Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation

Peptides

Volumn 27, Issue 10, 2006, Pages 2434-2444

  Zhao, Dezheng ^a   Pothoulakis, Charalabos ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

GI tract; Inflammation; motility; Neurotensin; Signaling

Indexed keywords

2 [5 (2,6 DIMETHOXYPHENYL) 1 [4 [N (3 DIMETHYLAMINOPROPYL) N METHYLCARBAMOYL] 2 ISOPROPYLPHENYL] 1H PYRAZOL 3 YLCARBONYLAMINO]ADAMANTANE 2 CARBOXYLIC ACID; 2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; FAT; NEUROTENSIN; NEUROTENSIN RECEPTOR; NEUROTENSIN RECEPTOR ANTAGONIST; SR 48642; UNCLASSIFIED DRUG;

CHRONIC DISEASE; COLITIS; ENDOTHELIUM CELL; ENTERITIS; EPITHELIUM CELL; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL SECRETION; GASTROINTESTINAL TRACT; HEALING; HORMONE ACTION; HORMONE RELEASE; HUMAN; LARGE INTESTINE; LEUKOCYTE; MAST CELL; NONHUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SMALL INTESTINE; STRESS; UPPER GASTROINTESTINAL TRACT;

ANIMALS; ENDOTHELIAL CELLS; GASTROENTERITIS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HUMANS; LEUKOCYTES; MAST CELLS; MODELS, BIOLOGICAL; NEUROTENSIN; RECEPTORS, NEUROTENSIN; STRESS; STRESS, PHYSIOLOGICAL;

EID: 33748749070     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.12.016     Document Type: Review

References (127)

1. Alexacos N., Pang X., Boucher W., Cochrane D.E., Sant G.R., and Theoharides T.C. Neurotensin mediates rat bladder mast cell degranulation triggered by acute psychological stress. Urology 53 (1999) 1035-1040
2. Al-Saffar A. Analysis of the control of intestinal motility in fasted rats, with special reference to neurotensin. Scand J Gastroenterol 19 (1984) 422-428
3. Andersson S., Chang D., Folkers K., and Rosell S. Inhibition of gastric acid secretion in dogs by neurotensin. Life Sci 19 (1976) 367-370
4. Anton P.A. Stress and mind-body impact on the course of inflammatory bowel diseases. Semin Gastrointest Dis 10 (1999) 14-19
5. Asselin M.L., Dubuc I., Coquerel A., and Costentin J. Localization of neurotensin NTS2 receptors in rat brain, using. Neuroreport 12 (2001) 1087-1091
6. Augeron C., Voisin T., Maoret J.J., Berthon B., Laburthe M., and Laboisse C.L. Neurotensin and neuromedin N stimulate mucin output from human goblet cells (Cl.16E) via neurotensin receptors. Am J Physiol 262 (1992) G470-G476
7. Barrocas A.M., Cochrane D.E., Carraway R.E., and Feldberg R.S. Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C. Immunopharmacology 41 (1999) 131-137
8. Besterman H.S., Bloom S.R., Sarson D.L., Blackburn A.M., Johnston D.I., Patel H.R., et al. Gut-hormone profile in coeliac disease. Lancet 1 (1978) 785-788
9. Blackburn A.M., Fletcher D.R., Bloom S.R., Christofides N.D., Long R.G., Fitzpatrick M.L., et al. Effect of neurotensin on gastric function in man. Lancet 1 (1980) 987-989
10. Brown D.R., and Treder B.G. Neurohormonal regulation of ion transport in the porcine distal jejunum. Actions of neurotensin and its natural homologs. J Pharmacol Exp Ther 249 (1989) 348-357
11. Brun P., Mastrotto C., Beggiao E., Stefani A., Barzon L., Sturniolo G.C., et al. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 288 (2005) G621-G629
12. Bueno L., Fargeas M.J., Fioramonti J., and Primi M.P. Central control of intestinal motility by prostaglandins: a mediator of the actions of several peptides in rats and dogs. Gastroenterology 88 (1985) 1888-1894
13. Bueno L., Fioramonti J., Fargeas M.J., and Primi M.P. Neurotensin: a central neuromodulator of gastrointestinal motility in the dog. Am J Physiol 248 (1985) G15-G19
14. Bunnett N.W. The stressed gut: contributions of intestinal stress peptides to inflammation and motility. Proc Natl Acad Sci USA 102 (2005) 7409-7410
15. Calam J., Unwin R., and Peart W.S. Neurotensin stimulates defaecation. Lancet 1 (1983) 737-738
16. Carraway R., Cochrane D.E., Lansman J.B., Leeman S.E., Paterson B.M., and Welch H.J. Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol 323 (1982) 403-414
17. Carraway R., and Leeman S.E. The amino acid sequence of a hypothalamic peptide, neurotensin. J Biol Chem 250 (1975) 1907-1911
18. Carraway R., and Leeman S.E. Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach. J Biol Chem 251 (1976) 7045-7052
19. Carraway R., and Leeman S.E. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 248 (1973) 6854-6861
20. Carraway R., and Leeman S.E. Radioimmunoassay for neurotensin, a hypothalamic peptide. J Biol Chem 251 (1976) 7035-7044
21. Carraway R., and Leeman S.E. The synthesis of neurotensin. J Biol Chem 250 (1975) 1912-1918
22. Carraway R.E., Cochrane D.E., Salmonsen R., Muraki K., and Boucher W. Neurotensin elevates hematocrit and plasma levels of the leukotrienes, LTB4, LTC4, LTD4 and LTE4, in anesthetized rats. Peptides 12 (1991) 1105-1111
23. Carraway R.E., and Mitra S.P. Binding and biologic activity of neurotensin in guinea pig ileum. Peptides 15 (1994) 1451-1459
24. Castagliuolo I., Lamont J.T., Qiu B., Fleming S.M., Bhaskar K.R., Nikulasson S.T., et al. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells. Am J Physiol 271 (1996) G884-G892
25. Castagliuolo I., Leeman S.E., Bartolak-Suki E., Nikulasson S., Qiu B., Carraway R.E., et al. A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats. Proc Natl Acad Sci USA 93 (1996) 12611-12615
26. Castagliuolo I., Wang C.C., Liu J., Valenick L., d'Inca' R., Sturniolo G.C., et al. Neurotensin type 1 receptor upregulation by mucosal microvascular endothelial cells in intestinal inflammation. Gastroenterology 116 (1999) 799
27. Castagliuolo I., Wang C.C., Valenick L., Pasha A., Nikulasson S., Carraway R.E., et al. Neurotensin is a proinflammatory neuropeptide in colonic inflammation. J Clin Invest 103 (1999) 843-849
28. Castagliuolo I., Wershil B.K., Karalis K., Pasha A., Nikulasson S.T., and Pothoulakis C. Colonic mucin release in response to immobilization stress is mast cell dependent. Am J Physiol 274 (1998) G1094-G1100
29. Chalon P., Vita N., Kaghad M., Guillemot M., Bonnin J., Delpech B., et al. Molecular cloning of a levocabastine-sensitive neurotensin binding site. FEBS Lett 386 (1996) 91-94
30. Cochrane D.E., Boucher W., and Bibb P. Neurotensin stimulates histamine release in in vivo skin 'blisters' in rats: an effect inhibited by cromolyn or somatostatin. Int Arch Allergy Appl Immunol 80 (1986) 225-230
31. Collins S.M. Stress and the gastrointestinal tract IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance. Am J Physiol Gastrointest Liver Physiol 280 (2001) G315-G318
32. De la Fuente M., Garrido J.J., Arahuetes R.M., and Hernanz A. Stimulation of phagocytic function in mouse macrophages by neurotensin and neuromedin N. J Neuroimmunol 42 (1993) 97-104
33. Denko C.W., and Gabriel P. Effects of peptide hormones in urate crystal inflammation. J Rheumatol 12 (1985) 971-975
34. Deutch A.Y., Bean A.J., Bissette G., Nemeroff C.B., Robbins R.J., and Roth R.H. Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions. Brain Res 417 (1987) 350-354
35. Dicou E., Vincent J.P., and Mazella J. Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line. J Neurosci Res 78 (2004) 92-99
36. Elde R., Schalling M., Ceccatelli S., Nakanishi S., and Hokfelt T. Localization of neuropeptide receptor mRNA in rat brain: initial observations using probes for neurotensin and substance P receptors. Neurosci Lett 120 (1990) 134-138
37. Evers B.M., Bold R.J., Ehrenfried J.A., Li J., Townsend Jr. C.M., and Klimpel G.R. Characterization of functional neurotensin receptors on human lymphocytes. Surgery 116 (1994) 134-139 discussion 139-40
38. Evers B.M., Izukura M., Chung D.H., Parekh D., Yoshinaga K., Greeley G.H., et al. Neurotensin stimulates growth of colonic mucosa in young and aged rats. Gastroenterology 103 (1992) 86-91
39. Farthing M.J. Irritable bowel, irritable body, or irritable brain?. BMJ 310 (1995) 171-175
40. Garrido J.J., Arahuetes R.M., Hernanz A., and De la Fuente M. Modulation by neurotensin and neuromedin N of adherence and chemotaxis capacity of murine lymphocytes. Regul Pept 41 (1992) 27-37
41. Goldman R., and Bar-Shavit Z. On the mechanism of the augmentation of the phagocytic capability of phagocytic cells by Tuftsin, substance P, neurotensin, and kentsin and the interrelationship between their receptors. Ann NY Acad Sci 419 (1983) 143-155
42. Goldman R., Bar-Shavit Z., Shezen E., Terry S., and Blumberg S. Enhancement of phagocytosis by neurotensin, a newly found biological activity of the neuropeptide. Adv Exp Med Biol 155 (1982) 133-141
43. Gui X., and Carraway R.E. Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats. Am J Physiol Gastrointest Liver Physiol 287 (2004) G408-G416
44. Gully D., Canton M., Boigegrain R., Jeanjean F., Molimard J.C., Poncelet M., et al. Biochemical and pharmacological profile of a potent and selective non-peptide antagonist of the neurotensin receptor. Proc Natl Acad Sci USA 90 (1993) 65-69
45. Gully D., Labeeuw B., Boigegrain R., Oury-Donat F., Bachy A., Poncelet M., et al. Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther 280 (1997) 802-812
46. Hammer R.A., Ochoa A., Fernandez C., Ertan A., and Arimura A. Somatostatin as a mediator of the effect of neurotensin on pentagastrin-stimulated acid secretion in rats. Peptides 13 (1992) 1175-1179
47. Hassan S., Dobner P.R., and Carraway R.E. Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. Regul Pept 120 (2004) 155-166
48. Hellstrom P.M., and Rosell S. Effects of neurotensin, substance P and methionine-enkephalin on colonic motility. Acta Physiol Scand 113 (1981) 147-154
49. Honkaniemi J. Colocalization of peptide- and tyrosine hydroxylase-like immunoreactivities with Fos-immunoreactive neurons in rat central amygdaloid nucleus after immobilization stress. Brain Res 598 (1992) 107-113
50. Kachur J.F., Miller R.J., Field M., and Rivier J. Neurohumoral control of ileal electrolyte transport. II. Neurotensin and substance P. J Pharmacol Exp Ther 220 (1982) 456-463
51. Karinch A.M., Schmidt G.L., and Kauffman Jr. G.L. Pretreatment with SR48692 has different effects on central neurotensin-induced gastric mucosal defense and inhibition of gastric acid secretion in rats. Brain Res 810 (1998) 123-129
52. Kelly C.P., Pothoulakis C., and LaMont J.T. Clostridium difficile colitis. N Engl J Med 330 (1994) 257-262
53. Kihl B., Rokaeus A., Rosell S., and Olbe L. The effect of intraduodenal installation of oleic acid on plasma neurotensin-like immunoreactivity and on gastric acid secretion stimulated by betazole and sham feeding in man. Scand J Gastroenterol 17 (1982) 633-639
54. Kihl B., Rokaeus A., Rosell S., and Olbe L. Fat inhibition of gastric acid secretion in man and plasma concentrations of neurotensin-like immunoreactivity. Scand J Gastroenterol 16 (1981) 513-526
55. Kihl B., Rokaeus A., Rosell S., and Olbe L. Inhibition of pentagastrin stimulated gastric acid secretion and rise in the plasma concentration of neurotensin-like immunoreactivity (NTLI) by intraduodenal oleic acid in man. Acta Physiol Scand 110 (1980) 329
56. Kitabgi P., and Vincent J.P. Neurotensin is a potent inhibitor of guinea-pig colon contractile activity. Eur J Pharmacol 74 (1981) 311-318
57. Konturek S.J., Bilski J., Tasler J., and Laskiewicz J. Gut hormones in stimulation of gastroduodenal alkaline secretion in conscious dogs. Am J Physiol 248 (1985) G687-G691
58. Kurose M., and Saeki K. Histamine release induced by neurotensin from rat peritoneal mast cells. Eur J Pharmacol 76 (1981) 129-136
59. Lazarus L.H., Perrin M.H., and Brown M.R. Mast cell binding of neurotensin. I. Iodination of neurotensin and characterization of the interaction of neurotensin with mast cell receptor sites. J Biol Chem 252 (1977) 7174-7179
60. Lazarus L.H., Perrin M.H., Brown M.R., and Rivier J.E. Mast cell binding of neurotensin. II. Molecular conformation of neurotensin involved in the stereospecific binding to mast cell receptor sites. J Biol Chem 252 (1977) 7180-7183
61. Lemaire I. Neurotensin enhances IL-1 production by activated alveolar macrophages. J Immunol 140 (1988) 2983-2988
62. Maoret J.J., Anini Y., Rouyer-Fessard C., Gully D., and Laburthe M. Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice. Int J Cancer 80 (1999) 448-454
63. Maoret J.J., Pospai D., Rouyer-Fessard C., Couvineau A., Laboisse C., Voisin T., et al. Neurotensin receptor and its mRNA are expressed in many human colon cancer cell lines but not in normal colonic epithelium: binding studies and RT-PCR experiments. Biochem Biophys Res Commun 203 (1994) 465-471
64. Martin S., Navarro V., Vincent J.P., and Mazella J. Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Gastroenterology 123 (2002) 1135-1143
65. Mayer E.A., Raybould H., and Koelbel C. Neuropeptides, inflammation, and motility. Dig Dis Sci 33 (1988) 71S-77S
66. Mazella J., Botto J.M., Guillemare E., Coppola T., Sarret P., and Vincent J.P. Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci 16 (1996) 5613-5620
67. Mazella J., Zsurger N., Navarro V., Chabry J., Kaghad M., Caput D., et al. The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J Biol Chem 273 (1998) 26273-26276
68. Miller L.A., Cochrane D.E., Carraway R.E., and Feldberg R.S. Blockade of mast cell histamine secretion in response to neurotensin by SR 48692 a non-peptide antagonist of the neurotensin brain receptor. Brit J Pharmacol 114 (1995) 1466-1470
69. Morris A.P., Cunningham S.A., Benos D.J., and Frizzell R.A. Cellular differentiation is required for cAMP but not Ca(2+)-dependent Cl-secretion in colonic epithelial cells expressing high levels of cystic fibrosis transmembrane conductance regulator. J Biol Chem 267 (1992) 5575-5583
70. Mule F., Postorino A., Geraci A., and Serio R. Neurotensin: dual effect on the motor activity of rat duodenum. Eur J Pharmacol 212 (1992) 215-224
71. Mule F., and Serio R. Inhibition of mechanical activity by neurotensin in rat proximal colon: involvement of nitric oxide. Am J Physiol 273 (1997) G491-G497
72. Mule F., and Serio R. Mode and mechanism of neurotensin action in rat proximal colon. Eur J Pharmacol 319 (1997) 269-272
73. Mule F., Serio R., and Postorino A. Motility pattern of isolated rat proximal colon and excitatory action of neurotensin. Eur J Pharmacol 275 (1995) 131-137
74. Navarro V., Vincent J.P., and Mazella J. Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line. Biochem Biophys Res Commun 298 (2002) 760-764
75. Olsen P.S., Pedersen J.H., Kirkegaard P., Been H., Stadil F., Fahrenkrug J., et al. Neurotensin induced inhibition of gastric acid secretion in duodenal ulcer patients before and after parietal cell vagotomy. Gut 25 (1984) 481-484
76. O'Sullivan M., Clayton N., Breslin N.P., Harman I., Bountra C., McLaren A., et al. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 12 (2000) 449-457
77. Pang X., Alexacos N., Letourneau R., Seretakis D., Gao W., Boucher W., et al. A neurotensin receptor antagonist inhibits acute immobilization stress-induced cardiac mast cell degranulation, a corticotropin-releasing hormone-dependent process. J Pharmacol Exp Ther 287 (1998) 307-314
78. Polak J.M., Sullivan S.N., Bloom S.R., Buchan A.M., Facer P., Brown M.R., et al. Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry. Nature 270 (1977) 183-184
79. Pothoulakis C. Effects of Clostridium difficile toxins on epithelial cell barrier. Ann NY Acad Sci 915 (2000) 347-356
80. Pothoulakis C. Pathogenesis of Clostridium difficile-associated diarrhoea. Eur J Gastroenterol Hepatol 8 (1996) 1041-1047
81. Pothoulakis C., Castagliuolo I., and Leeman S.E. Neuroimmune mechanisms of intestinal responses to stress. In: Crafford L.J., McCann S.M., Sternberg E.M., Chrousos G.P., Gold P.W., and Smith C.C. (Eds). Neuroimmunomodulation: molecular, integrative systems, and clinical advances vol. 840 (1998), New York Academy of Science, New York 635-648
82. Pothoulakis C., and Lamont J.T. Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins. Am J Physiol Gastrointest Liver Physiol 280 (2001) G178-G183
83. Prasad R., Venkatasubramanian J., Amde M., and Rao M.C. Phospholipase C and src tyrosine kinases mediate neurotensin-stimulated Cl-secretion in rabbit proximal colon. Dig Dis Sci 49 (2004) 1318-1326
84. Ramez M., Bagot M., Nikolova M., Boumsell L., Vita N., Chalon P., et al. Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes. J Invest Dermatol 117 (2001) 687-693
85. Robbins R.A., Nelson K.J., Gossman G.L., and Rubinstein I. Neurotensin stimulates neutrophil adherence to bronchial epithelial cells in vitro. Life Sci 56 (1995) 1353-1359
86. Rosell S. The role of neurotensin in the uptake and distribution of fat. Ann NY Acad Sci 400 (1982) 183-197
87. Rosell S., and Rokaeus A. The effect of ingestion of amino acids, glucose and fat on circulating neurotensin-like immunoreactivity (NTLI) in man. Acta Physiol Scand 107 (1979) 263-267
88. Rossie S.S., and Miller R.J. Regulation of mast cell histamine release by neurotensin. Life Sci 31 (1982) 509-516
89. Rothstein R.D., and Ouyang A. Mechanism of action of neurotensin at the ileocecal sphincter region. Life Sci 45 (1989) 1475-1482
90. Rowe W., Viau V., Meaney M.J., and Quirion R. Central administration of neurotensin stimulates hypothalamic-pituitary-adrenal activity. The paraventricular CRF neuron as a critical site of action. Ann NY Acad Sci 668 (1992) 365-367
91. Rowe W.B., Nicot A., Sharma S., Gully D., Walker C.D., Rostene W.H., et al. Central administration of the neurotensin receptor antagonist, SR48692, modulates diurnal and stress-related hypothalamic-pituitary-adrenal activity. Neuroendocrinology 66 (1997) 75-85
92. Roze C. Neurohumoral control of gastrointestinal motility. Reprod Nutr Dev 20 (1980) 1125-1141
93. Sahi J., Wiggins M.P., Gibori G.B., Layden T.J., and Rao M.C. Calcium regulated chloride permeabilities in primary cultures of rabbit colonocytes. J Cell Physiol 168 (1996) 276-283
94. Sakai Y., Daniel E.E., Jury J., and Fox J.E. Neurotensin inhibition of canine intestinal motility in vivo via alpha-adrenoceptors. Can J Physiol Pharmacol 62 (1984) 403-411
95. Sarret P., Perron A., Stroh T., and Beaudet A. Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system. J Comp Neurol 461 (2003) 520-538
96. Scarpa R.C., Carraway R.E., and Cochrane D.E. The effect of neurotensin on insulin-induced proliferation of human fibroblasts. Peptides 25 (2004) 1159-1169
97. Schaeffer P., Laplace M.C., Prabonnaud V., Bernat A., Gully D., Lespy L., et al. Neurotensin induces the release of prostacyclin from human umbilical vein endothelial cells in vitro and increases plasma prostacyclin levels in the rat. Eur J Pharmacol 323 (1997) 215-221
98. Schaeffer P., Laplace M.C., Savi P., Pflieger A.M., Gully D., and Herbert J.M. Human umbilical vein endothelial cells express high affinity neurotensin receptors coupled to intracellular calcium release. J Biol Chem 270 (1995) 3409-3413
99. Selbekk B.H. Neurotensin-induced mast cell degranulation in human jejunal mucosa. Additive effects of IgE or compound 48/80 and inhibition by sodium cromoglycate. Scand J Gastroenterol 19 (1984) 595-602
100. Selbekk B.H., Flaten O., and Hanssen L.E. The in vitro effect of neurotensin on human jejunal mast cells. Scand J Gastroenterol 15 (1980) 457-460
101. Seta K.A., Jansen H.T., Kreitel K.D., Lehman M., and Behbehani M.M. Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain. Brain Res Mol Brain Res 86 (2001) 145-152
102. Singh L.K., Pang X., Alexacos N., Letourneau R., and Theoharides T.C. Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: a link to neurogenic skin disorders. Brain Behav Immun 13 (1999) 225-239
103. Skov Olsen P., Holst Pedersen J., Kirkegaard P., Stadil F., Fahrenkrug J., and Christiansen J. Neurotensin inhibits meal-stimulated gastric acid secretion in man. Scand J Gastroenterol 18 (1983) 1073-1076
104. Souaze F., Rostene W., and Forgez P. Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms. J Biol Chem 272 (1997) 10087-10094
105. Sundler F., Alumets J., Hakanson R., Carraway R., and Leeman S.E. Ultrastructure of the gut neurotensin cell. Histochemistry 53 (1977) 25-34
106. Tache Y., Martinez V., Million M., and Wang L. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol 280 (2001) G173-G177
107. Tache Y., Monnikes H., Bonaz B., and Rivier J. Role of CRF in stress-related alterations of gastric and colonic motor function. Ann NY Acad Sci 697 (1993) 233-243
108. Tanaka K., Masu M., and Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron 4 (1990) 847-854
109. Thor K., Rokaeus A., Kager L., and Rosell S. (Gln4)-neurotensin and gastrointestinal motility in man. Acta Physiol Scand 110 (1980) 327-328
110. Thor K., and Rosell S. Neurotensin increases colonic motility. Gastroenterology 90 (1986) 27-31
111. Thor K., Rosell S., Rokaeus A., and Kager L. (Gln4)-neurotensin changes the motility pattern of the duodenum and proximal jejunum from a fasting-type to a fed-type. Gastroenterology 83 (1982) 569-574
112. Tsalis K.G., Yovos J.G., Botsios D.S., and Dadoukis D. Intracerebroventricular infusion of neurotensin suppresses gastric acid secretion in dogs. Eur Surg Res 25 (1993) 52-59
113. Ushiro S., Mizoguchi K., Yoshida S., Jimi S., Fujiwara T., Yoshida M., et al. Stimulation of cell-surface urokinase-type plasminogen activator activity and cell migration in vascular endothelial cells by a novel hexapeptide analogue of neurotensin. FEBS Lett 418 (1997) 341-345
114. van der Veek P.P., Schots E.D., and Masclee A.A. Effect of neurotensin on colorectal motor and sensory function in humans. Dis Colon Rectum 47 (2004) 210-218
115. Vincent J.P., Mazella J., and Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol Sci 20 (1999) 302-309
116. Vita N., Laurent P., Lefort S., Chalon P., Dumont X., Kaghad M., et al. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett 317 (1993) 139-142
117. Walker J.P., Fujimura M., Sakamoto T., Greeley Jr. G.H., Townsend Jr. C.M., and Thompson J.C. Importance of the ileum in neurotensin released by fat. Surgery 98 (1985) 224-249
118. Weston A.P., Biddle W.L., Bhatia P.S., and Miner Jr. P.B. Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci 38 (1993) 1590-1595
119. Wood J.G., Hoang H.D., Bussjaeger L.J., and Solomon T.E. Neurotensin stimulates growth of small intestine in rats. Am J Physiol 255 (1988) G813-G817
120. Yeh K.Y., Yeh M., Glass J., and Granger D.N. Rapid activation of NF-kappaB and AP-1 and target gene expression in postischemic rat intestine. Gastroenterology 118 (2000) 525-534
121. Yoshinaga K., Evers B.M., Izukura M., Parekh D., Uchida T., Townsend C.M., et al. Neurotensin stimulates growth of colon cancer. Surg Oncol 1 (1992) 127-134
122. Zhang L., Xing L.P., Demers L., Washington J., and Kauffman Jr. G.L. Central neurotensin inhibits gastric acid secretion: an adrenergic mechanism in rats. Gastroenterology 97 (1989) 1130-1134
123. Zhao D., Keates A.C., Kuhnt-Moore S., Moyer M.P., Kelly C.P., and Pothoulakis C. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. J Biol Chem 276 (2001) 44464-44471
124. Zhao D., Kuhnt-Moore S., Zeng H., Wu J.S., Moyer M.P., and Pothoulakis C. Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. Am J Physiol Cell Physiol 284 (2003) C1397-C1404
125. Zhao D., and Pothoulakis C. Rho GTPases as therapeutic targets for the treatment of inflammatory diseases. Expert Opin Ther Targets 7 (2003) 583-592
126. Zhao D., Zhan Y., Koon H.W., Zeng H., Keates S., Moyer M.P., et al. Metalloproteinase-dependent TGFa release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem. 279 (2004) 43547-43554
127. Zhao D., Zhan Y., Zeng H., Koon H.W., Moyer M.P., and Pothoulakis C. Neurotensin stimulates interleukin-8 expression through modulation of IκBα phosphorylation and p65 transcriptional activity: involvement of protein kinase Cα. Mol Pharmacol 67 (2005) 2025-2031