The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway

Biochemical Pharmacology

Volumn 70, Issue 3, 2005, Pages 369-380

  De La Vega, Laureano ^a   Muñoz, Eduardo ^a   Calzado, Marco A ^a   Lieb, Klaus ^b   Candelario Jalil, Eduardo ^b   Gschaidmeir, Harald ^c   Färber, Lothar ^c   Mueller, Wolfgang ^d   Stratz, Thomas ^d   Fiebich, Bernd L ^b,e  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Novartis Pharma GmbH   (Germany)

^d Hochrheininstitut für Rehabilitationsforschung EV ^*  (Germany)

^e VIVACELL BIOTECHNOLOGY GMBH   (Germany)

Author keywords

Calcineurin; IL 2; NF B; NFAT; T cells; Tropisetron

Indexed keywords

CALCINEURIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IONOMYCIN; PROTEIN INHIBITOR; SEROTONIN 3 ANTAGONIST; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; TROPISETRON; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; DRUG DESIGN; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION;

CALCINEURIN; CLONE CELLS; DRUG DELIVERY SYSTEMS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDOLES; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 21344464499     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.04.031     Document Type: Article

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