PACAP provides colonic protection against dextran sodium sulfate induced colitis

Journal of Cellular Physiology

Volumn 216, Issue 1, 2008, Pages 111-119

  Azuma, Yasu Taka ^a   Hagi, Kiyomi ^a   Shintani, Norihito ^b   Kuwamura, Mitsuru ^a   Nakajima, Hidemitsu ^a   Hashimoto, Hitoshi ^b,c   Baba, Akemichi ^b   Takeuchi, Tadayoshi ^a  

^a Osaka Prefecture University   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; GAMMA INTERFERON; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; CHEMOKINE; CYTOKINE; GROWTH PROMOTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; COLITIS; COLON; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESCENDING COLON; DISEASE ACTIVITY; ENTERITIS; FEMALE; HISTOLOGY; INTESTINE; INTROSPECTION; MONITORING; MORPHOLOGY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; SYMPTOM; UPREGULATION; WILD TYPE; ANIMAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; SURVIVAL RATE; TISSUE CULTURE TECHNIQUE;

MUS;

ANIMALS; CHEMOKINES; COLITIS; COLON; CYTOKINES; DEXTRAN SULFATE; FEMALE; GROWTH SUBSTANCES; HUMANS; INFLAMMATORY BOWEL DISEASES; MICE; MICE, KNOCKOUT; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; SURVIVAL RATE; TISSUE CULTURE TECHNIQUES;

EID: 44449159941     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21381     Document Type: Article

References (38)

1. Belai A, Boulos PB, Robson T, Burnstock G. 1997. Neurochemical coding in the small intestine of patients with Crohn's disease. Gut 40:767-774.
2. Bouma G, Strober W. 2003. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3:521-533.
3. Chatterjee TK, Sharma RV, Fisher RA. 1996. Molecular cloning of a novel variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor that stimulates calcium influx by activation of the L-type calcium channels. J Biol Chem 271:33226-33232.
4. Cong Y, Brandwein SL, McCabe RP, Lazenby A, Birkenmeier EH, Sundberg JP, Elson CO. 1998. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: Increased T helper cell type I response and ability to transfer disease. J Exp Med 187:855-864.
5. Cooper HS, Murthy SN, Shah RS, Sedergran DJ. 1993. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:249-283.
6. Delgado M, Martinez C, Johnson MC, Gomariz RP, Ganea D. 1996a. Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes. J Neuroimmunol 68:27-38.
7. Delgado M, Martinez C, Leceta J, Garrido E, Gomariz RP. 1996b. Differential VIP and VIP1 receptor gene expression in rat thymocytes subsets. Peptides 17:803-807.
8. Delgado M, Munoz-Elias EJ, Gomariz RP, Ganea D. 1999. VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFN-γ synthesis by T-cells. J Neuroimmunol 96:167-181.
9. Delgado M, Abad C, Martinez C, Juarranz MG, Leceta J, Ganea D, Gomariz RP. 2003. PACAP in immunity and inflammation. Ann NY Acad Sci 992:141-157.
10. Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, Elson CO. 1994. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107:1643-1652.
11. Fiocchi C. 1998. Inflammatory bowel disease: Etiology and pathogenesis. Gastroenterology 115:182-205.
12. Fuss U, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W. 1996. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157:1261-1270.
13. Gaytan F, Martinez-Fuentes AJ, Garcia-Navarro F, Vaudry H, Aguilar E. 1994. Pituitary adenylate cyclase activating peptide (PACAP) immunolocalization in lymphoid tissue of rat. Cell Tissue Res 276:233-237.
14. Gomariz RP, Garrido E, Leceta J, Martinez C, Abalo R, Delgado M. 1994. Gene expression of VIP receptor in rat lymphocytes. Biochem Biophys Res Commun 203:1599-1604.
15. Gomariz RP, Juarranz Y, Abad C, Arranz A, Leceta J, Martinez C. 2006. VIP-PACAP system in immunity new insights for multitarget therapy. Ann NY Acad Sci 1070:51-74.
16. Hashimoto H, Shintani N, Tanaka K, Mori W, Hirose M, Matsuda T, Sakaue M, Miyazaki J, Niwa J, Tashiro F, Yamamoto K, Koga K, Tomimoto S, Kunugi A, Suetake S, Baba A. 2001. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci USA 98:13355-13360.
17. Kihara N, de la Fuente SG, Fujino K, Takahashi T, Pappas TN, Mantyh CR. 2003. Vanilloid receptor-1 containing primary sensory neurons mediate dextran sulphate sodium induced colitis in rats. Gut 52:713-719.
18. Kitajima S, Takuma S, Morimoto M. 1999. Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium. Exp Anim 48:137-143.
19. Kojouharoff G. 1997. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice. Clin Exp Immunol 107:353-358.
20. Maaser C, Kagnoff MF. 2002. Role of the intestinal epithelium in orchestrating innate and adaptive mucosal immunity. Z Gastroenterol 40:525-529.
21. McKay DM. 1999. Intestinal inflammation and the gut microflora. Can J Gastroenterol 13:509-516.
22. Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Tache Y, Pisegna JR. 2002. Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons. Regul Pept 105:145-154.
23. Miyata A, Arimura A, Dahl RR, Minamino N, Uehara A, Jiang L, Culler MD, Coy DH. 1989. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164:567-574.
24. Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F. 1997. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112:1169-1178.
25. Naito Y. 2003. Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice. J Gastroenterol Hepatol 18:560-569.
26. Naito Y, Takagi T, Uchiyama K, Kuroda M, Kokura S, Ichikawa H, Yanagisawa R, Inoue K, Takano H, Satoh M, Yoshida N, Okanoue T, Yoshikawa T. 2004. Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. Int J Mol Med 14:191-196.
27. Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, Journot L. 1996. Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. J Biol Chem 271:22146-22151.
28. Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, Maggi E, Pupilli C, Tonelli F, Romagnani S. 1997. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crhon's disease. Am J Pathol 150:823-832.
29. Pozo D, Delgado M, Martinez C, Gomariz RP, Guerrero JM, Calvo JR. 1997. Functional characterization and mRNA expression of pituitary adenylate cyclase activating polypeptide (PACAP) type 1 receptors in rat peritoneal macrophages. Biochem Biophys Acta 1359:250-262.
30. Sartor RB. 1997. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res Immunol 148:567-576.
31. Segura JJ, Guerrero JM, Goberna R, Calvo JR. 1991. Characterization of functional receptors for vasoactive intestinal peptide (VIP) in rat peripheral macrophages. Regul Pept 33:133-143.
32. Siegmund B, Lehr HA, Fantuzzi G, Dinarello CA. 2001. IL-1β- converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci USA 98:13249-13254.
33. Spengler D, Waeber P, Pantaloni C, Holsboer F, Bockaert J, Seeburg PH, Journot L. 1993. Differential signal transduction by five splice variants of the PACAP receptor gene. Nature 365:170-175.
34. 3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: Findings obtained using muscarinic receptor knockout mouse. Am J Physiol Gastrointest Liver Physiol 292:154-164.
35. Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. 2006. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc Natl Acad Sci USA 103:13451-13456.
36. Van Heel D, McGovern D, Jewell D. 2001. Crohn's disease: Genetic susceptibility, bacteria, and innate immunity. Lancet 357:1902-1904.
37. Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H. 2000. Pituitary adenylate cyclase-activating polypeptide and its receptors: From structure to functions. Pharmacol Rev 52:269-324.
38. Yoshihara K, Yajima T, Kubo C, Yoshikai Y. 2006. Role of interleukin 15 in colitis induced by dextran sulfate sodium in mice. Gut 55:334-341.