Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1018-1028

  Strydom, Belinda ^a   Malan, Sarel F ^a   Castagnoli Jr , Neal ^b   Bergh, Jacobus J ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

8 Benzyloxycaffeine; Caffeine; Molecular docking; Monoamine oxidase; Quantitative structure activity relationship; Reversible inhibition

Indexed keywords

8 ( 3 BROMOBENZYLOXY)CAFFEINE; 8 ( 3 CHLOROBENZYLOXY)CAFFEINE; 8 ( 3 FLUOROBENZYLOXY)CAFFEINE; 8 ( 3 METHOXYBENZYLOXY)CAFFEINE; 8 ( 3 METHYLBENZYLOXY)CAFFEINE; 8 [( 3 TRIFLUOROMETHYL)BENZYLOXY]CAFFEINE; 8 BENZYLOXYCAFFEINE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BENZYL DERIVATIVE; CAFFEINE DERIVATIVE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BABOON; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON; ELECTRONICS; ENZYME INHIBITION; HUMAN; LIPOPHILICITY; LIVER; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RING OPENING; SUBSTITUTION REACTION;

ANIMALS; CAFFEINE; HUMANS; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PAPIO; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

PAPIO;

EID: 75149186558     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.064     Document Type: Article

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