation of CXCR4 signaling. Biochim Biophys Acta 1768: 952-963, 2007.
21. Müller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
22. Mitra P, Shibuta K, Mathai J, et al: CXCR4 mRNA expression in colon, esophageal and gastric cancers and hepatitis C infected liver. Int J Oncol 14: 917-925, 1999.
23. Kijima T, Maulik G, Ma PC, et al: Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res 62: 6304-6311, 2002.
24. Taichman RS, Cooper C, Keller ET, et al: Use of the SDF1/ CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 62: 1832-1837, 2002.
25. Retz MM, Sidhu SS, Blaveri E, et al: CXCR4 expression reflects tumor progression and regulates motility of bladder cancer cells. Int J Cancer 114: 182-189, 2005.
26. Koshiba T, Hosotani R, Miyamoto Y, et al: Expression of SDF1 and CXCR4 in pancreatic cancer. Clin Cancer Res 6: 3530-3535, 2000.
27. Yasumoto K, Koizumi K, Kawashima A, et al: Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res 66: 2181-2187, 2006.
28. Lee HJ, Kim SW, Kim HY, et al: Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int J Oncol 34: 473-480, 2009.
29. Arigami T, Natsugoe S, Uenosono Y, et al: CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol 35: 19-24, 2009.
30. Kaifi JT, Yekebas EF, Schurr P, et al: Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J Natl Cancer Inst 97: 1840-1847, 2005.
31. Sehgal A, Keener C, Boynton AL, et al: CXCR4 is overexpressed in and required for proliferation of glioblastoma tumor cells. J Surg Oncol 69: 99-104, 1998.
32. Chen GS, Yu HS, Lan CC, et al: CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma. Br J Dermatol 154: 910-918, 2006.
33. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by SDF1. Blood 91: 4523-4530, 1998.
34. Dürig J, Schmücker U and Dührsen U: Differential expression of chemokine receptors in B cell malignancies. Leukemia 15: 752-756, 2001.
35. Katoh Y and Katoh M: Conserved POU-binding site linked to SP1-binding site within FZD5 promoter. Int J Oncol 30: 751-755, 2007.
36. Katoh M and Katoh M: Comparative integromics on FZD7 orthologs. Int J Mol Med 19: 529-533, 2007.
37. Katoh M and Katoh M: Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules. Int J Mol Med 20: 405-409, 2007.
38. Katoh Y and Katoh Y: Integrative genomic analyses on GLI2. Int J Oncol 33: 881-886, 2008.
39. Katoh M and Katoh M: Transcriptional mechanisms of WNT5A based on NF-κB, Hedgehog, TGFß, and Notch signaling cascades. Int J Mol Med 23: 763-769, 2009.
40. Katoh M and Katoh M: Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κB. Int J Oncol 34: 1737-1742, 2009.
41. Katoh M and Katoh M: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. Int J Oncol 30: 1273-1277, 2007.
42. Katoh Y and Katoh M: Integrative genomic analyses on GLI1: Positive regulation of GLI1 by Hedgehog-GLI, TGFß-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. Int J Oncol 35: 187-192, 2009.
43. Caruz A, Samsom M, Alonso JM, et al: Genomic organization and promoter characterization of human CXCR4 gene. FEBS Lett 426: 271-278, 1998.
44. Helbig G, Christopherson KW II, Bhat-Nakshatri P, et al: NF-κB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278: 21631-21638, 2003.
45. Staller P, Sulitkova J, Lisztwan J, et al: Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425: 307-311, 2003.
46. Maroni P, Bendinelli P, Matteucci E and Desiderio MA: HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-κB. Carcinogenesis 28: 267-279, 2007.
47. Yoon JW, Gilbertson R, Iannaccone S, et al: Defining a role for Sonic hedgehog pathway activation in desmoplastic medullo-blastoma by identifying GLI1 target genes. Int J Cancer 124: 109-119, 2009.
48. Moustakas A and Heldin CH: Dynamic control of TGFß signaling and its links to the cytoskeleton. FEBS Lett 582: 2051-2065, 2008.
49. Massagué J: TGFß in cancer. Cell 134: 215-230, 2008.
50. Zhou S, Zawel L, Lengauer C, Kinzler KW and Vogelstein B: Characterization of human FAST-1, a TGFß and Activin signal transducer. Mol Cell 2: 121-127, 1998.
51. Labbé E, Letamendia A and Attisano L: Association of Smads with LEF1/TCF mediates cooperative signaling by TGFß and Wnt pathways. Proc Natl Acad Sci USA 97: 8358-8363, 2000.
52. Jiang J, Au M, Lu K, et al: Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 25: 1940-1953, 2007.
53. Takenaga M, Fukumoto M and Hori Y: Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells. J Cell Sci 120: 2078-2090, 2007.
54. Javelaud D, Mohammad KS, McKenna CR, et al: Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Cancer Res 67: 2317-2324, 2007.
55. Mehta SA, Christopherson KW, Bhat-Nakshatri P, et al: Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells. Oncogene 26: 3329-3337, 2007.
56. Liu Y, Elf SE, Miyata Y, et al: p53 regulates hematopoietic cell quiescence. Cell Stem Cell 4: 37-48, 2009.
57. Wei CL, Wu Q, Vega VB, et al: A global map of p53 transcription-factor binding sites in the human genome. Cell 124: 207-219, 2006.
58. Lefort K, Mandinova A, Ostano P, et al: NOTCH1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases. Genes Dev 21: 562-577, 2007.
59. Roberts T and Cowell JK: Cloning of the human GFI1 gene and its mapping to chromosome region 1p22. Oncogene 14: 1003-1005, 1997.
60. Katoh M and Katoh M: Identification and characterization of human SNAIL3 (SNAI3) gene in silico. Int J Mol Med 11: 383-388, 2003.
61. Radtke F and Raj K: The role of Notch in tumorigenesis. Nat Rev Cancer 3: 765-767, 2003.
62. Katoh M and Katoh M: Notch signaling in gastrointestinal tract. Int J Oncol 30: 247-251, 2007.
63. Mani SA, Yang J, Brooks M, et al: FOXC2 plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA 104: 10069-10074, 2007.
64. Katoh Y and Katoh M: Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant Hedgehog signaling activation. Curr Mol Med 9: 873-886, 2009.
65. Pogoda HM, Solnica-Krezel L, Driever W and Meyer D: Zebrafish FoxH1 is a modulator of nodal signaling required for organizer formation. Curr Biol 10: 1041-1049, 2000.
66. D'Amour KA, Agulnick AD, Eliazer S, et al: Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23: 1534-1541, 2005.
67. Zuba-Surma EK, Kucia M, Wu W, et al: Very small embryoniclike stem cells are present in adult murine organs: ImageStream-based morphological analysis and distribution studies. Cytometry A 73A: 1116-1127, 2008.
68. Semb H: Expandable endodermal progenitors: new tools to explore endoderm and its derivatives. Cell Stem Cell 3: 355-356, 2008.
69. Morrison GM, Oikonomopoulou I, Migueles RP, et al: Anterior definitive endoderm from ESCs reveals a role for FGF signaling. Cell Stem Cell 3: 402-415, 2008.
70. Spence JR, Lange AW, Lin SC, et al: Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17: 62-74, 2009.
71. Yuan H, Corbi N, Basilico C and Dailey L: Developmentalspecific activity of the FGF4 enhancer requires the synergistic action of Sox2 and Oct3. Genes Dev 9: 2635-2645, 1995.
72. Loh Y, Wu Q, Chew J, et al: Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38: 431-440, 2006.
73. De La Luz Sierra M, Gasperini P, McCormick PJ, et al: Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood 110: 2276-2285, 2007.
74. Hussain SP and Harris CC: p53 mutation spectrum and load. Mutat Res 428: 23-32, 1999.
75. Riley T, Sontag E, Chen P and Levine A: Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9: 402-412, 2008.
76. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nature Rev Cancer 2: 442-454, 2002.
77. Barrallo-Gimeno A and Nieto MA: The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132: 3151-3161, 2005.
78. Katoh M: Epithelial-mesenchymal transition in gastric cancer. Int J Oncol 27: 1677-1683, 2005.
79. Bailey J, Singh PK and Hollingsworth MA: Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenetic proteins. J Cell Biochem 102: 829-839, 2007.
80. Katoh Y and Katoh M: Hedgehog signaling, epithelial-tomesenchymal transition and miRNA. Int J Mol Med 22: 271-275, 2008.
81. Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432: 324-331, 2004.
82. Hooper JF and Scott MP: Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6: 306-317, 2005.
83. Katoh Y and Katoh M: Hedgehog signaling in gastric cancer. Cancer Biol Ther 4: 1050-1054, 2005.