Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide

Journal of Organic Chemistry

Volumn 75, Issue 2, 2010, Pages 368-374

  Zhang, Haoyi ^a   Zhang, Shilei ^a,c   Liu, Lu ^a   Luo, Guangshun ^a   Duan, Wenhu ^a,b   Wang, Wei ^a,b,c  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID ADDITIVES; ALDOL REACTIONS; ASYMMETRIC SYNTHESIS; BIOLOGICAL ACTIVITIES; CHEMICAL EQUATIONS; EFFICIENT METHOD; ENANTIOSELECTIVE; LACTONIZATION; MOLECULAR FRAMEWORKS; NATURAL PRODUCTS; ORGANIC SYNTHESIS; ORGANOCATALYTIC; PHTHALIDES; REACTION CONDITIONS; REACTION EFFICIENCY; SUBSTRATE STRUCTURE; THREE-STEP SYNTHESIS;

CATALYSIS; CATALYSTS; ELECTRON TRANSITIONS; ENANTIOSELECTIVITY; ESTERS; ORGANIC POLYMERS;

SYNTHESIS (CHEMICAL);

3 BUTYLPHTHALIDE; ALCOHOL; AMIDE; NATURAL PRODUCT; PHTHALIDE DERIVATIVE;

ALDOL REACTION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; LACTONIZATION; REACTION ANALYSIS;

ALDEHYDES; BENZOFURANS; CATALYSIS; CYCLIZATION; KETONES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75349106430     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo902118x     Document Type: Article

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