Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of duchenne muscular dystrophy

Journal of Molecular and Cellular Cardiology

Volumn 31, Issue 10, 1999, Pages 1857-1862

  Bia, Britta L ^a   Cassidy, Paul J ^a   Young, Martin E ^a   Rafael, Jill A ^a   Leighton, Brendan ^a   Davies, Kay E ^a   Radda, George K ^a   Clarke, Kieran ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Conduction abnormalities; Duchenne muscular dystrophy; Electrocardiogram; Endothelial nitric oxide synthase; Inducible nitric oxide synthase; mdx mouse heart; Neuronal nitric oxide synthase

Indexed keywords

DYSTROPHIN; HEART ENZYME; NITRIC OXIDE SYNTHASE; UTROPHIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; ELECTROCARDIOGRAM; ENZYME ACTIVITY; HEART MUSCLE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0032852539     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1999.1018     Document Type: Article

References (18)

1. Bia BL, Rafael JA, Davies KE, Radda GK, Clarke K. Decreased nNOS and elevated iNOS in both dystrophin deficient and dystrophin/utrophin knockout mouse hearts (Abstract). Circulation. 98:1998;I-731.
2. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 351:1991;714-718.
3. Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell. 82:1995;743-752.
4. Bridges LR. The association of cardiac muscle necrosis and inflammation with the degenerative and persistent myopathy ofmdx mice. J Neurol Sci. 72:1986;147-157.
5. Buchwalow IB, Schulze W, Park J-K, Krause E-G, Paul M, Luft FC, Haller H. Subcellular localization of neuronal and inducible nitric oxide synthases in rat cardiomyocytes (Abstract). Circulation. 98:1998;I-732.
6. Byers TJ, Kunkel LM, Watkins SC. The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle. J Cell Biol. 115:1991;411-421.
7. Chénard AA, Bécane H-M, Tertrain F, de Kermadec J-M, Weiss YA. Ventricular arrhythmia in Duchenne muscular dystrophy: Prevalence, significance and prognosis. Neuromusc Disord. 3:1993;201-206.
8. Deconinck AE, Rafael JA, Skinner JA, Brown SC, Potter AC, Metzinger L, Watt DJ, Dickson JG, Tinsley JM, Davies KE. Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy. Cell. 90:1997;717-727.
9. Denlinger LC, Fisette PL, Garis KA, Kwon G, Vasquez-Torres A, Simon AD, Nguyen B, Proctor RA, Bertics PJ, Corbett JA. Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. J Biol Chem. 271:1996;337-342.
10. 2+is elevated at all ages. J Neurol Sci. 103:1991;226-231.
11. Lonart G, Wang J, Johnson KM. Nitric oxide induces neurotransmitter release from hippocampal slices. Eur J Pharmacol. 220:1992;271-272.
12. Michel T, Lamas S. Molecular cloning of constitutive endothelial nitric oxide synthase: evidence for a family of related genes. J Cardiovasc Pharmacol. 20 (Suppl. 12):1992;S45-S49.
13. Nigro G, Comi LI, Politano L, Bain RJI. The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy. Int J Cardiol. 26:1990;271-277.
14. Peri V, Ajdukovic B, Holland P, Tuana BS. Dystrophin predominantly localizes to the transverse tubule/Z-line regions of single ventricular myocytes and exhibits distinct associations with the membrane. Mol Cell Biochem. 130:1994;57-65.
15. Perloff JK, Roberts WC, de Leon AC, O'Doherty D. The distinctive electrocardiogram of Duchenne's progressive muscular dystrophy. Am J Med. 42:1967;179-188.
16. Sanyal SK, Johnson WW. Cardiac conduction abnormalities in children with Duchenne's progressive muscular dystrophy: electrocardiographic features and morphologic correlates. Circulation. 66:1982;853-863.
17. Sanyal SK, Johnson WW, Thapar MK, Pitner SE. An ultrastructural basis for electrocardiographic alterations associated with Duchenne's progressive muscular dystrophy. Circulation. 57:1978;1122-1129.
18. Slucka C. The electrocardiogram in Duchenne progressive muscular dystrophy. Circulation. 38:1968;933-940.