Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy

Journal of Molecular and Cellular Cardiology

Volumn 46, Issue 3, 2009, Pages 420-430

  Matas, Jimmy ^a   Tien Sing Young, Nicholas ^b   Bourcier Lucas, Céline ^a   Ascah, Alexis ^a   Marcil, Mariannick ^a   Deschepper, Christian F ^b   Burelle, Yan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Cyclophilin D; Heart failure; Hypertrophy; Oxidative stress; Permeability transition pore

Indexed keywords

CALCIUM ION; CYCLOPHILIN D; HYDROPEROXIDE; REACTIVE OXYGEN METABOLITE; TERTBUTYLHYDROPEROXYDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL STRESS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; IN VITRO STUDY; MALE; MEMBRANE BINDING; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RESPIRATORY FUNCTION;

ANIMALS; CARDIOMEGALY; CELL DEATH; CELL SURVIVAL; CYCLOPHILINS; CYCLOSPORINE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXYGEN CONSUMPTION; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL;

ANIMALIA;

EID: 59149099105     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2008.10.020     Document Type: Article

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