An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues

Organic Letters

Volumn 10, Issue 23, 2008, Pages 5489-5492

  Song, Lirong ^a   Chen, Xiaobei ^a   Zhang, Shilei ^a   Zhang, Haoyi ^a   Li, Ping ^a   Luo, Guangshun ^a   Liu, Wenjing ^a   Duan, Wenhu ^a,b   Wang, Wei ^a,c  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; LINEZOLID; OXAZOLIDINONE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

ACETAMIDES; ANTI-BACTERIAL AGENTS; CATALYSIS; OXAZOLIDINONES; STEREOISOMERISM;

EID: 61349130056     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol802333n     Document Type: Article

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52. Chiral HPLC analysis of final products showed no racemization occurred during these transformations (see Supporting Information for product 2a).