Cellular remyelinating therapy in multiple sclerosis

Journal of the Neurological Sciences

Volumn 276, Issue 1-2, 2009, Pages 1-5

  Yang, Jingxian ^a   Rostami, Abdolmohamad ^a   Zhang, Guang Xian ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Cell transplantation; Multiple sclerosis; Neural stem cells; Remyelination

Indexed keywords

MYELIN;

ADULT STEM CELL; CELL LINEAGE; CELL THERAPY; CELL TRANSPLANTATION; CELL TYPE; CENTRAL NERVOUS SYSTEM; EMBRYONIC STEM CELL; HEMATOPOIETIC STEM CELL; HUMAN; MULTIPLE SCLEROSIS; NEURAL STEM CELL; NONHUMAN; OLFACTORY ENSHEATHING CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; REVIEW; SCHWANN CELL; STEM CELL;

ANIMALS; HUMANS; MULTIPLE SCLEROSIS; MYELIN SHEATH; STEM CELL TRANSPLANTATION;

EID: 58149165175     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2008.08.020     Document Type: Review

References (78)

1. Wingerchuk D.M. Current evidence and therapeutic strategies for multiple sclerosis. Semin Neurol 28 (2008) 56-68
2. Frohman E.M., Racke M.K., and Raine C.S. Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med 354 (2006) 942-955
3. Muraro P.A., Pette M., Bielekova B., McFarland H.F., and Martin R. Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity. J Immunol 164 (2000) 5474-5481
4. Li Y., Chu N., Hu A., Gran B., Rostami A., and Zhang G.X. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain 130 (2007) 490-501
5. Aktas O., Waiczies S., and Zipp F. Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets. J Neuroimmunol 184 (2007) 17-26
6. Franklin R.J. Why does remyelination fail in multiple sclerosis?. Nat Rev Neurosci 3 (2002) 705-714
7. Costello F., Stuve O., Weber M.S., Zamvil S.S., and Frohman E. Combination therapies for multiple sclerosis: scientific rationale, clinical trials, and clinical practice. Curr Opin Neurol 20 (2007) 281-285
8. Miller R.H., and Bai L. Cellular approaches for stimulating CNS remyelination. Regen Med 2 (2007) 817-829
9. Matysiak M., Stasiolek M., Orlowski W., Jurewicz A., Janczar S., Raine C.S., and Selmaj K. Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism. J Neuroimmunol 193 (2008) 12-23
10. Keirstead H.S. Stem cells for the treatment of myelin loss. Trends Neurosci 28 (2005) 677-683
11. Pluchino S., and Martino G. The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders. J Neurol Sci 233 (2005) 117-119
12. Karussis D., and Kassis I. The potential use of stem cells in multiple sclerosis: An overview of the preclinical experience. Clin Neurol Neurosurg (2008)
13. Peterson J.W., and Trapp B.D. Neuropathobiology of multiple sclerosis. Neurol Clin 23 (2005) 107-129 vi-vii
14. Zawadzka M., and Franklin R.J. Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology. Curr Opin Neurol 20 (2007) 294-298
15. Patrikios P., Stadelmann C., Kutzelnigg A., Rauschka H., Schmidbauer M., Laursen H., Sorensen P.S., Bruck W., Lucchinetti C., and Lassmann H. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 129 (2006) 3165-3172
16. Lavdas A.A., Papastefanaki F., Thomaidou D., and Matsas R. Schwann cell transplantation for CNS repair. Curr Med Chem 15 (2008) 151-160
17. Blakemore W.F. Regeneration and repair in multiple sclerosis: the view of experimental pathology. J Neurol Sci 265 (2008) 1-4
18. Akiyama Y., Radtke C., Honmou O., and Kocsis J.D. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 39 (2002) 229-236
19. Faulkner J., and Keirstead H.S. Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury. Transpl Immunol 15 (2005) 131-142
20. Honmou O., Felts P.A., Waxman S.G., and Kocsis J.D. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells. J Neurosci 16 (1996) 3199-3208
21. Payne N., Siatskas C., and Bernard C.C. The promise of stem cell and regenerative therapies for multiple sclerosis. J Autoimmun (2008)
22. Zappia E., Casazza S., Pedemonte E., Benvenuto F., Bonanni I., Gerdoni E., Giunti D., Ceravolo A., Cazzanti F., Frassoni F., Mancardi G., and Uccelli A. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106 (2005) 1755-1761
23. Einstein O., Fainstein N., Vaknin I., Mizrachi-Kol R., Reihartz E., Grigoriadis N., Lavon I., Baniyash M., Lassmann H., and Ben-Hur T. Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression. Ann Neurol 61 (2007) 209-218
24. Fandrich F., Lin X., Chai G.X., Schulze M., Ganten D., Bader M., Holle J., Huang D.S., Parwaresch R., Zavazava N., and Binas B. Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nat Med 8 (2002) 171-178
25. Keirstead H.S., Nistor G., Bernal G., Totoiu M., Cloutier F., Sharp K., and Steward O. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 25 (2005) 4694-4705
26. Perier C., Vila M., Feger J., Agid Y., and Hirsch E.C. Functional activity of zona incerta neurons is altered after nigrostriatal denervation in hemiparkinsonian rats. Exp Neurol 162 (2000) 215-224
27. Keirstead H.S. Stem cell transplantation into the central nervous system and the control of differentiation. J Neurosci Res 63 (2001) 233-236
28. Yoshizaki T., Inaji M., Kouike H., Shimazaki T., Sawamoto K., Ando K., Date I., Kobayashi K., Suhara T., Uchiyama Y., and Okano H. Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells. Neurosci Lett 363 (2004) 33-37
29. O'Leary M.T., and Blakemore W.F. Use of a rat Y chromosome probe to determine the long-term survival of glial cells transplanted into areas of CNS demyelination. J Neurocytol 26 (1997) 191-206
30. Rice C., and Scolding N. Strategies for achieving and monitoring myelin repair. J Neurol 254 (2007) 275-283
31. Pluchino S., Quattrini A., Brambilla E., Gritti A., Salani G., Dina G., Galli R., Del Carro U., Amadio S., Bergami A., Furlan R., Comi G., Vescovi A.L., and Martino G. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422 (2003) 688-694
32. Duncan I.D. Replacing cells in multiple sclerosis. J Neurol Sci 265 (2008) 89-92
33. Wolswijk G. Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Brain 123 Pt 1 (2000) 105-115
34. Maeda Y., Solanky M., Menonna J., Chapin J., Li W., and Dowling P. Platelet-derived growth factor-alpha receptor-positive oligodendroglia are frequent in multiple sclerosis lesions. Ann Neurol 49 (2001) 776-785
35. Lucchinetti C.F., Parisi J., and Bruck W. The pathology of multiple sclerosis. Neurol Clin 23 (2005) 77-105 vi
36. Crang A.J., Gilson J., and Blakemore W.F. The demonstration by transplantation of the very restricted remyelinating potential of post-mitotic oligodendrocytes. J Neurocytol 27 (1998) 541-553
37. Franklin R.J. Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia. Brain Res Bull 57 (2002) 827-832
38. Oudega M. Schwann cell and olfactory ensheathing cell implantation for repair of the contused spinal cord. Acta Physiol (Oxf) 189 (2007) 181-189
39. Kohama I., Lankford K.L., Preiningerova J., White F.A., Vollmer T.L., and Kocsis J.D. Transplantation of cryopreserved adult human Schwann cells enhances axonal conduction in demyelinated spinal cord. J Neurosci 21 (2001) 944-950
40. Papastefanaki F., Chen J., Lavdas A.A., Thomaidou D., Schachner M., and Matsas R. Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. Brain 130 (2007) 2159-2174
41. Shields S.A., Blakemore W.F., and Franklin R.J. Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated adult rat brain. J Neurosci Res 60 (2000) 571-578
42. Lavdas A.A., Franceschini I., Dubois-Dalcq M., and Matsas R. Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability in vitro. Glia 53 (2006) 868-878
43. Raisman G. Olfactory ensheathing cells and repair of brain and spinal cord injuries. Cloning Stem Cells 6 (2004) 364-368
44. Richter M.W., and Roskams A.J. Olfactory ensheathing cell transplantation following spinal cord injury: hype or hope?. Exp Neurol 209 (2008) 353-367
45. Sasaki M., Lankford K.L., Zemedkun M., and Kocsis J.D. Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin. J Neurosci 24 (2004) 8485-8493
46. Boyd J.G., Lee J., Skihar V., Doucette R., and Kawaja M.D. LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord. Proc Natl Acad Sci U S A 101 (2004) 2162-2166
47. Lakatos A., Franklin R.J., and Barnett S.C. Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes. Glia 32 (2000) 214-225
48. Karussis D., Kassis I., Kurkalli B.G., and Slavin S. Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases. J Neurol Sci 265 (2008) 131-135
49. Barnett S.C., and Riddell J.S. Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats. J Anat 204 (2004) 57-67
50. Barnett S.C., and Riddell J.S. Olfactory ensheathing cell transplantation as a strategy for spinal cord repair-what can it achieve?. Nat Clin Pract Neurol 3 (2007) 152-161
51. Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci 265 (2008) 102-104
52. Nistor G.I., Totoiu M.O., Haque N., Carpenter M.K., and Keirstead H.S. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 49 (2005) 385-396
53. Brustle O., Jones K.N., Learish R.D., Karram K., Choudhary K., Wiestler O.D., Duncan I.D., and McKay R.D. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 285 (1999) 754-756
54. Bjorklund L.M., Sanchez-Pernaute R., Chung S., Andersson T., Chen I.Y., McNaught K.S., Brownell A.L., Jenkins B.G., Wahlestedt C., Kim K.S., and Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 99 (2002) 2344-2349
55. Draper J.S., Smith K., Gokhale P., Moore H.D., Maltby E., Johnson J., Meisner L., Zwaka T.P., Thomson J.A., and Andrews P.W. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol 22 (2004) 53-54
56. Quesenberry P.J., Dooner G., Colvin G., and Abedi M. Stem cell biology and the plasticity polemic. Exp Hematol 33 (2005) 389-394
57. Nunes M.C., Roy N.S., Keyoung H.M., Goodman R.R., McKhann II G., Jiang L., Kang J., Nedergaard M., and Goldman S.A. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 9 (2003) 439-447
58. Iwanami A., Kaneko S., Nakamura M., Kanemura Y., Mori H., Kobayashi S., Yamasaki M., Momoshima S., Ishii H., Ando K., Tanioka Y., Tamaoki N., Nomura T., Toyama Y., and Okano H. Transplantation of human neural stem cells for spinal cord injury in primates. J Neurosci Res 80 (2005) 182-190
59. Magnus T., and Rao M.S. Neural stem cells in inflammatory CNS diseases: mechanisms and therapy. J Cell Mol Med 9 (2005) 303-319
60. Horner P.J., and Gage F.H. Regenerating the damaged central nervous system. Nature 407 (2000) 963-970
61. Ben-Hur T., Einstein O., Mizrachi-Kol R., Ben-Menachem O., Reinhartz E., Karussis D., and Abramsky O. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 41 (2003) 73-80
62. Magalon K., Cantarella C., Monti G., Cayre M., and Durbec P. Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models. Eur J Neurosci 25 (2007) 761-771
63. Politi L.S., Bacigaluppi M., Brambilla E., Cadioli M., Falini A., Comi G., Scotti G., Martino G., and Pluchino S. Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells 25 (2007) 2583-2592
64. Mezey E., Key S., Vogelsang G., Szalayova I., Lange G.D., and Crain B. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A 100 (2003) 1364-1369
65. Song S., and Sanchez-Ramos J. Preparation of neural progenitors from bone marrow and umbilical cord blood. Methods Mol Biol 438 (2008) 123-134
66. Alvarez-Dolado M., Pardal R., Garcia-Verdugo J.M., Fike J.R., Lee H.O., Pfeffer K., Lois C., Morrison S.J., and Alvarez-Buylla A. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425 (2003) 968-973
67. Castro R.F., Jackson K.A., Goodell M.A., Robertson C.S., Liu H., and Shine H.D. Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 297 (2002) 1299
68. Roybon L., Ma Z., Asztely F., Fosum A., Jacobsen S.E., Brundin P., and Li J.Y. Failure of transdifferentiation of adult hematopoietic stem cells into neurons. Stem Cells 24 (2006) 1594-1604
69. Bonilla S., Silva A., Valdes L., Geijo E., Garcia-Verdugo J.M., and Martinez S. Functional neural stem cells derived from adult bone marrow. Neuroscience 133 (2005) 85-95
70. Kabos P., Ehtesham M., Kabosova A., Black K.L., and Yu J.S. Generation of neural progenitor cells from whole adult bone marrow. Exp Neurol 178 (2002) 288-293
71. Brazelton T.R., Rossi F.M., Keshet G.I., and Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290 (2000) 1775-1779
72. Tropel P., Platet N., Platel J.C., Noel D., Albrieux M., Benabid A.L., and Berger F. Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells. Stem Cells 24 (2006) 2868-2876
73. Gerdoni E., Gallo B., Casazza S., Musio S., Bonanni I., Pedemonte E., Mantegazza R., Frassoni F., Mancardi G., Pedotti R., and Uccelli A. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol 61 (2007) 219-227
74. Zhang J., Li Y., Chen J., Cui Y., Lu M., Elias S.B., Mitchell J.B., Hammill L., Vanguri P., and Chopp M. Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp Neurol 195 (2005) 16-26
75. Krampera M., Pasini A., Pizzolo G., Cosmi L., Romagnani S., and Annunziato F. Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin Pharmacol 6 (2006) 435-441
76. Le Blanc K., Tammik L., Sundberg B., Haynesworth S.E., and Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 57 (2003) 11-20
77. Beyth S., Borovsky Z., Mevorach D., Liebergall M., Gazit Z., Aslan H., Galun E., and Rachmilewitz J. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 105 (2005) 2214-2219
78. Spaggiari G.M., Capobianco A., Becchetti S., Mingari M.C., and Moretta L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 107 (2006) 1484-1490