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Volumn 25, Issue 6, 2009, Pages 503-511

Neuropeptides and inflammatory bowel disease

Author keywords

Inflammatory bowel disease; Neuropeptides; Zintestinal inflammation

Indexed keywords

ACETYLCHOLINE; ASTRESSIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROPEPTIDE; NEUROTENSIN; SEROTONIN; SUBSTANCE P; UROCORTIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 74549154024     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328331b69e     Document Type: Review
Times cited : (85)

References (159)
  • 1
    • 25844525400 scopus 로고    scopus 로고
    • Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon
    • Linden DR, Couvrette JM, Ciolino A, et al. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon. Neurogastroenterol Motil 2005; 17:751-760.
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 751-760
    • Linden, D.R.1    Couvrette, J.M.2    Ciolino, A.3
  • 2
    • 0035170490 scopus 로고    scopus 로고
    • Nerve-driven immunity: Neuropeptides regulate cytokine secretion of T cells and intestinal epithelial cells in a direct, powerful and contextual manner
    • Levite M, Chowers Y. Nerve-driven immunity: neuropeptides regulate cytokine secretion of T cells and intestinal epithelial cells in a direct, powerful and contextual manner. Ann Oncol 2001; 12 (Suppl 2):S19-25.
    • (2001) Ann Oncol , vol.12 , Issue.SUPPL 2
    • Levite, M.1    Chowers, Y.2
  • 3
    • 0029837011 scopus 로고    scopus 로고
    • The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders
    • Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 1996; 111:1683-1699.
    • (1996) Gastroenterology , vol.111 , pp. 1683-1699
    • Collins, S.M.1
  • 4
    • 0026432216 scopus 로고
    • Inflammatorybowel disease
    • PodolskyDK. Inflammatorybowel disease. N Engl J Med 1991; 325:928-937.
    • (1991) N Engl J Med , vol.325 , pp. 928-937
    • Podolsky, D.K.1
  • 5
    • 34547627275 scopus 로고    scopus 로고
    • Role of neuropeptides in inflammatory bowel disease
    • Gross KJ, Pothoulakis C. Role of neuropeptides in inflammatory bowel disease. Inflamm Bowel Dis 2007; 13:918-932.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 918-932
    • Gross, K.J.1    Pothoulakis, C.2
  • 6
    • 0029921341 scopus 로고    scopus 로고
    • The enteric nervous system
    • Goyal RK, Hirano I. The enteric nervous system. N Engl J Med 1996; 334:1106-1115.
    • (1996) N Engl J Med , vol.334 , pp. 1106-1115
    • Goyal, R.K.1    Hirano, I.2
  • 7
    • 25444475525 scopus 로고    scopus 로고
    • Without nerves, immunology remains incomplete -in vivo veritas
    • Shepherd AJ, Downing JE, Miyan JA. Without nerves, immunology remains incomplete -in vivo veritas. Immunology 2005; 116:145-163.
    • (2005) Immunology , vol.116 , pp. 145-163
    • Shepherd, A.J.1    Downing, J.E.2    Miyan, J.A.3
  • 8
    • 0034073704 scopus 로고    scopus 로고
    • Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease
    • di Mola FF, Friess H, Zhu ZW, et al. Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease. Gut 2000; 46:670-679.
    • (2000) Gut , vol.46 , pp. 670-679
    • Di Mola, F.F.1    Friess, H.2    Zhu, Z.W.3
  • 9
    • 0029130042 scopus 로고
    • Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
    • Niessner M, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101:428-435.
    • (1995) Clin Exp Immunol , vol.101 , pp. 428-435
    • Niessner, M.1    Volk, B.A.2
  • 10
    • 0027517112 scopus 로고
    • Colonic vasoactive intestinal polypeptide in ulcerative colitis
    • Surrenti C, Renzi D, Garcea MR, et al. Colonic vasoactive intestinal polypeptide in ulcerative colitis. J Physiol Paris 1993; 87:307-311.
    • (1993) J Physiol Paris , vol.87 , pp. 307-311
    • Surrenti, C.1    Renzi, D.2    Garcea, M.R.3
  • 11
    • 0023148322 scopus 로고
    • The role of mast cells in inflammatory processes: Evidence for nerve/mast cell interactions
    • Bienenstock J, Tomioka M, Matsuda H, et al. The role of mast cells in inflammatory processes: evidence for nerve/mast cell interactions. Int Arch Allergy Appl Immunol 1987; 82:238-243.
    • (1987) Int Arch Allergy Appl Immunol , vol.82 , pp. 238-243
    • Bienenstock, J.1    Tomioka, M.2    Matsuda, H.3
  • 12
    • 0032702359 scopus 로고    scopus 로고
    • Stress and mind-body impact on the course of inflammatory bowel diseases
    • Anton PA. Stress and mind-body impact on the course of inflammatory bowel diseases. Semin Gastrointest Dis 1999; 10:14-19.
    • (1999) Semin Gastrointest Dis , vol.10 , pp. 14-19
    • Anton, P.A.1
  • 13
    • 0018417916 scopus 로고
    • Crohn's disease: A scanning electron microscopic study
    • Dvorak AM, Connell AB, Dickersin GR. Crohn's disease: a scanning electron microscopic study. Hum Pathol 1979; 10:165-177.
    • (1979) Hum Pathol , vol.10 , pp. 165-177
    • Dvorak, A.M.1    Connell, A.B.2    Dickersin, G.R.3
  • 14
    • 33744512952 scopus 로고    scopus 로고
    • Enteric neuroplasticity evoked by inflammation
    • Vasina V, Barbara G, Talamonti L, et al. Enteric neuroplasticity evoked by inflammation. Auton Neurosci 2006; 126-127:264-272.
    • (2006) Auton Neurosci , vol.126-127 , pp. 264-272
    • Vasina, V.1    Barbara, G.2    Talamonti, L.3
  • 15
    • 0008605142 scopus 로고
    • The myenteric plexus in regional enteritis: A study of the number of ganglion cells in the ileum in 24 cases
    • Davis DR, Dockerty MB, MayoCW. The myenteric plexus in regional enteritis: a study of the number of ganglion cells in the ileum in 24 cases. Surg Gynecol Obstet 1955; 101:208-216.
    • (1955) Surg Gynecol Obstet , vol.101 , pp. 208-216
    • Davis, D.R.1    Dockerty, M.B.2    Mayo, C.W.3
  • 16
    • 49749084030 scopus 로고    scopus 로고
    • Enteric nervous system abnormalities in inflammatory bowel diseases
    • Villanacci V, Bassotti G, Nascimbeni R, et al. Enteric nervous system abnormalities in inflammatory bowel diseases. Neurogastroenterol Motil 2008; 20:1009-1016.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1009-1016
    • Villanacci, V.1    Bassotti, G.2    Nascimbeni, R.3
  • 17
    • 0033855333 scopus 로고    scopus 로고
    • Neurokinin-1 receptor expression in inflammatory bowel disease: Molecular quantitation and localisation
    • Goode T, O'Connell J, Anton P, et al. Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation. Gut 2000; 47:387-396.
    • (2000) Gut , vol.47 , pp. 387-396
    • Goode, T.1    O'connell, J.2    Anton, P.3
  • 18
    • 0030996201 scopus 로고    scopus 로고
    • Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation
    • Holzer P, Holzer-Petsche U. Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation. Pharmacol Ther 1997; 73:219-263.
    • (1997) Pharmacol Ther , vol.73 , pp. 219-263
    • Holzer, P.1    Holzer-Petsche, U.2
  • 19
    • 0036070721 scopus 로고    scopus 로고
    • Roles of substance P receptors in human colon circular muscle: Alterations in diverticular disease
    • Liu L, Shang F,Markus I, Burcher E. Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease. J Pharmacol Exp Ther 2002; 302:627-635.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 627-635
    • Liu, L.1    Shang, F.2    Markus, I.3    Burcher, E.4
  • 20
    • 0030896270 scopus 로고    scopus 로고
    • Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats
    • Castagliuolo I, Keates AC, Qiu B, et al. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc Natl Acad Sci U S A 1997; 94:4788-4793.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4788-4793
    • Castagliuolo, I.1    Keates, A.C.2    Qiu, B.3
  • 21
    • 0031301905 scopus 로고    scopus 로고
    • Human monocytes and macrophages express substance P and neurokinin-1 receptor
    • Ho WZ, Lai JP, Zhu XH, et al. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J Immunol 1997; 159:5654-5660.
    • (1997) J Immunol , vol.159 , pp. 5654-5660
    • Ho, W.Z.1    Lai, J.P.2    Zhu, X.H.3
  • 22
    • 0032100709 scopus 로고    scopus 로고
    • Human lymphocytes express substance P and its receptor
    • Lai JP, Douglas SD, Ho WZ. Human lymphocytes express substance P and its receptor. J Neuroimmunol 1998; 86:80-86.
    • (1998) J Neuroimmunol , vol.86 , pp. 80-86
    • Lai, J.P.1    Douglas, S.D.2    Ho, W.Z.3
  • 23
    • 0023688665 scopus 로고
    • Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P
    • Weinstock JV, Blum A, Walder J, Walder R. Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P. J Immunol 1988; 141:961-966.
    • (1988) J Immunol , vol.141 , pp. 961-966
    • Weinstock, J.V.1    Blum, A.2    Walder, J.3    Walder, R.4
  • 24
    • 33645105327 scopus 로고    scopus 로고
    • Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells
    • Gallicchio M, Rosa AC, Benetti E, et al. Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. Br J Pharmacol 2006; 147:681-689.
    • (2006) Br J Pharmacol , vol.147 , pp. 681-689
    • Gallicchio, M.1    Rosa, A.C.2    Benetti, E.3
  • 25
    • 0031830614 scopus 로고    scopus 로고
    • Substance P receptor expression in intestinal epithelium in Clostridium difficile toxin A enteritis in rats
    • Pothoulakis C, Castagliuolo I, Leeman SE, et al. Substance P receptor expression in intestinal epithelium in Clostridium difficile toxin A enteritis in rats. Am J Physiol 1998; 275 (1 Pt 1):G68-75.
    • (1998) Am J Physiol , vol.275 , Issue.1 PART 1
    • Pothoulakis, C.1    Castagliuolo, I.2    Leeman, S.E.3
  • 26
    • 0031897473 scopus 로고    scopus 로고
    • Substance P and vasoactive intestinal polypeptide but not calcitonin gene-related peptide concentrations are reduced in patients with moderate and severe ulcerative colitis
    • Renzi D, Mantellini P, Calabró A, et al. Substance P and vasoactive intestinal polypeptide but not calcitonin gene-related peptide concentrations are reduced in patients with moderate and severe ulcerative colitis. Ital J Gastroenterol Hepatol 1998; 30:62-70.
    • (1998) Ital J Gastroenterol Hepatol , vol.30 , pp. 62-70
    • Renzi, D.1    Mantellini, P.2    Calabró, A.3
  • 27
    • 0026521158 scopus 로고
    • GAP-43 is expressed by nonmyelin-forming Schwann cells of the peripheral nervous system
    • Curtis R. GAP-43 is expressed by nonmyelin-forming Schwann cells of the peripheral nervous system. J Cell Biol 1992; 116:1455-1464.
    • (1992) J Cell Biol , vol.116 , pp. 1455-1464
    • Curtis, R.1
  • 28
    • 0027978626 scopus 로고
    • Changes in neuropeptide-containing nerves in human colonic mucosa with inflammatory bowel disease
    • Kimura M, Masuda T, Hiwatashi N, et al. Changes in neuropeptide- containing nerves in human colonic mucosa with inflammatory bowel disease. Pathol Int 1994; 44:624-634.
    • (1994) Pathol Int , vol.44 , pp. 624-634
    • Kimura, M.1    Masuda, T.2    Hiwatashi, N.3
  • 29
    • 0027193877 scopus 로고
    • Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease
    • Bernstein CN, Robert ME, Eysselein VE. Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. Am J Gastroenterol 1993; 88:908-913.
    • (1993) Am J Gastroenterol , vol.88 , pp. 908-913
    • Bernstein, C.N.1    Robert, M.E.2    Eysselein, V.E.3
  • 30
    • 0024390476 scopus 로고
    • Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation
    • Goldin E, Karmeli F, Selinger Z, Rachmilewitz D. Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation. Dig Dis Sci 1989; 34:754-757.
    • (1989) Dig Dis Sci , vol.34 , pp. 754-757
    • Goldin, E.1    Karmeli, F.2    Selinger, Z.3    Rachmilewitz, D.4
  • 31
    • 0026601086 scopus 로고
    • Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease
    • Mazumdar S, Das KM. Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease. Am J Gastroenterol 1992; 87: 176-181.
    • (1992) Am J Gastroenterol , vol.87 , pp. 176-181
    • Mazumdar, S.1    Das, K.M.2
  • 32
    • 2442680385 scopus 로고    scopus 로고
    • Cutting edge: Hemokinin has substance P-like function and expression in inflammation
    • Metwali A, Blum AM, Elliott DE, et al. Cutting edge: hemokinin has substance P-like function and expression in inflammation. J Immunol 2004; 172:6528-6532.
    • (2004) J Immunol , vol.172 , pp. 6528-6532
    • Metwali, A.1    Blum, A.M.2    Elliott, D.E.3
  • 33
    • 0034974997 scopus 로고    scopus 로고
    • Quantitative comparison of growthassociated protein-43 and substance P in ulcerative colitis
    • Vento P, Kiviluto T, Keránen U, et al. Quantitative comparison of growthassociated protein-43 and substance P in ulcerative colitis. J Histochem Cytochem 2001; 49:749-758.
    • (2001) J Histochem Cytochem , vol.49 , pp. 749-758
    • Vento, P.1    Kiviluto, T.2    Keránen, U.3
  • 34
    • 0023214646 scopus 로고
    • Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases
    • Koch TR, Carney JA, Go VL. Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases. Dig Dis Sci 1987; 32:369-376.
    • (1987) Dig Dis Sci , vol.32 , pp. 369-376
    • Koch, T.R.1    Carney, J.A.2    Go, V.L.3
  • 35
    • 33947152519 scopus 로고    scopus 로고
    • Increase in substance P precursor mRNA in noninflamed small-bowel sections in patients with Crohn's disease
    • Michalski CW, Autschbach F, Selvaggi F, et al. Increase in substance P precursor mRNA in noninflamed small-bowel sections in patients with Crohn's disease. Am J Surg 2007; 193:476-481.
    • (2007) Am J Surg , vol.193 , pp. 476-481
    • Michalski, C.W.1    Autschbach, F.2    Selvaggi, F.3
  • 36
    • 0005061019 scopus 로고
    • Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease
    • Mantyh CR, Gates TS, Zimmerman RP, et al. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc Natl Acad Sci U S A 1988; 85:3235-3239.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 3235-3239
    • Mantyh, C.R.1    Gates, T.S.2    Zimmerman, R.P.3
  • 37
    • 0033678445 scopus 로고    scopus 로고
    • Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine
    • Renzi D, Pellegrini B, Tonelli F, et al. Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine. Am J Pathol 2000; 157:1511-1522.
    • (2000) Am J Pathol , vol.157 , pp. 1511-1522
    • Renzi, D.1    Pellegrini, B.2    Tonelli, F.3
  • 38
    • 0029123521 scopus 로고
    • Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis
    • Mantyh CR, Vigna SR, Bollinger RR, et al. Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology 1995; 109:850-860.
    • (1995) Gastroenterology , vol.109 , pp. 850-860
    • Mantyh, C.R.1    Vigna, S.R.2    Bollinger, R.R.3
  • 39
    • 0031819311 scopus 로고    scopus 로고
    • Distribution of calcitonin gene-related peptide, somatostatin, substance P and vasoactive intestinal polypeptide in experimental colitis in rats
    • Miampamba M, Sharkey KA. Distribution of calcitonin gene-related peptide, somatostatin, substance P and vasoactive intestinal polypeptide in experimental colitis in rats. Neurogastroenterol Motil 1998; 10:315-329.
    • (1998) Neurogastroenterol Motil , vol.10 , pp. 315-329
    • Miampamba, M.1    Sharkey, K.A.2
  • 40
    • 0036057236 scopus 로고    scopus 로고
    • Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease
    • Niess JH, Mónnikes H, Dignass AU, et al. Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease. Digestion 2002; 65:131-140.
    • (2002) Digestion , vol.65 , pp. 131-140
    • Niess, J.H.1    Mónnikes, H.2    Dignass, A.U.3
  • 41
    • 13044264447 scopus 로고    scopus 로고
    • Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P
    • Sturiale S, Barbara G, Qiu B, et al. Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. Proc Natl Acad Sci U S A 1999; 96:11653-11658.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 11653-11658
    • Sturiale, S.1    Barbara, G.2    Qiu, B.3
  • 42
    • 58249101397 scopus 로고    scopus 로고
    • Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats
    • Ursino MG, Vasina V, De Ponti F. Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats. Eur J Pharmacol 2009; 603:133-137.
    • (2009) Eur J Pharmacol , vol.603 , pp. 133-137
    • Ursino, M.G.1    Vasina, V.2    De Ponti, F.3
  • 43
    • 0032933192 scopus 로고    scopus 로고
    • SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis
    • Di Sebastiano P, Grossi L, Di Mola FF, et al. SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis. Dig Dis Sci 1999; 44:439-444.
    • (1999) Dig Dis Sci , vol.44 , pp. 439-444
    • Di Sebastiano, P.1    Grossi, L.2    Di Mola, F.F.3
  • 44
    • 70349487326 scopus 로고    scopus 로고
    • Blockage of the neurokinin 1 receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis
    • Gad M, Pedersen AE, Kristensen NN, et al. Blockage of the neurokinin 1 receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis. Inflamm Bowel Dis 2009.
    • (2009) Inflamm Bowel Dis
    • Gad, M.1    Pedersen, A.E.2    Kristensen, N.N.3
  • 45
    • 0344687483 scopus 로고    scopus 로고
    • Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells
    • Azzolina A, Bongiovanni A, Lampiasi N. Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim Biophys Acta 2003; 1643:75-83.
    • (2003) Biochim Biophys Acta , vol.1643 , pp. 75-83
    • Azzolina, A.1    Bongiovanni, A.2    Lampiasi, N.3
  • 46
    • 0030590913 scopus 로고    scopus 로고
    • Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: Characterization of novel tachykinin receptor antagonists
    • Derocq JM, Ségui M, Blazy C, et al. Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists. FEBS Lett 1996; 399:321-325.
    • (1996) FEBS Lett , vol.399 , pp. 321-325
    • Derocq, J.M.1    Ségui, M.2    Blazy, C.3
  • 47
    • 0034669966 scopus 로고    scopus 로고
    • The neuropeptide substance P activates p38 mitogen-activated protein kinase resulting in IL-6 expression independently from NF-kappa B
    • Fiebich BL, Schleicher S, Butcher RD, et al. The neuropeptide substance P activates p38 mitogen-activated protein kinase resulting in IL-6 expression independently from NF-kappa B. J Immunol 2000; 165:5606-5611.
    • (2000) J Immunol , vol.165 , pp. 5606-5611
    • Fiebich, B.L.1    Schleicher, S.2    Butcher, R.D.3
  • 48
    • 33645521371 scopus 로고    scopus 로고
    • Induction of colitis causes inflammatory responses in fat depots: Evidence for substance P pathways in human mesenteric preadipocytes
    • Karagiannides I, Kokkotou E, Tansky M, et al. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A 2006; 103:5207-5212.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5207-5212
    • Karagiannides, I.1    Kokkotou, E.2    Tansky, M.3
  • 49
    • 23944448890 scopus 로고    scopus 로고
    • Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation
    • Koon HW, Zhao D, Zhan Y, et al. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation. J Pharmacol Exp Ther 2005; 314:1393-1400.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1393-1400
    • Koon, H.W.1    Zhao, D.2    Zhan, Y.3
  • 50
    • 0031573083 scopus 로고    scopus 로고
    • The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells
    • Lieb K, Fiebich BL, Berger M, et al. The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol 1997; 159:4952-4958.
    • (1997) J Immunol , vol.159 , pp. 4952-4958
    • Lieb, K.1    Fiebich, B.L.2    Berger, M.3
  • 51
    • 0036901591 scopus 로고    scopus 로고
    • Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases
    • Zhao D, Kuhnt-Moore S, Zeng H, et al. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochem J 2002; 368 (Pt 2):665-672.
    • (2002) Biochem J , vol.368 , Issue.PART 2 , pp. 665-672
    • Zhao, D.1    Kuhnt-Moore, S.2    Zeng, H.3
  • 52
    • 0036267412 scopus 로고    scopus 로고
    • Protective effects of neurokinin-1 receptor during colitis in mice: Role of the epidermal growth factor receptor
    • Castagliuolo I, Morteau O, Keates AC, et al. Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor. Br J Pharmacol 2002; 136:271-279.
    • (2002) Br J Pharmacol , vol.136 , pp. 271-279
    • Castagliuolo, I.1    Morteau, O.2    Keates, A.C.3
  • 53
    • 59849098702 scopus 로고    scopus 로고
    • The role of neurokinin-1 receptor antagonists for the management of postoperative nausea and vomiting
    • Apfel CC, Malhotra A, Leslie JB. The role of neurokinin-1 receptor antagonists for the management of postoperative nausea and vomiting. Curr Opin Anaesthesiol 2008; 21:427-432.
    • (2008) Curr Opin Anaesthesiol , vol.21 , pp. 427-432
    • Apfel, C.C.1    Malhotra, A.2    Leslie, J.B.3
  • 54
    • 53849095170 scopus 로고    scopus 로고
    • Aprepitant: Where do we stand in the control of chemotherapy-induced nausea and vomiting?
    • Sarcev T, Secen N, Zaric B, Milovancev A. Aprepitant: where do we stand in the control of chemotherapy-induced nausea and vomiting? J BUON 2008; 13:333-339.
    • (2008) J BUON , vol.13 , pp. 333-339
    • Sarcev, T.1    Secen, N.2    Zaric, B.3    Milovancev, A.4
  • 55
    • 58149328475 scopus 로고    scopus 로고
    • A new pharmacological treatment option for alcohol dependence discovered in transnational study: Neurokinin-1 receptor antagonist as a possible therapy for alcoholism?
    • Mutschler J, Grosshans M, Kiefer F. A new pharmacological treatment option for alcohol dependence discovered in transnational study: neurokinin-1 receptor antagonist as a possible therapy for alcoholism? Neuropsychiatr 2008; 22:283-285.
    • (2008) Neuropsychiatr , vol.22 , pp. 283-285
    • Mutschler, J.1    Grosshans, M.2    Kiefer, F.3
  • 56
    • 64949104350 scopus 로고    scopus 로고
    • Pharmacological management of chemotherapy-induced nausea and vomiting: Focus on recent developments
    • Navari RM. Pharmacological management of chemotherapy-induced nausea and vomiting: focus on recent developments. Drugs 2009; 69:515-533.
    • (2009) Drugs , vol.69 , pp. 515-533
    • Navari, R.M.1
  • 57
    • 65649136950 scopus 로고    scopus 로고
    • Antiemetic control: Toward a new standard of care for emetogenic chemotherapy
    • Navari RM. Antiemetic control: toward a new standard of care for emetogenic chemotherapy. Expert Opin Pharmacother 2009; 10:629-644.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 629-644
    • Navari, R.M.1
  • 58
    • 66349109016 scopus 로고    scopus 로고
    • Aprepitant for the prevention of cisplatine induced nausea and vomiting: An observational study
    • Galy G, Labidi SI, Tissier F, et al. Aprepitant for the prevention of cisplatine induced nausea and vomiting: an observational study. Bull Cancer 2009; 96:141-145.
    • (2009) Bull Cancer , vol.96 , pp. 141-145
    • Galy, G.1    Labidi, S.I.2    Tissier, F.3
  • 59
    • 59349121894 scopus 로고    scopus 로고
    • Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: A randomized, double-blind, placebo-controlled study of efficacy and tolerability
    • Gore L, Chawla S, Petrilli A, et al. Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: a randomized, double-blind, placebo-controlled study of efficacy and tolerability. Pediatr Blood Cancer 2009; 52:242-247.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 242-247
    • Gore, L.1    Chawla, S.2    Petrilli, A.3
  • 60
    • 60849089956 scopus 로고    scopus 로고
    • Fosaprepitant: A neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting
    • Navari RM. Fosaprepitant: a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther 2008; 8:1733-1742.
    • (2008) Expert Rev Anticancer Ther , vol.8 , pp. 1733-1742
    • Navari, R.M.1
  • 61
    • 52549130708 scopus 로고    scopus 로고
    • An FDA approved neurokinin-1 receptor antagonist is effective in reducing intraabdominal adhesions when administered intraperitoneally, but not orally
    • Lim R, Morrill JM, Prushik SG, et al. An FDA approved neurokinin-1 receptor antagonist is effective in reducing intraabdominal adhesions when administered intraperitoneally, but not orally. J Gastrointest Surg 2008; 12:1754-1761.
    • (2008) J Gastrointest Surg , vol.12 , pp. 1754-1761
    • Lim, R.1    Morrill, J.M.2    Prushik, S.G.3
  • 62
    • 0020689401 scopus 로고
    • Chemical and biological characterization of corticotropin releasing factor
    • Vale W, Rivier C, Brown MR, et al. Chemical and biological characterization of corticotropin releasing factor. Recent Prog Horm Res 1983; 39:245-270.
    • (1983) Recent Prog Horm Res , vol.39 , pp. 245-270
    • Vale, W.1    Rivier, C.2    Brown, M.R.3
  • 63
    • 0019782980 scopus 로고
    • Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and betaendorphin
    • Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and betaendorphin. Science 1981; 213:1394-1397.
    • (1981) Science , vol.213 , pp. 1394-1397
    • Vale, W.1    Spiess, J.2    Rivier, C.3    Rivier, J.4
  • 64
    • 0032801846 scopus 로고    scopus 로고
    • Corticotropin releasing factor receptors and their ligand family
    • Perrin MH, Vale WW. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci 1999; 885:312-328.
    • (1999) Ann N y Acad Sci , vol.885 , pp. 312-328
    • Perrin, M.H.1    Vale, W.W.2
  • 65
    • 0020683637 scopus 로고
    • Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study
    • Swanson LW, Sawchenko PE, Rivier J, Vale WW. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 1983; 36:165-186.
    • (1983) Neuroendocrinology , vol.36 , pp. 165-186
    • Swanson, L.W.1    Sawchenko, P.E.2    Rivier, J.3    Vale, W.W.4
  • 66
    • 0020183919 scopus 로고
    • Corticotropin-releasing factor: Actions on the sympathetic nervous system and metabolism
    • Brown MR, Fisher LA, Spiess J, et al. Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 1982; 111:928-931.
    • (1982) Endocrinology , vol.111 , pp. 928-931
    • Brown, M.R.1    Fisher, L.A.2    Spiess, J.3
  • 67
    • 0028806083 scopus 로고
    • Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis
    • Kawahito Y, Sano H, Mukai S, et al. Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis. Gut 1995; 37:544-551.
    • (1995) Gut , vol.37 , pp. 544-551
    • Kawahito, Y.1    Sano, H.2    Mukai, S.3
  • 68
    • 0021918387 scopus 로고
    • Corticotropin-releasing factor. Mechanisms to inhibit gastric acid secretion in conscious dogs
    • Lenz HJ, Hester SE, Brown MR. Corticotropin-releasing factor. Mechanisms to inhibit gastric acid secretion in conscious dogs. J Clin Invest 1985; 75:889-895.
    • (1985) J Clin Invest , vol.75 , pp. 889-895
    • Lenz, H.J.1    Hester, S.E.2    Brown, M.R.3
  • 69
    • 0032911862 scopus 로고    scopus 로고
    • Susceptibility of Lewis and Fischer rats to stressinduced worsening of TNB-colitis: Protective role of brain CRF
    • Million M, Tache Y, Anton P. Susceptibility of Lewis and Fischer rats to stressinduced worsening of TNB-colitis: protective role of brain CRF. Am J Physiol 1999; 276 (4 Pt 1):G1027-G1036.
    • (1999) Am J Physiol , vol.276 , Issue.4 PART 1
    • Million, M.1    Tache, Y.2    Anton, P.3
  • 70
    • 56649109885 scopus 로고    scopus 로고
    • Diverse mechanisms and consequences of immunoadoption of neuromediator systems
    • Goetzl EJ, Chan RC, Yadav M. Diverse mechanisms and consequences of immunoadoption of neuromediator systems. Ann N Y Acad Sci 2008; 1144:56-60.
    • (2008) Ann N y Acad Sci , vol.1144 , pp. 56-60
    • Goetzl, E.J.1    Chan, R.C.2    Yadav, M.3
  • 71
    • 0028284987 scopus 로고
    • Local secretion of corticotropinreleasing hormone by enterochromaffin cells in human colon
    • Kawahito Y, Sano H, Kawata M, et al. Local secretion of corticotropinreleasing hormone by enterochromaffin cells in human colon. Gastroenterology 1994; 106:859-865.
    • (1994) Gastroenterology , vol.106 , pp. 859-865
    • Kawahito, Y.1    Sano, H.2    Kawata, M.3
  • 72
    • 0020409215 scopus 로고
    • Corticotropin releasing factor produces behavioural activation in rats
    • Sutton RE, Koob GF, Le Moal M, et al. Corticotropin releasing factor produces behavioural activation in rats. Nature 1982; 297:331-333.
    • (1982) Nature , vol.297 , pp. 331-333
    • Sutton, R.E.1    Koob, G.F.2    Le Moal, M.3
  • 73
    • 8744285706 scopus 로고    scopus 로고
    • Urocortin 1 in colonic mucosa in patients with ulcerative colitis
    • Saruta M, Takahashi K, Suzuki T, et al. Urocortin 1 in colonic mucosa in patients with ulcerative colitis. J Clin Endocrinol Metab 2004; 89:5352-5361.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5352-5361
    • Saruta, M.1    Takahashi, K.2    Suzuki, T.3
  • 74
    • 33646779859 scopus 로고    scopus 로고
    • Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease
    • Gonzalez-Rey E, Fernandez-Martin A, Chorny A, Delgado M. Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease. Gut 2006; 55:824-832.
    • (2006) Gut , vol.55 , pp. 824-832
    • Gonzalez-Rey, E.1    Fernandez-Martin, A.2    Chorny, A.3    Delgado, M.4
  • 75
    • 51849127288 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension
    • Saito-Nakaya K, Hasegawa R, Nagura Y, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension. Neurogastroenterol Motil 2008; 20:1147-1156.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1147-1156
    • Saito-Nakaya, K.1    Hasegawa, R.2    Nagura, Y.3
  • 76
    • 46349102086 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis
    • Gay J, Kokkotou E, O'Brien M, et al. Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis. Endocrinology 2008; 149:3403-3409.
    • (2008) Endocrinology , vol.149 , pp. 3403-3409
    • Gay, J.1    Kokkotou, E.2    O'brien, M.3
  • 77
    • 33747762945 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses
    • Kokkotou E, Torres D, Moss AC, et al. Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. J Immunol 2006; 177:3355-3361.
    • (2006) J Immunol , vol.177 , pp. 3355-3361
    • Kokkotou, E.1    Torres, D.2    Moss, A.C.3
  • 78
    • 0036842131 scopus 로고    scopus 로고
    • Regulation of nuclear factor-kappaB by corticotropinreleasing hormone in mouse thymocytes
    • Zhao J, Karalis KP. Regulation of nuclear factor-kappaB by corticotropinreleasing hormone in mouse thymocytes. Mol Endocrinol 2002; 16:2561-2570.
    • (2002) Mol Endocrinol , vol.16 , pp. 2561-2570
    • Zhao, J.1    Karalis, K.P.2
  • 79
    • 26844535016 scopus 로고    scopus 로고
    • Urocortin 2 suppresses host resistance to Listeria monocytogenes infection via up-regulation of interleukin-10
    • Sashinami H, Kageyama K, Suda T, Nakane A. Urocortin 2 suppresses host resistance to Listeria monocytogenes infection via up-regulation of interleukin-10. Endocrinology 2005; 146:5003-5011.
    • (2005) Endocrinology , vol.146 , pp. 5003-5011
    • Sashinami, H.1    Kageyama, K.2    Suda, T.3    Nakane, A.4
  • 80
    • 23644441920 scopus 로고    scopus 로고
    • Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2
    • Tsatsanis C, Androulidaki A, Dermitzaki E, et al. Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2. FEBS Lett 2005; 579:4259-4264.
    • (2005) FEBS Lett , vol.579 , pp. 4259-4264
    • Tsatsanis, C.1    Androulidaki, A.2    Dermitzaki, E.3
  • 81
    • 0016635207 scopus 로고
    • The amino acid sequence of a hypothalamic peptide, neurotensin
    • Carraway R, Leeman SE. The amino acid sequence of a hypothalamic peptide, neurotensin. J Biol Chem 1975; 250:1907-1911.
    • (1975) J Biol Chem , vol.250 , pp. 1907-1911
    • Carraway, R.1    Leeman, S.E.2
  • 82
    • 0017114234 scopus 로고
    • Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach
    • Carraway R, Leeman SE. Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach. J Biol Chem 1976; 251:7045-7052.
    • (1976) J Biol Chem , vol.251 , pp. 7045-7052
    • Carraway, R.1    Leeman, S.E.2
  • 83
    • 0020371857 scopus 로고
    • A study of the concentrations of substance P and neurotensin in the gastrointestinal tract of various mammals
    • Holzer P, Bucsics A, Saria A, Lembeck F. A study of the concentrations of substance P and neurotensin in the gastrointestinal tract of various mammals. Neuroscience 1982; 7:2919-2924.
    • (1982) Neuroscience , vol.7 , pp. 2919-2924
    • Holzer, P.1    Bucsics, A.2    Saria, A.3    Lembeck, F.4
  • 84
    • 0029811945 scopus 로고    scopus 로고
    • Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain
    • Mazella J, Botto JM, Guillemare E, et al. Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci 1996; 16:5613-5620.
    • (1996) J Neurosci , vol.16 , pp. 5613-5620
    • Mazella, J.1    Botto, J.M.2    Guillemare, E.3
  • 85
    • 0025345759 scopus 로고
    • Structure and functional expression of the cloned rat neurotensin receptor
    • Tanaka K, Masu M, Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron 1990; 4:847-854.
    • (1990) Neuron , vol.4 , pp. 847-854
    • Tanaka, K.1    Masu, M.2    Nakanishi, S.3
  • 86
    • 15244344525 scopus 로고    scopus 로고
    • Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation
    • Brun P, Mastrotto C, Beggiao E, et al. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 2005; 288:G621-G629.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Brun, P.1    Mastrotto, C.2    Beggiao, E.3
  • 87
    • 0035976975 scopus 로고    scopus 로고
    • Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes
    • Zhao D, Keates AC, Kuhnt-Moore S, et al. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. J Biol Chem 2001; 276:44464-44471.
    • (2001) J Biol Chem , vol.276 , pp. 44464-44471
    • Zhao, D.1    Keates, A.C.2    Kuhnt-Moore, S.3
  • 88
    • 0026644123 scopus 로고
    • Modulation by neurotensin and neuromedin N of adherence and chemotaxis capacity of murine lymphocytes
    • Garrido JJ, Arahuetes RM, Hernanz A, De la Fuente M. Modulation by neurotensin and neuromedin N of adherence and chemotaxis capacity of murine lymphocytes. Regul Pept 1992; 41:27-37.
    • (1992) Regul Pept , vol.41 , pp. 27-37
    • Garrido, J.J.1    Arahuetes, R.M.2    Hernanz, A.3    De La Fuente, M.4
  • 89
    • 0023922010 scopus 로고
    • Neurotensin enhances IL-1 production by activated alveolar macrophages
    • Lemaire I. Neurotensin enhances IL-1 production by activated alveolar macrophages. J Immunol 1988; 140:2983-2988.
    • (1988) J Immunol , vol.140 , pp. 2983-2988
    • Lemaire, I.1
  • 90
    • 0018862094 scopus 로고
    • The in vitro effect of neurotensin on human jejunal mast cells
    • Selbekk BH, Flaten O, Hanssen LE. The in vitro effect of neurotensin on human jejunal mast cells. Scand J Gastroenterol 1980; 15:457-460.
    • (1980) Scand J Gastroenterol , vol.15 , pp. 457-460
    • Selbekk, B.H.1    Flaten, O.2    Hanssen, L.E.3
  • 91
    • 40549084686 scopus 로고    scopus 로고
    • Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats
    • Akcan A, Muhtaroglu S, Akgun H, et al. Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats. World J Gastroenterol 2008; 14:1222-1230.
    • (2008) World J Gastroenterol , vol.14 , pp. 1222-1230
    • Akcan, A.1    Muhtaroglu, S.2    Akgun, H.3
  • 92
    • 0028953017 scopus 로고
    • Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease
    • Alexander RJ, Panja A, Kaplan-Liss E, et al. Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease. Dig Dis Sci 1995; 40:485-494.
    • (1995) Dig Dis Sci , vol.40 , pp. 485-494
    • Alexander, R.J.1    Panja, A.2    Kaplan-Liss, E.3
  • 93
    • 6344226758 scopus 로고    scopus 로고
    • Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells
    • Zhao D, Zhan Y, Koon HW, et al. Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem 2004; 279:43547-43554.
    • (2004) J Biol Chem , vol.279 , pp. 43547-43554
    • Zhao, D.1    Zhan, Y.2    Koon, H.W.3
  • 94
    • 33748749070 scopus 로고    scopus 로고
    • Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation
    • Zhao D, Pothoulakis C. Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides 2006; 27:2434-2444.
    • (2006) Peptides , vol.27 , pp. 2434-2444
    • Zhao, D.1    Pothoulakis, C.2
  • 95
    • 0031855758 scopus 로고    scopus 로고
    • Regional difference in the distribution of vasoactive intestinal polypeptide-immunoreactive nerve fibres along the uterus and between myometrial muscle layers in the rat
    • Houdeau E, Prudhomme MJ, Rousseau JP. Regional difference in the distribution of vasoactive intestinal polypeptide-immunoreactive nerve fibres along the uterus and between myometrial muscle layers in the rat. Histochem J 1998; 30:525-529.
    • (1998) Histochem J , vol.30 , pp. 525-529
    • Houdeau, E.1    Prudhomme, M.J.2    Rousseau, J.P.3
  • 96
    • 0033427419 scopus 로고    scopus 로고
    • Projections of nitric oxide synthase and vasoactive intestinal polypeptide-reactive submucosal neurons in the human colon
    • Porter AJ, Wattchow DA, Brookes SJ, Costa M. Projections of nitric oxide synthase and vasoactive intestinal polypeptide-reactive submucosal neurons in the human colon. J Gastroenterol Hepatol 1999; 14:1180-1187.
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 1180-1187
    • Porter, A.J.1    Wattchow, D.A.2    Brookes, S.J.3    Costa, M.4
  • 98
    • 14744301711 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis
    • Newman R, Cuan N, Hampartzoumian T, et al. Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis. Clin Exp Immunol 2005; 139:411-420.
    • (2005) Clin Exp Immunol , vol.139 , pp. 411-420
    • Newman, R.1    Cuan, N.2    Hampartzoumian, T.3
  • 99
    • 0032126159 scopus 로고    scopus 로고
    • Similar involvement of VIP receptor type i and type II in lymphocyte chemotaxis
    • Schratzberger P,Geiseler A, Dunzendorfer S, et al. Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis. J Neuroimmunol 1998; 87:73-81.
    • (1998) J Neuroimmunol , vol.87 , pp. 73-81
    • Schratzberger, P.1    Geiseler, A.2    Dunzendorfer, S.3
  • 101
    • 43049113127 scopus 로고    scopus 로고
    • VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4
    • Arranz A, Juarranz Y, Leceta J, et al. VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4. Peptides 2008; 29:948-956.
    • (2008) Peptides , vol.29 , pp. 948-956
    • Arranz, A.1    Juarranz, Y.2    Leceta, J.3
  • 102
    • 41849087644 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide
    • Arranz A, Androulidaki A, Zacharioudaki V, et al. Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide. Mol Immunol 2008; 45:2970-2980.
    • (2008) Mol Immunol , vol.45 , pp. 2970-2980
    • Arranz, A.1    Androulidaki, A.2    Zacharioudaki, V.3
  • 103
    • 0038739348 scopus 로고    scopus 로고
    • VIP: A very important peptide in T helper differentiation
    • Delgado M. VIP: a very important peptide in T helper differentiation. Trends Immunol 2003; 24:221-224.
    • (2003) Trends Immunol , vol.24 , pp. 221-224
    • Delgado, M.1
  • 104
    • 49149092281 scopus 로고    scopus 로고
    • Cutting edge: Vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile
    • Yadav M, Rosenbaum J, Goetzl EJ. Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile. J Immunol 2008; 180:2772-2776.
    • (2008) J Immunol , vol.180 , pp. 2772-2776
    • Yadav, M.1    Rosenbaum, J.2    Goetzl, E.J.3
  • 105
    • 0037379777 scopus 로고    scopus 로고
    • Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease
    • Abad C, Martinez C, Juarranz MG, et al. Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease. Gastroenterology 2003; 124:961-971.
    • (2003) Gastroenterology , vol.124 , pp. 961-971
    • Abad, C.1    Martinez, C.2    Juarranz, M.G.3
  • 106
    • 0019171636 scopus 로고
    • Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's disease
    • Bishop AE, Polak JM, Bryant MG, et al. Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's disease. Gastroenterology 1980; 79 (5 Pt 1):853-860.
    • (1980) Gastroenterology , vol.79 , Issue.5 PART 1 , pp. 853-860
    • Bishop, A.E.1    Polak, J.M.2    Bryant, M.G.3
  • 107
    • 0021252379 scopus 로고
    • Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease
    • O'Morain C, Bishop AE, McGregor GP, et al. Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease. Gut 1984; 25:57-61.
    • (1984) Gut , vol.25 , pp. 57-61
    • O'morain, C.1    Bishop, A.E.2    McGregor, G.P.3
  • 108
    • 0035010386 scopus 로고    scopus 로고
    • Neurotransmitter coding of enteric neurones in the submucous plexus is changed in noninflamed rectum of patients with Crohn's disease
    • Schneider J, Jehle EC, Starlinger MJ, et al. Neurotransmitter coding of enteric neurones in the submucous plexus is changed in noninflamed rectum of patients with Crohn's disease. Neurogastroenterol Motil 2001; 13:255-264.
    • (2001) Neurogastroenterol Motil , vol.13 , pp. 255-264
    • Schneider, J.1    Jehle, E.C.2    Starlinger, M.J.3
  • 109
    • 0037215542 scopus 로고    scopus 로고
    • Changes in chemical coding of myenteric neurones in ulcerative colitis
    • Neunlist M, Aubert P, Toquet C, et al. Changes in chemical coding of myenteric neurones in ulcerative colitis. Gut 2003; 52:84-90.
    • (2003) Gut , vol.52 , pp. 84-90
    • Neunlist, M.1    Aubert, P.2    Toquet, C.3
  • 110
    • 34648826031 scopus 로고    scopus 로고
    • Decrease in binding for the neuropeptide VIP in response to marked inflammation of the mucosa in ulcerative colitis
    • Jonsson M, Norrgård O, Hansson M, Forsgren S. Decrease in binding for the neuropeptide VIP in response to marked inflammation of the mucosa in ulcerative colitis. Ann N Y Acad Sci 2007; 1107:280-289.
    • (2007) Ann N y Acad Sci , vol.1107 , pp. 280-289
    • Jonsson, M.1    Norrgård, O.2    Hansson, M.3    Forsgren, S.4
  • 111
    • 60549089799 scopus 로고    scopus 로고
    • Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis
    • Tan YV, Abad C, Lopez R, et al. Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2009; 106:2012-2017.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2012-2017
    • Tan, Y.V.1    Abad, C.2    Lopez, R.3
  • 112
    • 44449159941 scopus 로고    scopus 로고
    • PACAP provides colonic protection against dextran sodium sulfate induced colitis
    • Azuma YT, Hagi K, Shintani N, et al. PACAP provides colonic protection against dextran sodium sulfate induced colitis. J Cell Physiol 2008; 216: 111-119.
    • (2008) J Cell Physiol , vol.216 , pp. 111-119
    • Azuma, Y.T.1    Hagi, K.2    Shintani, N.3
  • 113
    • 40349093079 scopus 로고    scopus 로고
    • Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP
    • Nemetz N, Abad C, Lawson G, et al. Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP. Int J Cancer 2008; 122:1803-1809.
    • (2008) Int J Cancer , vol.122 , pp. 1803-1809
    • Nemetz, N.1    Abad, C.2    Lawson, G.3
  • 114
    • 58249094056 scopus 로고    scopus 로고
    • Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice
    • Kokkotou E, Espinoza DO, Torres D, et al. Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice. Gut 2009; 58:34-40.
    • (2009) Gut , vol.58 , pp. 34-40
    • Kokkotou, E.1    Espinoza, D.O.2    Torres, D.3
  • 115
    • 48749119360 scopus 로고    scopus 로고
    • Melanin-concentrating hormone as a mediator of intestinal inflammation
    • Kokkotou E, Moss AC, Torres D, et al. Melanin-concentrating hormone as a mediator of intestinal inflammation. Proc Natl Acad Sci U S A 2008; 105:10613-10618.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10613-10618
    • Kokkotou, E.1    Moss, A.C.2    Torres, D.3
  • 116
    • 65349092020 scopus 로고    scopus 로고
    • Role of serotonin in intestinal inflammation: Knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice
    • Bischoff SC, Mailer R, Pabst O, et al. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol 2009; 296:G685-G695.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Bischoff, S.C.1    Mailer, R.2    Pabst, O.3
  • 117
    • 23044439323 scopus 로고    scopus 로고
    • Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis
    • Linden DR, Foley KF, McQuoid C, et al. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastroenterol Motil 2005; 17:565-574.
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 565-574
    • Linden, D.R.1    Foley, K.F.2    McQuoid, C.3
  • 118
    • 0038339428 scopus 로고    scopus 로고
    • Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
    • Linden DR, Chen JX, Gershon MD, et al. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 2003; 285:G207-G216.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Linden, D.R.1    Chen, J.X.2    Gershon, M.D.3
  • 119
    • 62449290353 scopus 로고    scopus 로고
    • IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease
    • Kidd M, Gustafsson BI, Drozdov I, Modlin IM. IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease. Neurogastroenterol Motil 2009; 21:439-450.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 439-450
    • Kidd, M.1    Gustafsson, B.I.2    Drozdov, I.3    Modlin, I.M.4
  • 120
    • 53249142340 scopus 로고    scopus 로고
    • Targeted deletion of neuropeptide y (NPY) modulates experimental colitis
    • Chandrasekharan B, Bala V, Kolachala VL, et al. Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. PLoS One 2008; 3:e3304.
    • (2008) PLoS One , vol.3
    • Chandrasekharan, B.1    Bala, V.2    Kolachala, V.L.3
  • 121
    • 33749359621 scopus 로고    scopus 로고
    • Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide y
    • Anitha M, Chandrasekharan B, Salgado JR, et al. Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y. Gastroenterology 2006; 131:1164-1178.
    • (2006) Gastroenterology , vol.131 , pp. 1164-1178
    • Anitha, M.1    Chandrasekharan, B.2    Salgado, J.R.3
  • 122
    • 33645241599 scopus 로고    scopus 로고
    • Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease
    • Gonzalez-Rey E, Varela N, Sheibanie AF, et al. Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease. Proc Natl Acad Sci U S A 2006; 103:4228-4233.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4228-4233
    • Gonzalez-Rey, E.1    Varela, N.2    Sheibanie, A.F.3
  • 123
    • 54349104242 scopus 로고    scopus 로고
    • Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease
    • Hosomi S, Oshitani N, Kamata N, et al. Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease. Inflamm Bowel Dis 2008; 14:1205-1213.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1205-1213
    • Hosomi, S.1    Oshitani, N.2    Kamata, N.3
  • 124
    • 33645069631 scopus 로고    scopus 로고
    • Therapeutic action of ghrelin in a mouse model of colitis
    • Gonzalez-Rey E, Chorny A, Delgado M. Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology 2006; 130:1707-1720.
    • (2006) Gastroenterology , vol.130 , pp. 1707-1720
    • Gonzalez-Rey, E.1    Chorny, A.2    Delgado, M.3
  • 125
    • 48149107173 scopus 로고    scopus 로고
    • Targeting endocannabinoid degradation protects against experimental colitis in mice: Involvement of CB1 and CB2 receptors
    • Storr MA, Keenan CM, Emmerdinger D, et al. Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors. J Mol Med 2008; 86:925-936.
    • (2008) J Mol Med , vol.86 , pp. 925-936
    • Storr, M.A.1    Keenan, C.M.2    Emmerdinger, D.3
  • 126
    • 54349122276 scopus 로고    scopus 로고
    • Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: Not just trefoil peptides
    • Assimakopoulos SF, Scopa CD, Nikolopoulou VN, et al. Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: not just trefoil peptides. World J Gastroenterol 2008; 14:3602-3603.
    • (2008) World J Gastroenterol , vol.14 , pp. 3602-3603
    • Assimakopoulos, S.F.1    Scopa, C.D.2    Nikolopoulou, V.N.3
  • 127
    • 56649124805 scopus 로고    scopus 로고
    • Neuropeptides, mesenteric fat, and intestinal inflammation
    • Karagiannides I, Pothoulakis C. Neuropeptides, mesenteric fat, and intestinal inflammation. Ann N Y Acad Sci 2008; 1144:127-135.
    • (2008) Ann N y Acad Sci , vol.1144 , pp. 127-135
    • Karagiannides, I.1    Pothoulakis, C.2
  • 128
    • 48749124143 scopus 로고    scopus 로고
    • Substance P-mediated expression of the proangiogenic factor CCN1 modulates the course of colitis
    • Koon HW, Zhao D, Xu H, et al. Substance P-mediated expression of the proangiogenic factor CCN1 modulates the course of colitis. Am J Pathol 2008; 173:400-410.
    • (2008) Am J Pathol , vol.173 , pp. 400-410
    • Koon, H.W.1    Zhao, D.2    Xu, H.3
  • 129
    • 39149132101 scopus 로고    scopus 로고
    • Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism
    • Profita M, Bonanno A, Siena L, et al. Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. Eur J Pharmacol 2008; 582:145-153.
    • (2008) Eur J Pharmacol , vol.582 , pp. 145-153
    • Profita, M.1    Bonanno, A.2    Siena, L.3
  • 130
    • 33646711903 scopus 로고    scopus 로고
    • Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse
    • Coates MD, Johnson AC,Greenwood-VanMeerveld B, MaweGM. Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse. Neurogastroenterol Motil 2006; 18:464-471.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 464-471
    • Coates, M.D.1    Johnson, A.C.2    Greenwood-Vanmeerveld, B.3    Mawe, G.M.4
  • 132
    • 33750327836 scopus 로고    scopus 로고
    • 5-hydroxytryptamine induces mast cell adhesion and migration
    • Kushnir-Sukhov NM, Gilfillan AM, Coleman JW, et al. 5-hydroxytryptamine induces mast cell adhesion and migration. J Immunol 2006; 177:6422-6432.
    • (2006) J Immunol , vol.177 , pp. 6422-6432
    • Kushnir-Sukhov, N.M.1    Gilfillan, A.M.2    Coleman, J.W.3
  • 133
    • 34147125008 scopus 로고    scopus 로고
    • Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor
    • Leon-Ponte M, Ahern GP, O'Connell PJ. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood 2007; 109:3139-3146.
    • (2007) Blood , vol.109 , pp. 3139-3146
    • Leon-Ponte, M.1    Ahern, G.P.2    O'connell, P.J.3
  • 134
    • 48549092341 scopus 로고    scopus 로고
    • Serotonin regulates macrophagemediated angiogenesis in a mouse model of colon cancer allografts
    • Nocito A, Dahm F, Jochum W, et al. Serotonin regulates macrophagemediated angiogenesis in a mouse model of colon cancer allografts. Cancer Res 2007; 68:5152-5158.
    • (2007) Cancer Res , vol.68 , pp. 5152-5158
    • Nocito, A.1    Dahm, F.2    Jochum, W.3
  • 135
    • 34447136135 scopus 로고    scopus 로고
    • Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: Alterations in 5-HT signalling and metabolism in human disease
    • Spiller R. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease. Neurogastroenterol Motil 2007; 19 (Suppl 2):25-31.
    • (2007) Neurogastroenterol Motil , vol.19 , Issue.SUPPL 2 , pp. 25-31
    • Spiller, R.1
  • 136
    • 53449094757 scopus 로고    scopus 로고
    • Serotonin and GI clinical disorders
    • Spiller R. Serotonin and GI clinical disorders. Neuropharmacology 2008; 55:1072-1080.
    • (2008) Neuropharmacology , vol.55 , pp. 1072-1080
    • Spiller, R.1
  • 137
    • 0026720239 scopus 로고    scopus 로고
    • Innervation of mucosal immune cells in the gastrointestinal tract
    • Stead RH. Innervation of mucosal immune cells in the gastrointestinal tract. Regul Immunol 2002; 4:91-99.
    • (2002) Regul Immunol , vol.4 , pp. 91-99
    • Stead, R.H.1
  • 138
    • 2442538078 scopus 로고    scopus 로고
    • The serotoninergic receptors of human dendritic cells: Identification and coupling to cytokine release
    • Idzko M, Panther E, Stratz C, et al. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release. J Immunl 2004; 172:6011-6019.
    • (2004) J Immunl , vol.172 , pp. 6011-6019
    • Idzko, M.1    Panther, E.2    Stratz, C.3
  • 139
    • 39849108180 scopus 로고    scopus 로고
    • Role of muscarinic receptors in the regulation of immune and inflammatory responses
    • Razani-Boroujerdi S. Role of muscarinic receptors in the regulation of immune and inflammatory responses. J Neuroimmunol 2008; 194:83-88.
    • (2008) J Neuroimmunol , vol.194 , pp. 83-88
    • Razani-Boroujerdi, S.1
  • 140
    • 4444345410 scopus 로고    scopus 로고
    • Expression of 5-HT3A receptors in cells of the immune system
    • Fiebich BL, Akundi RS, Seidel M, et al. Expression of 5-HT3A receptors in cells of the immune system. Scand J Rheumatol Suppl 2004; 119:9-11.
    • (2004) Scand J Rheumatol Suppl , vol.119 , pp. 9-11
    • Fiebich, B.L.1    Akundi, R.S.2    Seidel, M.3
  • 141
    • 21344464499 scopus 로고    scopus 로고
    • The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway
    • Vega Lde L, Muñoz E, Calzado MA, et al. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol 2005; 70:369-380.
    • (2005) Biochem Pharmacol , vol.70 , pp. 369-380
    • Vega Lde, L.1    Muñoz, E.2    Calzado, M.A.3
  • 142
    • 37849186779 scopus 로고    scopus 로고
    • 5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes
    • Yin J, Albert RH, Tretiakova AP, Jameson BA. 5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes. J Neuroimmunol 2006; 181:68-81.
    • (2006) J Neuroimmunol , vol.181 , pp. 68-81
    • Yin, J.1    Albert, R.H.2    Tretiakova, A.P.3    Jameson, B.A.4
  • 143
    • 33748268092 scopus 로고    scopus 로고
    • Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques
    • Yang JB. Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques. J Neuroimmunol 2006; 178:24-29.
    • (2006) J Neuroimmunol , vol.178 , pp. 24-29
    • Yang, J.B.1
  • 144
    • 0028918920 scopus 로고
    • Serotonin regulation of T-cell subpopulations and of macrophage accessory function
    • Young MR, Matthews JP. Serotonin regulation of T-cell subpopulations and of macrophage accessory function. Immunology 1995; 84:148-152.
    • (1995) Immunology , vol.84 , pp. 148-152
    • Young, M.R.1    Matthews, J.P.2
  • 145
    • 0035222230 scopus 로고    scopus 로고
    • Neuropeptides as modulators of macrophage functions. Regulation of cytokine production and antigen presentation by VIP and PACAP
    • Ganea D, Delgado M. Neuropeptides as modulators of macrophage functions. Regulation of cytokine production and antigen presentation by VIP and PACAP. Arch Immunol Ther Exp (Warsz) 2001; 49:101-110.
    • (2001) Arch Immunol Ther Exp (Warsz) , vol.49 , pp. 101-110
    • Ganea, D.1    Delgado, M.2
  • 146
    • 36749079092 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide inhibits cyclooxygenase-2 expression in activated macrophages, microglia, and dendritic cells
    • Gonzalez-Rey E, Delgado M. Vasoactive intestinal peptide inhibits cyclooxygenase-2 expression in activated macrophages, microglia, and dendritic cells. Brain Behav Immun 2008; 22:35-41.
    • (2008) Brain Behav Immun , vol.22 , pp. 35-41
    • Gonzalez-Rey, E.1    Delgado, M.2
  • 147
    • 34249283363 scopus 로고    scopus 로고
    • Expression and function of genes encoding cholinergic components in murine immune cells
    • Kawashima K, Yoshikawa K, Fujii YX, et al. Expression and function of genes encoding cholinergic components in murine immune cells. Life Sci 2007; 80:2314-2319.
    • (2007) Life Sci , vol.80 , pp. 2314-2319
    • Kawashima, K.1    Yoshikawa, K.2    Fujii, Y.X.3
  • 148
    • 4143069154 scopus 로고    scopus 로고
    • Enteric neuroimmunophysiology and pathophysiology
    • Wood JD. Enteric neuroimmunophysiology and pathophysiology. Gastroenterology 2004; 127:635-657.
    • (2004) Gastroenterology , vol.127 , pp. 635-657
    • Wood, J.D.1
  • 149
    • 43049085167 scopus 로고    scopus 로고
    • Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: Future therapeutic targets
    • Kraneveld AD, Rijnierse A, Nijkamp FP, Garssen J. Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets. Eur J Pharmacol 2008; 585:361-374.
    • (2008) Eur J Pharmacol , vol.585 , pp. 361-374
    • Kraneveld, A.D.1    Rijnierse, A.2    Nijkamp, F.P.3    Garssen, J.4
  • 150
    • 0027097050 scopus 로고
    • Effect of inflammation of enteric nerves Cytokine-induced changes in neurotransmitter content and release
    • Collins SM, Hurst SM, Main C, et al. Effect of inflammation of enteric nerves. Cytokine-induced changes in neurotransmitter content and release. Ann N Y Acad Sci 1992; 664:415-424.
    • (1992) Ann N y Acad Sci , vol.664 , pp. 415-424
    • Collins, S.M.1    Hurst, S.M.2    Main, C.3
  • 151
    • 47249158160 scopus 로고    scopus 로고
    • The role of stress in the development and clinical course of inflammatory bowel disease: Epidemiological evidence
    • Maunder RG, Levenstein S. The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence. Curr Mol Med 2008; 8:247-252.
    • (2008) Curr Mol Med , vol.8 , pp. 247-252
    • Maunder, R.G.1    Levenstein, S.2
  • 152
    • 44949185318 scopus 로고    scopus 로고
    • The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis
    • Mawdsley JE, Jenkins DG, Macey MG, et al. The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis. Am J Gastroenterol 2008; 103:1460-1551.
    • (2008) Am J Gastroenterol , vol.103 , pp. 1460-1551
    • Mawdsley, J.E.1    Jenkins, D.G.2    MacEy, M.G.3
  • 153
    • 70349487326 scopus 로고    scopus 로고
    • Blockage of the neurokinin 1 receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis
    • Gad M, Pedersen AE, Kristensen NN, et al. Blockage of the neurokinin 1 receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis. Inflamm Bowel Dis 2009; 15:1174-1182.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1174-1182
    • Gad, M.1    Pedersen, A.E.2    Kristensen, N.N.3
  • 154
    • 57649183357 scopus 로고    scopus 로고
    • From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: Implication in stress-related functional bowel diseases
    • Tache Y, Brunnhuber S. From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases. Ann N Y Acad Sci 2008; 1148:29-41.
    • (2008) Ann N y Acad Sci , vol.1148 , pp. 29-41
    • Tache, Y.1    Brunnhuber, S.2
  • 155
    • 21044431964 scopus 로고    scopus 로고
    • The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: Potential therapeutic applications
    • Gravanis A, Margioris AN. The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications. Curr Med Chem 2005; 12:1503-1512.
    • (2005) Curr Med Chem , vol.12 , pp. 1503-1512
    • Gravanis, A.1    Margioris, A.N.2
  • 156
    • 0022650904 scopus 로고
    • Postnatal development of vasopressin mRNA content in supraoptic and paraventricular nucleus of the Wistar rat
    • Van Tol HH, Snijdewint FG, Boer GJ, Burbach JP. Postnatal development of vasopressin mRNA content in supraoptic and paraventricular nucleus of the Wistar rat. Neurosci Lett 1986; 6:1-6.
    • (1986) Neurosci Lett , vol.6 , pp. 1-6
    • Van Tol, H.H.1    Snijdewint, F.G.2    Boer, G.J.3    Burbach, J.P.4
  • 157
    • 0026565999 scopus 로고
    • Stimulation of nitric oxide from muscle cells by VIP: Prejunctional enhancement of VIP release
    • Grider Jr, Murthy KS, Jin JG, Makhlouf GM, et al. Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release. Am J Physiol 1992; 25:G774-G778.
    • (1992) Am J Physiol , vol.25
    • Grider, Jr.1    Murthy, K.S.2    Jin, J.G.3    Makhlouf, G.M.4
  • 158
    • 0003742258 scopus 로고    scopus 로고
    • 4th ed. Vol. 1. Enteric neural regulation of mucosal secretion. New York: Elsevier
    • Cooke HJ, Christofi F. Physiology of the gastrointestinal tract. 4th ed. Vol.1. Enteric neural regulation of mucosal secretion. New York: Elsevier: pp. 737-762.
    • Physiology of the Gastrointestinal Tract , pp. 737-762
    • Cooke, H.J.1    Christofi, F.2
  • 159
    • 2942525747 scopus 로고    scopus 로고
    • Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and IBS
    • Coates MD, Mahoney CR, Linden DR, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and IBS. Gastroenterology 2004; 126:1657-1664.
    • (2004) Gastroenterology , vol.126 , pp. 1657-1664
    • Coates, M.D.1    Mahoney, C.R.2    Linden, D.R.3


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