Blockage of the neurokinin 1 receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis

Inflammatory Bowel Diseases

Volumn 15, Issue 8, 2009, Pages 1174-1182

  Gad, Monika ^a   Pedersen, Anders Elm ^a   Kristensen, Nanna Ny ^a   Fernandez, Carmen de Felipe ^b   Claesson, Mogens H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Capsaicin; Colitis; Neurokinin 1 receptor; SCID; Substance P

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 2 BENZYL 1 (3,5 DIMETHYLBENZOYL) 4 (4 QUINOLINYLMETHYLAMINO)PIPERIDINE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CAM 2291; CAM 4092; CAPSAICIN; CP 96 345; CP 99 994; ELEDOISIN; GR 159897; LANEPITANT; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PP 67580; SAREDUTANT; SEPTIDE; SR 140 333; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 AGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CD4+ CD25+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENTERIC AFFERENT NERVE; EXPERIMENTAL MOUSE; FEMALE; LYMPHOCYTE PROLIFERATION; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; SENSORY NERVE; SIGNAL TRANSDUCTION; T CELL DEPLETION; T LYMPHOCYTE;

ANIMALS; CAPSAICIN; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; COLITIS; CYTOKINES; ENTERIC NERVOUS SYSTEM; FEMALE; FLOW CYTOMETRY; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTESTINAL MUCOSA; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, SCID; NEURONS, AFFERENT; RECEPTORS, NEUROKININ-1; SENSORY SYSTEM AGENTS; T-LYMPHOCYTES; TRPV CATION CHANNELS;

EID: 70349487326     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20902     Document Type: Article

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