Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine

European Journal of Pharmacology

Volumn 629, Issue 1-3, 2010, Pages 132-139

  Geraets, Liesbeth ^a   Haegens, Astrid ^b   Weseler, Antje R ^a   Brauers, Karen ^a   Vernooy, Juanita H J ^b   Wouters, Emiel F M ^b   Bast, Aalt ^a   Hageman, Geja J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

1,7 dimethylxanthine; COPD; Cytokine; Inflammation; Poly(ADP ribose) polymerase 1; Pulmonary disease

Indexed keywords

3 AMINOBENZAMIDE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MYELOPEROXIDASE; PARAXANTHINE; SERUM AMYLOID P; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; EX VIVO STUDY; FEMALE; GENETIC TRANSCRIPTION; HUMAN; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY TRACT INFLAMMATION;

ADMINISTRATION, ORAL; AGED; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZAMIDES; CASE-CONTROL STUDIES; CYTOKINES; ENZYME INHIBITORS; FEMALE; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MIDDLE AGED; PEROXIDASE; PNEUMONIA; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; THEOPHYLLINE; TRANSCRIPTION, GENETIC;

EID: 74149084617     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.11.064     Document Type: Article

References (50)

1. Atzeni F., Sarzi-Puttini P., Doria A., Iaccarino L., and Capsoni F. Potential off-label use of infliximab in autoimmune and non-autoimmune diseases: a review. Autoimmun. Rev. 4 (2005) 144-152
2. Berthou F., Guillois B., Riche C., Dreano Y., Jacqz-Aigrain E., and Beaune P.H. Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes. Xenobiotica 22 (1992) 671-680
3. Boots A.W., Haenen G.R., and Bast A. Oxidant metabolism in chronic obstructive pulmonary disease. Eur. Respir. J. 46 (2003) 14s-27s
4. Boulares A.H., Zoltoski A.J., Sherif Z.A., Jolly P., Massaro D., and Smulson M.E. Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 28 (2003) 322-329
5. Buters J.T., Tang B.K., Pineau T., Gelboin H.V., Kimura S., and Gonzalez F.J. Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2. Pharmacogenetics 6 (1996) 291-296
6. Chiarugi A. Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Br. J. Pharmacol. 137 (2002) 761-770
7. Chiarugi A., and Moskowitz M.A. Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J. Neurochem. 85 (2003) 306-317
8. D′Amours D., Desnoyers S., D′Silva I., and Poirier G.G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J. 342 Pt 2 (1999) 249-268
9. Daly J.W. Caffeine analogs: biomedical impact. Cell. Mol. Life Sci. 64 (2007) 2153-2169
10. Fredholm B. Are methylxanthine effects due to antagonism of endogenous adenosine?. Trends Pharmacol. Sci. 1 (1979-1980) 129-132
11. Garcia Soriano F., Virag L., Jagtap P., Szabo E., Mabley J.G., Liaudet L., Marton A., Hoyt D.G., Murthy K.G., Salzman A.L., Southan G.J., and Szabo C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat. Med. 7 (2001) 108-113
12. Geraets L., Moonen H.J., Wouters E.F., Bast A., and Hageman G.J. Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. Biochem. Pharmacol. 72 (2006) 902-910
13. Goto S., Xue R., Sugo N., Sawada M., Blizzard K.K., Poitras M.F., Johns D.C., Dawson T.M., Dawson V.L., Crain B.J., Traystman R.J., Mori S., and Hurn P.D. Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. Stroke 33 (2002) 1101-1106
14. Ha H.C., Hester L.D., and Snyder S.H. Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 3270-3275
15. Haegens A., Heeringa P., van Suylen R.J., Steele C., Aratani Y., O′Donoghue R.J., Mutsaers S.E., Mossman B.T., Wouters E.F., and Vernooy J.H. Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production. J. Immunol. 182 (2009) 7990-7996
16. Hageman G.J., Larik I., Pennings H.J., Haenen G.R., Wouters E.F., and Bast A. Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. Free Radic. Biol. Med. 35 (2003) 140-148
17. Hasday J.D., Bascom R., Costa J.J., Fitzgerald T., and Dubin W. Bacterial endotoxin is an active component of cigarette smoke. Chest 115 (1999) 829-835
18. Hassa P.O., and Hottiger M.O. A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation. Biol. Chem. 380 (1999) 953-959
19. Jijon H.B., Churchill T., Malfair D., Wessler A., Jewell L.D., Parsons H.G., and Madsen K.L. Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 279 (2000) G641-G651
20. Kalow W., and Tang B.K. The use of caffeine for enzyme assays: a critical appraisal. Clin. Pharmacol. Ther. 53 (1993) 503-514
21. Keatings V.M., Collins P.D., Scott D.M., and Barnes P.J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am. J. Respir. Crit. Care Med. 153 (1996) 530-534
22. Kiefmann R., Heckel K., Dorger M., Schenkat S., Stoeckelhuber M., Wesierska-Gadek J., and Goetz A.E. Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment. Am. J. Physiol. Lung Cell. Mol. Physiol. 285 (2003) L996-L1005
23. Kiefmann R., Heckel K., Doerger M., Schenkat S., Kupatt C., Stoeckelhuber M., Wesierska-Gadek J., and Goetz A.E. Role of PARP on iNOS pathway during endotoxin-induced acute lung injury. Intensive Care Med. 30 (2004) 1421-1431
24. Klebanoff S.J. Myeloperoxidase. Proc. Assoc. Am. Physicians 111 (1999) 383-389
25. Lelo A., Miners J.O., Robson R., and Birkett D.J. Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines. Clin. Pharmacol. Ther. 39 (1986) 54-59
26. Liaudet L., Pacher P., Mabley J.G., Virag L., Soriano F.G., Hasko G., and Szabo C. Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. Am. J. Respir. Crit. Care Med. 165 (2002) 372-377
27. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001) 402-408
28. Michel O., Kips J., Duchateau J., Vertongen F., Robert L., Collet H., Pauwels R., and Sergysels R. Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care Med. 154 (1996) 1641-1646
29. Moonen H.J.J., Geraets L., Vaarhorst A., Wouters E.F.M., Bast A., and Hageman G.J. Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells. Biochem. Biophys. Res. Commun. 338 (2005) 1805-1810
30. Oka Y., Hasegawa N., Nakayama M., Murphy G.A., Sussman H.H., and Raffin T.A. Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model. J. Surg. Res. 81 (1999) 147-155
31. Oliver F.J., Menissier-de Murcia J., Nacci C., Decker P., Andriantsitohaina R., Muller S., de la Rubia G., Stoclet G.C., and de Murcia G. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. Embo J. 18 (1999) 4446-4454
32. Poirier G.G., de Murcia G., Jongstra-Bilen J., Niedergang C., and Mandel P. Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure. Proc. Natl. Acad. Sci. U.S.A. 79 (1982) 3423-3427
33. Reimold A.M. New indications for treatment of chronic inflammation by TNF-alpha blockade. Am. J. Med. Sci. 325 (2003) 75-92
34. Rennard S.I., Fogarty C., Kelsen S., Long W., Ramsdell J., Allison J., Mahler D., Saadeh C., Siler T., Snell P., Korenblat P., Smith W., Kaye M., Mandel M., Andrews C., Prabhu R., Donohue J.F., Watt R., Lo K.H., Schlenker-Herceg R., Barnathan E.S., and Murray J. The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175 (2007) 926-934
35. Schraufstatter I.U., Hinshaw D.B., Hyslop P.A., Spragg R.G., and Cochrane C.G. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest. 77 (1986) 1312-1320
36. Schwartz D.A., Thorne P.S., Yagla S.J., Burmeister L.F., Olenchock S.A., Watt J.L., and Quinn T.J. The role of endotoxin in grain dust-induced lung disease. Am. J. Respir. Crit. Care Med. 152 (1995) 603-608
37. Siegel S., and Castellan N.J. Nonparametric statistics for the behavioral sciences (1988), McGraw-Hill Book Co., Inc., New York
38. Smid T., Heederik D., Houba R., and Quanjer P.H. Dust- and endotoxin-related acute lung function changes and work-related symptoms in workers in the animal feed industry. Am. J. Ind. Med. 25 (1994) 877-888
39. Swennen E.L., Bast A., and Dagnelie P.C. Immunoregulatory effects of adenosine 5′-triphosphate on cytokine release from stimulated whole blood. Eur. J. Immunol. 35 (2005) 852-858
40. Swennen E.L., Coolen E.J., Arts I.C., Bast A., and Dagnelie P.C. Time-dependent effects of ATP and its degradation products on inflammatory markers in human blood ex vivo. Immunobiology 213 (2008) 389-397
41. Szabo C., Cuzzocrea S., Zingarelli B., O′Connor M., and Salzman A.L. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J. Clin. Invest. 100 (1997) 723-735
42. Szabo C., Lim L.H., Cuzzocrea S., Getting S.J., Zingarelli B., Flower R.J., Salzman A.L., and Perretti M. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. J. Exp. Med. 186 (1997) 1041-1049
43. Tang-Liu D.D., Williams R.L., and Riegelman S. Disposition of caffeine and its metabolites in man. J. Pharmacol. Exp. Ther. 224 (1983) 180-185
44. Uchida K., Takahashi S., Fujiwara K., Ueda K., Nakae D., Emi Y., Tsutsumi M., Shiraiwa K., Ohnishi T., and Konishi Y. Preventive effect of 3-aminobenzamide on the reduction of NAD levels in rat liver following administration of diethylnitrosamine. Jpn. J. Cancer Res. 79 (1988) 1094-1100
45. van der Vaart H., Koeter G.H., Postma D.S., Kauffman H.F., and ten Hacken N.H. First study of infliximab treatment in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 172 (2005) 465-469
46. van Helvoort H.A., Heijdra Y.F., and Dekhuijzen P.N. Systemic immunological response to exercise in patients with chronic obstructive pulmonary disease: what does it mean?. Respiration 73 (2006) 255-264
47. Veres B., Radnai B., Gallyas Jr. F., Varbiro G., Berente Z., Osz E., and Sumegi B. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J. Pharmacol. Exp. Ther. 310 (2004) 247-255
48. Vernooy J.H., Dentener M.A., van Suylen R.J., Buurman W.A., and Wouters E.F. Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-alpha and infiltrating neutrophils. Am. J. Respir. Cell. Mol. Biol. 24 (2001) 569-576
49. Wu B.N., Chen C.W., Liou S.F., Yeh J.L., Chung H.H., and Chen I.J. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G. Mol. Pharmacol. 70 (2006) 977-985
50. Zingarelli B., Hake P.W., O′Connor M., Denenberg A., Wong H.R., Kong S., and Aronow B.J. Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H1408-H1415