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31444436439
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note
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The diamine 8b/TFA-catalyzed reaction in water: To a mixture of diamine 8b (0.05 mmol) in water (1.0 mL) trifluoroacetic acid (0.05 mmol) was added at 25 °C under air. The reaction mixture was stirred for 3 min in a closed system, and ketone (1.0 mmol) and aldehyde (0.5 mmol) were added. The reaction mixture was vigorously stirred for the indicated time. Removal of water by centrifugal separation and purification of crude product by column chromatography afforded the aldol product.
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23
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