Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2463-2472

  Ogunrombi, Modupe O ^a   Malan, Sarel F ^a   Terre'Blanche, Gisella ^a   Castagnoli Jr , Neal ^b   Bergh, Jacobus J ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

1 Methyl 3 phenylpyrrole; Competitive inhibition; Monoamine oxidase B; Reversible inhibitors; Structure activity relationship

Indexed keywords

1 METHYL 3 (3 BROMOPHENYL)PYRROLE; 1 METHYL 3 (3 CHLOROPHENYL)PYRROLE; 1 METHYL 3 (3 METHOXYPHENYL)PYRROLE; 1 METHYL 3 (3 METHYLPHENYL)PYRROLE; 1 METHYL 3 (3 TRIFLUOROMETHYLPHENYL)PYRROLE; 1 METHYL 3 (4 FLUOROPHENYL)PYRROLE; 1 METHYL 3 (4 TRIFLUOROMETHYLPHENYL)PYRROLE; 1 METHYL 3 PHENYLPYRROLE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; MOLECULAR DOCKING; NONHUMAN; OXIDATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATALYSIS; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PAPIO; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749116837     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.059     Document Type: Article

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