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1
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39049177883
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Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system
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Goldman SA, Lang J, Roy N, et al. Progenitor cell-based myelination as a model for cell-based therapy of the central nervous system. Ernst Schering Res Found Workshop 2006; 195-213.
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Goldman, S.A.1
Lang, J.2
Roy, N.3
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2
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34548858985
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Use of stem cells for the treatment of multiple sclerosis
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This study nicely summarizes the experience with the use of different types of stem cells in CNS disease models and discusses the advantages and disadvantages of each stem cell type for future clinical applications in MS
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Karussis D, Kassis I. Use of stem cells for the treatment of multiple sclerosis. Expert Rev Neurother 2007; 7:1189-1201. This study nicely summarizes the experience with the use of different types of stem cells in CNS disease models and discusses the advantages and disadvantages of each stem cell type for future clinical applications in MS.
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Expert Rev Neurother
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Karussis, D.1
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3
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Cellular approaches for stimulating CNS remyelination
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Good review and discussion on the use of stem cells for the treatment of demyelinating diseases
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Miller RH, Bai L Cellular approaches for stimulating CNS remyelination. Regen Med 2007; 2:817-829. Good review and discussion on the use of stem cells for the treatment of demyelinating diseases.
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Regen Med
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Miller, R.H.1
Bai, L.2
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Endoscopically harvested stem cells: A putative method in future autotransplantation
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Westerlund U, Svensson M, Moe MC, et al. Endoscopically harvested stem cells: a putative method in future autotransplantation. Neurosurgery 2005; 57:779-784.
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Neurosurgery
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Westerlund, U.1
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5
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35148845584
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**], has significantly altered embryonic stem cell research by demonstrating that it is possible to induce the generation of human pluripotent stem cells from skin fibroblasts.
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**], has significantly altered embryonic stem cell research by demonstrating that it is possible to induce the generation of human pluripotent stem cells from skin fibroblasts.
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6
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36248966518
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Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872. This study from the laboratory of Yamanaka is the human fibroblast follow-up of their very first groundbreaking study on the induction of pluripotent stem cells from mouse fibroblasts
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Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872. This study from the laboratory of Yamanaka is the human fibroblast follow-up of their very first groundbreaking study on the induction of pluripotent stem cells from mouse fibroblasts
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7
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36749043230
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**), has significantly altered embryonic stem cell research by demonstrating that it is possible to induce the generation of human pluripotent stem cells from skin fibroblasts.
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**), has significantly altered embryonic stem cell research by demonstrating that it is possible to induce the generation of human pluripotent stem cells from skin fibroblasts.
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8
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42649130264
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Wemig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 2008; 105:5856-5861. This elaborate study shows that IPS cells indeed can generate neural stem cells, which differentiate into neurons and functionally integrate into the Mat brain aftar implantation. With an embryonic stem-derived protocol to induce dopaminergic neuron formation, IPS cells can form dopamine-producing cells that improve symptoms in a rat model for Parkinson's disease.
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Wemig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 2008; 105:5856-5861. This elaborate study shows that IPS cells indeed can generate neural stem cells, which differentiate into neurons and functionally integrate into the Mat brain aftar implantation. With an embryonic stem-derived protocol to induce dopaminergic neuron formation, IPS cells can form dopamine-producing cells that improve symptoms in a rat model for Parkinson's disease.
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9
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41949098160
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Direct reprogrammingofterminatly differentiated mature B lymphocytes to pluripotency
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Although fully differentiated B-lymphocytes require additional adaptation of the IPS induction protocol with the four plunpotency genes, this study nicely demonstrates that also easily accessible somatic cells like B-lymphocytes can be transformed into pluripotent embryonic stem cell-like IPS cells
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Hanna J, Markoulaki S, Schorderet P, et al. Direct reprogrammingofterminatly differentiated mature B lymphocytes to pluripotency. Cell 2008; 133:250-264. Although fully differentiated B-lymphocytes require additional adaptation of the IPS induction protocol with the four plunpotency genes, this study nicely demonstrates that also easily accessible somatic cells like B-lymphocytes can be transformed into pluripotent embryonic stem cell-like IPS cells.
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Cell
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Hanna, J.1
Markoulaki, S.2
Schorderet, P.3
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10
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Multiple restricted origin of oligodendrocytes
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Spassky N, Goujet-Zalc C, Parmantier E, et al. Multiple restricted origin of oligodendrocytes. J Neurosci 1998; 18:8331-8343.
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Spassky, N.1
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Parmantier, E.3
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11
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33846977750
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AscII defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord
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Interesting study showing that AscH, Mash-1 expressing progenitors in the developing spinal cord give rise first to dorsal hom intemeurons and subsequently to late-bom oligodendrocytes
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Battiste J, Helms AW, Kim EJ, et al. AscII defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 2007; 134:285-293. Interesting study showing that AscH- (Mash-1) expressing progenitors in the developing spinal cord give rise first to dorsal hom intemeurons and subsequently to late-bom oligodendrocytes.
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Development
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Battiste, J.1
Helms, A.W.2
Kim, E.J.3
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12
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Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling
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Cai J, Qi Y, Hu X, et al. Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 2005; 45:41-53.
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Cai, J.1
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Hu, X.3
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Vallstedt A, Klos JM, Ericson J. Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 2005; 45:55-67.
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Kessaris N, Fogarty M, lamarelli P, et al. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci 2006; 9:173-179.
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15
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36448947971
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Specification of CNS glia from neural stem cells in the embryonic neuroepithelium
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Comprehensive review focusing on the different extracellular signals and intracellular responses that influence glial generation and the choice between oligodendrocyte and astrocyte fates
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Kessaris N, Pringle N, Richardson WD. Specification of CNS glia from neural stem cells in the embryonic neuroepithelium. Philos Trans R Soc Lond B Biol Sci 2008; 363:71-85. Comprehensive review focusing on the different extracellular signals and intracellular responses that influence glial generation and the choice between oligodendrocyte and astrocyte fates.
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Philos Trans R Soc Lond B Biol Sci
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Kessaris, N.1
Pringle, N.2
Richardson, W.D.3
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17
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33747076381
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Origin of oligodendrocytes in the subventricular zone of the adult brain
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Menn B, Garcia-Verdugo JM, Yaschine C, et al. Origin of oligodendrocytes in the subventricular zone of the adult brain. J Neurosci 2006; 26:7907-7918.
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Menn, B.1
Garcia-Verdugo, J.M.2
Yaschine, C.3
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18
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34248366120
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Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors
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This is the first study on human postmortem brains from patients with MS specifically addressing the mobilization of PSA-NCAM, progenitors to periventricular lesions
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Nait-Oumesmar B, Picard-Riera N, Keminon C, et al. Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors. Proc Natl Acad Sci U S A 2007; 104:4694-4609. This is the first study on human postmortem brains from patients with MS specifically addressing the mobilization of PSA-NCAM(+) progenitors to periventricular lesions.
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Proc Natl Acad Sci U S A
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Nait-Oumesmar, B.1
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Keminon, C.3
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19
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38049061646
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The rote of SVZ-derived neural precursors in demyelinating diseases: From animal models to multiple sclerosis
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Comprehensive review on the role of endogenous neural stem cells in myelin repair in both animal models of demyelination and MS
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Nait-Oumesmar B, Picard-Riera N, Keminon C, Baron-VanEvercooren A. The rote of SVZ-derived neural precursors in demyelinating diseases: from animal models to multiple sclerosis. J Neural Sci 2007; 265:26-31. Comprehensive review on the role of endogenous neural stem cells in myelin repair in both animal models of demyelination and MS.
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J Neural Sci
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Nait-Oumesmar, B.1
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20
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34548204310
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Nicolay DJ, Doucette JR, Nazarali AJ. Transcriptional control of oligodendrogenesis. Glia 2007; 55:1287-1299. An excellent and comprehensive review of all known extrinsic and intrinsic factors involved in oligodendrogenesis. It gives a very detailed overview of the expression of the major transcription factors in oligodendrocytes at different embryonic stages.
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Nicolay DJ, Doucette JR, Nazarali AJ. Transcriptional control of oligodendrogenesis. Glia 2007; 55:1287-1299. An excellent and comprehensive review of all known extrinsic and intrinsic factors involved in oligodendrogenesis. It gives a very detailed overview of the expression of the major transcription factors in oligodendrocytes at different embryonic stages.
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1842454960
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Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signaling pathways in neocortical precursors
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Kessaris N. Jamen F, Rubin LL, Richardson WD. Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signaling pathways in neocortical precursors. Development 2004; 131:1289-1298.
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Kessaris, N.1
Jamen, F.2
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Richardson, W.D.4
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Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord
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Mekki-Dauriac S, Agius E, Kan P, Cochard P. Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord. Development 2002; 129:5117-5130.
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Development
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Mekki-Dauriac, S.1
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Baron-Van EA. fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor AB (PDGF AB) promote adult SVZ-derived oligodendrogenesis in vivo
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Lachapelle F, vellana-Adalid V, Nait-Oumesmar B, Baron-Van EA. fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor AB (PDGF AB) promote adult SVZ-derived oligodendrogenesis in vivo. Mol Cell Neurosci 2002; 20:390-403.
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Mol Cell Neurosci
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Lachapelle, F.1
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0347753249
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IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
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Hsieh J, Aimone JB, Kaspar BK, et al. IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol 2004; 164:111-122.
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J Cell Biol
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Wegner M. A matter of identity: transcriptional control in oligodendrocytes. J Mol Neurosci 2008; 35:3-12.
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Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice
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Xin M, Yue T, Ma Z, et al. Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. J Neurosci 2005; 25:1354-1365.
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Xin, M.1
Yue, T.2
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Neuronal fate determinants of adult olfactory bulb neurogenesis
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Hack MA, Saghatelyan A, deChevigny A, et al. Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci 2005; 8:865-872.
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Hack, M.A.1
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29
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Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells
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Experiments described in this study on adult spinal cord OPCs suggest that blocking BMP signalling combined with Olig1/2 overexpression could be a useful therapeutic strategy to enhance endogenous remyelination
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Cheng X, Wang Y, He Q, et al. Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem Cells 2007; 25:3204-3214. Experiments described in this study on adult spinal cord OPCs suggest that blocking BMP signalling combined with Olig1/2 overexpression could be a useful therapeutic strategy to enhance endogenous remyelination.
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Stem Cells
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Cheng, X.1
Wang, Y.2
He, Q.3
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30
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34247368943
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The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes
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This study shows for the first time that Mashi cooperates in vivo with Olig2 in oligodendrocyte specification
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Parras CM, Hunt C, Sugimori M, et al. The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. J Neurosci 2007; 27:4233-4242. This study shows for the first time that Mashi cooperates in vivo with Olig2 in oligodendrocyte specification.
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J Neurosci
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Parras, C.M.1
Hunt, C.2
Sugimori, M.3
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31
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Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression
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Gokhan S, Marin-Husstege M, Yung SY, et al. Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. J Neurosci 2005; 25:8311-8321.
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Gokhan, S.1
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Multiple roles of Id4 in developmental myelination: Predicted outcomes and unexpected findings
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Marin-Husstege M, He Y, Li J, et al. Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings. Glia 2006; 54:285-296.
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Glia
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From stem cells to neurons and glia: A Soxist's view of neural development
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Wegner M, Stolt CC. From stem cells to neurons and glia: a Soxist's view of neural development. Trends Neurosci 2005; 28:583-588.
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Trends Neurosci
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Wegner, M.1
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SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
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Stolt CC, Schlierf A, Lommes P, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell 2006; 11:697-709.
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Dev Cell
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35
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He Y, Dupree J, Wang J, et al. The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron 2007; 55:217-230. Good, interesting study in which the authors have identified the transcription factor YY1 as a critical regulator of oligodendrocyte progenitor differentiation.
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He Y, Dupree J, Wang J, et al. The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron 2007; 55:217-230. Good, interesting study in which the authors have identified the transcription factor YY1 as a critical regulator of oligodendrocyte progenitor differentiation.
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36
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Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells
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Nielsen JA, Berndt JA, Hudson LD, Armstrong RC. Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. Mol Cell Neurosci 2004; 25:111-123.
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Mol Cell Neurosci
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Nielsen, J.A.1
Berndt, J.A.2
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Armstrong, R.C.4
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Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells
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Balasubramaniyan V, Boddeke E, Bakels R, et al. Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. Neuroscience 2006; 143:939-951.
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Boddeke, E.2
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38
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This review focuses on the role of DNA methylation and histone modifications in neural lineage differentiation
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Feng J, Fouse S, Fan G. Epigenetic regulation of neural gene expression and neuronal function. Pediatr Res 2007; 61:58R-63R. This review focuses on the role of DNA methylation and histone modifications in neural lineage differentiation.
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Feng, J.1
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Hsieh J, Gage FH. Epigenetic control of neural stem cell fate. Curr Opin Genet Dev 2004; 14:461-469.
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Curr Opin Genet Dev
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Hsieh, J.1
Gage, F.H.2
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40
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Another timely review focusing on new insights into the epigenetic mechanism for neural stem cell fate
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Tang HL, Zhu JH. Epigenetics and neural stem cell commitment. Neurosci Bull 2007; 23:241-248. Another timely review focusing on new insights into the epigenetic mechanism for neural stem cell fate.
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Tang, H.L.1
Zhu, J.H.2
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41
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Posttranslational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease
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Excellent review on epigenetics and oligodendrogenesis
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Shen S, Casaccia-Bonnefil P. Posttranslational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci 2008; 35:13-22. Excellent review on epigenetics and oligodendrogenesis.
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Shen, S.1
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Marin-Husstege M, Muggironi M, Liu A, Casaccia-Bonnefil P. Histone deacetylase activity is necessary for oligodendrocyte lineage progression. J Neurosci 2002; 22:10333-10345.
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Marin-Husstege, M.1
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Liu, A.3
Casaccia-Bonnefil, P.4
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43
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34447130226
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The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory
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This study reports on extensive studies on NG2+ oligodendrocyte progenitors demonstrating that the ability of these cells to acquire the identity of myelinexpressing cells is dependent on the activity of HDAC
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Liu A, Han YR, Li J, et al. The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. J Neurosci 2007; 27:7339-7343. This study reports on extensive studies on NG2+ oligodendrocyte progenitors demonstrating that the ability of these cells to acquire the identity of myelinexpressing cells is dependent on the activity of HDAC.
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J Neurosci
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Liu, A.1
Han, Y.R.2
Li, J.3
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44
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33846632355
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Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
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Interesting study using novel inhibitors of histone deacetylases (iHDAC) for oligodendrogenesis research
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Siebzehnrubl FA, Buslei R, Eyupoglu IY, et al. Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells. Exp Brain Res 2007; 176:672-678. Interesting study using novel inhibitors of histone deacetylases (iHDAC) for oligodendrogenesis research.
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Exp Brain Res
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Siebzehnrubl, F.A.1
Buslei, R.2
Eyupoglu, I.Y.3
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45
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35348850693
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Concise review: Roles of polycomb group proteins in development and disease: a stem cell perspective
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This well written review adequately summarizes the increasing knowledge of the role of polycomb group proteins in stem cell physiology
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Rajasekhar VK, Begemann M. Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective. Stem Cells 2007; 25:2498-2510. This well written review adequately summarizes the increasing knowledge of the role of polycomb group proteins in stem cell physiology.
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Rajasekhar, V.K.1
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Sparmann A, van LM. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6:846-856.
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van, L.M.2
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47
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The very first study describing the involvement of RNA-binding proteins in oligodendrogenesis
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Dobson NR, Zhou YX, Flint NC, Armstrong RC. Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival. Glia 2008; 56:318-330. The very first study describing the involvement of RNA-binding proteins in oligodendrogenesis.
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Glia
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Dobson, N.R.1
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Hu JG, Fu SL, Wang YX, et al. Platelet-derived growth factor-AA mediates oligodendrocyte lineage differentiation through activation of extracellular signal-regulated kinase signaling pathway. Neuroscience 2008; 151:138-147. The authors show the dual role of PDGF-AA in oligodendrocyte precursor cell proliferation as well as their differentiation; the pathways underlying the switch from division into differentiation remain unclear.
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Hu JG, Fu SL, Wang YX, et al. Platelet-derived growth factor-AA mediates oligodendrocyte lineage differentiation through activation of extracellular signal-regulated kinase signaling pathway. Neuroscience 2008; 151:138-147. The authors show the dual role of PDGF-AA in oligodendrocyte precursor cell proliferation as well as their differentiation; the pathways underlying the switch from division into differentiation remain unclear.
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Kang SM, Cho MS, Seo H, et al. Efficient induction of oligodendrocytes from human embryonic stem cells. Stem Cells 2007; 25:419-424. This study provides a good, simple recipe to obtain a high percentage of functional oligodendrocytes from human embryonic stem cells.
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