Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy

PLoS ONE

Volumn 2, Issue 8, 2007, Pages

  Asai, Akihiro ^a,b   Sahani, Nita ^a   Kaneki, Masao ^a   Ouchi, Yasuyoshi ^b   Jeevendra Martyn, J A ^a   Yasuhara, Shingo Egusa ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; TADALAFIL; CARBOLINE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; ERYTHROCYTE; IN VIVO STUDY; MALE; MOUSE; MUSCLE FIBER CONTRACTION; MUSCLE ISCHEMIA; NONHUMAN; PATHOGENESIS; QUANTITATIVE STUDY; VASODILATATION; ANIMAL; ANIMAL MUSCULAR DYSTROPHY; BIOSYNTHESIS; DISEASE MODEL; DRUG ANTAGONISM; ENZYMOLOGY; ISCHEMIA; METABOLISM; MUSCLE CONTRACTION; TRANSGENIC MOUSE;

MURINAE; MUS;

ANIMALS; CARBOLINES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DISEASE MODELS, ANIMAL; HYDROGEN PEROXIDE; ISCHEMIA; MICE; MICE, TRANSGENIC; MUSCLE CONTRACTION; MUSCULAR DYSTROPHY, ANIMAL; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITORS;

EID: 40749137005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000806     Document Type: Article

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