The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 1, 1999, Pages 129-134

  Smith, Stephen N ^b   Middleton, Peter G ^b   Chadwick, Sharon ^b   Jaffe, Adam ^b   Bush, Katy A ^b   Rolleston, Sarah ^b   Farley, Ray ^b   Delaney, Stephen J ^b   Wainwright, Brandon ^b   Geddes, Duncan M ^b   Alton, Eric W F W ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CFTR PROTEIN, HUMAN; CHLORIDE; ISOPRENALINE; MILRINONE; PHOSPHODIESTERASE INHIBITOR; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; CYSTIC FIBROSIS; DRUG EFFECT; EPITHELIUM; GENETICS; HUMAN; LUNG; MALE; METABOLISM; MOUSE; MUTATION; NOSE; PATHOPHYSIOLOGY; RESPIRATORY SYSTEM; SOLUTION AND SOLUBILITY;

AMILORIDE; ANIMALS; CHLORIDES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIUM; HUMANS; ISOPROTERENOL; LUNG; MALE; MEMBRANE POTENTIALS; MICE; MILRINONE; MUTATION; NOSE; PHOSPHODIESTERASE INHIBITORS; RESPIRATORY SYSTEM; SOLUTIONS;

EID: 0032615611     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.1.3278     Document Type: Article

References (28)

1. Welsh, M. J., and A. E. Smith. 1993. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 73:1251-1254.
2. Joris, L., I. Dab, and P. M. Quinton. 1993. Elemental composition of human airway surface fluid in healthy and diseased airways. Am. Rev. Respir. Dis. 148:1633-1637.
3. Smith, J. J., S. M. Travis, E. P. Greenberg, and M. J. Welsh. 1996. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85:229-236.
4. Davies, J. C., M. Stern, A. Dewar, N. J. Caplen, F. M. Munkonge, T. Pitt, F. Sorgi, L. Huang, A. Bush, D. M. Geddes, and E. W. F. W. Alton. 1997. Cftr gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium. Am. J. Respir. Cell Mol. Biol. 16:657-663.
5. Baldwin, A. S., Jr. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
6. Zahm, J. M., D. Gaillard, F. Dupuit, J. Hinnrasky, D. Porteous, J. R. Dorin, and E. Puchelle. 1997. Early alterations in airway mucociliary clearance and inflammation of the lamina propria in CF mice. Am. J. Physiol. 272: C853-C859.
7. Alton, E. W. F. W., and D. M. Geddes. 1997. Gene therapy for cystic fibrosis: steady progress, should do well. Eur. Respir. J. 10:257-259.
8. Knowles, M. R., K. N. Olivier, K. W. Hohneker, J. Robinson, W. D. Bennett, and R. C. Boucher. 1995. Pharmacologic treatment of abnormal ion transport in the airway epithelium in cystic fibrosis. Adv. Exp. Med. Biol. 290:119-128.
9. Dorin, J. R., R. Farley, S. Webb, S. N. Smith, E. Farini, S. J. Delaney, B. J. Wainwright, E. W. F. W. Alton, and D. J. Porteous. 1996. A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Ther. 3:797-801.
10. Beavo, J. A. 1995. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75:725-748.
11. Becq, F., T. J. Jensen, X.-B. Chang, A. Savoia, J. M. Rommens, L.-C. Tsui, M. Buchwald, J. R. Riordan, and J. W. Hanrahan. 1994. Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc. Natl. Acad. Sci. USA 91:9160-9164.
12. Smith, S. N., S. J. Delaney, J. R. Dorin, R. Farley, D. M. Geddes, D. J. Porteous, B. J. Wainwright, and E. W. F. W. Alton. 1998. Effect of IBMX and alkaline phosphatase inhibitors on Cl secretion in G551D cystic fibrosis mutant mice. Am. J. Physiol. 274:C492-C499.
13. Grubb, B. R., E. Lazarowski, M. Knowles, and R. C. Boucher. 1993. Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia. Am. J. Respir. Cell Mol. Biol. 8:454-460.
14. Kelley, T. J., L. Al-Nakkash, and M. L. Drumm. 1995. CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 113:657-664.
15. Alousi, A. A., and D. C. Johnson. 1986. Pharmacology of the bypiridines: amrinone and milrinone. Circulation 73:11110-11124.
16. Butterworth, J. F., IV, R. L. Hines, R. L. Royster, and R. L. James. 1995. A pharmacokinetic and pharmacodynamic evaluation of milrinone in adults undergoing cardiac surgery. Anesth. Analg. 81:783-792.
17. Kelley, T. J., L. Al-Nakkash, C. U. Cotton, and M. L. Drumm. 1995. CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 13:657-664.
18. Drumm, M. L., and T. J. Kelley. 1995. Inhibition of specific phosphodiesterases in CF airway epithelial cells activates mutant CFTRs. Pediatr. Pulmonol. 20(Suppl. 12):150-151.
19. Kelley, T. J., K. Thomas, L. J. H. Milgram, and M. L. Drumm. 1997. In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant DF508 in murine nasal epithelium. Proc. Natl. Acad. Sci. USA 94: 2604-2608.
20. Yang, Y., J. F. Engelhardt, and J. M. Wilson. 1994. Ultrastructural localization of variant forms of cystic fibrosis transmembrane regulator in human bronchial epithelia of xenographs. Am. J. Respir. Cell Mol. Biol. 11:7-15.
21. Delaney, S. J., E. W. F. W. Alton, S. N. Smith, D. P. Lunn, R. Farley, P. K. Lovelock, S. A. Thompson, D. A. Hume, D. Lamb, D. J. Porteous, J. R. Dorin, and B. J. Wainwright. 1996. Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO J. 15:955-963.
22. Colledge, W. H., B. S. Abella, K. W. Southern, R. Ratcliff, C. Jiang, S. H. Cheng, L. J. Macvinish, J. R. Anderson, A. W. Cuthbert, and M. J. Evans. 1995. Generation and characterization of a delta F508 cystic fibrosis mouse model. Nat. Genet. 10:445-452.
23. Middleton, P. G., D. M. Geddes, and E. W. F. W. Alton. 1994. Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium. Eur. Respir. J. 7:2050-2056.
24. Knowles, M. R., A. M. Paradiso, and R. C. Boucher. 1995. In vivo nasal potential difference techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis. Hum. Gene Ther. 6:445-455.
25. Polla, B., V. Cappelli, M. Canepari, M. C. Zanardi, and C. Reggiani. 1995. Direct depressant effect of phosphodiesterase inhibitors on ATPase activity of rat cardiac myofibrils. Can. J. Physiol. Pharmacol. 73:661-664.
26. Smith, S. N., D. M. Steel, P. G. Middleton, F. M. Munkonge, D. M. Geddes, N. J. Caplen, D. J. Porteous, J. R. Dorin, and E. W. F. W. Alton. 1995. Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans. Am. J. Physiol. 268:C297-C307.
27. 2+ - mediated Cl secretion in nasal epithelia of CF mice. Am. J. Physiol. 266:C1478-C183.
28. Laurenza, A., E. M. Sutkowski, and K. B. Seamon. 1989. Forskolin, a specific stimulator of adenylate cyclase or a diterpene with multiple sites of action? Trends Pharmacol. Sci. 10:442-147.