GENIS: Gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo

Molecular Therapy

Volumn 8, Issue 3, 2003, Pages 508-518

  Barton, Kenneth N ^a   Tyson, Donald ^a   Stricker, Hans ^b   Lew, Young S ^a   Heisey, Gregory ^a   Koul, Sweaty ^a   de la Zerda, Alberto ^a   Yin, Fang Fang ^a   Yan, Hui ^a   Nagaraja, Tavarekere N ^a   Randall, Kelly Ann ^a   Jin, Guk Kim ^a   Fenstermacher, Joseph D ^a   Jhiang, Sissy ^c   Kim, Jae Ho ^a   Freytag, Svend O ^a   Brown, Stephen L ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Adenovirus; Nuclear medicine; Reporter gene; Sodium iodide symporter; Suicide gene therapy

Indexed keywords

ADENOVIRUS VECTOR; CYTOSINE DEAMINASE; PERTECHNETIC ACID TC 99M; SODIUM IODIDE SYMPORTER; THYMIDINE KINASE;

ADENOVIRUS 5; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLADDER; CONTROLLED STUDY; DEFECTIVE VIRUS; DOG; FUSION GENE; GAMMA SCINTIGRAPHY; GENE EXPRESSION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IN VIVO STUDY; NON INVASIVE MEASUREMENT; NONHUMAN; PROSTATE CANCER; QUANTITATIVE ANALYSIS; REPORTER GENE; SCINTILLATION CAMERA; SUICIDE GENE THERAPY; VIRUS PARTICLE; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALIA; CANIS FAMILIARIS; CUCUMBER MOSAIC VIRUS; HUMAN ADENOVIRUS TYPE 5; SIMPLEXVIRUS;

EID: 10744229097     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00153-9     Document Type: Article

References (42)

1. Rabbini, F., Stroumbakis, N., Kava, B., Cookson, M., and Fair, W. (1998). Incidence and clinical significance of false-negative sextant prostate biopsies. J. Urol. 159: 1247-1250.
2. - symporter: Mechanism, stoichiometry, and specificity. J. Biol. Chem. 272: 27230-27238.
3. Smanik, P., et al. (1996). Cloning of the human sodium iodide symporter. Biochem. Biophys. Res. Commun. 226: 339-345.
4. Dai, G., Levy, O., and Carrasco, N. (1996). Cloning and characterization of the thyroid iodide transporter. Nature 379: 458-460.
5. 131I therapy in transplanted undifferentiated thyroid cancer cells expressing the Na/l symporter gene. Endocrinology 138: 4493-4496.
6. Mandell, R., Mandell, L., and Link, C. (1999). Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Cancer Res. 59: 661-698.
7. Spitzweg, C., O'Connor, M., Bergert, E., Tindall, D., Young, C., and Morris, J. (2000). Treatment of prostate cancer by radioiodine therapy after tissue-specific expression of the sodium iodide symporter. Cancer Res. 60: 6526-6530.
8. Boland, A., et al. (2000). Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy. Cancer Res. 60: 3484-3492.
9. Haberkorn, U., et al. (2001). Transfer of the human Nal symporter gene enhances iodide uptake in hepatoma cells. J. Nucl. Med. 42: 317-325.
10. Groot-Wassink, T., Aboagye, E. O., Glaser, M., Lemoine, N. R., and Vassaux, G. (2002). Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene. Hum. Gene Ther. 13: 1723-1735.
11. Freytag, S., Rogulski, K., Paielli, D., Gilbert, J., and Kim, J. H. (1998). A novel three-pronged approach to selectively kill cancer cells: Concomitant viral, double suicide gene, and radiotherapy. Hum. Gene Ther. 9: 1323-1333.
12. Freytag, S., et al. (2002). Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 62: 4968-4976.
13. Kievit, E., et al. (1999). Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res. 59:1417-1421.
14. Black, M., Kokoris, M., and Sabo, P. (2001 ). Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing. Cancer Res. 61: 3022-3026.
15. - symporter in human glioma cells by adenovirus-mediated gene delivery. Gene Ther. 7: 740-749.
16. Blum, M., et al. (1995). The Thyroid. Principles of Nuclear Medicine (In H. Wagner, Z. Szabo, and J. Buchanan, Eds.), pp. 595-627. Saunders, Philadelphia. 2nd ed..
17. Tjuvajev, J., et al. (1999). Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res. 59: 5186-5193.
18. 18F]-Fluoropenciclovir: An improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET. J. Nucl. Med. 42: 96-105.
19. Tindall, D., Scardino, P. (1998). Defeating prostate cancer: Crucial directions for research. Report of the Progress Review Group on Prostate Cancer, National Cancer Institute, Frederick, MD.
20. Stern, H., McAfee, J., and Subramanian, G. (1966). Preparation, distribution and utilization of technetium-99m-sulfur colloid. J. Nucl. Med. 7: 665-675.
21. Vrancken Peeters, M., Patijn, G., Liber, A., Meuse, L., and Kay, M. (1996). Adenovirus-mediated hepatic gene transfer in mice: Comparison of intravascular and biliary administration. Hum. Gene Ther. 7: 1693-1699.
22. Lieber, A., et al. (1997). The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J. Virol. 71: 8798-8807.
23. Herman, J., et al. (1999). In situ gene therapy for adenocarcinoma of the prostate: A phase I clinical trial. Hum. Gene Ther. 10: 1239-1249.
24. DeWeese, T., et al. (2001). A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Res. 61: 7464-7472.
25. Tjuvajev, J., et al (1996). Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy. Cancer Res. 56: 4087-4095.
26. Tjuvajev, J., et al (1998). Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 58: 4333-4341.
27. Gambhir, S., et al. (1999). Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc. Natl. Acad. Sci. USA 96: 2333-2338.
28. Herschman, H., et al. (2000). Seeing is believing: Non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J. Neurosci. Res. 59: 699-705.
29. Yu, Y., et al. (2000). Quantification of target gene expression by imaging reporter gene expression in living animals. Nat. Med. 6: 933-937.
30. Gambhir, S., et al. (2000). A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc. Natl. Acad. Sci. USA 97: 2785-2790.
31. Jacobs, A., et al. (2001). Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res. 61: 2983-2995.
32. Tjuvajev, J., et al. (2002). Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J. Nucl. Med. 43: 1072-1083.
33. Sharma, V., Luker, G. D., and Piwnica-Worms, D. (2002). Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J. Magn. Reson. Imaging 16: 336-351.
34. Blankenberg, F. G., and Strauss, H. W. (2002). Nuclear medicine applications in molecular imaging. J. Magn. Reson. Imaging 16: 352-361.
35. MacLaren, D., et al. (1999). Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther. 6: 785-791.
36. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W., and Prasher, D. (1994). Green fluorescent protein as a marker for gene expression. Science 263: 802-805.
37. Brasier, A., Tate, J., and Habener, J. (1989). Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques 7: 1116-1122.
38. Stegman, L., et al. (1999). Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc. Natl. Acad. Sci. 96: 9821-9826.
39. Ray, P., et al. (2001). Monitoring gene therapy with reporter gene imaging. Semin. Nucl. Med. 31: 312-320.
40. Gillies, R. J. (2002). In vivo molecular imaging. J. Cell. Biochem. Suppl. 39: 231-238.
41. Yaghoubi, S., et al. (2001 ). Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: A reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J. Nucl. Med. 42: 1225-1234.
42. Brand, K., et al. (1997). Liver-associated toxicity of the HSV-tk/GCV approach and adenoviral vectors. Cancer Gene Ther. 4: 9-16.