Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production

Journal of Immunology

Volumn 182, Issue 12, 2009, Pages 7990-7996

  Haegens, Astrid ^a   Heeringa, Peter ^b   Van Suylen, Robert Jan ^c   Steele, Chad ^d   Aratani, Yasuaki ^e   O'Donoghue, Robert J J ^f   Mutsaers, Steven E ^f   Mossman, Brooke T ^g   Wouters, Emiel F M ^a   Vernooy, Juanita H J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d University of Alabama at Birmingham   (United States)

^e YOKOHAMA CITY UNIVERSITY   (Japan)

^f Lung Institute of Western Australia   (Australia)

^g UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; RANTES; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; CYTOKINE; HEME OXYGENASE 1; MESSENGER RNA; PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL ISOLATION; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME DEFICIENCY; EXTRAVASATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; T LYMPHOCYTE; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL MOTION; CYTOLOGY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT;

ACUTE DISEASE; ANIMALS; CELL MOVEMENT; CYTOKINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PEROXIDASE; PNEUMONIA; RNA, MESSENGER;

EID: 67649201004     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0800377     Document Type: Article

References (16)

1. Weiland, J. E., W. B. Davis, J. F. Holter, J. R. Mohammed, P. M. Dorinsky, and J. E. Gadek. 1986. Lung neutrophils in the adult respiratory distress syndrome: clinical and pathophysiologic significance. Am. Rev. Respir. Dis. 133: 218-225. (Pubitemid 16123913)
2. Saleh, D., P. J. Barnes, and A. Giaid. 1997. Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 155: 1763-1769. (Pubitemid 27216690)
3. Cullen, M. R., and W. W. Merrill. 1992. Association between neutrophil concentration in bronchoalveolar lavage fluid and recent losses in diffusing capacity in men formerly exposed to asbestos. Chest 102: 682-687.
4. Hogg, J. C., F. Chu, S. Utokaparch, R. Woods, W. M. Elliott, L. Buzatu, R. M. Cherniack, R. M. Rogers, F. C. Sciurba, H. O. Coxson, and P. D. Pare. 2004. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350: 2645-2653.
5. Papi, A., C. M. Bellettato, F. Braccioni, M. Romagnoli, P. Casolari, G. Caramori, L. M. Fabbri, and S. L. Johnston. 2006. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am. J. Respir. Crit. Care Med. 173: 1114-1121. (Pubitemid 43726892)
6. Lau, D., H. Mollnau, J. P. Eiserich, B. A. Freeman, A. Daiber, U. M. Gehling, J. Brummer, V. Rudolph, T. Munzel, T. Heitzer, T. Meinertz, and S. Baldus. 2005. Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc. Natl. Acad. Sci. USA 102: 431-436.
7. Haegens, A., A. van der Vliet, K. J. Butnor, N. Heintz, D. Taatjes, D. Hemenway, P. Vacek, B. A. Freeman, S. L. Hazen, M. L. Brennan, and B. T. Mossman. 2005. Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice. Cancer Res. 65: 9670-9677.
8. Aratani, Y., H. Koyama, S. Nyui, K. Suzuki, F. Kura, and N. Maeda. 1999. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect. Immun. 67: 1828-1836. (Pubitemid 29144403)
9. Starcher, B., and I. Williams. 1989. A method for intratracheal instillation of endotoxin into the lungs of mice. Lab. Anim. 23: 234-240.
10. Sabo-Attwood, T., M. Ramos-Nino, J. Bond, K. J. Butnor, N. Heintz, A. D. Gruber, C. Steele, D. J. Taatjes, P. Vacek, and B. T. Mossman. 2005. Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. Am. J. Pathol. 167: 1243-1256. (Pubitemid 41541411)
11. Klebanoff, S. J. 1999. Myeloperoxidase. Proc. Assoc. Am. Physicians 111: 383-389.
12. Komatsu, J., H. Koyama, N. Maeda, and Y. Aratani. 2006. Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase. Inflamm. Res. 55: 200-206.
13. Vernooy, J. H., M. A. Dentener, R. J. van Suylen, W. A. Buurman, and E. F. Wouters. 2001. Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-αand infiltrating neutrophils. Am. J. Respir. Cell Mol. Biol. 24: 569-576.
14. Aratani, Y., F. Kura, H. Watanabe, H. Akagawa, Y. Takano, K. Suzuki, M. C. Dinauer, N. Maeda, and H. Koyama. 2002. Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus. Med. Mycol. 40: 557-563. (Pubitemid 36050146)
15. Aratani, Y., F. Kura, H. Watanabe, H. Akagawa, Y. Takano, A. Ishida-Okawara, K. Suzuki, N. Maeda, and H. Koyama. 2006. Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans. J. Med. Microbiol. 55: 1291-1299.
16. Zurawski, G., and J. E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15: 19-26. (Pubitemid 24035090)