4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1181-1193

  Vitorović Todorović, Maja D ^a,b   Juranić, Ivan O ^b   Mandić, Ljuba M ^b   Drakulić, Branko J ^c  

^a Military Technical Institute in Belgrade   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

4 Aryl 4 oxo N phenyl 2 aminylbutyramides; Alignment independent 3D QSAR; Anticholinesterase activity; Docking study; Mixed type reversible inhibitors

Indexed keywords

4 (2,4 DIISOPROPYLPHENYL) 2 [7 [3 (4 ISOPROPYLPHENYL) 3 OXO 1 PHENYLCARBAMOYLPROPYLAMINO]HEPTYLAMINO] 4 OXO N PHENYLBUTYRAMIDE; 4 (2,4 DIISOPROPYLPHENYL) 4 OXO N PHENYL 2 (1 IMIDAZOLYL) BUTYRAMIDE; 4 (2,4 DIISOPROPYLPHENYL) 4 OXO N PHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; 4 (2,4 DIISOPROPYLPHENYL) 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; 4 (2,5 DIMETHYLPHENYL) 2 [7 [3 (2,5 DIMETHYLPHENYL) 3 OXO 1 PHENYLCARBAMOYLPROPYLAMINO]HEPTYLAMINO] 4 OXO N PHENYLBUTYRAMIDE; 4 (2,5 DIMETHYLPHENYL) 4 OXO N PHENYL 2 (1 IMIDAZOLYL)BUTYRAMIDE; 4 (2,5 DIMETHYLPHENYL) 4 OXO N PHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; 4 (2,5 DIMETHYLPHENYL) 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; 4 (4 CHLOROPHENYL) 2 [7 [3 (4 CHLOROPHENYL) 3 OXO 1 PHENYLCARBAMOYLPROPYLAMINO]HEPTYLAMINO] 4 OXO N PHENYLBUTYRAMIDE; 4 (4 CHLOROPHENYL) 4 OXO N PHENYL 2 (1 IMIDAZOLYL)BUTYRAMIDE; 4 (4 CHLOROPHENYL) 4 OXO N PHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; 4 (4 CHLOROPHENYL) 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; 4 (4 ISOPROPYLPHENYL) 2 [7 [3 (4 ISOPROPYLPHENYL) 3 OXO 1 PHENYLCARBAMOYLPROPYLAMINO]HEPTYLAMINO]4 OXO N PHENYLBUTYRAMIDE; 4 (4 ISOPROPYLPHENYL) 4 OXO N PHENYL 2 (1 IMIDAZOLYL)BUTYRAMIDE; 4 (4 ISOPROPYLPHENYL) 4 OXO N PHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; 4 (4 ISOPROPYLPHENYL) 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; 4 (4 METOXYPHENYL) 2 [7 [3 (4 METOXYPHENYL) 3 OXO 1 PHENYLCARBAMOYLPROPYLAMINO]HEPTYLAMINO] 4 OXO N PHENYLBUTYRAMIDE; 4 (4 METOXYPHENYL) 4 OXO N PHENYL 2 (1 IMIDAZOLYL)BUTYRAMIDE; 4 (4 METOXYPHENYL) 4 OXO N PHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; 4 (4 METOXYPHENYL) 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; 4 (5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL) 2 [7 [3 (5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL) 3 OXO 1 PHENYLCARBAMOYLPROPYLAMINO]HEPTYLAMINO] 4 OXO N PHENYLBUTYRAMIDE; 4 (5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL) 4 OXO N PHENYL 2 (1 IMIDAZOLYL)BUTYRAMIDE; 4 (5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL) 4 OXO N PHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; 4 (5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL) 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; 4 PHENYL 4 OXO N PHENYL 2 (4 MORPHOLINYL)BUTYRAMIDE; CHOLINESTERASE INHIBITOR; PHENYL 4 OXO NPHENYL 2 (1 PIPERIDINYL)BUTYRAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; AMIDES; AMINES; ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; EELS; HORSES; HUMANS; MICE; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75349114471     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.042     Document Type: Article

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