-
1
-
-
33747030845
-
Protein biomarker discovery and validation: the long and uncertain path to clinical utility
-
Rifai N., et al. Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat. Biotechnol. 24 (2006) 971-983
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 971-983
-
-
Rifai, N.1
-
2
-
-
44449131940
-
High clinical trials attrition rate is boosting drug development costs
-
Lang L. High clinical trials attrition rate is boosting drug development costs. Gastroenterology 127 (2004) 1026
-
(2004)
Gastroenterology
, vol.127
, pp. 1026
-
-
Lang, L.1
-
4
-
-
0025894713
-
p53 mutations in human cancers
-
Hollstein M., et al. p53 mutations in human cancers. Science 253 (1991) 49-53
-
(1991)
Science
, vol.253
, pp. 49-53
-
-
Hollstein, M.1
-
5
-
-
0034964458
-
Detection of the mutated K-Ras biomarker in colorectal carcinoma
-
Doolittle B.R., et al. Detection of the mutated K-Ras biomarker in colorectal carcinoma. Exp. Mol. Pathol. 70 (2001) 289-301
-
(2001)
Exp. Mol. Pathol.
, vol.70
, pp. 289-301
-
-
Doolittle, B.R.1
-
6
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
Maheswaran S., et al. Detection of mutations in EGFR in circulating lung-cancer cells. N. Engl. J. Med. 359 (2008) 366-377
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 366-377
-
-
Maheswaran, S.1
-
7
-
-
0028806048
-
Quantitative monitoring of gene expression patterns with a complementary DNA microarray
-
Schena M., et al. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270 (1995) 467-470
-
(1995)
Science
, vol.270
, pp. 467-470
-
-
Schena, M.1
-
8
-
-
13944251747
-
Alterations of pre-mRNA splicing in cancer
-
Kalnina Z., et al. Alterations of pre-mRNA splicing in cancer. Genes Chromosomes Cancer 42 (2005) 342-357
-
(2005)
Genes Chromosomes Cancer
, vol.42
, pp. 342-357
-
-
Kalnina, Z.1
-
9
-
-
33750143779
-
Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells
-
Chen Y.R., et al. Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells. J. Proteome Res. 5 (2006) 2727-2742
-
(2006)
J. Proteome Res.
, vol.5
, pp. 2727-2742
-
-
Chen, Y.R.1
-
10
-
-
33846542649
-
A serum glycomics approach to breast cancer biomarkers
-
Kirmiz C., et al. A serum glycomics approach to breast cancer biomarkers. Mol. Cell. Proteomics 6 (2007) 43-55
-
(2007)
Mol. Cell. Proteomics
, vol.6
, pp. 43-55
-
-
Kirmiz, C.1
-
11
-
-
34249277739
-
Alterations in the serum glycome due to metastatic prostate cancer
-
Kyselova Z., et al. Alterations in the serum glycome due to metastatic prostate cancer. J. Proteome Res. 6 (2007) 1822-1832
-
(2007)
J. Proteome Res.
, vol.6
, pp. 1822-1832
-
-
Kyselova, Z.1
-
12
-
-
33947237776
-
Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer
-
Barrabés S., et al. Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer. Glycobiology 17 (2007) 388-400
-
(2007)
Glycobiology
, vol.17
, pp. 388-400
-
-
Barrabés, S.1
-
13
-
-
34948905277
-
Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer
-
Ueda K., et al. Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer. J. Proteome Res. 6 (2007) 3475-3483
-
(2007)
J. Proteome Res.
, vol.6
, pp. 3475-3483
-
-
Ueda, K.1
-
15
-
-
0001644020
-
The human plasma proteome: history, character, and diagnostic prospects
-
Anderson N.L., and Anderson N.G. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell. Proteomics 1 (2002) 845-867
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 845-867
-
-
Anderson, N.L.1
Anderson, N.G.2
-
16
-
-
41749116116
-
Applications of proteomics to lab diagnosis
-
Chaerkady R., and Pandey A. Applications of proteomics to lab diagnosis. Annu. Rev. Pathol. 3 (2008) 485-498
-
(2008)
Annu. Rev. Pathol.
, vol.3
, pp. 485-498
-
-
Chaerkady, R.1
Pandey, A.2
-
17
-
-
0036583926
-
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
-
Ong S.E., et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteomics 1 (2002) 376-386
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 376-386
-
-
Ong, S.E.1
-
18
-
-
47549099572
-
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
-
Krüger M., et al. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell 134 (2008) 353-364
-
(2008)
Cell
, vol.134
, pp. 353-364
-
-
Krüger, M.1
-
19
-
-
4444346217
-
Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis
-
Wu C.C., et al. Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal. Chem. 76 (2004) 4951-4959
-
(2004)
Anal. Chem.
, vol.76
, pp. 4951-4959
-
-
Wu, C.C.1
-
20
-
-
38349037650
-
Isotope-labeled protein standards: toward absolute quantitative proteomics
-
Brun V., et al. Isotope-labeled protein standards: toward absolute quantitative proteomics. Mol. Cell. Proteomics 6 (2007) 2139-2149
-
(2007)
Mol. Cell. Proteomics
, vol.6
, pp. 2139-2149
-
-
Brun, V.1
-
21
-
-
34247627759
-
Two-dimensional fluorescence difference gel electrophoresis for comparative proteomics profiling
-
Tannu N.S., and Hemby S.E. Two-dimensional fluorescence difference gel electrophoresis for comparative proteomics profiling. Nat. Protocols 1 (2006) 1732-1742
-
(2006)
Nat. Protocols
, vol.1
, pp. 1732-1742
-
-
Tannu, N.S.1
Hemby, S.E.2
-
22
-
-
0036208704
-
Differential gel exposure, a new methodology for the two-dimensional comparison of protein samples
-
Monribot-Espagne C., and Boucherie H. Differential gel exposure, a new methodology for the two-dimensional comparison of protein samples. Proteomics 2 (2002) 229-240
-
(2002)
Proteomics
, vol.2
, pp. 229-240
-
-
Monribot-Espagne, C.1
Boucherie, H.2
-
23
-
-
29144449941
-
Differential radioactive proteomic analysis of microdissected renal cell carcinoma tissue by 54 cm isoelectric focusing in serial immobilized pH gradient gels
-
Poznanović S., et al. Differential radioactive proteomic analysis of microdissected renal cell carcinoma tissue by 54 cm isoelectric focusing in serial immobilized pH gradient gels. J. Proteome Res. 4 (2005) 2117-2125
-
(2005)
J. Proteome Res.
, vol.4
, pp. 2117-2125
-
-
Poznanović, S.1
-
24
-
-
40949105935
-
Quantitative 2-D gel electrophoresis-based expression proteomics of albumin and IgG immunodepleted plasma
-
Seferovic M.D., et al. Quantitative 2-D gel electrophoresis-based expression proteomics of albumin and IgG immunodepleted plasma. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 865 (2008) 147-152
-
(2008)
J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci.
, vol.865
, pp. 147-152
-
-
Seferovic, M.D.1
-
25
-
-
39749189974
-
Stoichiometry and absolute quantification of proteins with mass spectrometry using fluorescent and isotope-labeled concatenated peptide standards
-
Nanavati D., et al. Stoichiometry and absolute quantification of proteins with mass spectrometry using fluorescent and isotope-labeled concatenated peptide standards. Mol. Cell. Proteomics 7 (2008) 442-447
-
(2008)
Mol. Cell. Proteomics
, vol.7
, pp. 442-447
-
-
Nanavati, D.1
-
26
-
-
0032875697
-
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
-
Gygi S.P., et al. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat. Biotechnol. 17 (1999) 994-999
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 994-999
-
-
Gygi, S.P.1
-
27
-
-
0037307816
-
Advances in quantitative proteomics via stable isotope tagging and mass spectrometry
-
Tao W.A., and Aebersold R. Advances in quantitative proteomics via stable isotope tagging and mass spectrometry. Curr. Opin. Biotechnol. 14 (2003) 110-118
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 110-118
-
-
Tao, W.A.1
Aebersold, R.2
-
28
-
-
14644417774
-
Stable isotope methods for high-precision proteomics
-
Schneider L.V., and Hall M.P. Stable isotope methods for high-precision proteomics. Drug Discov. Today 10 (2005) 353-363
-
(2005)
Drug Discov. Today
, vol.10
, pp. 353-363
-
-
Schneider, L.V.1
Hall, M.P.2
-
29
-
-
38349068918
-
Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution
-
Keshishian H., et al. Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol. Cell. Proteomics 6 (2007) 2212-2229
-
(2007)
Mol. Cell. Proteomics
, vol.6
, pp. 2212-2229
-
-
Keshishian, H.1
-
30
-
-
19944432197
-
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
-
Ross P.L., et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol. Cell. Proteomics 3 (2004) 1154-1169
-
(2004)
Mol. Cell. Proteomics
, vol.3
, pp. 1154-1169
-
-
Ross, P.L.1
-
31
-
-
0037795741
-
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS
-
Gerber S.A., et al. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6940-6945
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 6940-6945
-
-
Gerber, S.A.1
-
32
-
-
0030068923
-
18O into peptide fragments and its application for protein sequencing by electrospray and matrix-assisted laser desorption/ionization mass spectrometry
-
18O into peptide fragments and its application for protein sequencing by electrospray and matrix-assisted laser desorption/ionization mass spectrometry. Electrophoresis 17 (1996) 945-953
-
(1996)
Electrophoresis
, vol.17
, pp. 945-953
-
-
Schnolzer, M.1
-
33
-
-
28644451439
-
Proteomic analysis of formalin-fixed prostate cancer tissue
-
Hood B.L., et al. Proteomic analysis of formalin-fixed prostate cancer tissue. Mol. Cell. Proteomics 4 (2005) 1741-1753
-
(2005)
Mol. Cell. Proteomics
, vol.4
, pp. 1741-1753
-
-
Hood, B.L.1
-
34
-
-
33751011581
-
Proteomic analysis of plasma membrane from hypoxia-adapted malignant melanoma
-
Stockwin L.H., et al. Proteomic analysis of plasma membrane from hypoxia-adapted malignant melanoma. J. Proteome Res. 5 (2006) 2996-3007
-
(2006)
J. Proteome Res.
, vol.5
, pp. 2996-3007
-
-
Stockwin, L.H.1
-
35
-
-
14644392991
-
Isotope-differentiated binding energy shift tags (IDBEST) for improved targeted biomarker discovery and validation
-
Hall M.P., and Schneider L.V. Isotope-differentiated binding energy shift tags (IDBEST) for improved targeted biomarker discovery and validation. Expert Rev. Proteomics 1 (2004) 421-431
-
(2004)
Expert Rev. Proteomics
, vol.1
, pp. 421-431
-
-
Hall, M.P.1
Schneider, L.V.2
-
36
-
-
33645859323
-
Cell-surface and cytokine biomarkers in autoimmune and inflammatory disease
-
O'Hara R.M., et al. Cell-surface and cytokine biomarkers in autoimmune and inflammatory disease. Drug Discov. Today 11 (2006) 342-347
-
(2006)
Drug Discov. Today
, vol.11
, pp. 342-347
-
-
O'Hara, R.M.1
-
37
-
-
1842528125
-
13C-labeled peptide standards
-
13C-labeled peptide standards. Proteomics 4 (2004) 1175-1186
-
(2004)
Proteomics
, vol.4
, pp. 1175-1186
-
-
Kuhn, E.1
-
38
-
-
27944468660
-
Biomarkers for neurodegenerative diseases
-
Henley S.M., et al. Biomarkers for neurodegenerative diseases. Curr. Opin. Neurol. 18 (2005) 698-705
-
(2005)
Curr. Opin. Neurol.
, vol.18
, pp. 698-705
-
-
Henley, S.M.1
-
39
-
-
0031839522
-
Infectious causes of chronic inflammatory diseases and cancer
-
Cassell G.H. Infectious causes of chronic inflammatory diseases and cancer. Emerg. Infect. Dis. 4 (1998) 475-487
-
(1998)
Emerg. Infect. Dis.
, vol.4
, pp. 475-487
-
-
Cassell, G.H.1
-
40
-
-
0029963677
-
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
-
Censini S., et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 14648-14653
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 14648-14653
-
-
Censini, S.1
-
41
-
-
29244438438
-
Dynamics of Helicobacter pylori infection in a US-Mexico cohort during the first two years of life
-
Goodman K.J., et al. Dynamics of Helicobacter pylori infection in a US-Mexico cohort during the first two years of life. Int. J. Epidemiol. 34 (2005) 1348-1355
-
(2005)
Int. J. Epidemiol.
, vol.34
, pp. 1348-1355
-
-
Goodman, K.J.1
-
42
-
-
41149133368
-
Translational control of the innate immune response through IRF-7
-
Colina R., et al. Translational control of the innate immune response through IRF-7. Nature 452 (2008) 323-328
-
(2008)
Nature
, vol.452
, pp. 323-328
-
-
Colina, R.1
-
43
-
-
0033809383
-
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus
-
Stojdl D.F., et al. The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. J. Virol. 74 (2000) 9580-9585
-
(2000)
J. Virol.
, vol.74
, pp. 9580-9585
-
-
Stojdl, D.F.1
-
44
-
-
3643134833
-
The application of isotopes to the study of intermediary metabolism
-
Schoenheimer R., and Rittenberg D. The application of isotopes to the study of intermediary metabolism. Science 87 (1938) 221-226
-
(1938)
Science
, vol.87
, pp. 221-226
-
-
Schoenheimer, R.1
Rittenberg, D.2
-
45
-
-
0036645750
-
n and the chemiluminescent nitrogen detector
-
n and the chemiluminescent nitrogen detector. Anal. Chem. 74 (2002) 3232-3236
-
(2002)
Anal. Chem.
, vol.74
, pp. 3232-3236
-
-
Taylor, E.W.1
-
46
-
-
0036948686
-
Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene
-
Liang Q., et al. Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene. Gene Ther. 9 (2002) 1659-1666
-
(2002)
Gene Ther.
, vol.9
, pp. 1659-1666
-
-
Liang, Q.1
-
47
-
-
45149112158
-
13C-labeled bicarbonate
-
13C-labeled bicarbonate. Nature 453 (2008) 940-943
-
(2008)
Nature
, vol.453
, pp. 940-943
-
-
Gallagher, F.A.1
-
48
-
-
46149125288
-
Quantifying changes in the thiol redox proteome upon oxidative stress in vivo
-
Leichert L.I., et al. Quantifying changes in the thiol redox proteome upon oxidative stress in vivo. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 8197-8202
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 8197-8202
-
-
Leichert, L.I.1
-
49
-
-
33745376733
-
Redox proteomics in some age-related neurodegenerative disorders or models thereof
-
Butterfield D.A., et al. Redox proteomics in some age-related neurodegenerative disorders or models thereof. NeuroRx 3 (2006) 344-357
-
(2006)
NeuroRx
, vol.3
, pp. 344-357
-
-
Butterfield, D.A.1
-
50
-
-
4444239787
-
Proteomic approach to studying Parkinson's disease
-
Zhang J., and Goodlett D.R. Proteomic approach to studying Parkinson's disease. Mol. Neurobiol. 29 (2004) 271-288
-
(2004)
Mol. Neurobiol.
, vol.29
, pp. 271-288
-
-
Zhang, J.1
Goodlett, D.R.2
-
51
-
-
6344267152
-
Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity
-
Hansel B., et al. Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity. J. Clin. Endocrinol. Metab. 89 (2004) 4963-4971
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 4963-4971
-
-
Hansel, B.1
-
52
-
-
33846308173
-
Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults
-
Van Guilder G.P., et al. Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity (Silver Spring) 14 (2006) 2127-2131
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 2127-2131
-
-
Van Guilder, G.P.1
-
53
-
-
0034241796
-
Positron emission tomography provides molecular imaging of biological processes
-
Phelps M.E. Positron emission tomography provides molecular imaging of biological processes. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 9226-9233
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 9226-9233
-
-
Phelps, M.E.1
-
54
-
-
38449107451
-
Technology insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs
-
Weber W.A., et al. Technology insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs. Nat. Clin. Pract. Oncol. 5 (2008) 44-54
-
(2008)
Nat. Clin. Pract. Oncol.
, vol.5
, pp. 44-54
-
-
Weber, W.A.1
-
55
-
-
23444462507
-
High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors
-
Mishani E., et al. High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors. J. Med. Chem. 48 (2005) 5337-5348
-
(2005)
J. Med. Chem.
, vol.48
, pp. 5337-5348
-
-
Mishani, E.1
-
56
-
-
33748423744
-
11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
-
11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase. Bioorg. Med. Chem. Lett. 16 (2006) 4102-4106
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 4102-4106
-
-
Wang, J.Q.1
-
57
-
-
15044349250
-
18F-fluoroazomycin arabinoside
-
18F-fluoroazomycin arabinoside. J. Nucl. Med. 46 (2005) 106-113
-
(2005)
J. Nucl. Med.
, vol.46
, pp. 106-113
-
-
Piert, M.1
-
58
-
-
38949212117
-
18F-Galacto-RGD PET
-
18F-Galacto-RGD PET. J. Nucl. Med. 49 (2008) 255-259
-
(2008)
J. Nucl. Med.
, vol.49
, pp. 255-259
-
-
Beer, A.J.1
-
59
-
-
34147191481
-
Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes
-
Backer M.V., et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat. Med. 13 (2007) 504-509
-
(2007)
Nat. Med.
, vol.13
, pp. 504-509
-
-
Backer, M.V.1
-
60
-
-
33747393705
-
99mTc-Annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms
-
99mTc-Annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 2153-2159
-
(2006)
Arterioscler. Thromb. Vasc. Biol.
, vol.26
, pp. 2153-2159
-
-
Sarda-Mantel, L.1
-
62
-
-
41849093686
-
Simultaneous PET-MRI: a new approach for functional and morphological imaging
-
Judenhofer M.S., et al. Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat. Med. 14 (2008) 459-465
-
(2008)
Nat. Med.
, vol.14
, pp. 459-465
-
-
Judenhofer, M.S.1
-
63
-
-
41649110649
-
Imaging in the era of molecular oncology
-
Weissleder R., and Pittet M.J. Imaging in the era of molecular oncology. Nature 452 (2008) 580-589
-
(2008)
Nature
, vol.452
, pp. 580-589
-
-
Weissleder, R.1
Pittet, M.J.2
-
64
-
-
34548230533
-
Molecular imaging of cardiovascular disease
-
Jaffer F.A., et al. Molecular imaging of cardiovascular disease. Circulation 116 (2007) 1052-1061
-
(2007)
Circulation
, vol.116
, pp. 1052-1061
-
-
Jaffer, F.A.1
-
65
-
-
29144503167
-
Imaging in cell-based therapy for neurodegenerative diseases
-
Kirik D., et al. Imaging in cell-based therapy for neurodegenerative diseases. Eur. J. Nucl. Med. Mol. Imaging 32 Suppl 2 (2005) S417-S434
-
(2005)
Eur. J. Nucl. Med. Mol. Imaging
, vol.32
, Issue.SUPPL. 2
-
-
Kirik, D.1
-
66
-
-
46749110051
-
Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [(18)F]-labeled 2′-deoxycytidine analog
-
Radu C.G., et al. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [(18)F]-labeled 2′-deoxycytidine analog. Nat. Med. 14 (2008) 783-788
-
(2008)
Nat. Med.
, vol.14
, pp. 783-788
-
-
Radu, C.G.1
-
67
-
-
35948970970
-
13C magnetic resonance imaging and spectroscopy
-
13C magnetic resonance imaging and spectroscopy. Nat. Med. 13 (2007) 1382-1387
-
(2007)
Nat. Med.
, vol.13
, pp. 1382-1387
-
-
Day, S.E.1
-
68
-
-
20444439491
-
Radioligand-binding and molecular-imaging techniques for the quantitative analysis of established and emerging orphan receptor systems
-
Davenport A.P., and Kuc R.E. Radioligand-binding and molecular-imaging techniques for the quantitative analysis of established and emerging orphan receptor systems. Methods Mol. Biol. 306 (2005) 93-120
-
(2005)
Methods Mol. Biol.
, vol.306
, pp. 93-120
-
-
Davenport, A.P.1
Kuc, R.E.2
-
69
-
-
48949087161
-
GPCR signalling in hypertension: role of GRKs
-
Harris D.M., et al. GPCR signalling in hypertension: role of GRKs. Clin. Sci. 115 (2008) 79-89
-
(2008)
Clin. Sci.
, vol.115
, pp. 79-89
-
-
Harris, D.M.1
-
70
-
-
0032489093
-
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
Sakurai T., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
-
71
-
-
0037337310
-
Proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
-
Blagoev B., et al. Proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat. Biotechnol. 21 (2003) 315-318
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 315-318
-
-
Blagoev, B.1
-
72
-
-
0037022597
-
Noninvasive quantitative imaging of protein-protein interactions in living subjects
-
Ray P., et al. Noninvasive quantitative imaging of protein-protein interactions in living subjects. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 3105-3110
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 3105-3110
-
-
Ray, P.1
-
73
-
-
0035979208
-
Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo
-
Doubrovin M., et al. Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9300-9305
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 9300-9305
-
-
Doubrovin, M.1
-
74
-
-
6544233317
-
2 receptor as a reporter gene in living animals
-
2 receptor as a reporter gene in living animals. Gene Ther. 6 (1999) 785-791
-
(1999)
Gene Ther.
, vol.6
, pp. 785-791
-
-
MacLaren, D.C.1
-
76
-
-
0036169350
-
Functional genomics and proteomics - the role of nuclear medicine
-
Haberkorn U., et al. Functional genomics and proteomics - the role of nuclear medicine. Eur. J. Nucl. Med. Mol. Imaging 29 (2002) 115-132
-
(2002)
Eur. J. Nucl. Med. Mol. Imaging
, vol.29
, pp. 115-132
-
-
Haberkorn, U.1
-
77
-
-
10744229097
-
GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo
-
Barton K.N., et al. GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo. Mol. Ther. 8 (2003) 508-518
-
(2003)
Mol. Ther.
, vol.8
, pp. 508-518
-
-
Barton, K.N.1
-
78
-
-
20444466384
-
Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
-
Peñuelas I., et al. Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. Gastroenterology 128 (2005) 1787-1795
-
(2005)
Gastroenterology
, vol.128
, pp. 1787-1795
-
-
Peñuelas, I.1
-
79
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
Riley T., et al. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9 (2008) 402-412
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 402-412
-
-
Riley, T.1
-
80
-
-
0033827201
-
Quantification of target gene expression by imaging reporter gene expression in living animals
-
Yu Y., et al. Quantification of target gene expression by imaging reporter gene expression in living animals. Nat. Med. 6 (2000) 933-937
-
(2000)
Nat. Med.
, vol.6
, pp. 933-937
-
-
Yu, Y.1
-
81
-
-
49149086250
-
Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer
-
Burton J.B., et al. Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nat. Med. 14 (2008) 882-888
-
(2008)
Nat. Med.
, vol.14
, pp. 882-888
-
-
Burton, J.B.1
-
82
-
-
65549165773
-
Regulatory variation in hepcidin expression as a heritable quantitative trait
-
Bayele H.K., and Srai S.K. Regulatory variation in hepcidin expression as a heritable quantitative trait. Biochem. Biophys. Res. Commun. 384 (2009) 22-27
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.384
, pp. 22-27
-
-
Bayele, H.K.1
Srai, S.K.2
-
83
-
-
3042686120
-
Antibody-targeted radiation cancer therapy
-
Milenic D.E., et al. Antibody-targeted radiation cancer therapy. Nat. Rev. Drug Discov. 3 (2004) 488-499
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 488-499
-
-
Milenic, D.E.1
-
84
-
-
34247876138
-
Development trends for monoclonal antibody cancer therapeutics
-
Reichert J.M., and Valge-Archer V.E. Development trends for monoclonal antibody cancer therapeutics. Nat. Rev. Drug Discov. 6 (2007) 349-356
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 349-356
-
-
Reichert, J.M.1
Valge-Archer, V.E.2
-
85
-
-
27144449009
-
Monoclonal antibody therapy of cancer
-
Adams G.P., and Weiner L.M. Monoclonal antibody therapy of cancer. Nat. Biotechnol. 23 (2005) 1147-1157
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1147-1157
-
-
Adams, G.P.1
Weiner, L.M.2
-
86
-
-
27144550160
-
Arming antibodies: prospects and challenges for immunoconjugates
-
Wu A.M., and Senter P.D. Arming antibodies: prospects and challenges for immunoconjugates. Nat. Biotechnol. 23 (2005) 1137-1146
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1137-1146
-
-
Wu, A.M.1
Senter, P.D.2
-
87
-
-
0013110937
-
Monoclonal antibody therapy of cancer
-
von Mehren M., et al. Monoclonal antibody therapy of cancer. Annu. Rev. Med. 54 (2003) 343-369
-
(2003)
Annu. Rev. Med.
, vol.54
, pp. 343-369
-
-
von Mehren, M.1
-
88
-
-
38949180586
-
A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies
-
Li L., et al. A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies. Bioconjug. Chem. 19 (2008) 89-96
-
(2008)
Bioconjug. Chem.
, vol.19
, pp. 89-96
-
-
Li, L.1
-
89
-
-
58849115567
-
Radioimmunotherapy of infectious diseases
-
Dadachova E., and Casadevall A. Radioimmunotherapy of infectious diseases. Semin. Nucl. Med. 39 (2009) 146-153
-
(2009)
Semin. Nucl. Med.
, vol.39
, pp. 146-153
-
-
Dadachova, E.1
Casadevall, A.2
-
90
-
-
67650796408
-
Medical isotope shortage reaches crisis level
-
Gould P. Medical isotope shortage reaches crisis level. Nature 460 (2009) 312-313
-
(2009)
Nature
, vol.460
, pp. 312-313
-
-
Gould, P.1
-
91
-
-
0035900395
-
Tumor therapy with targeted atomic nanogenerators
-
McDevitt M.R., et al. Tumor therapy with targeted atomic nanogenerators. Science 294 (2001) 1537-1540
-
(2001)
Science
, vol.294
, pp. 1537-1540
-
-
McDevitt, M.R.1
-
92
-
-
3543022686
-
In vivo cancer targeting and imaging with semiconductor quantum dots
-
Gao X., et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22 (2004) 969-976
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 969-976
-
-
Gao, X.1
-
93
-
-
0030964277
-
The biology of replicative senescence
-
Campisi J. The biology of replicative senescence. Eur. J. Cancer 33 (1997) 703-709
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 703-709
-
-
Campisi, J.1
-
94
-
-
0035895515
-
Dissecting human disease in the postgenomic era
-
Peltonen L., and McKusick V.A. Dissecting human disease in the postgenomic era. Science 291 (2001) 1224-1229
-
(2001)
Science
, vol.291
, pp. 1224-1229
-
-
Peltonen, L.1
McKusick, V.A.2
-
95
-
-
12444326165
-
18F]FMAU and positron emission tomography in patients with cancer
-
18F]FMAU and positron emission tomography in patients with cancer. Eur. J. Nucl. Med. Mol. Imaging 32 (2005) 15-22
-
(2005)
Eur. J. Nucl. Med. Mol. Imaging
, vol.32
, pp. 15-22
-
-
Sun, H.1
|