The nasal epithelium as a factory for systemic protein delivery

Molecular Therapy

Volumn 5, Issue 2, 2002, Pages 98-103

  Griesenbach, Uta ^a   Cassady, Robin L ^a   Ferrari, Stefano ^a   Fukumura, Masayuki ^b   Müller, Christian ^c,d   Schmitt, Edgar ^c,d   Zhu, Jie ^a   Jeffery, Peter K ^a   Nagai, Yoshiyuki ^c,d   Geddes, Duncan M ^a   Hasegawa, Mamoru ^b   Alton, Eric W F W ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b DNA VEC Research Inc   (Japan)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Gene therapy; Interleukin 10; Sendai virus

Indexed keywords

RECOMBINANT INTERLEUKIN 10; VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENCY; GENE THERAPY; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG; MOUSE; NONHUMAN; NOSE MUCOSA; PROTEIN BLOOD LEVEL; SENDAI VIRUS; SKELETAL MUSCLE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS LOAD; VIRUS RECOMBINANT;

ANIMALIA; SENDAI VIRUS;

EID: 0036166302     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0524     Document Type: Article

References (29)

1. Gene therapy for hemophilia
2. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA
3. Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector
4. Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor
5. Adeno-associated viral vector-mediated gene transfer results in long-term enzymatic and functional correction in multiple organs of Fabry mice
6. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
7. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for viral pathogenesis
8. Creation of an infectious recombinant Sendai virus expressing the firefly luciferase gene from the 3′ proximal first locus
9. Efficient gene transfer to airway epithelium using recombinant Sendai virus
10. Interleukin-10 and the interleukin-10 receptor
11. Interleukin 10 treatment of psoriasis: Clinical results of a phase 2 trial
12. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease
13. A pilot trial of recombinant human interleukin-10 in kidney transplant recipients receiving OKT3 induction therapy
14. Murine bone marrow-derived mast cells as potent producers of IL-9: Costimulatory function of IL-10 and kit ligand in the presence of IL-1
15. Tubulin: A factor necessary for the synthesis of both Sendai virus and vesicular stomatitis virus RNAs
16. Adenovirus-mediated interleukin-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of bronchiolitis obliterans
17. Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice
18. Modulation of virus-induced delayed-type hypersensitivity by plasmid DNA encoding the cytokine interleukin-10
19. Immune modulation by IL-10 gene transfer via viral vector and plasmid DNA: Implication for gene therapy
20. Interleukin 10 gene transfer prevents experimental colitis in rats
21. Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses
22. Introduction of the interleukin-10 gene into mice inhibited bleomycin- induced lung injury in vivo
23. Interleukin-10 produced by recombinant adenovirus prolongs survival of cardiac allografts in rats
24. Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin
25. A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression
26. In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE
27. Quality of life of patients with perennial allergic rhinitis: Preliminary validation of the Rhinoconjunctivitis Quality of Life Questionnaire in Singapore
28. Effects of altering dosing on cationic liposome-mediated gene transfer to the respiratory epithelium
29. Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung