Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8676-8684

  Pretorius, Judey ^a   Malan, Sarel F ^a   Castagnoli Jr , Neal ^b   Bergh, Jacobus J ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

Adenosine A2A receptor; Antagonism; Caffeine; Dual target directed drug; Monoamine oxidase B; Reversible inhibition

Indexed keywords

8 (4 PHENYLBUTADIEN 1 YL)CAFFEINE DERIVATIVE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ANTIPARKINSON AGENT; ISTRADEFYLLINE; MONOAMINE OXIDASE B INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BABOON; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BUTADIENES; CAFFEINE; MALE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

PARKINSONIA;

EID: 51449101712     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.088     Document Type: Article

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