The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways

Biomaterials

Volumn 31, Issue 9, 2010, Pages 2665-2672

  Griesenbach, Uta ^a,g   Meng, Cuixiang ^a,g   Farley, Raymond ^a,g   Wasowicz, Marguerite Y ^a,g   Munkonge, Felix M ^a,g   Chan, Mario ^a,g   Stoneham, Charlotte ^b,g   Sumner Jones, Stephanie G ^b,g   Pringle, Ian A ^b,g   Gill, Deborah R ^b,g   Hyde, Stephen C ^b,g   Stevenson, Barbara ^c,g   Holder, Emma ^c,g   Ban, Hiroshi ^d   Hasegawa, Mamoru ^d   Cheng, Seng H ^e   Scheule, Ronald K ^e   Sinn, Patrick L ^f   McCray Jr , Paul B ^f   Alton, Eric W F W ^a,g  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d DNAVEC Corporation   (Japan)

^e GENZYME CORPORATION   (United States)

^f UNIVERSITY OF IOWA   (United States)

^g The UK Cystic Fibrosis Gene Therapy Consortium ^*  (United Kingdom)

Author keywords

Epithelium; Gene therapy; Gene transfer; Lung

Indexed keywords

CARBOXY METHYLCELLULOSE; CATIONIC LIPIDS; CONTACT TIME; CYSTIC FIBROSIS; EPITHELIUM; GENE DELIVERY; ION TRANSPORTS; KEY FACTORS; METHYLCELLULOSE; MOUSE LUNG; MUCOCILIARY CLEARANCE; NEBULISATION; NONVIRAL; TRANSFER AGENTS; TRANSGENE; VISCOELASTIC GELS; VISCOUS SOLUTION; WHOLE BODY;

BIOACTIVITY; BIOLOGICAL ORGANS; DYES; GELS; GENE EXPRESSION; GENE THERAPY;

GENE TRANSFER;

CARBOXYMETHYLCELLULOSE; LIPOSOME; METHYLCELLULOSE; PLASMID DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; GENE EXPRESSION; ION TRANSPORT; MALE; MOUSE; MUCOCILIARY CLEARANCE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NOSE MUCOSA; PRIORITY JOURNAL; TRANSGENE;

ANIMALS; CARBOXYMETHYLCELLULOSE; CELL LINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GELS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; MEMBRANE POTENTIALS; MICE; NEBULIZERS AND VAPORIZERS; PERFUSION; RECOMBINANT FUSION PROTEINS; RESPIRATORY SYSTEM; RNA, MESSENGER; TIME FACTORS; VIRUSES;

MUS;

EID: 74449092542     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.12.005     Document Type: Article

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