N-heterocyclic carbene-catalyzed generation of homoenolates: γ-butyrolactones by direct annulations of enals and aldehydes

Journal of the American Chemical Society

Volumn 126, Issue 44, 2004, Pages 14370-14371

  Sohn, Stephanie S ^a   Rosen, Evelyn L ^a   Bode, Jeffrey W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; CARBENOID; ENAL DERIVATIVE; GAMMA BUTYROLACTONE DERIVATIVE; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ANNULATION REACTION; ARTICLE; CATALYSIS; CHEMICAL BINDING; CONJUGATION; ENANTIOSELECTIVITY; PROCESS DESIGN; REACTION ANALYSIS;

EID: 7744232978     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja044714b     Document Type: Article

References (21)

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19. Crotonaldehyde, 4,4-dimethyl-pent-2-enal, and α- methylcinnamaldehyde were unreactive under these conditions.
20. See Supporting Information for details.
21. We have observed protonation at the β-position, including deuterium incorporation, under more forcing conditions.