메뉴 건너뛰기




Volumn 48, Issue 2, 2010, Pages 310-321

Alterations in mitochondrial function as a harbinger of cardiomyopathy: Lessons from the dystrophic heart

Author keywords

Cardioprotection; Cyclic GMP signalling; Duchenne muscular dystrophy; Energy substrate metabolism; Mitochondrial transition pore

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CALCIUM; CYCLIC GMP; CYCLOPHILIN A; CYCLOPHILIN D; CYCLOSPORIN A; CYCLOSPORIN A [3 N METHYL DEXTRO ALANINE 4 N ETHYLVALINE]; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; CYTOSKELETON PROTEIN; DYSTROPHIN; IDEBENONE; MITO Q; NITRIC OXIDE; PLACEBO; REACTIVE OXYGEN METABOLITE; SANGLIFEHRIN A; SELENIUM; SILDENAFIL; SNT MC 17; TADALAFIL; UNCLASSIFIED DRUG;

EID: 74149088716     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.09.004     Document Type: Review
Times cited : (47)

References (167)
  • 1
    • 14644425217 scopus 로고    scopus 로고
    • Mitochondrial energy metabolism in heart failure: a question of balance
    • Huss J.M., and Kelly D.P. Mitochondrial energy metabolism in heart failure: a question of balance. J. Clin. Invest. 115 (2005) 547-555
    • (2005) J. Clin. Invest. , vol.115 , pp. 547-555
    • Huss, J.M.1    Kelly, D.P.2
  • 2
    • 41249086364 scopus 로고    scopus 로고
    • Mitochondrial centrality in heart failure
    • Marin-Garcia J., and Goldenthal M.J. Mitochondrial centrality in heart failure. Heart Fail. Rev. 13 2 (2008) 137-150
    • (2008) Heart Fail. Rev. , vol.13 , Issue.2 , pp. 137-150
    • Marin-Garcia, J.1    Goldenthal, M.J.2
  • 4
    • 59449104627 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and dysfunction in myocardial remodelling
    • Tsutsui H., Kinugawa S., and Matsushima S. Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc. Res. 81 (2009) 449-456
    • (2009) Cardiovasc. Res. , vol.81 , pp. 449-456
    • Tsutsui, H.1    Kinugawa, S.2    Matsushima, S.3
  • 5
    • 46749125376 scopus 로고    scopus 로고
    • Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha
    • Ventura-Clapier R., Garnier A., and Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovasc. Res. 79 (2008) 208-217
    • (2008) Cardiovasc. Res. , vol.79 , pp. 208-217
    • Ventura-Clapier, R.1    Garnier, A.2    Veksler, V.3
  • 7
    • 51749113618 scopus 로고    scopus 로고
    • Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation
    • Rosca M.G., Vazquez E.J., Kerner J., Parland W., Chandler M.P., Stanley W., et al. Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. Cardiovasc. Res. 80 (2008) 30-39
    • (2008) Cardiovasc. Res. , vol.80 , pp. 30-39
    • Rosca, M.G.1    Vazquez, E.J.2    Kerner, J.3    Parland, W.4    Chandler, M.P.5    Stanley, W.6
  • 9
    • 44349134115 scopus 로고    scopus 로고
    • Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency
    • Khairallah M., Khairallah R.J., Young M.E., Allen B.G., Gillis M.A., Danialou G., et al. Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 7028-7033
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 7028-7033
    • Khairallah, M.1    Khairallah, R.J.2    Young, M.E.3    Allen, B.G.4    Gillis, M.A.5    Danialou, G.6
  • 10
    • 0033017374 scopus 로고    scopus 로고
    • Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy
    • Badorff C., Lee G.H., Lamphear B.J., Martone M.E., Campbell K.P., Rhoads R.E., et al. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat. Med. 5 (1999) 320-326
    • (1999) Nat. Med. , vol.5 , pp. 320-326
    • Badorff, C.1    Lee, G.H.2    Lamphear, B.J.3    Martone, M.E.4    Campbell, K.P.5    Rhoads, R.E.6
  • 11
    • 17844363973 scopus 로고    scopus 로고
    • Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury
    • Rodriguez M., Cai W.J., Kostin S., Lucchesi B.R., and Schaper J. Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury. J. Mol. Cell. Cardiol. 38 (2005) 723-733
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 723-733
    • Rodriguez, M.1    Cai, W.J.2    Kostin, S.3    Lucchesi, B.R.4    Schaper, J.5
  • 12
    • 0037117144 scopus 로고    scopus 로고
    • Molecular remodelling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance-device therapy
    • Vatta M., Stetson S.J., Perez-Verdia A., Entman M.L., Noon G.P., Torre-Amione G., et al. Molecular remodelling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance-device therapy. Lancet 359 (2002) 936-941
    • (2002) Lancet , vol.359 , pp. 936-941
    • Vatta, M.1    Stetson, S.J.2    Perez-Verdia, A.3    Entman, M.L.4    Noon, G.P.5    Torre-Amione, G.6
  • 13
    • 67149122523 scopus 로고    scopus 로고
    • Mechanisms of muscle degeneration, regeneration, and repair in the muscular dystrophies
    • Wallace G.Q., and McNally E.M. Mechanisms of muscle degeneration, regeneration, and repair in the muscular dystrophies. Annu. Rev. Physiol. 71 (2009) 37-57
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 37-57
    • Wallace, G.Q.1    McNally, E.M.2
  • 14
    • 0037050022 scopus 로고    scopus 로고
    • The failing heart
    • Towbin J.A., and Bowles N.E. The failing heart. Nature 415 (2002) 227-233
    • (2002) Nature , vol.415 , pp. 227-233
    • Towbin, J.A.1    Bowles, N.E.2
  • 15
    • 27144512277 scopus 로고    scopus 로고
    • Cardiac involvement in muscular dystrophies: molecular mechanisms
    • Goodwin F.C., and Muntoni F. Cardiac involvement in muscular dystrophies: molecular mechanisms. Muscle Nerve 32 (2005) 577-588
    • (2005) Muscle Nerve , vol.32 , pp. 577-588
    • Goodwin, F.C.1    Muntoni, F.2
  • 17
    • 0025017751 scopus 로고
    • The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy
    • Nigro G., Comi L.I., Politano L., and Bain R.J. The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy. Int. J. Cardiol. 26 (1990) 271-277
    • (1990) Int. J. Cardiol. , vol.26 , pp. 271-277
    • Nigro, G.1    Comi, L.I.2    Politano, L.3    Bain, R.J.4
  • 18
    • 0030981051 scopus 로고    scopus 로고
    • Dystrophies and heart disease
    • Cox G.F., and Kunkel L.M. Dystrophies and heart disease. Curr. Opin. Cardiol. 12 (1997) 329-343
    • (1997) Curr. Opin. Cardiol. , vol.12 , pp. 329-343
    • Cox, G.F.1    Kunkel, L.M.2
  • 19
    • 0041592634 scopus 로고    scopus 로고
    • Cardiomyopathic features associated with muscular dystrophy are independent of dystrophin absence in cardiovasculature
    • Hainsey T.A., Senapati S., Kuhn D.E., and Rafael J.A. Cardiomyopathic features associated with muscular dystrophy are independent of dystrophin absence in cardiovasculature. Neuromuscular Disord. 13 (2003) 294-302
    • (2003) Neuromuscular Disord. , vol.13 , pp. 294-302
    • Hainsey, T.A.1    Senapati, S.2    Kuhn, D.E.3    Rafael, J.A.4
  • 20
    • 0036633384 scopus 로고    scopus 로고
    • Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy
    • Zhu X., Wheeler M.T., Hadhazy M., Lam M.Y., and McNally E.M. Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. FASEB J. 16 (2002) 1096-1098
    • (2002) FASEB J. , vol.16 , pp. 1096-1098
    • Zhu, X.1    Wheeler, M.T.2    Hadhazy, M.3    Lam, M.Y.4    McNally, E.M.5
  • 21
    • 0028268254 scopus 로고
    • Prevalence of left ventricular systolic dysfunction in Duchenne muscular dystrophy: an echocardiographic study
    • de Kermadec J.M., Becane H.M., Chenard A., Tertrain F., and Weiss Y. Prevalence of left ventricular systolic dysfunction in Duchenne muscular dystrophy: an echocardiographic study. Am. Heart J. 127 (1994) 618-623
    • (1994) Am. Heart J. , vol.127 , pp. 618-623
    • de Kermadec, J.M.1    Becane, H.M.2    Chenard, A.3    Tertrain, F.4    Weiss, Y.5
  • 22
    • 0023270887 scopus 로고
    • Life spans of Duchenne muscular dystrophy patients in the hospital care program in Japan
    • Mukoyama M., Kondo K., Hizawa K., and Nishitani H. Life spans of Duchenne muscular dystrophy patients in the hospital care program in Japan. J. Neurol. Sci. 81 (1987) 155-158
    • (1987) J. Neurol. Sci. , vol.81 , pp. 155-158
    • Mukoyama, M.1    Kondo, K.2    Hizawa, K.3    Nishitani, H.4
  • 24
    • 0032852539 scopus 로고    scopus 로고
    • Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy
    • Bia B.L., Cassidy P.J., Young M.E., Rafael J.A., Leighton B., Davies K.E., et al. Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy. J. Mol. Cell. Cardiol. 31 (1999) 1857-1862
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 1857-1862
    • Bia, B.L.1    Cassidy, P.J.2    Young, M.E.3    Rafael, J.A.4    Leighton, B.5    Davies, K.E.6
  • 25
    • 11244256463 scopus 로고    scopus 로고
    • Dystrophin-and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteins
    • Wilding J.R., Schneider J.E., Sang A.E., Davies K.E., Neubauer S., and Clarke K. Dystrophin-and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteins. FASEB J. 19 (2005) 79-81
    • (2005) FASEB J. , vol.19 , pp. 79-81
    • Wilding, J.R.1    Schneider, J.E.2    Sang, A.E.3    Davies, K.E.4    Neubauer, S.5    Clarke, K.6
  • 27
    • 0035403114 scopus 로고    scopus 로고
    • Dystrophin-deficient cardiomyocytes are abnormally vulnerable to mechanical stress-induced contractile failure and injury
    • Danialou G., Comtois A.S., Dudley R., Karpati G., Vincent G., Des Rosiers C., et al. Dystrophin-deficient cardiomyocytes are abnormally vulnerable to mechanical stress-induced contractile failure and injury. FASEB J. 15 (2001) 1655-1657
    • (2001) FASEB J. , vol.15 , pp. 1655-1657
    • Danialou, G.1    Comtois, A.S.2    Dudley, R.3    Karpati, G.4    Vincent, G.5    Des Rosiers, C.6
  • 29
    • 0037024377 scopus 로고    scopus 로고
    • Progression of dystrophic features and activation of mitogen-activated protein kinases and calcineurin by physical exercise in hearts of mdx mice
    • Nakamura A., Yoshida K., Takeda S., Dohi N., and Ikeda S. Progression of dystrophic features and activation of mitogen-activated protein kinases and calcineurin by physical exercise in hearts of mdx mice. FEBS Lett. 520 (2002) 18-24
    • (2002) FEBS Lett. , vol.520 , pp. 18-24
    • Nakamura, A.1    Yoshida, K.2    Takeda, S.3    Dohi, N.4    Ikeda, S.5
  • 30
    • 0031908112 scopus 로고    scopus 로고
    • The molecular basis of activity-induced muscle injury in Duchenne muscular dystrophy
    • Petrof B.J. The molecular basis of activity-induced muscle injury in Duchenne muscular dystrophy. Mol. Cell. Biochem. 179 (1998) 111-123
    • (1998) Mol. Cell. Biochem. , vol.179 , pp. 111-123
    • Petrof, B.J.1
  • 31
    • 0036839039 scopus 로고    scopus 로고
    • Molecular pathophysiology of myofiber injury in deficiencies of the dystrophin-glycoprotein complex
    • Petrof B.J. Molecular pathophysiology of myofiber injury in deficiencies of the dystrophin-glycoprotein complex. Am. J. Phys. Med. Rehabil. 81 (2002) S162-S174
    • (2002) Am. J. Phys. Med. Rehabil. , vol.81
    • Petrof, B.J.1
  • 32
    • 33846605594 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b
    • Oceandy D., Cartwright E.J., Emerson M., Prehar S., Baudoin F.M., Zi M., et al. Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 115 (2007) 483-492
    • (2007) Circulation , vol.115 , pp. 483-492
    • Oceandy, D.1    Cartwright, E.J.2    Emerson, M.3    Prehar, S.4    Baudoin, F.M.5    Zi, M.6
  • 33
    • 0035923615 scopus 로고    scopus 로고
    • Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection
    • Kanai A.J., Pearce L.L., Clemens P.R., Birder L.A., VanBibber M.M., Choi S.Y., et al. Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 14126-14131
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 14126-14131
    • Kanai, A.J.1    Pearce, L.L.2    Clemens, P.R.3    Birder, L.A.4    VanBibber, M.M.5    Choi, S.Y.6
  • 34
    • 6444242933 scopus 로고    scopus 로고
    • Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat
    • Bendall J.K., Damy T., Ratajczak P., Loyer X., Monceau V., Marty I., et al. Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. Circulation 110 (2004) 2368-2375
    • (2004) Circulation , vol.110 , pp. 2368-2375
    • Bendall, J.K.1    Damy, T.2    Ratajczak, P.3    Loyer, X.4    Monceau, V.5    Marty, I.6
  • 35
  • 36
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart-an engine out of fuel
    • Neubauer S. The failing heart-an engine out of fuel. N. Engl. J. Med. 356 (2007) 1140-1151
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 37
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley W.C., Recchia F.A., and Lopaschuk G.D. Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 85 (2005) 1093-1129
    • (2005) Physiol. Rev. , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 39
    • 59449085388 scopus 로고    scopus 로고
    • Energy metabolism in heart failure and remodelling
    • Ingwall J.S. Energy metabolism in heart failure and remodelling. Cardiovasc. Res. 81 (2009) 412-419
    • (2009) Cardiovasc. Res. , vol.81 , pp. 412-419
    • Ingwall, J.S.1
  • 41
    • 33744521893 scopus 로고    scopus 로고
    • Specific and sustained down-regulation of genes involved in fatty acid metabolism is not a hallmark of progression to cardiac failure in mice
    • de Brouwer K.F., Degens H., Aartsen W.M., Lindhout M., Bitsch N.J., Gilde A.J., et al. Specific and sustained down-regulation of genes involved in fatty acid metabolism is not a hallmark of progression to cardiac failure in mice. J. Mol. Cell. Cardiol. 40 (2006) 838-845
    • (2006) J. Mol. Cell. Cardiol. , vol.40 , pp. 838-845
    • de Brouwer, K.F.1    Degens, H.2    Aartsen, W.M.3    Lindhout, M.4    Bitsch, N.J.5    Gilde, A.J.6
  • 44
    • 13944250273 scopus 로고    scopus 로고
    • Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid
    • Labarthe F., Khairallah M., Bouchard B., Stanley W.C., and Des Rosiers C. Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H1425-H1436
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288
    • Labarthe, F.1    Khairallah, M.2    Bouchard, B.3    Stanley, W.C.4    Des Rosiers, C.5
  • 45
    • 0345708433 scopus 로고    scopus 로고
    • Regulation of myocardial triacylglycerol synthesis and metabolism
    • Lewin T.M., and Coleman R.A. Regulation of myocardial triacylglycerol synthesis and metabolism. Biochim. Biophys. Acta 1634 (2003) 63-75
    • (2003) Biochim. Biophys. Acta , vol.1634 , pp. 63-75
    • Lewin, T.M.1    Coleman, R.A.2
  • 46
    • 11144346132 scopus 로고    scopus 로고
    • Mouse models of mitochondrial dysfunction and heart failure
    • Russell L.K., Finck B.N., and Kelly D.P. Mouse models of mitochondrial dysfunction and heart failure. J. Mol. Cell. Cardiol. 38 (2005) 81-91
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 81-91
    • Russell, L.K.1    Finck, B.N.2    Kelly, D.P.3
  • 47
    • 7744234747 scopus 로고    scopus 로고
    • Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
    • Sharma S., Adrogue J.V., Golfman L., Uray I., Lemm J., Youker K., et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB. J. 18 (2004) 1692-1700
    • (2004) FASEB. J. , vol.18 , pp. 1692-1700
    • Sharma, S.1    Adrogue, J.V.2    Golfman, L.3    Uray, I.4    Lemm, J.5    Youker, K.6
  • 50
    • 48849089048 scopus 로고    scopus 로고
    • Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation
    • Khairallah R.J., Khairallah M., Gelinas R., Bouchard B., Young M.E., Allen B.G., et al. Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation. J. Mol. Cell. Cardiol. 45 (2008) 230-239
    • (2008) J. Mol. Cell. Cardiol. , vol.45 , pp. 230-239
    • Khairallah, R.J.1    Khairallah, M.2    Gelinas, R.3    Bouchard, B.4    Young, M.E.5    Allen, B.G.6
  • 54
    • 33646462136 scopus 로고    scopus 로고
    • Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    • Haemmerle G., Lass A., Zimmermann R., Gorkiewicz G., Meyer C., Rozman J., et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312 (2006) 734-737
    • (2006) Science , vol.312 , pp. 734-737
    • Haemmerle, G.1    Lass, A.2    Zimmermann, R.3    Gorkiewicz, G.4    Meyer, C.5    Rozman, J.6
  • 56
    • 1642306943 scopus 로고    scopus 로고
    • Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons
    • Khairallah M., Labarthe F., Bouchard B., Danialou G., Petrof B.J., and Des Rosiers C. Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H1461-H1470
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • Khairallah, M.1    Labarthe, F.2    Bouchard, B.3    Danialou, G.4    Petrof, B.J.5    Des Rosiers, C.6
  • 57
    • 0034981033 scopus 로고    scopus 로고
    • Depressed myocardial fatty acid metabolism in patients with muscular dystrophy
    • Momose M., Iguchi N., Imamura K., Usui H., Ueda T., Miyamoto K., et al. Depressed myocardial fatty acid metabolism in patients with muscular dystrophy. Neuromuscul. Disord. 11 (2001) 464-469
    • (2001) Neuromuscul. Disord. , vol.11 , pp. 464-469
    • Momose, M.1    Iguchi, N.2    Imamura, K.3    Usui, H.4    Ueda, T.5    Miyamoto, K.6
  • 58
    • 3142586950 scopus 로고    scopus 로고
    • The relationship between clinical stage, prognosis and myocardial damage in patients with Duchenne-type muscular dystrophy: five-year follow-up study
    • Naruse H., Miyagi J., Arii T., Ohyanagi M., Iwasaki T., and Jinnai K. The relationship between clinical stage, prognosis and myocardial damage in patients with Duchenne-type muscular dystrophy: five-year follow-up study. Ann. Nucl. Med. 18 (2004) 203-208
    • (2004) Ann. Nucl. Med. , vol.18 , pp. 203-208
    • Naruse, H.1    Miyagi, J.2    Arii, T.3    Ohyanagi, M.4    Iwasaki, T.5    Jinnai, K.6
  • 59
    • 0021360614 scopus 로고
    • Alterations in regional myocardial metabolism, perfusion, and wall motion in Duchenne muscular dystrophy studied by radionuclide imaging
    • Perloff J.K., Henze E., and Schelbert H.R. Alterations in regional myocardial metabolism, perfusion, and wall motion in Duchenne muscular dystrophy studied by radionuclide imaging. Circulation 69 (1984) 33-42
    • (1984) Circulation , vol.69 , pp. 33-42
    • Perloff, J.K.1    Henze, E.2    Schelbert, H.R.3
  • 61
    • 11144253483 scopus 로고    scopus 로고
    • Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt
    • Matsui T., and Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J. Mol. Cell. Cardiol. 38 (2005) 63-71
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 63-71
    • Matsui, T.1    Rosenzweig, A.2
  • 62
    • 22544469153 scopus 로고    scopus 로고
    • AMP-activated protein kinase: a key stress signaling pathway in the heart
    • Young L.H., Li J., Baron S.J., and Russell R.R. AMP-activated protein kinase: a key stress signaling pathway in the heart. Trends Cardiovasc. Med. 15 (2005) 110-118
    • (2005) Trends Cardiovasc. Med. , vol.15 , pp. 110-118
    • Young, L.H.1    Li, J.2    Baron, S.J.3    Russell, R.R.4
  • 63
    • 0035977050 scopus 로고    scopus 로고
    • Kelly DP. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response
    • Barger P.M., Browning A.C., and Garner A.N. Kelly DP. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J. Biol. Chem. 276 (2001) 44495-44501
    • (2001) J. Biol. Chem. , vol.276 , pp. 44495-44501
    • Barger, P.M.1    Browning, A.C.2    Garner, A.N.3
  • 64
    • 1342333897 scopus 로고    scopus 로고
    • Regulation of nitric oxide and soluble guanylyl cyclase
    • Krumenacker J.S., Hanafy K.A., and Murad F. Regulation of nitric oxide and soluble guanylyl cyclase. Brain Res. Bull. 62 (2004) 505-515
    • (2004) Brain Res. Bull. , vol.62 , pp. 505-515
    • Krumenacker, J.S.1    Hanafy, K.A.2    Murad, F.3
  • 65
    • 30744450770 scopus 로고    scopus 로고
    • The role of natriuretic peptides in cardioprotection
    • Nishikimi T., Maeda N., and Matsuoka H. The role of natriuretic peptides in cardioprotection. Cardiovasc. Res. 69 (2006) 318-328
    • (2006) Cardiovasc. Res. , vol.69 , pp. 318-328
    • Nishikimi, T.1    Maeda, N.2    Matsuoka, H.3
  • 67
    • 26444450721 scopus 로고    scopus 로고
    • Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium
    • Wehling-Henricks M., Jordan M.C., Roos K.P., Deng B., and Tidball J.G. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Hum. Mol. Genet. 14 (2005) 1921-1933
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 1921-1933
    • Wehling-Henricks, M.1    Jordan, M.C.2    Roos, K.P.3    Deng, B.4    Tidball, J.G.5
  • 69
    • 0036278874 scopus 로고    scopus 로고
    • Role of nitric oxide in the regulation of substrate metabolism in heart failure
    • Recchia F.A. Role of nitric oxide in the regulation of substrate metabolism in heart failure. Heart Fail. Rev. 7 (2002) 141-148
    • (2002) Heart Fail. Rev. , vol.7 , pp. 141-148
    • Recchia, F.A.1
  • 71
    • 0026767326 scopus 로고
    • Metabolic heterogeneity of carbon substrate utilization in mammalian heart: NMR determinations of mitochondrial versus cytosolic compartmentation
    • Lewandowski E.D. Metabolic heterogeneity of carbon substrate utilization in mammalian heart: NMR determinations of mitochondrial versus cytosolic compartmentation. Biochemistry 31 (1992) 8916-8923
    • (1992) Biochemistry , vol.31 , pp. 8916-8923
    • Lewandowski, E.D.1
  • 72
    • 0029584711 scopus 로고
    • Calcium regulation of glycolysis, glucose oxidation, and fatty acid oxidation in the aerobic and ischemic heart
    • Schonekess B.O., Brindley P.G., and Lopaschuk G.D. Calcium regulation of glycolysis, glucose oxidation, and fatty acid oxidation in the aerobic and ischemic heart. Can. J. Physiol. Pharmacol. 73 (1995) 1632-1640
    • (1995) Can. J. Physiol. Pharmacol. , vol.73 , pp. 1632-1640
    • Schonekess, B.O.1    Brindley, P.G.2    Lopaschuk, G.D.3
  • 73
    • 0034638834 scopus 로고    scopus 로고
    • Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology
    • Chen Y.W., Zhao P., Borup R., and Hoffman E.P. Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J. Cell. Biol. 151 (2000) 1321-1336
    • (2000) J. Cell. Biol. , vol.151 , pp. 1321-1336
    • Chen, Y.W.1    Zhao, P.2    Borup, R.3    Hoffman, E.P.4
  • 74
    • 56049107038 scopus 로고    scopus 로고
    • PGC-1 coactivators and skeletal muscle adaptations in health and disease
    • Arany Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr. Opin. Genet. Dev. 18 (2008) 426-434
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 426-434
    • Arany, Z.1
  • 75
    • 34147109662 scopus 로고    scopus 로고
    • PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
    • Handschin C., Kobayashi Y.M., Chin S., Seale P., Campbell K.P., and Spiegelman B.M. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev. 21 (2007) 770-783
    • (2007) Genes Dev. , vol.21 , pp. 770-783
    • Handschin, C.1    Kobayashi, Y.M.2    Chin, S.3    Seale, P.4    Campbell, K.P.5    Spiegelman, B.M.6
  • 76
    • 55649122277 scopus 로고    scopus 로고
    • Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study
    • Zhang W., ten Hove M., Schneider J.E., Stuckey D.J., Sebag-Montefiore L., Bia B.L., et al. Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study. J. Mol. Cell. Cardiol. 45 (2008) 754-760
    • (2008) J. Mol. Cell. Cardiol. , vol.45 , pp. 754-760
    • Zhang, W.1    ten Hove, M.2    Schneider, J.E.3    Stuckey, D.J.4    Sebag-Montefiore, L.5    Bia, B.L.6
  • 77
    • 0033118649 scopus 로고    scopus 로고
    • Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death
    • Duchen M.R. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J. Physiol. 516 Pt 1 (1999 Apr 1) 1-17
    • (1999) J. Physiol. , vol.516 , Issue.PART 1 , pp. 1-17
    • Duchen, M.R.1
  • 78
    • 0031587822 scopus 로고    scopus 로고
    • Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals
    • Ichas F., Jouaville L.S., and Mazat J.P. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89 (1997) 1145-1153
    • (1997) Cell , vol.89 , pp. 1145-1153
    • Ichas, F.1    Jouaville, L.S.2    Mazat, J.P.3
  • 79
    • 0028342740 scopus 로고
    • Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling
    • Ichas F., Jouaville L.S., Sidash S.S., Mazat J.P., and Holmuhamedov E.L. Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling. FEBS Lett. 348 (1994) 211-215
    • (1994) FEBS Lett. , vol.348 , pp. 211-215
    • Ichas, F.1    Jouaville, L.S.2    Sidash, S.S.3    Mazat, J.P.4    Holmuhamedov, E.L.5
  • 80
    • 0032504717 scopus 로고    scopus 로고
    • From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low-to high-conductance state
    • Ichas F., and Mazat J.P. From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low-to high-conductance state. Biochim. Biophys. Acta 1366 (1998) 33-50
    • (1998) Biochim. Biophys. Acta , vol.1366 , pp. 33-50
    • Ichas, F.1    Mazat, J.P.2
  • 81
    • 0034467521 scopus 로고    scopus 로고
    • Analysis of the pathways of nitric oxide utilization in mitochondria
    • Cadenas E., Poderoso J.J., Antunes F., and Boveris A. Analysis of the pathways of nitric oxide utilization in mitochondria. Free Radic. Res. 33 (2000) 747-756
    • (2000) Free Radic. Res. , vol.33 , pp. 747-756
    • Cadenas, E.1    Poderoso, J.J.2    Antunes, F.3    Boveris, A.4
  • 82
    • 0036139856 scopus 로고    scopus 로고
    • The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology
    • Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 52 (2001) 159-164
    • (2001) IUBMB Life , vol.52 , pp. 159-164
    • Lenaz, G.1
  • 83
    • 0033627864 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress: a self-propagating process with implications for signaling cascades
    • Poderoso J.J., Boveris A., and Cadenas E. Mitochondrial oxidative stress: a self-propagating process with implications for signaling cascades. Biofactors 11 (2000) 43-45
    • (2000) Biofactors , vol.11 , pp. 43-45
    • Poderoso, J.J.1    Boveris, A.2    Cadenas, E.3
  • 84
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens J.F. Mitochondrial formation of reactive oxygen species. J. Physiol. 552 (2003) 335-344
    • (2003) J. Physiol. , vol.552 , pp. 335-344
    • Turrens, J.F.1
  • 85
    • 0032544268 scopus 로고    scopus 로고
    • Apoptotic pathways: the roads to ruin
    • Green D.R. Apoptotic pathways: the roads to ruin. Cell 94 (1998) 695-698
    • (1998) Cell , vol.94 , pp. 695-698
    • Green, D.R.1
  • 86
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 87
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 88
    • 0013198976 scopus 로고    scopus 로고
    • Mitochondria in cell death: novel targets for neuroprotection and cardioprotection
    • Mattson M.P., and Kroemer G. Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. Trends Mol. Med. 9 (2003) 196-205
    • (2003) Trends Mol. Med. , vol.9 , pp. 196-205
    • Mattson, M.P.1    Kroemer, G.2
  • 89
    • 0036479001 scopus 로고    scopus 로고
    • And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis
    • Waterhouse N.J., Ricci J.E., and Green D.R. And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie 84 (2002) 113-121
    • (2002) Biochimie , vol.84 , pp. 113-121
    • Waterhouse, N.J.1    Ricci, J.E.2    Green, D.R.3
  • 90
    • 11144300815 scopus 로고    scopus 로고
    • Mitochondrial permeability transitions: how many doors to the house?
    • Zoratti M., Szabo I., and De Marchi U. Mitochondrial permeability transitions: how many doors to the house?. Biochim. Biophys. Acta 1706 (2005) 40-52
    • (2005) Biochim. Biophys. Acta , vol.1706 , pp. 40-52
    • Zoratti, M.1    Szabo, I.2    De Marchi, U.3
  • 94
    • 0035896205 scopus 로고    scopus 로고
    • Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction
    • Ide T., Tsutsui H., Hayashidani S., Kang D., Suematsu N., Nakamura K., et al. Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ. Res. 88 (2001) 529-535
    • (2001) Circ. Res. , vol.88 , pp. 529-535
    • Ide, T.1    Tsutsui, H.2    Hayashidani, S.3    Kang, D.4    Suematsu, N.5    Nakamura, K.6
  • 95
    • 0033588198 scopus 로고    scopus 로고
    • Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium
    • Ide T., Tsutsui H., Kinugawa S., Utsumi H., Kang D., Hattori N., et al. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ. Res. 85 (1999) 357-363
    • (1999) Circ. Res. , vol.85 , pp. 357-363
    • Ide, T.1    Tsutsui, H.2    Kinugawa, S.3    Utsumi, H.4    Kang, D.5    Hattori, N.6
  • 96
    • 0342445429 scopus 로고    scopus 로고
    • Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy
    • Jarreta D., Orus J., Barrientos A., Miro O., Roig E., Heras M., et al. Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovasc. Res. 45 (2000) 860-865
    • (2000) Cardiovasc. Res. , vol.45 , pp. 860-865
    • Jarreta, D.1    Orus, J.2    Barrientos, A.3    Miro, O.4    Roig, E.5    Heras, M.6
  • 97
    • 11144293491 scopus 로고    scopus 로고
    • NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat
    • Javadov S., Huang C., Kirshenbaum L., and Karmazyn M. NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat. J. Mol. Cell. Cardiol. 38 (2005) 135-143
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 135-143
    • Javadov, S.1    Huang, C.2    Kirshenbaum, L.3    Karmazyn, M.4
  • 98
    • 4744348381 scopus 로고    scopus 로고
    • In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure
    • Moe G.W., Marin-Garcia J., Konig A., Goldenthal M., Lu X., and Feng Q. In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H1813-H1820
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.287
    • Moe, G.W.1    Marin-Garcia, J.2    Konig, A.3    Goldenthal, M.4    Lu, X.5    Feng, Q.6
  • 99
    • 0037132631 scopus 로고    scopus 로고
    • Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression
    • Scheubel R.J., Tostlebe M., Simm A., Rohrbach S., Prondzinsky R., Gellerich F.N., et al. Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression. J. Am. Coll. Cardiol. 40 (2002) 2174-2181
    • (2002) J. Am. Coll. Cardiol. , vol.40 , pp. 2174-2181
    • Scheubel, R.J.1    Tostlebe, M.2    Simm, A.3    Rohrbach, S.4    Prondzinsky, R.5    Gellerich, F.N.6
  • 101
    • 0015594940 scopus 로고
    • Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure
    • Sordahl L.A., McCollum W.B., Wood W.G., and Schwartz A. Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am. J. Physiol. 224 (1973) 497-502
    • (1973) Am. J. Physiol. , vol.224 , pp. 497-502
    • Sordahl, L.A.1    McCollum, W.B.2    Wood, W.G.3    Schwartz, A.4
  • 102
    • 0021935929 scopus 로고
    • Oxygen radicals and tissue damage in heart hypertrophy
    • Guarnieri C., Muscari C., and Caldarera C.M. Oxygen radicals and tissue damage in heart hypertrophy. Adv. Myocardiol. 5 (1985) 191-199
    • (1985) Adv. Myocardiol. , vol.5 , pp. 191-199
    • Guarnieri, C.1    Muscari, C.2    Caldarera, C.M.3
  • 104
    • 0032819735 scopus 로고    scopus 로고
    • Is age a contributory factor of mitochondrial bioenergetic decline and DNA defects in idiopathic dilated cardiomyopathy?
    • Marin-Garcia J., Goldenthal M.J., Pierpont E.M., Ananthakrishnan R., and Perez-Atayde A. Is age a contributory factor of mitochondrial bioenergetic decline and DNA defects in idiopathic dilated cardiomyopathy?. Cardiovasc. Pathol. 8 (1999) 217-222
    • (1999) Cardiovasc. Pathol. , vol.8 , pp. 217-222
    • Marin-Garcia, J.1    Goldenthal, M.J.2    Pierpont, E.M.3    Ananthakrishnan, R.4    Perez-Atayde, A.5
  • 105
    • 33646679144 scopus 로고    scopus 로고
    • Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice
    • Matsushima S., Ide T., Yamato M., Matsusaka H., Hattori F., Ikeuchi M., et al. Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation 113 (2006) 1779-1786
    • (2006) Circulation , vol.113 , pp. 1779-1786
    • Matsushima, S.1    Ide, T.2    Yamato, M.3    Matsusaka, H.4    Hattori, F.5    Ikeuchi, M.6
  • 106
    • 0036271486 scopus 로고    scopus 로고
    • Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure
    • Moe G.W., Naik G., Konig A., Lu X., and Feng Q. Early and persistent activation of myocardial apoptosis, bax and caspases: insights into mechanisms of progression of heart failure. Pathophysiology 8 (2002) 183-192
    • (2002) Pathophysiology , vol.8 , pp. 183-192
    • Moe, G.W.1    Naik, G.2    Konig, A.3    Lu, X.4    Feng, Q.5
  • 109
    • 33845628634 scopus 로고    scopus 로고
    • Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure
    • Sharov V.G., Todor A., Khanal S., Imai M., and Sabbah H.N. Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure. J. Mol. Cell. Cardiol. 42 (2007) 150-158
    • (2007) J. Mol. Cell. Cardiol. , vol.42 , pp. 150-158
    • Sharov, V.G.1    Todor, A.2    Khanal, S.3    Imai, M.4    Sabbah, H.N.5
  • 110
    • 0033529281 scopus 로고    scopus 로고
    • Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
    • Narula J., Pandey P., Arbustini E., Haider N., Narula N., Kolodgie F.D., et al. Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 8144-8149
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 8144-8149
    • Narula, J.1    Pandey, P.2    Arbustini, E.3    Haider, N.4    Narula, N.5    Kolodgie, F.D.6
  • 111
    • 0037028646 scopus 로고    scopus 로고
    • Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival?
    • Scheubel R.J., Bartling B., Simm A., Silber R.E., Drogaris K., Darmer D., et al. Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival?. J. Am. Coll. Cardiol. 39 (2002) 481-488
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 481-488
    • Scheubel, R.J.1    Bartling, B.2    Simm, A.3    Silber, R.E.4    Drogaris, K.5    Darmer, D.6
  • 112
    • 8844235617 scopus 로고    scopus 로고
    • The mitochondrial death pathway and cardiac myocyte apoptosis
    • Crow M.T., Mani K., Nam Y.J., and Kitsis R.N. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ. Res. 95 (2004) 957-970
    • (2004) Circ. Res. , vol.95 , pp. 957-970
    • Crow, M.T.1    Mani, K.2    Nam, Y.J.3    Kitsis, R.N.4
  • 113
    • 33751210925 scopus 로고    scopus 로고
    • Compensated volume overload increases the vulnerability of heart mitochondria without affecting their functions in the absence of stress
    • Marcil M., Ascah A., Matas J., Belanger S., Deschepper C.F., and Burelle Y. Compensated volume overload increases the vulnerability of heart mitochondria without affecting their functions in the absence of stress. J. Mol. Cell. Cardiol. 41 (2006) 998-1009
    • (2006) J. Mol. Cell. Cardiol. , vol.41 , pp. 998-1009
    • Marcil, M.1    Ascah, A.2    Matas, J.3    Belanger, S.4    Deschepper, C.F.5    Burelle, Y.6
  • 114
    • 59149099105 scopus 로고    scopus 로고
    • Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy
    • Matas J., Young N.T., Bourcier-Lucas C., Ascah A., Marcil M., Deschepper C.F., et al. Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy. J. Mol. Cell. Cardiol. 46 (2009) 420-430
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 420-430
    • Matas, J.1    Young, N.T.2    Bourcier-Lucas, C.3    Ascah, A.4    Marcil, M.5    Deschepper, C.F.6
  • 117
    • 0025072082 scopus 로고
    • Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts
    • Anderson P.G., Allard M.F., Thomas G.D., Bishop S.P., and Digerness S.B. Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts. Circ. Res. 67 (1990) 948-959
    • (1990) Circ. Res. , vol.67 , pp. 948-959
    • Anderson, P.G.1    Allard, M.F.2    Thomas, G.D.3    Bishop, S.P.4    Digerness, S.B.5
  • 118
    • 0025216047 scopus 로고
    • Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy
    • Gaasch W.H., Zile M.R., Hoshino P.K., Weinberg E.O., Rhodes D.R., and Apstein C.S. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation 81 (1990) 1644-1653
    • (1990) Circulation , vol.81 , pp. 1644-1653
    • Gaasch, W.H.1    Zile, M.R.2    Hoshino, P.K.3    Weinberg, E.O.4    Rhodes, D.R.5    Apstein, C.S.6
  • 119
    • 33750921779 scopus 로고    scopus 로고
    • Short term training attenuates opening of the mitochondrial permeability transition pore without affecting myocardial function following ischemia-reperfusion
    • Ciminelli M., Ascah A., Bourduas K., and Burelle Y. Short term training attenuates opening of the mitochondrial permeability transition pore without affecting myocardial function following ischemia-reperfusion. Mol. Cell. Biochem. 291 (2006) 39-47
    • (2006) Mol. Cell. Biochem. , vol.291 , pp. 39-47
    • Ciminelli, M.1    Ascah, A.2    Bourduas, K.3    Burelle, Y.4
  • 120
    • 0028968606 scopus 로고
    • Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
    • Griffiths E.J., and Halestrap A.P. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem. J. 307 (1995) 93-98
    • (1995) Biochem. J. , vol.307 , pp. 93-98
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 121
    • 41849118741 scopus 로고    scopus 로고
    • Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy
    • Millay D.P., Sargent M.A., Osinska H., Baines C.P., Barton E.R., Vuagniaux G., et al. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat. Med. 14 (2008) 442-447
    • (2008) Nat. Med. , vol.14 , pp. 442-447
    • Millay, D.P.1    Sargent, M.A.2    Osinska, H.3    Baines, C.P.4    Barton, E.R.5    Vuagniaux, G.6
  • 122
    • 58849108906 scopus 로고    scopus 로고
    • Cyclosporine A treatment for Ullrich congenital muscular dystrophy: a cellular study of mitochondrial dysfunction and its rescue
    • Hicks D., Lampe A.K., Laval S.H., Allamand V., Jimenez-Mallebrera C., Walter M.C., et al. Cyclosporine A treatment for Ullrich congenital muscular dystrophy: a cellular study of mitochondrial dysfunction and its rescue. Brain 132 (2009) 147-155
    • (2009) Brain , vol.132 , pp. 147-155
    • Hicks, D.1    Lampe, A.K.2    Laval, S.H.3    Allamand, V.4    Jimenez-Mallebrera, C.5    Walter, M.C.6
  • 123
    • 33846477445 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins
    • Angelin A., Tiepolo T., Sabatelli P., Grumati P., Bergamin N., Golfieri C., et al. Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 991-996
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 991-996
    • Angelin, A.1    Tiepolo, T.2    Sabatelli, P.3    Grumati, P.4    Bergamin, N.5    Golfieri, C.6
  • 124
    • 53849097675 scopus 로고    scopus 로고
    • Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy
    • Reutenauer J., Dorchies O.M., Patthey-Vuadens O., Vuagniaux G., and Ruegg U.T. Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy. Br. J. Pharmacol. 155 (2008) 574-584
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 574-584
    • Reutenauer, J.1    Dorchies, O.M.2    Patthey-Vuadens, O.3    Vuagniaux, G.4    Ruegg, U.T.5
  • 125
    • 0032735294 scopus 로고    scopus 로고
    • Cardiomyopathy in duchenne, becker, and sarcoglycanopathies: a role for coronary dysfunction?
    • Gnecchi-Ruscone T., Taylor J., Mercuri E., Paternostro G., Pogue R., Bushby K., et al. Cardiomyopathy in duchenne, becker, and sarcoglycanopathies: a role for coronary dysfunction?. Muscle Nerve 22 (1999) 1549-1556
    • (1999) Muscle Nerve , vol.22 , pp. 1549-1556
    • Gnecchi-Ruscone, T.1    Taylor, J.2    Mercuri, E.3    Paternostro, G.4    Pogue, R.5    Bushby, K.6
  • 126
    • 0015219671 scopus 로고
    • Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions
    • Mendell J.R., Engel W.K., and Derrer E.C. Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions. Science 172 (1971) 1143-1145
    • (1971) Science , vol.172 , pp. 1143-1145
    • Mendell, J.R.1    Engel, W.K.2    Derrer, E.C.3
  • 127
    • 0029116916 scopus 로고
    • The mitochondrial permeability transition
    • Zoratti M., and Szabo I. The mitochondrial permeability transition. Biochim. Biophys. Acta 1241 (1995) 139-176
    • (1995) Biochim. Biophys. Acta , vol.1241 , pp. 139-176
    • Zoratti, M.1    Szabo, I.2
  • 128
    • 0037020667 scopus 로고    scopus 로고
    • New aspects of calcium signaling in skeletal muscle cells: implications in Duchenne muscular dystrophy
    • Gailly P. New aspects of calcium signaling in skeletal muscle cells: implications in Duchenne muscular dystrophy. Biochim. Biophys. Acta 1600 (2002) 38-44
    • (2002) Biochim. Biophys. Acta , vol.1600 , pp. 38-44
    • Gailly, P.1
  • 129
    • 33846958084 scopus 로고    scopus 로고
    • Intracellular calcium handling in ventricular myocytes from mdx mice
    • Williams I.A., and Allen D.G. Intracellular calcium handling in ventricular myocytes from mdx mice. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H846-H855
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Williams, I.A.1    Allen, D.G.2
  • 132
    • 30744439614 scopus 로고    scopus 로고
    • Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes
    • Vandebrouck A., Ducret T., Basset O., Sebille S., Raymond G., Ruegg U., et al. Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes. FASEB J. 20 (2006) 136-138
    • (2006) FASEB J. , vol.20 , pp. 136-138
    • Vandebrouck, A.1    Ducret, T.2    Basset, O.3    Sebille, S.4    Raymond, G.5    Ruegg, U.6
  • 133
    • 61949338001 scopus 로고    scopus 로고
    • Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
    • Bellinger A.M., Reiken S., Carlson C., Mongillo M., Liu X., Rothman L., et al. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat. Med. 15 (2009) 325-330
    • (2009) Nat. Med. , vol.15 , pp. 325-330
    • Bellinger, A.M.1    Reiken, S.2    Carlson, C.3    Mongillo, M.4    Liu, X.5    Rothman, L.6
  • 134
    • 0027340729 scopus 로고
    • 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria
    • 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262 (1993) 744-747
    • (1993) Science , vol.262 , pp. 744-747
    • Rizzuto, R.1    Brini, M.2    Murgia, M.3    Pozzan, T.4
  • 135
    • 0035801541 scopus 로고    scopus 로고
    • Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells
    • Robert V., Gurlini P., Tosello V., Nagai T., Miyawaki A., Di Lisa F., et al. Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells. EMBO J. 20 (2001) 4998-5007
    • (2001) EMBO J. , vol.20 , pp. 4998-5007
    • Robert, V.1    Gurlini, P.2    Tosello, V.3    Nagai, T.4    Miyawaki, A.5    Di Lisa, F.6
  • 139
    • 17144405644 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity
    • Fisher P.W., Salloum F., Das A., Hyder H., and Kukreja R.C. Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation 111 (2005) 1601-1610
    • (2005) Circulation , vol.111 , pp. 1601-1610
    • Fisher, P.W.1    Salloum, F.2    Das, A.3    Hyder, H.4    Kukreja, R.C.5
  • 140
    • 0036350615 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits
    • Ockaili R., Salloum F., Hawkins J., and Kukreja R.C. Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H1263-H1269
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283
    • Ockaili, R.1    Salloum, F.2    Hawkins, J.3    Kukreja, R.C.4
  • 141
    • 0037418950 scopus 로고    scopus 로고
    • Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart
    • Salloum F., Yin C., Xi L., and Kukreja R.C. Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. Circ. Res. 92 (2003) 595-597
    • (2003) Circ. Res. , vol.92 , pp. 595-597
    • Salloum, F.1    Yin, C.2    Xi, L.3    Kukreja, R.C.4
  • 142
    • 24044492874 scopus 로고    scopus 로고
    • Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria
    • Costa A.D., Garlid K.D., West I.C., Lincoln T.M., Downey J.M., Cohen M.V., et al. Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ. Res. 97 (2005) 329-336
    • (2005) Circ. Res. , vol.97 , pp. 329-336
    • Costa, A.D.1    Garlid, K.D.2    West, I.C.3    Lincoln, T.M.4    Downey, J.M.5    Cohen, M.V.6
  • 144
    • 66149148931 scopus 로고    scopus 로고
    • ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice
    • Das A., Salloum F.N., Xi L., Rao Y.J., and Kukreja R.C. ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. Am. J. Physiol. Heart Circ. Physiol. 296 (2009) H1236-H1243
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.296
    • Das, A.1    Salloum, F.N.2    Xi, L.3    Rao, Y.J.4    Kukreja, R.C.5
  • 145
    • 14644424693 scopus 로고    scopus 로고
    • Viagra: now mending hearts
    • Mendelsohn M.E. Viagra: now mending hearts. Nat. Med. 11 (2005) 115-116
    • (2005) Nat. Med. , vol.11 , pp. 115-116
    • Mendelsohn, M.E.1
  • 146
    • 0037233025 scopus 로고    scopus 로고
    • Signaling through NO and cGMP-dependent protein kinases
    • Schlossmann J., Feil R., and Hofmann F. Signaling through NO and cGMP-dependent protein kinases. Ann. Med. 35 (2003) 21-27
    • (2003) Ann. Med. , vol.35 , pp. 21-27
    • Schlossmann, J.1    Feil, R.2    Hofmann, F.3
  • 147
    • 0141841602 scopus 로고    scopus 로고
    • Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart
    • Yue Y., Li Z., Harper S.Q., Davisson R.L., Chamberlain J.S., and Duan D. Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart. Circulation 108 (2003) 1626-1632
    • (2003) Circulation , vol.108 , pp. 1626-1632
    • Yue, Y.1    Li, Z.2    Harper, S.Q.3    Davisson, R.L.4    Chamberlain, J.S.5    Duan, D.6
  • 148
    • 0036823499 scopus 로고    scopus 로고
    • The role of utrophin in the potential therapy of Duchenne muscular dystrophy
    • Perkins K.J., and Davies K.E. The role of utrophin in the potential therapy of Duchenne muscular dystrophy. Neuromuscul. Disord. 12 Suppl. 1 (2002) S78-S89
    • (2002) Neuromuscul. Disord. , vol.12 , Issue.SUPPL. 1
    • Perkins, K.J.1    Davies, K.E.2
  • 151
    • 34047145129 scopus 로고    scopus 로고
    • New approaches in the therapy of cardiomyopathy in muscular dystrophy
    • McNally E.M. New approaches in the therapy of cardiomyopathy in muscular dystrophy. Annu. Rev. Med. 58 (2007) 75-88
    • (2007) Annu. Rev. Med. , vol.58 , pp. 75-88
    • McNally, E.M.1
  • 153
    • 0028075423 scopus 로고
    • Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel
    • Connern C.P., and Halestrap A.P. Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem. J. 302 (1994) 321-324
    • (1994) Biochem. J. , vol.302 , pp. 321-324
    • Connern, C.P.1    Halestrap, A.P.2
  • 155
    • 0033565557 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore and its role in cell death
    • Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341 (1999) 233-249
    • (1999) Biochem. J. , vol.341 , pp. 233-249
    • Crompton, M.1
  • 156
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection
    • Halestrap A.P., Clarke S.J., and Javadov S.A. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc. Res. 61 (2004) 372-385
    • (2004) Cardiovasc. Res. , vol.61 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 157
    • 0032941253 scopus 로고    scopus 로고
    • Potential role of calcineurin for brain ischemia and traumatic injury
    • Morioka M., Hamada J., Ushio Y., and Miyamoto E. Potential role of calcineurin for brain ischemia and traumatic injury. Prog. Neurobiol. 58 (1999) 1-30
    • (1999) Prog. Neurobiol. , vol.58 , pp. 1-30
    • Morioka, M.1    Hamada, J.2    Ushio, Y.3    Miyamoto, E.4
  • 158
    • 0027462048 scopus 로고
    • Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart
    • Nishinaka Y., Sugiyama S., Yokota M., Saito H., and Ozawa T. Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart. J. Cardiovasc. Pharmacol. 21 (1993) 448-454
    • (1993) J. Cardiovasc. Pharmacol. , vol.21 , pp. 448-454
    • Nishinaka, Y.1    Sugiyama, S.2    Yokota, M.3    Saito, H.4    Ozawa, T.5
  • 160
    • 0024230749 scopus 로고
    • Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function
    • Backman E., Nylander E., Johansson I., Henriksson K.G., and Tagesson C. Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function. Acta Neurol. Scand. 78 (1988) 429-435
    • (1988) Acta Neurol. Scand. , vol.78 , pp. 429-435
    • Backman, E.1    Nylander, E.2    Johansson, I.3    Henriksson, K.G.4    Tagesson, C.5
  • 161
    • 34147152905 scopus 로고    scopus 로고
    • The role of free radicals in the pathophysiology of muscular dystrophy
    • Tidball J.G., and Wehling-Henricks M. The role of free radicals in the pathophysiology of muscular dystrophy. J. Appl. Physiol. 102 (2007) 1677-1686
    • (2007) J. Appl. Physiol. , vol.102 , pp. 1677-1686
    • Tidball, J.G.1    Wehling-Henricks, M.2
  • 162
    • 58149173164 scopus 로고    scopus 로고
    • Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance
    • Buyse G.M., Van der Mieren G., Erb M., D'Hooge J., Herijgers P., Verbeken E., et al. Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance. Eur. Heart J. 30 (2009) 116-124
    • (2009) Eur. Heart J. , vol.30 , pp. 116-124
    • Buyse, G.M.1    Van der Mieren, G.2    Erb, M.3    D'Hooge, J.4    Herijgers, P.5    Verbeken, E.6
  • 163
    • 21744450416 scopus 로고    scopus 로고
    • Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    • Adlam V.J., Harrison J.C., Porteous C.M., James A.M., Smith R.A., Murphy M.P., et al. Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J. 19 9 (2005) 1088-1095
    • (2005) FASEB J. , vol.19 , Issue.9 , pp. 1088-1095
    • Adlam, V.J.1    Harrison, J.C.2    Porteous, C.M.3    James, A.M.4    Smith, R.A.5    Murphy, M.P.6
  • 164
    • 0348136710 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
    • Jauslin M.L., Meier T., Smith R.A., and Murphy M.P. Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J. 17 (2003) 1972-1974
    • (2003) FASEB J. , vol.17 , pp. 1972-1974
    • Jauslin, M.L.1    Meier, T.2    Smith, R.A.3    Murphy, M.P.4
  • 166
    • 40749137005 scopus 로고    scopus 로고
    • Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy
    • Asai A., Sahani N., Kaneki M., Ouchi Y., Martyn J.A., and Yasuhara S.E. Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS ONE e806 (2007) 2
    • (2007) PLoS ONE , vol.e806 , pp. 2
    • Asai, A.1    Sahani, N.2    Kaneki, M.3    Ouchi, Y.4    Martyn, J.A.5    Yasuhara, S.E.6
  • 167
    • 33646069690 scopus 로고    scopus 로고
    • Dystrophin is a possible end-target of ischemic preconditioning against cardiomyocyte oncosis during the early phase of reperfusion
    • Kyoi S., Otani H., Hamano A., Matsuhisa S., Akita Y., Fujiwara H., et al. Dystrophin is a possible end-target of ischemic preconditioning against cardiomyocyte oncosis during the early phase of reperfusion. Cardiovasc. Res. 70 (2006) 354-363
    • (2006) Cardiovasc. Res. , vol.70 , pp. 354-363
    • Kyoi, S.1    Otani, H.2    Hamano, A.3    Matsuhisa, S.4    Akita, Y.5    Fujiwara, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.