메뉴 건너뛰기




Volumn 29, Issue 6, 2008, Pages 948-956

VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4

Author keywords

Crohn's disease; LPS; Lymph node; Pam3Cys; TLRs

Indexed keywords

CXCL1 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PROTEIN P70; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRINITROBENZENESULFONIC ACID; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 43049113127     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.01.019     Document Type: Article
Times cited : (39)

References (50)
  • 1
    • 21844436593 scopus 로고    scopus 로고
    • cDNA array analysis of cytokines, chemokines, and receptors involved in the development of TNBS-induced colitis: homeostatic role of VIP
    • Abad C., Juarranz Y., Martinez C., Arranz A., Rosignoli F., Garcia-Gomez M., et al. cDNA array analysis of cytokines, chemokines, and receptors involved in the development of TNBS-induced colitis: homeostatic role of VIP. Inflamm Bowel Dis 11 (2005) 674-684
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 674-684
    • Abad, C.1    Juarranz, Y.2    Martinez, C.3    Arranz, A.4    Rosignoli, F.5    Garcia-Gomez, M.6
  • 2
    • 0037379777 scopus 로고    scopus 로고
    • Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease
    • Abad C., Martinez C., Juarranz M.G., Arranz A., Leceta J., Delgado M., et al. Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease. Gastroenterology 124 (2003) 961-971
    • (2003) Gastroenterology , vol.124 , pp. 961-971
    • Abad, C.1    Martinez, C.2    Juarranz, M.G.3    Arranz, A.4    Leceta, J.5    Delgado, M.6
  • 3
    • 0034177888 scopus 로고    scopus 로고
    • Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
    • Akashi S., Shimazu R., Ogata H., Nagai Y., Takeda K., Kimoto M., et al. Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol 16 (2000) 3471-3475
    • (2000) J Immunol , vol.16 , pp. 3471-3475
    • Akashi, S.1    Shimazu, R.2    Ogata, H.3    Nagai, Y.4    Takeda, K.5    Kimoto, M.6
  • 4
    • 33746441017 scopus 로고    scopus 로고
    • Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis
    • Arranz A., Abad C., Juarranz Y., Torroba M., Rosignoli F., Leceta J., et al. Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis. Ann N Y Acad Sci 1070 (2006) 129-134
    • (2006) Ann N Y Acad Sci , vol.1070 , pp. 129-134
    • Arranz, A.1    Abad, C.2    Juarranz, Y.3    Torroba, M.4    Rosignoli, F.5    Leceta, J.6
  • 5
    • 0036604930 scopus 로고    scopus 로고
    • Control of adaptive immune responses by Toll-like receptors
    • Barton G.M., and Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol 14 (2002) 380-383
    • (2002) Curr Opin Immunol , vol.14 , pp. 380-383
    • Barton, G.M.1    Medzhitov, R.2
  • 6
    • 0033775615 scopus 로고    scopus 로고
    • Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
    • Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25 (2000) 169-193
    • (2000) J Mol Endocrinol , vol.25 , pp. 169-193
    • Bustin, S.A.1
  • 7
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., and Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 197 (2003) 403-411
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 8
    • 0035033922 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease
    • Delgado M., Abad C., Martinez C., Leceta J., and Gomariz R.P. Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease. Nat Med 7 (2001) 563-568
    • (2001) Nat Med , vol.7 , pp. 563-568
    • Delgado, M.1    Abad, C.2    Martinez, C.3    Leceta, J.4    Gomariz, R.P.5
  • 9
    • 0032832033 scopus 로고    scopus 로고
    • Shedding of membrane-bound CD14 from lipopolysaccharide-stimulated macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide
    • Delgado M., Leceta J., Abad C., Martinez C., Ganea D., and Gomariz R.P. Shedding of membrane-bound CD14 from lipopolysaccharide-stimulated macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide. J Neuroimmunol 99 (1999) 61-71
    • (1999) J Neuroimmunol , vol.99 , pp. 61-71
    • Delgado, M.1    Leceta, J.2    Abad, C.3    Martinez, C.4    Ganea, D.5    Gomariz, R.P.6
  • 10
    • 0033555396 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activation polypeptide (PACAP) protect mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-6
    • Delgado M., Martinez C., Pozo D., Calvo J.R., Leceta J., Ganea D., et al. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activation polypeptide (PACAP) protect mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-6. J Immunol 162 (1999) 1200-1205
    • (1999) J Immunol , vol.162 , pp. 1200-1205
    • Delgado, M.1    Martinez, C.2    Pozo, D.3    Calvo, J.R.4    Leceta, J.5    Ganea, D.6
  • 11
    • 33947643643 scopus 로고    scopus 로고
    • Pivotal advance: vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages
    • Foster N., Lea S.R., Preshaw P.M., and Taylor J.J. Pivotal advance: vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages. J Leukoc Biol 81 (2007) 893-903
    • (2007) J Leukoc Biol , vol.81 , pp. 893-903
    • Foster, N.1    Lea, S.R.2    Preshaw, P.M.3    Taylor, J.J.4
  • 12
    • 23044442144 scopus 로고    scopus 로고
    • Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP
    • Gomariz R.P., Arranz A., Abad C., Torroba M., Martinez C., Rosignoli F., et al. Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP. J Leukoc Biol 78 (2005) 491-502
    • (2005) J Leukoc Biol , vol.78 , pp. 491-502
    • Gomariz, R.P.1    Arranz, A.2    Abad, C.3    Torroba, M.4    Martinez, C.5    Rosignoli, F.6
  • 14
    • 33646205361 scopus 로고    scopus 로고
    • VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts
    • Gutiérrez-Cañas I., Juarranz Y., Santiago B., Arranz A., Martinez C., Galindo M., et al. VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts. Rheumatology 45 (2006) 527-532
    • (2006) Rheumatology , vol.45 , pp. 527-532
    • Gutiérrez-Cañas, I.1    Juarranz, Y.2    Santiago, B.3    Arranz, A.4    Martinez, C.5    Galindo, M.6
  • 15
    • 22544473593 scopus 로고    scopus 로고
    • TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production
    • Hart O.M., Athie-Morales V., O'Connor G.M., and Gardiner C.M. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol 175 (2005) 1636-1642
    • (2005) J Immunol , vol.175 , pp. 1636-1642
    • Hart, O.M.1    Athie-Morales, V.2    O'Connor, G.M.3    Gardiner, C.M.4
  • 16
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 17
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 5 (2004) 987-995
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 18
    • 0346996879 scopus 로고    scopus 로고
    • The regulatory T cell family: distinct subsets and their interrelations
    • Jonuleit H., and Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol 171 (2003) 6323-6327
    • (2003) J Immunol , vol.171 , pp. 6323-6327
    • Jonuleit, H.1    Schmitt, E.2
  • 19
    • 33846123950 scopus 로고    scopus 로고
    • Expression and function of Toll-like receptors in T lymphocytes
    • Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Curr Opin Immunol 19 (2007) 39-45
    • (2007) Curr Opin Immunol , vol.19 , pp. 39-45
    • Kabelitz, D.1
  • 20
    • 0033486007 scopus 로고    scopus 로고
    • T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal
    • Kalinski P., Hilkens C.M., Wierenga E.A., and Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 20 (1999) 561-567
    • (1999) Immunol Today , vol.20 , pp. 561-567
    • Kalinski, P.1    Hilkens, C.M.2    Wierenga, E.A.3    Kapsenberg, M.L.4
  • 21
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4 + CD25 + T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., and Ramsdell F. An essential role for Scurfin in CD4 + CD25 + T regulatory cells. Nat Immunol 4 (2003) 337-342
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 22
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • Kobayashi M., Kweon M.N., Kuwata H., Schreiber R.D., Kiyono H., Takeda K., et al. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 111 (2003) 1297-1308
    • (2003) J Clin Invest , vol.111 , pp. 1297-1308
    • Kobayashi, M.1    Kweon, M.N.2    Kuwata, H.3    Schreiber, R.D.4    Kiyono, H.5    Takeda, K.6
  • 23
    • 1542297739 scopus 로고    scopus 로고
    • TLR2 is expressed on activated T cells as a costimulatory receptor
    • Komai-Koma M., Jones L., Ogg G.S., Xu D., and Liew F.Y. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci USA 101 (2004) 3029-3034
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3029-3034
    • Komai-Koma, M.1    Jones, L.2    Ogg, G.S.3    Xu, D.4    Liew, F.Y.5
  • 24
    • 0035366248 scopus 로고    scopus 로고
    • The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
    • Lanzavecchia A., and Sallusto F. The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr Opin Immunol 13 (2001) 291-298
    • (2001) Curr Opin Immunol , vol.13 , pp. 291-298
    • Lanzavecchia, A.1    Sallusto, F.2
  • 25
    • 33750836410 scopus 로고    scopus 로고
    • Lipopolysaccharide-activated CD4 + CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death
    • Lewkowicz P., Lewkowicz N., Sasiak A., and Tchorzewski H. Lipopolysaccharide-activated CD4 + CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death. J Immunol 177 (2006) 7155-7163
    • (2006) J Immunol , vol.177 , pp. 7155-7163
    • Lewkowicz, P.1    Lewkowicz, N.2    Sasiak, A.3    Tchorzewski, H.4
  • 26
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S., Dayan C.M., Bishop A., Roep B.O., Peakman M., and Tree T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54 (2005) 92-99
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.6
  • 27
    • 0242580070 scopus 로고    scopus 로고
    • CD4 + CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4
    • Liu H., Hu B., Xu D., and Liew F.Y. CD4 + CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol 171 (2003) 5012-5017
    • (2003) J Immunol , vol.171 , pp. 5012-5017
    • Liu, H.1    Hu, B.2    Xu, D.3    Liew, F.Y.4
  • 28
    • 33646487278 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling modulates the functions of CD4 + CD25+ regulatory T cells
    • Liu H., Komai-Koma M., Xu D., and Liew F.Y. Toll-like receptor 2 signaling modulates the functions of CD4 + CD25+ regulatory T cells. Proc Natl Acad Sci USA 103 (2006) 7048-7053
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7048-7053
    • Liu, H.1    Komai-Koma, M.2    Xu, D.3    Liew, F.Y.4
  • 29
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy K.J., and Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2 (2001) 816-822
    • (2001) Nat Immunol , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 31
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov R., and Janeway Jr. C.A. Decoding the patterns of self and nonself by the innate immune system. Science 296 (2002) 298-300
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 32
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 33
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: cure of colitis by CD4 + CD25 + regulatory T cells
    • Mottet C., Uhlig H.H., and Powrie F. Cutting edge: cure of colitis by CD4 + CD25 + regulatory T cells. J Immunol 170 (2003) 3939-3943
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 34
    • 1642577126 scopus 로고    scopus 로고
    • TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • Nakamura K., Kitani A., Fuss I., Pedersen A., Harada N., Nawata H., et al. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 172 (2004) 834-842
    • (2004) J Immunol , vol.172 , pp. 834-842
    • Nakamura, K.1    Kitani, A.2    Fuss, I.3    Pedersen, A.4    Harada, N.5    Nawata, H.6
  • 35
    • 0036284984 scopus 로고    scopus 로고
    • The role of Th1/Th2 polarization in mucosal immunity
    • Neurath M.F., Finotto S., and Glimcher L.H. The role of Th1/Th2 polarization in mucosal immunity. Nat Med 8 (2002) 567-573
    • (2002) Nat Med , vol.8 , pp. 567-573
    • Neurath, M.F.1    Finotto, S.2    Glimcher, L.H.3
  • 36
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath M.F., Fuss I., Kelsall B.L., Stuber E., and Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 182 (1995) 1281-1290
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 37
    • 33750556412 scopus 로고    scopus 로고
    • Innate immunity in the mucosal immune system
    • Nochi T., and Kiyono H. Innate immunity in the mucosal immune system. Curr Pharm Des 12 (2006) 4203-4213
    • (2006) Curr Pharm Des , vol.12 , pp. 4203-4213
    • Nochi, T.1    Kiyono, H.2
  • 38
    • 20444393509 scopus 로고    scopus 로고
    • TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells
    • Patel M., Xu D., Kewin P., Choo-Kang B., McSharry C., Thomson N.C., et al. TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J Immunol 174 (2005) 7558-7563
    • (2005) J Immunol , vol.174 , pp. 7558-7563
    • Patel, M.1    Xu, D.2    Kewin, P.3    Choo-Kang, B.4    McSharry, C.5    Thomson, N.C.6
  • 39
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky D.K. Inflammatory bowel disease. N Engl J Med 347 (2002) 417-429
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 40
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • Powrie F., Correa-Oliveira R., Mauze S., and Coffman R.L. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 179 (1994) 589-600
    • (1994) J Exp Med , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 41
    • 0035813157 scopus 로고    scopus 로고
    • Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
    • Re F., and Strominger J.L. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 276 (2001) 37692-37699
    • (2001) J Biol Chem , vol.276 , pp. 37692-37699
    • Re, F.1    Strominger, J.L.2
  • 43
    • 0014954352 scopus 로고
    • Polypeptide with broad biological activity: isolation from small intestine
    • Said S.I., and Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science 169 (1970) 1217-1218
    • (1970) Science , vol.169 , pp. 1217-1218
    • Said, S.I.1    Mutt, V.2
  • 44
    • 0037022008 scopus 로고    scopus 로고
    • Crohn's disease
    • Shanahan F. Crohn's disease. Lancet 359 (2002) 62-69
    • (2002) Lancet , vol.359 , pp. 62-69
    • Shanahan, F.1
  • 45
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359 (1992) 693-699
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6
  • 46
    • 0035104961 scopus 로고    scopus 로고
    • Toll-like receptors; their physiological role and signal transduction system
    • Takeuchi O., and Akira S. Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol 1 (2001) 625-635
    • (2001) Int Immunopharmacol , vol.1 , pp. 625-635
    • Takeuchi, O.1    Akira, S.2
  • 47
    • 0036467392 scopus 로고    scopus 로고
    • Toll-like receptors: key mediators of microbe detection
    • Underhill D.M., and Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol 14 (2002) 103-110
    • (2002) Curr Opin Immunol , vol.14 , pp. 103-110
    • Underhill, D.M.1    Ozinsky, A.2
  • 48
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V., Baecher-Allan C., Weiner H.L., and Hafler D.A. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 199 (2004) 971-979
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 49
    • 23044454798 scopus 로고    scopus 로고
    • Expression and function of Toll-like receptor on T cells
    • Xu D., Komai-Koma M., and Liew F.Y. Expression and function of Toll-like receptor on T cells. Cell Immunol 233 (2005) 85-89
    • (2005) Cell Immunol , vol.233 , pp. 85-89
    • Xu, D.1    Komai-Koma, M.2    Liew, F.Y.3
  • 50
    • 10844295809 scopus 로고    scopus 로고
    • TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats
    • Zipris D., Lien E., Xie J.X., Greiner D.L., Mordes J.P., and Rossini A.A. TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol 174 (2005) 131-142
    • (2005) J Immunol , vol.174 , pp. 131-142
    • Zipris, D.1    Lien, E.2    Xie, J.X.3    Greiner, D.L.4    Mordes, J.P.5    Rossini, A.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.