Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 15, 2006, Pages 3932-3936

  Sadashiva, C T ^a   Narendra Sharath Chandra, J N ^a   Ponnappa, K C ^a   Veerabasappa Gowda, T ^a   Rangappa, Kanchugarakoppal S ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

AchE; Alzheimer's disease; Piperazine; Rodent memory evaluator

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; N,N DIMETHYLFORMAMIDE; PIPERAZINE DERIVATIVE; POTASSIUM CARBONATE;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CHOLINERGIC ACTIVITY; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NEUROTRANSMISSION; NONHUMAN; RAT; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; HUMAN; PATHOPHYSIOLOGY; SYNAPTIC TRANSMISSION; SYNTHESIS;

RODENTIA;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; HUMANS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC TRANSMISSION;

EID: 33748439845     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.030     Document Type: Article

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