Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors

American Journal of Respiratory Cell and Molecular Biology

Volumn 32, Issue 5, 2005, Pages 404-410

  Sinn, Patrick L ^b   Shah, Ankur J ^b   Donovan, Maureen D ^b   McCray Jr , Paul B ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

Gene transfer; Viral vectors; Viscoelastic gel

Indexed keywords

ADENOVIRUS VECTOR; AQUALON 7 MF; BETA GALACTOSIDASE; CARBOXYMETHYLCELLULOSE; EGTAZIC ACID; ENHANCED GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; LUCIFERASE; METHOCEL A 4C; METHYLCELLULOSE; PARVOVIRUS VECTOR; POLOXAMER; UNCLASSIFIED DRUG; VIRUS VECTOR;

AIRWAY CONDUCTANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG FORMULATION; GEL; GENE TRANSFER; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; MUCOCILIARY CLEARANCE; NONHUMAN; RESPIRATORY EPITHELIUM; VIRAL GENE DELIVERY SYSTEM; VISCOELASTICITY;

ADENOVIRIDAE; ADMINISTRATION, INTRANASAL; ANIMALS; GELS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LENTIVIRUS; LUMINESCENT PROTEINS; MICE; MUCOCILIARY CLEARANCE; NASAL MUCOSA;

ADENOVIRIDAE; ANIMALIA; LENTIVIRUS; PARVOVIRUS;

EID: 18244409874     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2004-0410OC     Document Type: Article

References (35)

1. Ferrari S, Geddes DM, Alton EW. Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis. Adv Drug Deliv Rev 2002;54:1373-1393.
2. Parsons DW, Grubb BR, Johnson LG, Boucher RC. Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent. Hum Gene Ther 1998;9:2661-2672.
3. Coyne CB, Kelly MM, Boucher RC, Johnson LG. Enhanced epithelial gene transfer by modulation of tight junctions with sodium caprate. Am J Respir Cell Mol Biol 2000;23:602-609.
4. Chu Q, St George JA, Lukason M, Cheng SH, Scheule RK, Eastman SJ. EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo. Hum Gene Ther 2001;12:455-467.
5. Wang G, Zabner J, Deering C, Launspach J, Shao J, Bodner M, Jolly DJ, Davidson BL, McCray PB Jr. Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo. Am J Respir Cell Mol Biol 2000;22:129-138.
6. Wang G, Slepushkin V, Zabner J, Keshavjee S, Johnston JC, Sauter SL, Jolly DJ, Dubensky TW Jr, Davidson BL, McCray PB Jr. Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect. J Clin invest 1999;104:R55-R62.
7. Walters RW, Grunst T, Bergelson JM, Finberg RW, Welsh MJ, Zabner J. Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. J Biol Chem 1999;274:10219-10226.
8. Croyle MA, Cheng X, Sandhu A, Wilson JM. Development of novel formulations that enhance adenoviral-mediated gene expression in the lung in vitro and in vivo. Mol Ther 2001;4:22-28.
9. Sinn PL, Hickey MA, Staber PD, Dylla DE, Jeffers SA, Davidson BL, Sanders DA, McCray PB Jr. Lentivirus pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independent of folate receptor-alpha. J Virol 2003;77:5902-5910.
10. Kobinger GP, Weiner DJ, Yu QC, Wilson JM. Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo. Nat Biotechnol 2001;19:225-230.
11. Halbert CL, Allen JM, Miller AD. Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors. J Virol 2001;75:6615-6624.
12. Duan D, Yue Y, Yan Z, Yang J, Engelhardt JF. Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus. J Clin Invest 2000;105:1573-1587.
13. Zabner J. Seiler M, Walters R, Kotin RM, Fulgeras W, Davidson BL, Chiorini JA. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. J Virol 2000;74:3852-3858.
14. Gao G, Vandenberghe LH, Alvira MR, Lu Y, Calcedo R, Zhou X, Wilson JM. Clades of Adeno-associated viruses are widely disseminated in human tissues. J Virol 2004;78:6381-6388.
15. Suarez S, Hickey AJ. Drug properties affecting aerosol behavior. Respir Care 2000;45:652-666.
16. Seiler MP, Luner P, Moninger TO, Karp PH, Keshavjee S, Zabner J. Thixotropic solutions enhance viral-mediated gene transfer to airway epithelia. Am J Respir Cell Mol Biol 2002;27:133-140.
17. Anderson RD, Haskell RE, Xia H, Roessler BJ, Davidson BL. A simple method for the rapid generation of recombinant adenovirus vectors. Gene Ther 2000;7:1034-1038.
18. Davidson BL, Chiorini JA. Recombinant adeno-associated viral vector types 4 and 5: preparation and application for CNS gene transfer. Methods Mol Med 2003;76:269-285.
19. Johnston JC, Gasmi M, Lim LE, Elder JH, Yee J-K, Jolly DJ, Campbell KP, Davidson BL, Sauter SL. Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors. J Virol 1999;73:4991-5000.
20. Kumar M, Bradow BP, Zimmerberg J. Large-scale production of pseudotyped lentiviral vectors using baculovirus gp64. Hum Gene Ther 2003;14:67-77.
21. Zabner J, Karp P, Seiler M, Phillips SL, Mitchell CJ, Saavedra M, Welsh M, Klingelhutz AJ. Development of cystic fibrosis and noncystic fibrosis airway cell lines. Am J Physiol Lung Cell Mol Physiol 2003;284: L844-L854.
22. Chen TM, Dulfano MJ. Mucus viscoelasticity and mucociliary transport rate. J Lab Clin Med 1978;91:423-431.
23. Wills P, Pritchard K, Cole P. Mucus transportability: the bovine trachea and frog palate models compared. Eur Respir J 1998;12:837-841.
24. Zabner J, Zeiher BG, Friedman E, Welsh MJ. Adenovirus-mediated gene transfer to cilitaed airway epithelia requires prolonged incubation time. J Virol 1996;70:6994-7003.
25. Wang G, Davidson BL, Melchert P, Slepushkin VA, Es HHGv, Bodner M, Jolly DJ, McCray PB Jr. Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia. J Virol 1998;72:9818-9826.
26. Walters RW, Grunst T, Bergelson JM. Finberg RW, Welsh MJ. Zabner J. Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. J Biol Chem 1999;274:10219-10226.
27. Zeiher BG, Eichwald E, Zabner J, Smith JJ, Puga AP, McCray PB Jr, Capecchi MR, Welsh MJ, Thomas KR. A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest 1995;96:2051-2064.
28. Parsons DW, Hopkins PJ, Bourne AJ, Boucher RC, Martin AJ. Airway gene transfer in mouse nasal-airways: importance of identification of epithelial type for assessment of gene transfer. Gene Ther 2000;7:1810-1815.
29. Mercer RR, Russell ML, Roggli VL, Crapo JD. Cell number and distribution in human and rat airways. Am J Respir Cell Mol Biol 1994;10:613-624.
30. Parent RH. Treatise on pulmonary toxicology: comparative biology of the normal lung. Boca Raton, FL: CRC Press, Inc.; 1999.
31. Di Pasquale G, Davidson BL, Stein CS, Martins I, Scudiero D, Monks A, Chiorini JA. Identification of PDGFR as a receptor for AAV5 transduction. Nat Med 2003;9:1306-1312.
32. Grindel JM, Jaworski T, Piraner O, Emanuele RM, Balasubramanian M. Distribution, metabolism, and excretion of a novel surface-active agent, purified poloxamer 188. in rats, dogs, and humans. J Pharm Sci 2002;91:1936-1947.
33. Ismail FA, Napaporn J, Hughes JA, Brazeau GA. In situ gel formulations for gene delivery: release and myotoxicity studies. Pharm Dev Technol 2000;5:391-397.
34. Johnston TP, Miller SC. Toxicological evaluation of poloxamer vehicles for intramuscular use. J Parenter Sci Technol 1985;39:83-89.
35. Ugwoke MI, Agu RU, Jorissen M, Augustijns P, Sciot R, Verbeke N, Kinget R. Toxicological investigations of the effects carboxymethyl-cellulose on ciliary beat frequency of human nasal epithelial cells in primary suspension culture and in vivo on rabbit nasal mucosa. Int J Pharm 2000;205:43-51.