Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis

American Journal of Pathology

Volumn 173, Issue 2, 2008, Pages 400-410

  Koon, Hon Wai ^a,b   Zhao, Dezheng ^a   Xu, Hua ^a   Bowe, Collin ^a,b   Moss, Alan ^a   Moyer, Mary P ^c   Pothoulakis, Charalabos ^a,b,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INCELL Corporation ^*  (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; CJ 12255; CYSTEINE RICH PROTEIN 61; DEXTRAN; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; SODIUM SULFATE; SUBSTANCE P; VITRONECTIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; COLITIS; COLON; CONTROLLED STUDY; CROHN DISEASE; DISEASE COURSE; ENDOTHELIUM CELL; ENTERITIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULCERATIVE COLITIS;

EID: 48749124143     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.080222     Document Type: Article

References (49)

1. Chang MM, Leeman SE: Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J Biol Chem 1970, 245:4784-4790
2. Mantyh PW: Neurobiology of substance P and the NK1 receptor. J Clin Psychiatry 2002, 63(Suppl 11):6-10
3. Maggi CA: Capsaicin-sensitive nerves in the gastrointestinal tract. Arch Int Pharmacodyn Ther 1990, 303:157-166
4. Costa M, Furness JB, Franco R, Llewellyn-Smith I, Murphy R, Beardsley AM: Substance P in nerve tissue in the gut. Ciba Found Symp 1982, 91:129-144
5. Bost KL: Quantification of macrophage-derived substance P receptor mRNA using competitive polymerase chain reaction. Adv Exp Med Biol 1995, 373:219-223
6. Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O'Keane JC, Snider RM, Leeman SE: CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci USA 1994, 91:947-951
7. Holzer P, Holzer-Petsche U: Tachykinins in the gut. Part I. Expression, release and motor function. Pharmacol Ther 1997, 73:173-217
8. Riegler M, Castagliuolo I, So PT, Lotz M, Wang C, Wlk M, Sogukoglu T, Cosentini E, Bischof G, Hamilton G, Teleky B, Wenzl E, Matthews JB, Pothoulakis C: Effects of substance P on human colonic mucosa in vitro. Am J Physiol 1999, 276:G1473-G1483
9. Koon HW, Zhao D, Zhan Y, Rhee SH, Moyer MP, Pothoulakis C: Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. J Immunol 2006, 176:5050-5059
10. Koon HW, Zhao D, Zhan Y, Simeonidis S, Moyer MP, Pothoulakis C: Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation. J Pharmacol Exp Ther 2005, 314:1393-1400
11. Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C: Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem 2004, 279:45519-45527
12. Koon HW, Zhao D, Zhan Y, Moyer MP, Pothoulakis C: Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proc Natl Acad Sci USA 2007, 104:2013-2018
13. Danese S, Sans M, de la Motte C, Graziani C, West G, Phillips MH, Pola R, Rutella S, Willis J, Gasbarrini A, Fiocchi C: Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 2006, 130:2060-2073
14. Fan TP, Hu DE, Guard S, Gresham GA, Watling KJ: Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol 1993, 110:43-49
15. Brigstock DR: The CCN family: a new stimulus package. J Endocrinol 2003, 178:169-175
16. Moussad EE, Brigstock DR: Connective tissue growth factor: what's in a name? Mol Genet Metab 2000, 71:276-292
17. Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF: CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol 2002, 22:8709-8720
18. Brigstock DR: Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 2002, 5:153-165
19. Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis C: Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2{alpha}. Gut 2007, 56:1210-1217
20. Chang CC, Shih JY, Jeng YM, Su JL, Lin BZ, Chen ST, Chau YP, Yang PC, Kuo ML: Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. J Natl Cancer Inst 2004, 96:364-375
21. Vermeulen PB, Gasparini G, Fox SB, Toi M, Martin L, McCulloch P, Pezzella F, Viale G, Weidner N, Harris AL, Dirix LY: Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 1996, 32A:2474-2484
22. Weidner N: Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995, 36:169-180
23. Madri JA, Pratt BM: Endothelial cell-matrix interactions: in vitro models of angiogenesis. J Histochem Cytochem 1986, 34:85-91
24. Goligorsky MS, Budzikowski AS, Tsukahara H, Noiri E: Co-operation between endothelin and nitric oxide in promoting endothelial cell migration and angiogenesis. Clin Exp Pharmacol Physiol 1999, 26:269-271
25. Athanasopoulos AN, Schneider D, Keiper T, Alt V, Pendurthi UR, Liegibel UM, Sommer U, Nawroth PP, Kasperk C, Chavakis T: Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing. J Biol Chem 2007, 282:26746-26753
26. Norrby K: In vivo models of angiogenesis. J Cell Mol Med 2006, 10:588-612
27. Goode T, O'Connell J, Anton P, Wong H, Reeve J, O'Sullivan GC, Collins JK, Shanahan F: Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation. Gut 2000, 47:387-396
28. Danese S, Sans M, Spencer DM, Beck I, Donate F, Plunkett ML, de la Motte C, Redline R, Shaw DE, Levine AD, Mazar AP, Fiocchi C: Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2007, 56:855-862
29. Stucchi AF, Shofer S, Leeman S, Materne O, Beer E, McClung J, Shebani K, Moore F, O'Brien M, Becker JM: NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats. Am J Physiol 2000, 279:G1298-G1306
30. Reed KL, Fruin AB, Gower AC, Gonzales KD, Stucchi AF, Andry CD, O'Brien M, Becker JM: NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci 2005, 50:2366-2378
31. Leu SJ, Lam SC, Lau LF: Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem 2002, 277:46248-46255
32. Babic AM, Kireeva ML, Kolesnikova TV, Lau LF: CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci USA 1998, 95:6355-6360
33. Ruscica M, Dozio E, Motta M, Magni P: Relevance of the neuropeptide Y system in the biology of cancer progression. Curr Top Med Chem 2007, 7:1682-1691
34. Grabowska AM, Watson SA: Role of gastrin peptides in carcinogenesis. Cancer Lett 2007, 257:1-15
35. Walsh DA, McWilliams DF: Tachykinins and the cardiovascular system. Curr Drug Targets 2006, 7:1031-1042
36. Seegers HC, Hood VC, Kidd BL, Cruwys SC, Walsh DA: Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther 2003, 306:8-12
37. Baluk P, Bowden JJ, Lefevre PM, McDonald DM: Upregulation of substance P receptors in angiogenesis associated with chronic airway inflammation in rats. Am J Physiol 1997, 273:L565-L571
38. Tominaga K, Honda K, Akahoshi A, Makino Y, Kawarabayashi T, Takano Y, Kamiya H: Substance P causes adhesion of neutrophils to endothelial cells via protein kinase C. Biol Pharm Bull 1999, 22:1242-1245
39. Marion-Audibert AM, Nejjari M, Pourreyron C, Anderson W, Gouysse G, Jacquier MF, Dumortier J, Scoazec JY: Effects of endocrine peptides on proliferation, migration and differentiation of human endothelial cells. Gastroenterol Clin Biol 2000, 24:644-648
40. Gallicchio M, Rosa AC, Benetti E, Collino M, Dianzani C, Fantozzi R: Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. Br J Pharmacol 2006, 147:681-689
41. Dianzani C, Collino M, Lombardi G, Garbarino G, Fantozzi R: Substance P increases neutrophil adhesion to human umbilical vein endothelial cells. Br J Pharmacol 2003, 139:1103-1110
42. Binion DG, West GA, Ina K, Ziats NP, Emancipator SN, Fiocchi C: Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997, 112:1895-1907
43. Pendurthi UR, Tran TT, Post M, Rao LV: Proteolysis of CCN1 by plasmin: functional implications. Cancer Res 2005, 65:9705-9711
44. Newby DE, Wright RA, Ludlam CA, Fox KA, Boon NA, Webb DJ: An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium. Thromb Haemost 1997, 78:1242-1248
45. Firestein GS: Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis. J Clin Invest 1999, 103:3-4
46. Szekanecz Z, Koch AE: Vascular endothelium and immune responses: implications for inflammation and angiogenesis. Rheum Dis Clin North Am 2004, 30:97-114
47. Tarnawski A: Gene therapy for ulcerations of the gastrointestinal tract. Drugs Today (Barc) 2006, 42:193-203
48. Sandor Z, Deng XM, Khomenko T, Tarnawski AS, Szabo S: Altered angiogenic balance in ulcerative colitis: a key to impaired healing? Biochem Biophys Res Commun 2006, 350:147-150
49. Chen Y, Du XY: Functional properties and intracellular signaling of CCN1/Cyr61. J Cell Biochem 2007, 100:1337-1345